JP2017530964A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017530964A5 JP2017530964A5 JP2017514844A JP2017514844A JP2017530964A5 JP 2017530964 A5 JP2017530964 A5 JP 2017530964A5 JP 2017514844 A JP2017514844 A JP 2017514844A JP 2017514844 A JP2017514844 A JP 2017514844A JP 2017530964 A5 JP2017530964 A5 JP 2017530964A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- chch
- pharmaceutical composition
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051760P | 2014-09-17 | 2014-09-17 | |
| US62/051,760 | 2014-09-17 | ||
| PCT/US2015/050275 WO2016044331A1 (en) | 2014-09-17 | 2015-09-15 | Bicyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530964A JP2017530964A (ja) | 2017-10-19 |
| JP2017530964A5 true JP2017530964A5 (Direct) | 2018-11-01 |
| JP6833677B2 JP6833677B2 (ja) | 2021-02-24 |
Family
ID=55454101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514844A Expired - Fee Related JP6833677B2 (ja) | 2014-09-17 | 2015-09-15 | 二環式化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10308609B2 (Direct) |
| EP (1) | EP3193855B1 (Direct) |
| JP (1) | JP6833677B2 (Direct) |
| KR (1) | KR20170048588A (Direct) |
| CN (1) | CN106999451B (Direct) |
| AR (1) | AR101905A1 (Direct) |
| CA (1) | CA2961605C (Direct) |
| TW (1) | TWI686376B (Direct) |
| WO (1) | WO2016044331A1 (Direct) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6506248B2 (ja) | 2013-03-14 | 2019-04-24 | ゾーン・ロイヤリティズ・アンド・マイルストーンズ・エルエルシー | 二環式鎮痛化合物 |
| US10189780B2 (en) | 2013-12-12 | 2019-01-29 | Zeno Royalties & Milestones, LLC | Bicyclic alkyl compounds and synthesis |
| US10654812B2 (en) | 2014-03-07 | 2020-05-19 | Recurium Ip Holdings Llc | Propellane derivates and synthesis |
| CA2961605C (en) | 2014-09-17 | 2023-01-10 | Kalyra Pharmaceuticals, Inc. | Bicyclic compounds |
| KR102443575B1 (ko) | 2015-07-06 | 2022-09-16 | 길리애드 사이언시즈, 인코포레이티드 | Cot 조정제 및 그의 사용 방법 |
| CN111094259B (zh) * | 2017-05-15 | 2023-08-11 | 里科瑞尔姆Ip控股有限责任公司 | 止痛化合物 |
| SG11202000532SA (en) | 2017-08-09 | 2020-02-27 | Denali Therapeutics Inc | Compounds, compositions and methods |
| EP4248965A3 (en) | 2017-09-01 | 2023-11-22 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| IL272875B2 (en) * | 2017-09-11 | 2023-10-01 | Recurium Ip Holdings Llc | Continuous flow processes for the preparation of bicyclic compounds |
| ES3013457T3 (en) * | 2018-01-10 | 2025-04-14 | Recurium Ip Holdings Llc | Benzamide compounds as bci inhibitors for the treatment of hiv |
| US11478461B2 (en) | 2018-04-19 | 2022-10-25 | Merck Sharp & Dohme Llc | [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| EP3810116B1 (en) * | 2018-05-31 | 2023-11-15 | Merck Sharp & Dohme LLC | Novel substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| TWI877136B (zh) | 2019-02-13 | 2025-03-21 | 美商戴納立製藥公司 | 化合物、組合物及方法 |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| US11718612B2 (en) | 2019-09-06 | 2023-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase I for the treatment of disease |
| IL291665B2 (en) | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| CN114981248A (zh) | 2019-11-26 | 2022-08-30 | 德州大学系统董事会 | 用于治疗疾病的受体相互作用蛋白激酶i的抑制剂 |
| US11655237B2 (en) | 2020-03-30 | 2023-05-23 | Gilead Sciences, Inc. | Solid forms of a Cot inhibitor compound |
| KR102850022B1 (ko) | 2020-04-02 | 2025-08-26 | 길리애드 사이언시즈, 인코포레이티드 | Cot 저해제 화합물의 제조 방법 |
| CN114349774B (zh) * | 2021-12-23 | 2024-06-04 | 凯美克(上海)医药科技有限公司 | 一种双环[1.1.1]戊基角位硼酸酯类化合物的制备方法 |
| CN115010593B (zh) * | 2022-07-15 | 2023-08-25 | 上海毕得医药科技股份有限公司 | 一种3-甲基双环[1.1.1]戊烷-1-羧酸的合成方法 |
| CN116082201B (zh) * | 2023-02-22 | 2024-06-21 | 浙江工业大学 | 一种氯代双环［1.1.1］戊胺衍生物的合成方法 |
