JP2017523985A5 - - Google Patents
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- Publication number
- JP2017523985A5 JP2017523985A5 JP2017506294A JP2017506294A JP2017523985A5 JP 2017523985 A5 JP2017523985 A5 JP 2017523985A5 JP 2017506294 A JP2017506294 A JP 2017506294A JP 2017506294 A JP2017506294 A JP 2017506294A JP 2017523985 A5 JP2017523985 A5 JP 2017523985A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- amino acid
- polypeptide
- identity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 18
- 150000001720 carbohydrates Chemical class 0.000 claims 8
- 241000194017 Streptococcus Species 0.000 claims 6
- 101150078778 SPB1 gene Proteins 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 241000193985 Streptococcus agalactiae Species 0.000 claims 1
- 108700010638 Streptococcus agalactiae Spb1 Proteins 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- -1 linker amino acid Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14179945.2 | 2014-08-05 | ||
| EP14179945 | 2014-08-05 | ||
| PCT/EP2015/068012 WO2016020413A1 (en) | 2014-08-05 | 2015-08-05 | Carrier molecule for antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017523985A JP2017523985A (ja) | 2017-08-24 |
| JP2017523985A5 true JP2017523985A5 (https=) | 2018-07-19 |
Family
ID=51298571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506294A Pending JP2017523985A (ja) | 2014-08-05 | 2015-08-05 | 抗原用担体分子 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10245310B2 (https=) |
| EP (1) | EP3177324A1 (https=) |
| JP (1) | JP2017523985A (https=) |
| KR (1) | KR20170039709A (https=) |
| CN (1) | CN108064174A (https=) |
| AR (1) | AR101455A1 (https=) |
| AU (1) | AU2015299008B2 (https=) |
| BE (1) | BE1022792B1 (https=) |
| BR (1) | BR112017002183A2 (https=) |
| CA (1) | CA2957118A1 (https=) |
| EA (1) | EA201790239A1 (https=) |
| IL (1) | IL250238A0 (https=) |
| MX (1) | MX2017001638A (https=) |
| SG (1) | SG11201700673RA (https=) |
| WO (1) | WO2016020413A1 (https=) |
| ZA (1) | ZA201700824B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8398983B2 (en) * | 2005-06-27 | 2013-03-19 | Glaxosmithkline Biologicals, S.A. | Immunogenic composition |
| EP3551668A1 (en) | 2016-12-06 | 2019-10-16 | GlaxoSmithKline Biologicals S.A. | Purification process for capsular polysaccharide |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| ES3024474T3 (en) | 2016-12-30 | 2025-06-04 | Vaxcyte Inc | Polypeptide-antigen conjugates with non-natural amino acids |
| WO2018187515A1 (en) * | 2017-04-04 | 2018-10-11 | Avidea Technologies, Inc. | Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response |
| CA3066020A1 (en) | 2017-06-16 | 2018-12-20 | Glaxosmithkline Biologicals Sa | Method of treatment |
| WO2019217665A1 (en) * | 2018-05-09 | 2019-11-14 | West Virginia University | Iron-acquisition receptor peptide administration for vaccination against pseudomonas aeruginosa |
| EP3574915A1 (en) * | 2018-05-29 | 2019-12-04 | Neovacs | Immunogenic product comprising il-4 and/or il-13 for treating disorders associated with aberrant il-4 and/or il 13 expression or activity |
| CN112543649B (zh) * | 2018-07-04 | 2026-03-31 | Vaxcyte公司 | 免疫原性缀合物的改进 |
| WO2020010000A1 (en) * | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Improved methods for the preparation of immunogenic conjugates |
| CN108840914B (zh) * | 2018-08-13 | 2022-07-01 | 内蒙古民族大学 | 一种具有免疫原性的多肽、其抗体的制备方法以及用途 |
| WO2020205584A1 (en) * | 2019-04-02 | 2020-10-08 | Vaxcyte, Inc. | Optimized cell-free synthesis of invasion plasmid antigen b and related compositions and methods of use |
| US12533418B2 (en) | 2019-11-22 | 2026-01-27 | Glaxosmithkline Biologicals Sa | Dosage and administration of a bacterial saccharide glycoconjugate vaccine |
| EP4165064A2 (en) * | 2020-06-12 | 2023-04-19 | GlaxoSmithKline Biologicals S.A. | Dock tag system |
| US20230303637A1 (en) | 2020-06-12 | 2023-09-28 | Glaxosmithkline Biologicals Sa | Gbs ferritin nanoparticles |
| CN112979797B (zh) * | 2021-04-28 | 2022-04-01 | 中国检验检疫科学研究院 | 一种抗赤羽病病毒单克隆抗体及其制备方法与应用 |
| GB202215634D0 (en) * | 2022-10-21 | 2022-12-07 | Glaxosmithkline Biologicals Sa | Polypeptide scaffold |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1784211A4 (en) | 2004-07-29 | 2010-06-30 | Novartis Vaccines & Diagnostic | IMMUNOGENIC COMPOSITIONS FOR GRAMPOSITIVE BACTERIA SUCH AS STREPTOCOCCUS AGALACTIAE |
| EP1828231A2 (en) * | 2004-12-22 | 2007-09-05 | Novartis Vaccines and Diagnostics, Inc. | Group b streptococcus |
| GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| GB0605757D0 (en) * | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| WO2009027768A2 (en) * | 2006-07-26 | 2009-03-05 | Novartis Ag | Immunogenic compositions for gram positive bacteria |
| GB0802503D0 (en) * | 2008-02-11 | 2008-03-19 | Novartis Ag | Hybrid polypeptide |
| CN102481349B (zh) * | 2009-01-12 | 2014-10-15 | 诺华股份有限公司 | 抗革兰氏阳性细菌疫苗中的Cna_B结构域 |
| GB201003333D0 (en) * | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
| GB201005625D0 (en) * | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
| GB201114923D0 (en) * | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
| RU2014138418A (ru) * | 2012-02-24 | 2016-04-10 | Новартис Аг | Белки пилей и композиции |
-
2015
- 2015-08-05 AR ARP150102512A patent/AR101455A1/es unknown
- 2015-08-05 CN CN201580053997.XA patent/CN108064174A/zh active Pending
- 2015-08-05 BR BR112017002183-8A patent/BR112017002183A2/pt not_active IP Right Cessation
- 2015-08-05 WO PCT/EP2015/068012 patent/WO2016020413A1/en not_active Ceased
- 2015-08-05 BE BE2015/5496A patent/BE1022792B1/fr not_active IP Right Cessation
- 2015-08-05 EP EP15744610.5A patent/EP3177324A1/en not_active Withdrawn
- 2015-08-05 JP JP2017506294A patent/JP2017523985A/ja active Pending
- 2015-08-05 EA EA201790239A patent/EA201790239A1/ru unknown
- 2015-08-05 SG SG11201700673RA patent/SG11201700673RA/en unknown
- 2015-08-05 CA CA2957118A patent/CA2957118A1/en not_active Abandoned
- 2015-08-05 MX MX2017001638A patent/MX2017001638A/es unknown
- 2015-08-05 AU AU2015299008A patent/AU2015299008B2/en not_active Expired - Fee Related
- 2015-08-05 US US15/501,474 patent/US10245310B2/en active Active
- 2015-08-05 KR KR1020177005840A patent/KR20170039709A/ko not_active Withdrawn
-
2017
- 2017-01-23 IL IL250238A patent/IL250238A0/en unknown
- 2017-02-02 ZA ZA2017/00824A patent/ZA201700824B/en unknown