JP2017527299A5 - - Google Patents

Download PDF

Info

Publication number
JP2017527299A5
JP2017527299A5 JP2017514828A JP2017514828A JP2017527299A5 JP 2017527299 A5 JP2017527299 A5 JP 2017527299A5 JP 2017514828 A JP2017514828 A JP 2017514828A JP 2017514828 A JP2017514828 A JP 2017514828A JP 2017527299 A5 JP2017527299 A5 JP 2017527299A5
Authority
JP
Japan
Prior art keywords
curved
inlet
microfluidic system
microchannel
outlets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017514828A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017527299A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/050604 external-priority patent/WO2016044537A1/en
Publication of JP2017527299A publication Critical patent/JP2017527299A/ja
Publication of JP2017527299A5 publication Critical patent/JP2017527299A5/ja
Pending legal-status Critical Current

Links

JP2017514828A 2014-09-17 2015-09-17 灌流バイオリアクター細胞保持のためのマイクロ流体システム及び方法 Pending JP2017527299A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051497P 2014-09-17 2014-09-17
US62/051,497 2014-09-17
PCT/US2015/050604 WO2016044537A1 (en) 2014-09-17 2015-09-17 Microfluidic system and method for perfusion bioreactor cell retention

Publications (2)

Publication Number Publication Date
JP2017527299A JP2017527299A (ja) 2017-09-21
JP2017527299A5 true JP2017527299A5 (enExample) 2018-10-25

Family

ID=55533830

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017514828A Pending JP2017527299A (ja) 2014-09-17 2015-09-17 灌流バイオリアクター細胞保持のためのマイクロ流体システム及び方法

Country Status (5)

Country Link
US (1) US20170292104A1 (enExample)
EP (1) EP3194560A4 (enExample)
JP (1) JP2017527299A (enExample)
CN (1) CN107250341A (enExample)
WO (1) WO2016044537A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3628401B1 (en) 2012-09-21 2021-06-23 Massachusetts Institute Of Technology Micro-fluidic device and uses thereof
SG11201606832YA (en) 2014-02-18 2016-09-29 Massachusetts Inst Technology Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs)
WO2016044555A1 (en) 2014-09-17 2016-03-24 Massachusetts Institute Of Technology System and method for inertial focusing microfiltration for intra-operative blood salvage autotransfusion
JP6912161B2 (ja) * 2016-02-25 2021-07-28 株式会社神戸製鋼所 流路装置及び液滴形成方法
US20190275521A1 (en) 2016-07-21 2019-09-12 Agency For Science, Technology And Research Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof
EP3523003B1 (en) * 2016-10-07 2023-09-13 Massachusetts Institute of Technology Particle isolation/enrichment using continuous closed-loop micro-fluidics
US10697964B2 (en) 2016-11-15 2020-06-30 Massachusetts Institute Of Technology Liquid biopsy detection of leukemia using closed-loop microfluidics
CN108435265A (zh) * 2017-01-25 2018-08-24 富士康(昆山)电脑接插件有限公司 微流体盒及其堆叠测试组件
KR101901672B1 (ko) 2017-01-25 2018-10-25 주식회사 디오스템스 줄기세포 배양기 및 배양 방법, 줄기세포 연속 배양, 추출 및 분리 시스템 및 방법
JP2020513798A (ja) * 2017-03-17 2020-05-21 イスタンブール・テクニック・ユニヴェルシテシＩｓｔａｎｂｕｌ Ｔｅｋｎｉｋ Ｕｎｉｖｅｒｓｉｔｅｓｉ ガン細胞の血液からの連続的分離および循環系でのその豊富化のための非対称カールにより構成されるらせん形状を有するマイクロチャネル
CN106994369A (zh) * 2017-05-22 2017-08-01 东南大学 通量可调控的微流控集成器件及其制作方法
JP7124475B2 (ja) * 2018-01-17 2022-08-24 株式会社Ihi 細胞培養システム及び細胞培養方法
CN108517284A (zh) * 2018-03-19 2018-09-11 复旦大学 一种用于研究藻类生长和生殖的微流控芯片
TWI898645B (zh) 2018-05-04 2025-09-21 美商健臻公司 灌注式細胞培養裝置
US20210163868A1 (en) * 2018-05-22 2021-06-03 Nantkwest, Inc. Methods and systems for cell bed formation during bioprocessing
EP4477315A3 (en) 2018-05-31 2025-03-05 Donaldson Company, Inc. Droplet sensors for fuel systems
JP7087704B2 (ja) * 2018-06-13 2022-06-21 株式会社Ihi 細胞培養システム及び細胞培養方法
WO2019245070A1 (ko) * 2018-06-20 2019-12-26 주식회사 디오스템스 줄기세포 증식기 및 증식 방법, 줄기세포 연속 증식, 추출 및 분리 시스템 및 방법
WO2020102533A1 (en) 2018-11-15 2020-05-22 Massachusetts Institute Of Technology Multi-dimensional double spiral device and methods of use thereof
JP2021013333A (ja) * 2019-07-12 2021-02-12 株式会社Ihi 微生物選別システム及び微生物選別方法
CN111774103B (zh) * 2020-06-01 2021-09-07 东南大学 一种高通量血浆分离的多核螺旋惯性分选微流控器件
SE544733C2 (en) * 2020-07-20 2022-10-25 Javier Cruz Microfluidic device and method for manipulation of particles in fluids
US20240002772A1 (en) * 2020-10-13 2024-01-04 Boehringer Ingelheim International Gmbh Systems and methods for producing a biologic molecule with hydrocyclone cell retention device
KR102474060B1 (ko) * 2020-10-14 2022-12-05 한국과학기술연구원 미세유체칩 유동에 의한 세포입자의 크기별 분리 장치와 방법
EP4251296B1 (en) * 2020-11-25 2025-06-25 Donaldson Company, Inc. Hydrodynamic separator with optimal microchannel length
US12478899B2 (en) 2021-06-02 2025-11-25 Donaldson Company, Inc. Maintenance of hydrodynamic separators
US12252678B2 (en) 2021-12-01 2025-03-18 Microfluidx Ltd Systems and methods for bioprocessing
CN114260037B (zh) * 2021-12-27 2023-02-03 杭州电子科技大学 一种3d堆叠式多级惯性微流控分选芯片及其制备方法
WO2023211901A1 (en) 2022-04-28 2023-11-02 Massachusetts Institute Of Technology Spiral inertial microfluidic devices and methods to remove contaminants
CN114813466B (zh) * 2022-05-05 2025-02-18 山东大学 一种预测水力旋流器分选细胞活性的方法及系统
WO2024062903A1 (ja) * 2022-09-21 2024-03-28 キヤノン株式会社 マイクロ流路デバイス、分離装置、および分離方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486812B2 (en) * 2006-11-30 2016-11-08 Palo Alto Research Center Incorporated Fluidic structures for membraneless particle separation
US8931644B2 (en) * 2006-11-30 2015-01-13 Palo Alto Research Center Incorporated Method and apparatus for splitting fluid flow in a membraneless particle separation system
US8186913B2 (en) * 2007-04-16 2012-05-29 The General Hospital Corporation Systems and methods for particle focusing in microchannels
WO2010115025A2 (en) * 2009-04-01 2010-10-07 University Of Louisville Research Foundation, Inc. Device and methods for isolating cells
SG10201501485QA (en) * 2010-03-04 2015-04-29 Univ Singapore Microfluidics sorter for cell detection and isolation
CA2861270C (en) * 2012-01-18 2021-08-03 Bayer Healthcare Llc Perfusion bioreactor systems comprising a cell aggregate trap and methods of operating the same
US9987632B2 (en) * 2012-02-03 2018-06-05 University Of Cincinnati Microfluidic methods for passive separation of cells and particles
US9416344B2 (en) * 2012-03-15 2016-08-16 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US20150072413A1 (en) * 2012-03-29 2015-03-12 Arizona Board Of Regents On Behalf University Of Arizona Cell culture apparatus and culture methods using same
EP3628401B1 (en) * 2012-09-21 2021-06-23 Massachusetts Institute Of Technology Micro-fluidic device and uses thereof
JP6501709B2 (ja) * 2012-09-28 2019-04-17 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． スパイラル慣性濾過を使用する粒子分離及び濃縮
US20140093952A1 (en) * 2012-10-02 2014-04-03 David Serway Bioreactor Tangential Flow Perfusion Filter System
CN103981093B (zh) * 2014-04-24 2017-01-04 上海泰因生物技术有限公司 一种用生物反应器进行细胞特性筛选的装置与方法