| WO2026004939A1 (ja) * | 2024-06-28 | 2026-01-02 | キッセイ薬品工業株式会社 | ジ置換ビシクロ［１．１．１］ペンタン化合物 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL54795A (en) | 1978-05-26 | 1980-10-26 | Yeda Res & Dev | Analgesic compositions comprising substituted bicyclic and spiroaliphatic amines and certain novel compounds of these types |
| KR900701960A (ko) | 1988-06-03 | 1990-12-05 | 한스 마크 | [1,1,1]프로펠란을 기본으로하는 화합물 및 제조방법 |
| AU4743890A (en) | 1988-12-06 | 1990-06-26 | Upjohn Company, The | Antibacterial quinolone compounds |
| AU626949B2 (en) | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
| ATE272608T1 (de) | 1998-03-17 | 2004-08-15 | Pfizer Prod Inc | Bicyclo (2.2.1) heptane und verwandte verbindungen |
| AU3898000A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of neuropathic pain or fibromyalgia |
| DE10025946A1 (de) | 2000-05-26 | 2001-11-29 | Gruenenthal Gmbh | Wirkstoffkombination |
| WO2001091736A2 (en) | 2000-05-31 | 2001-12-06 | Warner-Lambert Company | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
| WO2005009421A2 (en) | 2003-07-28 | 2005-02-03 | Merz Pharma Gmbh & Co. Kgaa | The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity |
| GB0329693D0 (en) * | 2003-12-22 | 2004-01-28 | Pfizer Ltd | Compounds useful in therapy |
| CA2551038C (en) * | 2003-12-22 | 2010-04-27 | Pfizer Inc. | Triazole derivatives as vasopressin antagonists |
| US20060052370A1 (en) | 2004-08-24 | 2006-03-09 | Meyerson Laurence R | Methods and compositions for treating nociceptive pain |
| US7763607B2 (en) | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
| JP2008120797A (ja) | 2006-10-19 | 2008-05-29 | Dainippon Sumitomo Pharma Co Ltd | Ｎ−置換フェニルアセトアミド誘導体からなる医薬 |
| BRPI0720859A2 (pt) | 2006-12-27 | 2014-03-25 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona substituídos com cicloalquilamina |
| KR20090116789A (ko) | 2007-02-06 | 2009-11-11 | 화이자 인코포레이티드 | 암을 치료하기 위한 ｈｓｐ-90 억제제로서의 2-아미노-5,7-다이하이드로-6ｈ-피롤로[3,4-ｄ]피리미딘 유도체 |
| KR101565469B1 (ko) | 2007-10-01 | 2015-11-03 | 코멘티스, 인코포레이티드 | 알츠하이머병의 치료를 위한 알파 7 니코틴 아세틸콜린 수용체 리간드로서 퀴누클리딘-4-일메틸 1ｈ-인돌-3-카르복실레이트 유도체 |
| WO2009153720A1 (en) * | 2008-06-18 | 2009-12-23 | Pfizer Limited | Nicotinamide derivatives |
| WO2011035159A1 (en) | 2009-09-18 | 2011-03-24 | Zalicus Pharmaceuticals Ltd. | Aryl sulphone derivatives as calcium channel blockers |
| AU2011271429B2 (en) | 2010-06-30 | 2016-04-21 | Upsher-Smith Laboratories, Llc | Sustained release composition comprising an amine as active agent and a salt of a cyclic organic acid |
| EP2624698A4 (en) | 2010-10-08 | 2014-10-08 | Abbvie Inc | Furo [3,2-D] PYRIMIDINE COMPOUNDS |
| TW201305178A (zh) | 2010-10-29 | 2013-02-01 | Glenmark Pharmaceuticals Sa | 作為ｍＰＧＥＳ－１抑制物的三環化合物 |
| ES2581848T3 (es) * | 2011-04-05 | 2016-09-07 | Pfizer Limited | Derivados de pirrolo[2,3-d]pirimidina como inhibidores de quinasas relacionadas con tropomiosina |
| PT2699576E (pt) | 2011-04-22 | 2016-03-09 | Pfizer | Derivados de pirazoloespirocetona para utilização como inibidores de acetil-coa carboxilase |
| KR101962488B1 (ko) | 2011-04-22 | 2019-03-26 | 시그날 파마소티칼 엘엘씨 | 치환된 디아미노카르복스아미드 및 디아미노카르보니트릴 피리미딘, 그의 조성물, 및 그를 사용하는 치료 방법 |
| RU2632870C2 (ru) | 2011-08-12 | 2017-10-11 | Ниссан Кемикал Индастриз, Лтд. | Трициклические гетероциклические соединения и ингибиторы jak |
| US9326973B2 (en) * | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2013126856A1 (en) | 2012-02-23 | 2013-08-29 | Vanderbilt University | Substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| WO2013131018A1 (en) | 2012-03-02 | 2013-09-06 | Zalicus Pharmaceuticals Ltd. | Biaryl inhibitors of the sodium channel |
| KR20150013147A (ko) | 2012-04-27 | 2015-02-04 | 니폰 조키 세야쿠 가부시키가이샤 | 진통제 |
| SG11201503065PA (en) | 2012-10-30 | 2015-05-28 | Gilead Sciences Inc | Therapeutic and diagnostic methods related to lysyl oxidase-like 2 (loxl2) |
| JP6506248B2 (ja) | 2013-03-14 | 2019-04-24 | ゾーン・ロイヤリティズ・アンド・マイルストーンズ・エルエルシー | 二環式鎮痛化合物 |
