JP2017523798A5 - - Google Patents
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- Publication number
- JP2017523798A5 JP2017523798A5 JP2017507704A JP2017507704A JP2017523798A5 JP 2017523798 A5 JP2017523798 A5 JP 2017523798A5 JP 2017507704 A JP2017507704 A JP 2017507704A JP 2017507704 A JP2017507704 A JP 2017507704A JP 2017523798 A5 JP2017523798 A5 JP 2017523798A5
- Authority
- JP
- Japan
- Prior art keywords
- culture medium
- metatyrosine
- phenylalanine
- polypeptide
- cho
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000001963 growth medium Substances 0.000 claims description 20
- JZKXXXDKRQWDET-QMMMGPOBSA-N L-m-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC(O)=C1 JZKXXXDKRQWDET-QMMMGPOBSA-N 0.000 claims description 15
- JZKXXXDKRQWDET-UHFFFAOYSA-N meta-tyrosine Natural products OC(=O)C(N)CC1=CC=CC(O)=C1 JZKXXXDKRQWDET-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 210000004027 cell Anatomy 0.000 claims description 13
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 10
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 10
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 241000699802 Cricetulus griseus Species 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 230000004927 fusion Effects 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 210000001672 ovary Anatomy 0.000 claims description 4
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14180586.1 | 2014-08-11 | ||
| EP14180586 | 2014-08-11 | ||
| PCT/EP2015/067733 WO2016023775A1 (en) | 2014-08-11 | 2015-07-31 | Method for increasing the specific production rate of eukaryotic cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523798A JP2017523798A (ja) | 2017-08-24 |
| JP2017523798A5 true JP2017523798A5 (enExample) | 2018-08-30 |
| JP6697442B2 JP6697442B2 (ja) | 2020-05-20 |
Family
ID=51298668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017507704A Active JP6697442B2 (ja) | 2014-08-11 | 2015-07-31 | 真核細胞の比生産速度を増加させる方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10336983B2 (enExample) |
| EP (1) | EP3180422B2 (enExample) |
| JP (1) | JP6697442B2 (enExample) |
| KR (1) | KR102467730B1 (enExample) |
| CN (1) | CN106661557B (enExample) |
| BR (1) | BR112016030659B1 (enExample) |
| CA (1) | CA2953450C (enExample) |
| MX (1) | MX383347B (enExample) |
| RU (1) | RU2725191C2 (enExample) |
| SG (1) | SG11201700908TA (enExample) |
| WO (1) | WO2016023775A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6697442B2 (ja) | 2014-08-11 | 2020-05-20 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 真核細胞の比生産速度を増加させる方法 |
| CN111233996A (zh) * | 2020-01-20 | 2020-06-05 | 北京交通大学 | 一种将丁酸钠用于促进工程细胞株分泌表达rhIL-24的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY143847A (en) * | 2001-08-04 | 2011-07-15 | Samsung Electronics Co Ltd | Method and apparatus for recording and reproducing video data, and information storage medium in which video data is recorded by the same |
| WO2007045465A1 (en) | 2005-10-21 | 2007-04-26 | F. Hoffmann-La Roche Ag | Method for the recombinant expression of a polypeptide |
| DK2154244T3 (en) * | 2007-04-26 | 2017-06-12 | Chugai Pharmaceutical Co Ltd | CELL CULTIVATION PROCEDURE WHEN AN ACID-ENRICHED MEDIUM IS USED |
| MX2009012467A (es) | 2007-06-29 | 2010-03-30 | Hoffmann La Roche | Celula de ovario de hamster chino. |
| RU2486245C2 (ru) * | 2007-10-15 | 2013-06-27 | Чугаи Сейяку Кабусики Кайся | Способ получения клетки, способной продуцировать гетеропротеины с высоким выходом |
| CA2703493C (en) | 2007-10-24 | 2016-11-08 | Chugai Seiyaku Kabushiki Kaisha | A cell for use in production of heteroproteins and production method using the same |
| US20110262965A1 (en) | 2010-04-23 | 2011-10-27 | Life Technologies Corporation | Cell culture medium comprising small peptides |
| RU2577972C2 (ru) * | 2010-04-26 | 2016-03-20 | Новартис Аг | Способ получения рекомбинантного полипептида |
| JP6697442B2 (ja) | 2014-08-11 | 2020-05-20 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 真核細胞の比生産速度を増加させる方法 |
-
2015
- 2015-07-31 JP JP2017507704A patent/JP6697442B2/ja active Active
- 2015-07-31 RU RU2017105852A patent/RU2725191C2/ru active
- 2015-07-31 MX MX2017000715A patent/MX383347B/es unknown
- 2015-07-31 KR KR1020177003576A patent/KR102467730B1/ko active Active
- 2015-07-31 CN CN201580042225.6A patent/CN106661557B/zh active Active
- 2015-07-31 CA CA2953450A patent/CA2953450C/en active Active
- 2015-07-31 BR BR112016030659-7A patent/BR112016030659B1/pt active IP Right Grant
- 2015-07-31 EP EP15744593.3A patent/EP3180422B2/en active Active
- 2015-07-31 WO PCT/EP2015/067733 patent/WO2016023775A1/en not_active Ceased
- 2015-07-31 SG SG11201700908TA patent/SG11201700908TA/en unknown
-
2017
- 2017-02-09 US US15/428,279 patent/US10336983B2/en active Active
-
2019
- 2019-05-16 US US16/414,500 patent/US20200080048A1/en not_active Abandoned
-
2022
- 2022-11-22 US US17/992,039 patent/US12338456B2/en active Active
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