Similar Documents

Publication Publication Date Title
JP2017527299A5 (enExample)
Warkiani et al. Large-volume microfluidic cell sorting for biomedical applications
US10583438B2 (en) Combined sorting and concentrating particles in a microfluidic device
US20160252436A1 (en) Cell collecting device
CN102743974A (zh) 海水淡化系统及能量交换腔
JP2015529155A5 (enExample)
WO2012097450A1 (en) Apparatus and method for particle separation
US20200238217A1 (en) Peristaltic Pump Microfluidic Separator
SG10201903038PA (en) Point of use or point of dispense filter with multiple pleat packs
ES2918374T3 (es) Dispositivo de filtración de fluidos y ensamblaje
CN112195094A (zh) 一种微流控芯片盒
CN106434304A (zh) 一种去除细胞低温保护剂的微装置
JP2020099256A (ja) 分離方法
EP2196253A3 (en) Membrane container
CN205382177U (zh) 一种内置细胞拦截器的高通量多单元微流控芯片装置
Bayareh et al. Cancer cell separation using passive mechanisms: A review
CN214781742U (zh) 一种微流控芯片盒
CN104388299B (zh) 一种用于细胞捕获的微流控芯片
JP5699710B2 (ja) 液体クロマトグラフィー装置及び充填剤の充填方法
CN214071413U (zh) 一种多级添加细胞低温保护剂的上层芯片和微装置
US20160258928A1 (en) Microfluidic device for separating liquid from the same liquid containing deformable particles without external sources of energy
JP7501830B2 (ja) マイクロ流体デバイスおよびシステム
CN102989256B (zh) 一种多级过滤器
Wewala et al. Design, simulation and comparison of ascending and descending curvilinear microchannels for cancer cell separation from blood
Mohammadali et al. Cancer Cell Separation Using Passive Mechanisms: a Review.