JP2017523200A5 - - Google Patents

Info

Publication number

JP2017523200A5

JP2017523200A5 JP2017505455A JP2017505455A JP2017523200A5 JP 2017523200 A5 JP2017523200 A5 JP 2017523200A5 JP 2017505455 A JP2017505455 A JP 2017505455A JP 2017505455 A JP2017505455 A JP 2017505455A JP 2017523200 A5 JP2017523200 A5 JP 2017523200A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

inhibitor

tgfβ1

lung disease

Prior art date

2015-08-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 18
• 239000003112 inhibitor Substances 0.000 claims 10
• 208000029523 Interstitial Lung disease Diseases 0.000 claims 8
• 108010041834 Growth Differentiation Factor 15 Proteins 0.000 claims 5
• 102000000597 Growth Differentiation Factor 15 Human genes 0.000 claims 5
• 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 5
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
• 239000003446 ligand Substances 0.000 claims 4
• 208000005069 pulmonary fibrosis Diseases 0.000 claims 4
• 206010016654 Fibrosis Diseases 0.000 claims 3
• 230000004761 fibrosis Effects 0.000 claims 3
• 108010006654 Bleomycin Proteins 0.000 claims 2
• 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims 2
• 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims 2
• 206010020772 Hypertension Diseases 0.000 claims 2
• 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
• 208000004852 Lung Injury Diseases 0.000 claims 2
• 208000019693 Lung disease Diseases 0.000 claims 2
• 206010036590 Premature baby Diseases 0.000 claims 2
• 208000011191 Pulmonary vascular disease Diseases 0.000 claims 2
• 206010039710 Scleroderma Diseases 0.000 claims 2
• 206010069363 Traumatic lung injury Diseases 0.000 claims 2
• IYIKLHRQXLHMJQ-UHFFFAOYSA-N amiodarone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN(CC)CC)C(I)=C1 IYIKLHRQXLHMJQ-UHFFFAOYSA-N 0.000 claims 2
• 229960005260 amiodarone Drugs 0.000 claims 2
• 239000003416 antiarrhythmic agent Substances 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 239000010425 asbestos Substances 0.000 claims 2
• 229960001561 bleomycin Drugs 0.000 claims 2
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 2
• 206010006475 bronchopulmonary dysplasia Diseases 0.000 claims 2
• 229940044683 chemotherapy drug Drugs 0.000 claims 2
• 230000001684 chronic effect Effects 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 208000036971 interstitial lung disease 2 Diseases 0.000 claims 2
• 231100000515 lung injury Toxicity 0.000 claims 2
• 229960000485 methotrexate Drugs 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• 201000003086 pulmonary systemic sclerosis Diseases 0.000 claims 2
• 229910052895 riebeckite Inorganic materials 0.000 claims 2
• 239000000377 silicon dioxide Substances 0.000 claims 2
• UDEJEOLNSNYQSX-UHFFFAOYSA-J tetrasodium;2,4,6,8-tetraoxido-1,3,5,7,2$l^{5},4$l^{5},6$l^{5},8$l^{5}-tetraoxatetraphosphocane 2,4,6,8-tetraoxide Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)O1 UDEJEOLNSNYQSX-UHFFFAOYSA-J 0.000 claims 2
• 239000003053 toxin Substances 0.000 claims 2
• 231100000765 toxin Toxicity 0.000 claims 2
• 108700012359 toxins Proteins 0.000 claims 2
• 208000019553 vascular disease Diseases 0.000 claims 2
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 208000018631 connective tissue disease Diseases 0.000 claims 1
• 230000002685 pulmonary effect Effects 0.000 claims 1
• 208000002815 pulmonary hypertension Diseases 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1