| US20160076098A1 (en) | 2013-04-12 | 2016-03-17 | Drexel University | Methods of diagnosing and treating chronic pain |
| DK3013805T3 (en) | 2013-06-28 | 2018-04-23 | Evotec Int Gmbh | Sulfoximine-substituted quinazolines and their use as MNK1 and / or MNK2 kinase inhibitors |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| HRP20191430T1 (hr) | 2013-10-21 | 2019-11-01 | Merck Patent Gmbh | Spojevi heteroarila kao inhibitori btk i njihove uporabe |
| CN103588668A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 化合物 |
| CN103588672A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 一种治疗癌性疼痛的药物 |
| US10189780B2 (en) | 2013-12-12 | 2019-01-29 | Zeno Royalties & Milestones, LLC | Bicyclic alkyl compounds and synthesis |
| WO2015095679A1 (en) | 2013-12-20 | 2015-06-25 | Signal Pharmaceuticals, Llc | Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith |
| US10654812B2 (en) | 2014-03-07 | 2020-05-19 | Recurium Ip Holdings Llc | Propellane derivates and synthesis |
| US9603850B2 (en) | 2014-04-11 | 2017-03-28 | The University Of North Carolina At Chapel Hill | MerTK-specific pyrazolopyrimidine compounds |
| US20170197939A1 (en) | 2014-04-15 | 2017-07-13 | Pfizer Inc. | Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety |
| WO2015162459A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| EP3174859B1 (en) | 2014-07-31 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Flt3 receptor antagonists |
| CA2961605C (en) | 2014-09-17 | 2023-01-10 | Kalyra Pharmaceuticals, Inc. | Bicyclic compounds |
| CN107849053B (zh) * | 2015-04-03 | 2020-10-30 | 里科瑞尔姆Ip控股有限责任公司 | 螺环化合物 |
| WO2017160926A1 (en) | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Analgesic compounds |
-
2015
- 2015-09-15 CA CA2961605A patent/CA2961605C/en active Active
- 2015-09-15 WO PCT/US2015/050275 patent/WO2016044331A1/en not_active Ceased
- 2015-09-15 US US14/855,102 patent/US10308609B2/en active Active
- 2015-09-15 CN CN201580061363.9A patent/CN106999451B/zh not_active Expired - Fee Related
- 2015-09-15 JP JP2017514844A patent/JP6833677B2/ja not_active Expired - Fee Related
- 2015-09-15 EP EP15842230.3A patent/EP3193855B1/en active Active
- 2015-09-15 KR KR1020177009800A patent/KR20170048588A/ko not_active Ceased
- 2015-09-16 TW TW104130651A patent/TWI686376B/zh not_active IP Right Cessation
- 2015-09-17 AR ARP150102980A patent/AR101905A1/es not_active Application Discontinuation
-
2019
- 2019-04-09 US US16/379,487 patent/US10975035B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017530964A5 (Direct) | ||
| JP2013541567A5 (Direct) | ||
| NZ612837A (en) | A combination of an opioid agonist and an opioid antagonist in the treatment of parkinson’s disease | |
| JP2008534564A5 (Direct) | ||
| JP2017525753A5 (Direct) | ||
| AR095160A1 (es) | Formulaciones farmacéuticas a prueba de alteraciones | |
| JP2005530798A5 (Direct) | ||
| JP2014507445A5 (Direct) | ||
| JP2012519675A5 (Direct) | ||
| AR089130A1 (es) | FORMAS DE DOSIS FARMACEUTICA QUE COMPRENDEN POLI(e-CAPROLACTONA) Y OXIDO DE POLIETILENO | |
| JP2010511717A5 (Direct) | ||
| JP2011137020A5 (Direct) | ||
| JP2010511683A5 (Direct) | ||
| CA2547334A1 (en) | Methods and compositions for deterring abuse of opioid containing dosage forms | |
| JP2014088422A5 (Direct) | ||
| JP2009167214A5 (Direct) | ||
| JP2015521988A5 (Direct) | ||
| CN111836807A (zh) | 氧杂螺环类化合物及其制备方法和用途 | |
| NZ603170A (en) | Combination of active loaded granules with additional actives | |
| RU2009101082A (ru) | Фармацевтические композиции | |
| RU2009125597A (ru) | Пролекарства и способы их получения и применения | |
| JP2008525321A5 (Direct) | ||
| RU2019139286A (ru) | Фармацевтический состав | |
| JP2014510094A5 (Direct) | ||
| JP2017517565A5 (Direct) |