JP2017524689A5 - - Google Patents

Download PDF

Info

Publication number
JP2017524689A5
JP2017524689A5 JP2017500864A JP2017500864A JP2017524689A5 JP 2017524689 A5 JP2017524689 A5 JP 2017524689A5 JP 2017500864 A JP2017500864 A JP 2017500864A JP 2017500864 A JP2017500864 A JP 2017500864A JP 2017524689 A5 JP2017524689 A5 JP 2017524689A5
Authority
JP
Japan
Prior art keywords
antibody
snap25
bont
seq
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017500864A
Other languages
English (en)
Japanese (ja)
Other versions
JP6630717B2 (ja
JP2017524689A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/039372 external-priority patent/WO2016007508A1/en
Publication of JP2017524689A publication Critical patent/JP2017524689A/ja
Publication of JP2017524689A5 publication Critical patent/JP2017524689A5/ja
Application granted granted Critical
Publication of JP6630717B2 publication Critical patent/JP6630717B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017500864A 2014-07-07 2015-07-07 組織試料における切断ｓｎａｐ２５の検出方法 Expired - Fee Related JP6630717B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462021379P 2014-07-07 2014-07-07
US62/021,379 2014-07-07
US201562158900P 2015-05-08 2015-05-08
US62/158,900 2015-05-08
US201562163829P 2015-05-19 2015-05-19
US62/163,829 2015-05-19
PCT/US2015/039372 WO2016007508A1 (en) 2014-07-07 2015-07-07 Method of detecting cleaved snap25 in tissue samples

Publications (3)

Publication Number Publication Date
JP2017524689A JP2017524689A (ja) 2017-08-31
JP2017524689A5 true JP2017524689A5 (enExample) 2018-08-16
JP6630717B2 JP6630717B2 (ja) 2020-01-15

Family

ID=55016834

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017500864A Expired - Fee Related JP6630717B2 (ja) 2014-07-07 2015-07-07 組織試料における切断ｓｎａｐ２５の検出方法

Country Status (6)

Country Link
US (2) US10527620B2 (enExample)
EP (2) EP3567055A1 (enExample)
JP (1) JP6630717B2 (enExample)
KR (1) KR20170026624A (enExample)
CN (1) CN107001451A (enExample)
CA (1) CA2954504A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198034B2 (en) * 2008-03-14 2012-06-12 Allergan, Inc. Immuno-based botulinum toxin serotype A activity assays
EP3660509B1 (en) 2018-11-29 2022-03-09 Hugel Inc. A cell-based method for determining an activity of botulinum toxin
KR101983216B1 (ko) * 2018-11-29 2019-05-29 주식회사 에이비바이오 보툴리눔 독소 활성을 결정하기 위한 항체, 및 이를 이용한 활성 측정방법
EP4204566A1 (en) * 2020-08-28 2023-07-05 Galderma Holding SA Novel x-aptamers for the use in detection of snap25
CN119044508B (zh) * 2024-10-31 2025-01-28 兰州生物技术开发有限公司 检测肉毒毒素活性或突触体相关蛋白的试剂盒及检测方法
CN119044510B (zh) * 2024-10-31 2025-01-28 兰州生物技术开发有限公司 一种测定肉毒毒素活性或snap25的试剂盒、抗体及方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB9411138D0 (en) 1994-06-03 1994-07-27 Microbiological Res Authority Toxin assay
US5962637A (en) 1994-06-03 1999-10-05 Microbiological Research Authority Toxin assay
GB9508204D0 (en) 1995-04-21 1995-06-07 Speywood Lab Ltd A novel agent able to modify peripheral afferent function
US20040219619A1 (en) 2000-07-21 2004-11-04 Ester Fernandez-Salas Methods of identifying compounds that alter toxin persistence and/or protease activity
WO2003011902A1 (en) * 2001-07-27 2003-02-13 Kenton S.R.L. Identification of specific tumour antigens by selection of cdna libraries with sera
US7208285B2 (en) 2001-08-28 2007-04-24 Allergan, Inc. Fret protease assays for botulinum serotype A/E toxins
US7332567B2 (en) 2001-08-28 2008-02-19 Allergan, Inc. Fret protease assays for clostridial toxins
US7183066B2 (en) 2002-09-27 2007-02-27 Allergan, Inc. Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins
DK1718756T3 (da) 2004-02-24 2012-02-27 Allergan Inc Botulinumtoksinscreeningassays
US7399607B2 (en) 2004-09-22 2008-07-15 Allergan, Inc. Fluorescence polarization assays for determining clostridial toxin activity
US20070258992A1 (en) 2004-10-06 2007-11-08 Atassi M Zouhair Determining and Reducing Immunoresistance to Botulinum Toxin Therapy Using Botulinum Toxin a Peptides
ATE552500T1 (de) 2005-04-05 2012-04-15 Allergan Inc Lipophile, farbstoffbasierte fret-assays für die clostridientoxinaktivität
US20100227868A1 (en) 2007-09-20 2010-09-09 Johnson Brent A Treatment methods with brimonidine
KR101604515B1 (ko) * 2008-03-14 2016-03-17 알러간, 인코포레이티드 면역-기반 보툴리눔 독소 세로타입 ａ 활성 검정
US8198034B2 (en) 2008-03-14 2012-06-12 Allergan, Inc. Immuno-based botulinum toxin serotype A activity assays
WO2010105236A1 (en) * 2009-03-13 2010-09-16 Allergan, Inc. Immuno-based retargeted endopeptidase activity assays
CN102439138B (zh) 2009-03-13 2018-03-30 阿勒根公司 可用于基于免疫的肉毒杆菌毒素血清a型活性测定的细胞
CN102548549A (zh) * 2009-08-25 2012-07-04 细胞研究有限公司 利用外代谢转换剂(辅酶q10)治疗肉瘤的方法
CN105683212B (zh) * 2013-08-21 2020-03-17 香港理工大学 高催化活性的基因改造梭菌属神经毒素

