JP2017530943A5 - - Google Patents
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- Publication number
- JP2017530943A5 JP2017530943A5 JP2017506931A JP2017506931A JP2017530943A5 JP 2017530943 A5 JP2017530943 A5 JP 2017530943A5 JP 2017506931 A JP2017506931 A JP 2017506931A JP 2017506931 A JP2017506931 A JP 2017506931A JP 2017530943 A5 JP2017530943 A5 JP 2017530943A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- hydrocarbyl
- hydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000004678 hydrides Chemical class 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000001145 hydrido group Chemical group *[H] 0.000 claims 3
- 150000001540 azides Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000852 azido group Chemical class *N=[N+]=[N-] 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- NQMWSLIHWDKBNB-UHXSJXRISA-N CC(/C=C\C(\CCOc1cc(C(NCc(cc2)ccc2Cl)=O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=C/C)O Chemical compound CC(/C=C\C(\CCOc1cc(C(NCc(cc2)ccc2Cl)=O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=C/C)O NQMWSLIHWDKBNB-UHXSJXRISA-N 0.000 description 1
- UDONUCIRFUXGIS-UHFFFAOYSA-N CC(C)(CC(NC(c(cc1OCCc(cc2)ccc2O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=O)[IH]C)Cc(cc1)ccc1F Chemical compound CC(C)(CC(NC(c(cc1OCCc(cc2)ccc2O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=O)[IH]C)Cc(cc1)ccc1F UDONUCIRFUXGIS-UHFFFAOYSA-N 0.000 description 1
- 0 CC(C*(C)Cc1ccccc1)NC(c(cc1OCCc(cc2)ccc2O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=O Chemical compound CC(C*(C)Cc1ccccc1)NC(c(cc1OCCc(cc2)ccc2O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=O 0.000 description 1
- AMMBMVABWQUVRF-UHFFFAOYSA-N Oc1ccc(CCOc2cc(C(NCCc3cc(Cl)ccc3)=O)ccc2NC(c2cc(cccc3)c3[o]2)=O)cc1 Chemical compound Oc1ccc(CCOc2cc(C(NCCc3cc(Cl)ccc3)=O)ccc2NC(c2cc(cccc3)c3[o]2)=O)cc1 AMMBMVABWQUVRF-UHFFFAOYSA-N 0.000 description 1
- MIRCOJZCTWWZPT-UHFFFAOYSA-N Oc1ccc(CCOc2cc(C(NCc3cc(F)ccc3)=O)ccc2NC(c2cc(cccc3)c3[o]2)=O)cc1 Chemical compound Oc1ccc(CCOc2cc(C(NCc3cc(F)ccc3)=O)ccc2NC(c2cc(cccc3)c3[o]2)=O)cc1 MIRCOJZCTWWZPT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462033918P | 2014-08-06 | 2014-08-06 | |
| US62/033,918 | 2014-08-06 | ||
| PCT/US2015/043830 WO2016022700A2 (en) | 2014-08-06 | 2015-08-05 | Tlr-independent small molecule adjuvants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530943A JP2017530943A (ja) | 2017-10-19 |
| JP2017530943A5 true JP2017530943A5 (enExample) | 2017-12-14 |
| JP6353159B2 JP6353159B2 (ja) | 2018-07-04 |
Family
ID=55264758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506931A Active JP6353159B2 (ja) | 2014-08-06 | 2015-08-05 | Ｔｌｒ非依存性低分子アジュバント |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9918959B2 (enExample) |
| EP (1) | EP3177601B1 (enExample) |
| JP (1) | JP6353159B2 (enExample) |
| AU (1) | AU2015301100B2 (enExample) |
| CA (1) | CA2957372C (enExample) |
| ES (1) | ES2944541T3 (enExample) |
| WO (1) | WO2016022700A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6964298B2 (ja) * | 2016-06-29 | 2021-11-10 | ザ スクリプス リサーチ インスティテュート | ジプロボシム：新規かつ強力なクラスのｔｌｒアゴニスト |
| EP3829571B1 (en) * | 2018-08-02 | 2025-04-09 | The Board Of Regents Of The University Of Texas System | Adjuvant effect of the tlr1/2 agonist diprovocim synergizes with checkpoint-inhibiting antibodies to eliminate cancerous or infectious diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101304748A (zh) | 2005-08-22 | 2008-11-12 | 加利福尼亚大学董事会 | Tlr激动剂 |
| HUE025555T2 (en) | 2007-02-07 | 2016-02-29 | Univ California | Conjugates and applications of synthetic tlr agonists |
| WO2008112938A2 (en) * | 2007-03-13 | 2008-09-18 | New England Medical Center Hospitals, Inc. | Composition and method for the treatment of diseases affected by a peptide receptor |
| PL2268618T3 (pl) * | 2008-03-03 | 2015-11-30 | Novartis Ag | Związki i kompozycje jako modulatory aktywności receptorów TLR |
-
2015
- 2015-08-05 WO PCT/US2015/043830 patent/WO2016022700A2/en not_active Ceased
- 2015-08-05 ES ES15830729T patent/ES2944541T3/es active Active
- 2015-08-05 AU AU2015301100A patent/AU2015301100B2/en active Active
- 2015-08-05 CA CA2957372A patent/CA2957372C/en active Active
- 2015-08-05 US US15/502,117 patent/US9918959B2/en active Active
- 2015-08-05 JP JP2017506931A patent/JP6353159B2/ja active Active
- 2015-08-05 EP EP15830729.8A patent/EP3177601B1/en active Active