JP2017525766A5 - - Google Patents
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- Publication number
- JP2017525766A5 JP2017525766A5 JP2017529592A JP2017529592A JP2017525766A5 JP 2017525766 A5 JP2017525766 A5 JP 2017525766A5 JP 2017529592 A JP2017529592 A JP 2017529592A JP 2017529592 A JP2017529592 A JP 2017529592A JP 2017525766 A5 JP2017525766 A5 JP 2017525766A5
- Authority
- JP
- Japan
- Prior art keywords
- hemagglutinin
- influenza
- alkylating agent
- influenza vaccine
- cysteine residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960003971 influenza vaccine Drugs 0.000 claims description 55
- 229940100198 alkylating agent Drugs 0.000 claims description 53
- 239000002168 alkylating agent Substances 0.000 claims description 53
- 238000000034 method Methods 0.000 claims description 53
- 101710154606 Hemagglutinin Proteins 0.000 claims description 46
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 46
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 46
- 101710176177 Protein A56 Proteins 0.000 claims description 46
- 239000000185 hemagglutinin Substances 0.000 claims description 44
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 30
- 241000712461 unidentified influenza virus Species 0.000 claims description 28
- 241000700605 Viruses Species 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 235000018102 proteins Nutrition 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 230000029936 alkylation Effects 0.000 claims description 11
- 238000005804 alkylation reaction Methods 0.000 claims description 11
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims description 10
- 230000000415 inactivating effect Effects 0.000 claims description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 6
- 230000003612 virological effect Effects 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- BSSNZUFKXJJCBG-UPHRSURJSA-N (z)-but-2-enediamide Chemical compound NC(=O)\C=C/C(N)=O BSSNZUFKXJJCBG-UPHRSURJSA-N 0.000 claims description 4
- FSSPGSAQUIYDCN-UHFFFAOYSA-N 1,3-Propane sultone Chemical compound O=S1(=O)CCCO1 FSSPGSAQUIYDCN-UHFFFAOYSA-N 0.000 claims description 4
- ACGVKXZPAUDGMM-UHFFFAOYSA-N 2-(4-methylphenyl)sulfonylacetamide Chemical compound CC1=CC=C(S(=O)(=O)CC(N)=O)C=C1 ACGVKXZPAUDGMM-UHFFFAOYSA-N 0.000 claims description 4
- JUIKUQOUMZUFQT-UHFFFAOYSA-N 2-bromoacetamide Chemical compound NC(=O)CBr JUIKUQOUMZUFQT-UHFFFAOYSA-N 0.000 claims description 4
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 claims description 4
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 4
- 241000195493 Cryptophyta Species 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 4
- 241000238631 Hexapoda Species 0.000 claims description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical group SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 4
- GHAZCVNUKKZTLG-UHFFFAOYSA-N N-ethyl-succinimide Natural products CCN1C(=O)CCC1=O GHAZCVNUKKZTLG-UHFFFAOYSA-N 0.000 claims description 4
- HDFGOPSGAURCEO-UHFFFAOYSA-N N-ethylmaleimide Chemical compound CCN1C(=O)C=CC1=O HDFGOPSGAURCEO-UHFFFAOYSA-N 0.000 claims description 4
- HANVEJJSIBVHGH-GEMLJDPKSA-N NC(=O)CBr.N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O Chemical compound NC(=O)CBr.N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O HANVEJJSIBVHGH-GEMLJDPKSA-N 0.000 claims description 4
- 238000004113 cell culture Methods 0.000 claims description 4
- 229960003964 deoxycholic acid Drugs 0.000 claims description 4
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims description 4
- WBJINCZRORDGAQ-UHFFFAOYSA-N ethyl formate Chemical compound CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims description 4
- YLEAHEKEZRNPIM-UHFFFAOYSA-N ethyl-hydroxy-oxo-sulfanylidene-$l^{6}-sulfane Chemical compound CCS(O)(=O)=S YLEAHEKEZRNPIM-UHFFFAOYSA-N 0.000 claims description 4
- 230000002779 inactivation Effects 0.000 claims description 4
- JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- FDGBKPKLBZGFKU-UHFFFAOYSA-N methyl (methyldisulfanyl)formate Chemical compound COC(=O)SSC FDGBKPKLBZGFKU-UHFFFAOYSA-N 0.000 claims description 4
- 230000011987 methylation Effects 0.000 claims description 4
- 238000007069 methylation reaction Methods 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 4
- 210000005253 yeast cell Anatomy 0.000 claims description 4
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims description 3
- 210000004102 animal cell Anatomy 0.000 claims description 3
- 238000011026 diafiltration Methods 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- IEORSVTYLWZQJQ-UHFFFAOYSA-N 2-(2-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=CC=C1OCCO IEORSVTYLWZQJQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000592 Artificial Cell Substances 0.000 claims description 2
- 241000271566 Aves Species 0.000 claims description 2
- 229940124873 Influenza virus vaccine Drugs 0.000 claims description 2
