JP2017530143A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017530143A5 JP2017530143A5 JP2017517262A JP2017517262A JP2017530143A5 JP 2017530143 A5 JP2017530143 A5 JP 2017530143A5 JP 2017517262 A JP2017517262 A JP 2017517262A JP 2017517262 A JP2017517262 A JP 2017517262A JP 2017530143 A5 JP2017530143 A5 JP 2017530143A5
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- cancer
- pharmaceutically acceptable
- dispersible
- amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003826 tablet Substances 0.000 claims description 49
- 239000007919 dispersible tablet Substances 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 22
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 21
- 239000000654 additive Substances 0.000 claims description 19
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 15
- OAWXZFGKDDFTGS-BYPYZUCNSA-N (2s)-pyrrolidine-1,2-dicarboxylic acid Chemical compound OC(=O)[C@@H]1CCCN1C(O)=O OAWXZFGKDDFTGS-BYPYZUCNSA-N 0.000 claims description 14
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 210000000481 breast Anatomy 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000001506 calcium phosphate Substances 0.000 claims description 11
- 230000002062 proliferating effect Effects 0.000 claims description 11
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 11
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 11
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 11
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 11
- 208000035269 cancer or benign tumor Diseases 0.000 claims description 10
- 239000007884 disintegrant Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 201000001441 melanoma Diseases 0.000 claims description 10
- 230000000996 additive effect Effects 0.000 claims description 9
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 9
- 239000004376 Sucralose Substances 0.000 claims description 8
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 8
- 239000000314 lubricant Substances 0.000 claims description 8
- 235000019408 sucralose Nutrition 0.000 claims description 8
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 8
- -1 2,2,2-trifluoro-1,1-dimethyl-ethyl Chemical group 0.000 claims description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 6
- 239000006185 dispersion Substances 0.000 claims description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 6
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 6
- 239000008109 sodium starch glycolate Substances 0.000 claims description 6
- 229920003109 sodium starch glycolate Polymers 0.000 claims description 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 5
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 5
- 206010004146 Basal cell carcinoma Diseases 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 5
- 206010048832 Colon adenoma Diseases 0.000 claims description 5
- 206010009944 Colon cancer Diseases 0.000 claims description 5
- 208000012609 Cowden disease Diseases 0.000 claims description 5
- 201000002847 Cowden syndrome Diseases 0.000 claims description 5
- 206010014733 Endometrial cancer Diseases 0.000 claims description 5
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 5
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 5
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims description 5
- 208000032612 Glial tumor Diseases 0.000 claims description 5
- 206010018338 Glioma Diseases 0.000 claims description 5
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims description 5
- 206010025323 Lymphomas Diseases 0.000 claims description 5
- 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 claims description 5
- 208000034578 Multiple myelomas Diseases 0.000 claims description 5
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 5
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 5
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 5
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 5
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 5
- 206010039491 Sarcoma Diseases 0.000 claims description 5
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 5
- 210000001015 abdomen Anatomy 0.000 claims description 5
- 208000009621 actinic keratosis Diseases 0.000 claims description 5
- 210000004100 adrenal gland Anatomy 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 5
- 210000004556 brain Anatomy 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 210000003679 cervix uteri Anatomy 0.000 claims description 5
- 210000001072 colon Anatomy 0.000 claims description 5
- 208000029742 colonic neoplasm Diseases 0.000 claims description 5
- 201000002758 colorectal adenoma Diseases 0.000 claims description 5
- 201000004101 esophageal cancer Diseases 0.000 claims description 5