Similar Documents

Publication Publication Date Title
GT201300149A (es) Proteinas de union al tnf-a
CY1123750T1 (el) Μεθοδοι για την αξιολογηση μιας ανοσοαποκρισης σε εναν θεραπευτικο παραγοντα
MX367046B (es) Marcadores especificos de via para diagnosticar sindrome del intestino irritable.
UA102247C2 (ru) Иммунологические анализы активности ботулинического токсина серотипа а
JP2013060443A5 (enExample)
JP2014061000A5 (enExample)
MX2018008421A (es) Métodos para tratar cáncer y el uso de biomarcadores como predictor de sensibilidad clínica a terapias.
AR098126A1 (es) Anticuerpos anti-ly6e (locus e del complejo del antígeno 6 linfocítico), inmunoconjugados y métodos para usarlos
EA201792679A1 (ru) Способы диагностики и лечения злокачественной опухоли
BR112014031365A2 (pt) métodos de detectar doenças ou condições
BR112013023540A2 (pt) anticorpo, kit e método para a determinação de peptídeos amilóides
BR112014025384A8 (pt) método e sistema para executar ensaio automatizado e métodos para executar teste reflexivo em vários exemplares
BR112013008602A2 (pt) dispositivo imunocromatográfico, método para a determinação de um carreador gênico, método para o diagnóstico, dispositivo para ensaio imunológico, método para a detecção e determinação da presença de uma proteína e kit
BR112014012590A8 (pt) Anticorpos anti-cd98 e métodos de uso dos mesmos
CL2012001980A1 (es) Uso de un anticuerpo monoclonal anti-cd44 o fragmento de unión del mismo, en el tratamiento del carcinoma escamocelular de cabeza y cuello (hnscc) en un mamífero, donde el hnscc se distingue según la expresión de cd44.
WO2013159872A8 (en) Biomarkers for the diagnosis, prognosis, assessment and therapy stratification of syncope
MX2015012825A (es) Anticuerpos monoclonales del dominio de union de lipido del núcleo del virus de la hepatitis c vhc.
BR112016023238A2 (pt) processos de tratamento seletivo de asma usando antagonistas de il-13
JP2016026303A5 (enExample)
CA2839777C (en) Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease
EA201991464A1 (ru) АНТИТЕЛО К α-СИНУКЛЕИНУ И ЕГО ПРИМЕНЕНИЕ
MX2020010387A (es) Metodos para detectar y cuantificar fgf21.
JP2012073260A5 (enExample)
BR112013021056A2 (pt) anticorpo monoclonal, linhagem de células de hibridoma, kit para diagnóstico, métodos para a produção de um anticorpo monoclonal e de um agente de ligação, agente de ligação sequência de aminoácidos purificada, método para a obtenção de uma sequência do ácido nucleico codificante, molécula do ácido nucleico isolado codificante, vetor, célula hospedeira isolada, proteína de fusão, método de triagem para a presença de uma doença, de uma condição, métodos de diagnóstico de um indivíduo, de prognóstico para um indivíduo, e de monitoramento de um indivúdo, e, método para detecção da presença ou ausência de um câncer cervical
BR112013007329A2 (pt) método para diagnostificar o estado de doença de lyme em um mamífero, e, composição