- 230000002152 alkylating effect Effects 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 claims description 2
- 230000000593 degrading effect Effects 0.000 claims description 2
- 238000009792 diffusion process Methods 0.000 claims description 2
- 230000000951 immunodiffusion Effects 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 238000004949 mass spectrometry Methods 0.000 claims description 2
- 229920000847 nonoxynol Polymers 0.000 claims description 2
- 229960000380 propiolactone Drugs 0.000 claims description 2
- 229940045946 sodium taurodeoxycholate Drugs 0.000 claims description 2
- YXHRQQJFKOHLAP-FVCKGWAHSA-M sodium;2-[[(4r)-4-[(3r,5r,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 YXHRQQJFKOHLAP-FVCKGWAHSA-M 0.000 claims description 2
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 230000000937 inactivator Effects 0.000 claims 1
- PGLTVOMIXTUURA-HQMMCQRPSA-N 2-iodoacetamide Chemical group N[14C](=O)CI PGLTVOMIXTUURA-HQMMCQRPSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 2
- 241001500351 Influenzavirus A Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038753P | 2014-08-18 | 2014-08-18 | |
| US62/038,753 | 2014-08-18 | ||
| PCT/US2015/045689 WO2016028776A1 (en) | 2014-08-18 | 2015-08-18 | Alkylated influenza vaccines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017525766A JP2017525766A (ja) | 2017-09-07 |
| JP2017525766A5 true JP2017525766A5 (enExample) | 2018-09-20 |
Family
ID=54008038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529592A Pending JP2017525766A (ja) | 2014-08-18 | 2015-08-18 | アルキル化インフルエンザワクチン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10124056B2 (enExample) |
| EP (1) | EP3182998A1 (enExample) |
| JP (1) | JP2017525766A (enExample) |
| KR (1) | KR20170042605A (enExample) |
| CN (1) | CN106794241A (enExample) |
| AU (1) | AU2015305690A1 (enExample) |
| CA (1) | CA2957570A1 (enExample) |
| SG (1) | SG11201701279VA (enExample) |
| WO (1) | WO2016028776A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY204177A (en) * | 2017-09-04 | 2024-08-14 | Japan As Represented By Director General Of Nat Institute Of Infectious Diseases | Method for producing influenza ha split vaccine |
| JP7403733B2 (ja) | 2017-09-04 | 2023-12-25 | 国立感染症研究所長 | インフルエンザｈａスプリットワクチンの製造方法 |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| US12059462B2 (en) | 2018-07-23 | 2024-08-13 | Japan As Represented By Director General Of National Institute Of Infectious Diseases | Composition containing influenza vaccine |
| CA3132578A1 (en) | 2019-03-04 | 2020-09-10 | Japan As Represented By Director General Of National Institute Of Infectious Diseases | Method for producing influenza ha split vaccine |
| CN112618709B (zh) * | 2019-09-24 | 2023-11-03 | 华南理工大学 | 一种猪口服接种疫苗缓释佐剂及其制备方法与应用 |
| CN112708599B (zh) * | 2019-10-25 | 2022-02-18 | 中国农业大学 | 一株禽流感病毒疫苗株及其应用 |
| US12428372B2 (en) | 2022-04-14 | 2025-09-30 | Saudi Arabian Oil Company | ODSO acid medium, ODSO acid mixture medium, and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62221636A (ja) | 1986-03-20 | 1987-09-29 | Chemo Sero Therapeut Res Inst | Ｂ型肝炎ウイルス抗原蛋白の可溶化方法 |
| FR2773156B1 (fr) * | 1997-12-26 | 2000-03-31 | Biovacs Inc | Nouveaux immunogenes anti-retroviraux (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida |
| WO2003014338A1 (en) | 2001-08-02 | 2003-02-20 | Anges Mg, Inc. | Process for producing inactivated virus envelope |
| EP1481985A1 (en) | 2003-05-28 | 2004-12-01 | Innogenetics N.V. | Modified hepatitis C virus (HCV) NS3 for medical treatment |
| AU2005223371B2 (en) * | 2004-03-17 | 2011-06-09 | Crucell Holland B.V. | Novel assay for the separation and quantification of hemagglutinin antigens |
| GB0502901D0 (en) * | 2005-02-11 | 2005-03-16 | Nat Inst Biological Standards & Control | New detoxification method |
| CN101161285A (zh) * | 2007-09-06 | 2008-04-16 | 上海荣盛生物技术有限公司 | 流感病毒裂解疫苗 |
| WO2011138229A1 (en) | 2010-05-03 | 2011-11-10 | Glaxosmithkline Biologicals S.A. | Novel method |
| WO2011154976A2 (en) | 2010-06-08 | 2011-12-15 | Panacea Biotec Limited | Improved influenza vaccine |
| CN102406931B (zh) * | 2011-11-25 | 2014-02-05 | 成都康华生物制品有限公司 | 大流行流感病毒裂解疫苗 |
-
2015
- 2015-08-18 CN CN201580044445.2A patent/CN106794241A/zh active Pending
- 2015-08-18 AU AU2015305690A patent/AU2015305690A1/en not_active Abandoned
- 2015-08-18 JP JP2017529592A patent/JP2017525766A/ja active Pending
- 2015-08-18 KR KR1020177004533A patent/KR20170042605A/ko not_active Withdrawn
- 2015-08-18 CA CA2957570A patent/CA2957570A1/en not_active Abandoned
- 2015-08-18 US US14/829,158 patent/US10124056B2/en not_active Expired - Fee Related
- 2015-08-18 SG SG11201701279VA patent/SG11201701279VA/en unknown
- 2015-08-18 WO PCT/US2015/045689 patent/WO2016028776A1/en not_active Ceased
- 2015-08-18 EP EP15754404.0A patent/EP3182998A1/en not_active Withdrawn
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