JP2017523805A5 - - Google Patents

Info

Publication number

JP2017523805A5

JP2017523805A5 JP2017523183A JP2017523183A JP2017523805A5 JP 2017523805 A5 JP2017523805 A5 JP 2017523805A5 JP 2017523183 A JP2017523183 A JP 2017523183A JP 2017523183 A JP2017523183 A JP 2017523183A JP 2017523805 A5 JP2017523805 A5 JP 2017523805A5

Authority

JP

Japan

Prior art keywords

seq

lcdr

hcdr

antibody

influenza

Prior art date

2015-07-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000012634 fragment Substances 0.000 claims description 77
• 239000000427 antigen Substances 0.000 claims description 73
• 102000036639 antigens Human genes 0.000 claims description 73
• 108091007433 antigens Proteins 0.000 claims description 73
• 241000713196 Influenza B virus Species 0.000 claims description 26
• 101710154606 Hemagglutinin Proteins 0.000 claims description 18
• 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 18
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 18
• 101710176177 Protein A56 Proteins 0.000 claims description 18
• 239000000185 hemagglutinin Substances 0.000 claims description 18
• 230000003472 neutralizing effect Effects 0.000 claims description 15
• 208000037798 influenza B Diseases 0.000 claims description 14
• 101900234398 Influenza B virus Hemagglutinin Proteins 0.000 claims description 10
• 208000015181 infectious disease Diseases 0.000 claims description 10
• 241000712431 Influenza A virus Species 0.000 claims description 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
• 208000037797 influenza A Diseases 0.000 claims description 8
• 101900159346 Influenza A virus Hemagglutinin Proteins 0.000 claims description 6
• 230000002265 prevention Effects 0.000 claims description 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
• 150000007523 nucleic acids Chemical class 0.000 claims description 5
• 102000039446 nucleic acids Human genes 0.000 claims description 5
• 108020004707 nucleic acids Proteins 0.000 claims description 5
• 238000003556 assay Methods 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 4
• 241000700605 Viruses Species 0.000 claims description 3
• 108060003951 Immunoglobulin Proteins 0.000 claims description 2
• 241000713174 Influenza B virus (B/Ann Arbor/1/1966 [wild- type]) Species 0.000 claims description 2
• 241000831652 Salinivibrio sharmensis Species 0.000 claims description 2
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 2
• 150000001413 amino acids Chemical class 0.000 claims description 2
• 238000012258 culturing Methods 0.000 claims description 2
• 238000012217 deletion Methods 0.000 claims description 2
• 230000037430 deletion Effects 0.000 claims description 2
• 238000003745 diagnosis Methods 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 230000009977 dual effect Effects 0.000 claims description 2
• 102000018358 immunoglobulin Human genes 0.000 claims description 2
• 238000000338 in vitro Methods 0.000 claims description 2
• 206010022000 influenza Diseases 0.000 claims description 2
• 230000002401 inhibitory effect Effects 0.000 claims description 2
• 238000003780 insertion Methods 0.000 claims description 2
• 230000037431 insertion Effects 0.000 claims description 2
• 238000006467 substitution reaction Methods 0.000 claims description 2
• 241000712461 unidentified influenza virus Species 0.000 claims 3
• 235000001630 Pyrus pyrifolia var culta Nutrition 0.000 claims 1
• 240000002609 Pyrus pyrifolia var. culta Species 0.000 claims 1
• 238000000034 method Methods 0.000 description 6
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 239000003814 drug Substances 0.000 description 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1