- 206010017758 gastric cancer Diseases 0.000 claims description 5
- 230000002496 gastric effect Effects 0.000 claims description 5
- 208000005017 glioblastoma Diseases 0.000 claims description 5
- 201000010536 head and neck cancer Diseases 0.000 claims description 5
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 5
- 210000003494 hepatocyte Anatomy 0.000 claims description 5
- 210000003228 intrahepatic bile duct Anatomy 0.000 claims description 5
- 210000003734 kidney Anatomy 0.000 claims description 5
- 210000000244 kidney pelvis Anatomy 0.000 claims description 5
- 210000000867 larynx Anatomy 0.000 claims description 5
- 208000032839 leukemia Diseases 0.000 claims description 5
- 210000004185 liver Anatomy 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 5
- 208000003747 lymphoid leukemia Diseases 0.000 claims description 5
- 208000025113 myeloid leukemia Diseases 0.000 claims description 5
- 210000000496 pancreas Anatomy 0.000 claims description 5
- 210000003800 pharynx Anatomy 0.000 claims description 5
- 208000003476 primary myelofibrosis Diseases 0.000 claims description 5
- 210000002307 prostate Anatomy 0.000 claims description 5
- 206010038038 rectal cancer Diseases 0.000 claims description 5
- 201000001275 rectum cancer Diseases 0.000 claims description 5
- 201000002314 small intestine cancer Diseases 0.000 claims description 5
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 5
- 201000011549 stomach cancer Diseases 0.000 claims description 5
- 210000001685 thyroid gland Anatomy 0.000 claims description 5
- 210000003932 urinary bladder Anatomy 0.000 claims description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 210000000621 bronchi Anatomy 0.000 claims description 4
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical group CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 239000005913 Maltodextrin Substances 0.000 claims description 2
- 229920002774 Maltodextrin Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 229960001375 lactose Drugs 0.000 claims description 2
- 239000000845 maltitol Substances 0.000 claims description 2
- 235000010449 maltitol Nutrition 0.000 claims description 2
- 229940035436 maltitol Drugs 0.000 claims description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 2
- 229940035034 maltodextrin Drugs 0.000 claims description 2
- 229960001855 mannitol Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 229940032147 starch Drugs 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 239000006068 taste-masking agent Substances 0.000 claims description 2
- 238000005550 wet granulation Methods 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 208000017733 acquired polycythemia vera Diseases 0.000 claims 2
- 150000004683 dihydrates Chemical class 0.000 claims 2
- 208000037244 polycythemia vera Diseases 0.000 claims 2
- 210000001215 vagina Anatomy 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 201000010700 sporadic breast cancer Diseases 0.000 description 3
- 208000023516 stroke disease Diseases 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462059331P | 2014-10-03 | 2014-10-03 | |
| US62/059,331 | 2014-10-03 | ||
| PCT/IB2015/057523 WO2016051374A1 (en) | 2014-10-03 | 2015-10-01 | Pharmaceutical compositions comprising alpelisib |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530143A JP2017530143A (ja) | 2017-10-12 |
| JP2017530143A5 true JP2017530143A5 (enExample) | 2018-11-08 |
| JP6723229B2 JP6723229B2 (ja) | 2020-07-15 |
Family
ID=54292871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017517262A Active JP6723229B2 (ja) | 2014-10-03 | 2015-10-01 | アルペリシブを含む医薬組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20170296523A1 (enExample) |
| EP (2) | EP3200772B1 (enExample) |
| JP (1) | JP6723229B2 (enExample) |
| KR (2) | KR102598782B1 (enExample) |
| CN (2) | CN107106497A (enExample) |
| AU (1) | AU2015326392B2 (enExample) |
| BR (1) | BR112017004694A2 (enExample) |
| CA (1) | CA2962714C (enExample) |
| ES (1) | ES2929554T3 (enExample) |
| MX (1) | MX2017004359A (enExample) |
| PL (1) | PL3200772T3 (enExample) |
| PT (1) | PT3200772T (enExample) |
| RU (1) | RU2690685C2 (enExample) |
| WO (1) | WO2016051374A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919957A (zh) * | 2016-06-13 | 2016-09-07 | 佛山市腾瑞医药科技有限公司 | 一种艾代拉利司分散片及其制备方法 |
| ES2923412T3 (es) | 2018-09-07 | 2022-09-27 | Sanofi Sa | Sales de 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxilato de metilo y proceso de preparación de las mismas |
| JP7680438B2 (ja) | 2019-10-01 | 2025-05-20 | サノフイ | 新規の置換６，７－ジヒドロ－５ｈ－ベンゾ［７］アンヌレン化合物、その製造方法およびその治療的使用 |
| BR112022009705A2 (pt) | 2019-12-09 | 2022-08-09 | Sanofi Sa | Forma cristalina anidra de um derivado de ácido 7h-benzo[7]anuleno-2-carboxílico, seus usos e processos de preparação, forma sólida, medicamento e composição farmacêutica |
| TW202146007A (zh) | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 |
| US12595230B2 (en) | 2020-10-19 | 2026-04-07 | Sanofi | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof |
| AU2021366223A1 (en) | 2020-10-19 | 2023-06-22 | Sanofi | Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof |
| AU2022232924A1 (en) * | 2021-03-11 | 2023-07-06 | Atossa Therapeutics, Inc. | Endoxifen for treatment of ovarian cancer |
| CN117279627A (zh) * | 2021-05-03 | 2023-12-22 | 诺华股份有限公司 | 阿培利司配制品 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| ES2082723B1 (es) * | 1994-07-20 | 1996-10-01 | Lilly Sa | Formulacion farmaceutica de fluoxetina en forma dispersable. |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| WO2011080502A2 (en) * | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
| AR082418A1 (es) * | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
| US20140066474A1 (en) * | 2011-04-25 | 2014-03-06 | Novartis Ag | Combination of phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
| WO2012170488A1 (en) * | 2011-06-07 | 2012-12-13 | Zx Pharma, Llc | Multiparticulate s-adenosylmethionine compositions and related methods |
| RU2014101626A (ru) * | 2011-06-21 | 2015-07-27 | Новартис Аг | Полиморфы 2-амид 1-({4-метил-5-[2-(2, 2, 2-трифтор-1, 1-диметил-этил)-пиридин-4-ил]тиазол-2-ил}амида) (s)-пирролидин-1, 2-дикарбоновой кислоты |
| KR20140138771A (ko) * | 2012-03-29 | 2014-12-04 | 노파르티스 아게 | 제약학적 진단법 |
| BR112014026292B1 (pt) * | 2012-04-24 | 2022-09-27 | Daiichi Sankyo Company, Limited | Comprimido oralmente desintegrável, e, processo para a produção de um comprimido oralmente desintegrável |
| WO2014007780A1 (en) * | 2012-07-06 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally-disintegrating formulations of dexketoprofen |
| EP2742940B1 (en) * | 2012-12-13 | 2017-07-26 | IP Gesellschaft für Management mbH | Fumarate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane for adminstration once daily, twice daily or thrice daily |
-
2015
- 2015-10-01 KR KR1020237000178A patent/KR102598782B1/ko active Active
- 2015-10-01 PL PL15778761.5T patent/PL3200772T3/pl unknown
- 2015-10-01 MX MX2017004359A patent/MX2017004359A/es unknown
- 2015-10-01 KR KR1020177008575A patent/KR102486126B1/ko active Active
- 2015-10-01 CA CA2962714A patent/CA2962714C/en active Active
- 2015-10-01 ES ES15778761T patent/ES2929554T3/es active Active
- 2015-10-01 RU RU2017114195A patent/RU2690685C2/ru active
- 2015-10-01 WO PCT/IB2015/057523 patent/WO2016051374A1/en not_active Ceased
- 2015-10-01 EP EP15778761.5A patent/EP3200772B1/en active Active
- 2015-10-01 BR BR112017004694A patent/BR112017004694A2/pt not_active Application Discontinuation
- 2015-10-01 CN CN201580054000.2A patent/CN107106497A/zh active Pending
- 2015-10-01 JP JP2017517262A patent/JP6723229B2/ja active Active
- 2015-10-01 CN CN202110187770.1A patent/CN112957334B/zh active Active
- 2015-10-01 AU AU2015326392A patent/AU2015326392B2/en active Active
- 2015-10-01 EP EP22187029.8A patent/EP4169508B1/en active Active
- 2015-10-01 US US15/515,621 patent/US20170296523A1/en not_active Abandoned
- 2015-10-01 PT PT157787615T patent/PT3200772T/pt unknown
-
2019
- 2019-04-15 US US16/363,004 patent/US20190314353A1/en not_active Abandoned
-
2022
- 2022-06-29 US US17/853,537 patent/US20220331305A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2017114195A (ru) | Фармацевтические композиции, содержащие алпелисиб | |
| CN106456626B (zh) | 喹啉衍生物用于治疗软组织肉瘤的方法和用途以及用于治疗软组织肉瘤的药物组合物 | |
| KR102490547B1 (ko) | 퀴놀린 유도체로 갑상선암을 치료하기 위한 방법과 용도 및 갑상선암을 치료하기 위한 약학적 조성물 | |
| CN115624550B (zh) | 一种用于治疗胃癌的喹啉衍生物 | |
| JP2017537126A (ja) | 非小細胞肺癌に対するキノリン誘導体 | |
| JP7374885B2 (ja) | 子宮内膜症、子宮筋腫、多嚢胞性卵巣症候群又は腺筋症を治療するための医薬製剤 | |
| JP6220485B2 (ja) | コロイドビスマスペクチンを含有する分散製剤及びその製造方法 | |
| CN104755463A (zh) | 非晶态形式的喹啉衍生物及其生产方法 | |
| CN114767680A (zh) | 治疗非小细胞肺癌的喹啉衍生物 | |
| JP2022521683A (ja) | 過剰増殖性疾患の治療における使用のためのａｔｒキナーゼ阻害剤ｂａｙ１８９５３４４ | |
| CN115279347A (zh) | Ahr抑制剂和其用途 | |
| JP2016079102A (ja) | ソリフェナシン含有製剤 | |
| CN102488681A (zh) | 布洛芬苯海拉明口腔崩解片及其制备方法 | |
| JP2015533165A (ja) | 組み合わせ | |
| JP7583729B2 (ja) | 経口投与されるジオキソランヌクレオチドを抗ｐｄ１又は抗ｐｄｌ１モノクローナル抗体と組み合わせて用いる肝臓がんの治療法 | |
| KR101567937B1 (ko) | 안정성이 개선된 다층 고형 제제 | |
| KR101601794B1 (ko) | 클로미프라민 함유 맛 차폐된 구강 투여용 약학 제제 | |
| CN103585125B (zh) | 一种甲磺酸卡莫司他口崩片及其制备方法和其新应用 | |
| KR102744499B1 (ko) | 비인두암을 치료하기 위한 퀴놀린 유도체 | |
| CN102846571A (zh) | 一种埃索美拉唑镁微型片剂 | |
| JP2016098190A (ja) | テルミサルタンを含む経口医薬組成物 | |
| CN103349652A (zh) | 含有四氢萘酰胺化合物或其可药用盐的高药物载荷片剂 | |
| TW201521792A (zh) | ＰＩ３Ｋα抑制劑之錠劑調配物 | |
| WO2016080357A1 (ja) | 口腔内崩壊錠の製造方法 | |
| KR20230137321A (ko) | 소아암 치료용 의약 조성물 |