JP2019520550A5 - - Google Patents
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- Publication number
- JP2019520550A5 JP2019520550A5 JP2018555652A JP2018555652A JP2019520550A5 JP 2019520550 A5 JP2019520550 A5 JP 2019520550A5 JP 2018555652 A JP2018555652 A JP 2018555652A JP 2018555652 A JP2018555652 A JP 2018555652A JP 2019520550 A5 JP2019520550 A5 JP 2019520550A5
- Authority
- JP
- Japan
- Prior art keywords
- dpp3
- pharmaceutical composition
- inhibitor
- composition according
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003112 inhibitor Substances 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 102100020750 Dipeptidyl peptidase 3 Human genes 0.000 claims 9
- 101000931862 Homo sapiens Dipeptidyl peptidase 3 Proteins 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 2
- 206010007556 Cardiac failure acute Diseases 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 208000033626 Renal failure acute Diseases 0.000 claims 2
- 201000011040 acute kidney failure Diseases 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000001338 necrotic effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010019663 Hepatic failure Diseases 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 238000002617 apheresis Methods 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 230000008499 blood brain barrier function Effects 0.000 claims 1
- 210000001218 blood-brain barrier Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022110620A JP2022163014A (ja) | 2016-04-21 | 2022-07-08 | Ｄｐｐ３の定量方法および治療方法 |
| JP2024178873A JP2025011237A (ja) | 2016-04-21 | 2024-10-11 | Ｄｐｐ３の定量方法および治療方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16166476.8 | 2016-04-21 | ||
| EP16166476 | 2016-04-21 | ||
| PCT/EP2017/059377 WO2017182561A1 (en) | 2016-04-21 | 2017-04-20 | Methods for determining dpp3 and therapeutic methods |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076521A Division JP7219737B2 (ja) | 2016-04-21 | 2020-04-23 | Ｄｐｐ３の定量方法および治療方法 |
| JP2022110620A Division JP2022163014A (ja) | 2016-04-21 | 2022-07-08 | Ｄｐｐ３の定量方法および治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019520550A JP2019520550A (ja) | 2019-07-18 |
| JP2019520550A5 true JP2019520550A5 (cg-RX-API-DMAC7.html) | 2020-05-28 |
Family
ID=56014788
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555652A Pending JP2019520550A (ja) | 2016-04-21 | 2017-04-20 | Ｄｐｐ３の定量方法および治療方法 |
| JP2020076521A Active JP7219737B2 (ja) | 2016-04-21 | 2020-04-23 | Ｄｐｐ３の定量方法および治療方法 |
| JP2022110620A Pending JP2022163014A (ja) | 2016-04-21 | 2022-07-08 | Ｄｐｐ３の定量方法および治療方法 |
| JP2024178873A Pending JP2025011237A (ja) | 2016-04-21 | 2024-10-11 | Ｄｐｐ３の定量方法および治療方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076521A Active JP7219737B2 (ja) | 2016-04-21 | 2020-04-23 | Ｄｐｐ３の定量方法および治療方法 |
| JP2022110620A Pending JP2022163014A (ja) | 2016-04-21 | 2022-07-08 | Ｄｐｐ３の定量方法および治療方法 |
| JP2024178873A Pending JP2025011237A (ja) | 2016-04-21 | 2024-10-11 | Ｄｐｐ３の定量方法および治療方法 |
Country Status (15)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190145981A1 (en) * | 2016-04-21 | 2019-05-16 | Sphingotec Therapeutics Gmbh | Methods for determining dpp3 and therapeutic methods |
| US11530276B2 (en) * | 2017-10-25 | 2022-12-20 | 4TEEN4 Pharmaceuticals GmbH | DPP3 binder directed to and binding to specific DPP3-epitopes and its use in the prevention or treatment of diseases / acute conditions that are associated with oxidative stress |
| CN113557031A (zh) * | 2018-12-21 | 2021-10-26 | 4Teen4制药有限公司 | 使用血管紧张肽受体激动剂和/或其前体的治疗的疗法指导和/或疗法监测 |
| EP4552649A3 (en) * | 2019-08-30 | 2025-06-25 | 4TEEN4 Pharmaceuticals GmbH | Therapy guidance and/or therapy monitoring for treatment of shock |
| IL295728A (en) | 2020-02-27 | 2022-10-01 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock |
| AU2021228207A1 (en) * | 2020-02-27 | 2022-10-20 | 4TEEN4 Pharmaceuticals GmbH | DPP3 for therapy guidance, monitoring and stratification of nt-ADM antibodies in patients with shock |
| IL295951A (en) | 2020-02-27 | 2022-10-01 | Adrenomed Ag | Anti-adrenomedullin (adm) binder for use in therapy of patients in shock |
| EP4121763A1 (en) * | 2020-03-16 | 2023-01-25 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 in patients infected with coronavirus |
| EP3922993A1 (en) * | 2020-06-12 | 2021-12-15 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 in patients infected with coronavirus |
| WO2023175035A1 (en) | 2022-03-15 | 2023-09-21 | Adrenomed Ag | Stable aqueous formulation of an anti-adrenomedullin (adm) antibody or anti-adm antibody fragment |
| CN117186177B (zh) * | 2022-05-31 | 2024-08-23 | 中国农业大学 | 一种具有降尿酸活性的鸭血球蛋白肽及其制备方法 |
| CN119630969A (zh) | 2022-07-29 | 2025-03-14 | 4Teen4制药有限公司 | 预测患有败血症性休克的患者中的dpp3增加 |
| KR20250042158A (ko) | 2022-07-29 | 2025-03-26 | 아드레노메드 아게 | 쇼크의 요법 또는 예방에 사용하기 위한 항-아드레노메둘린 (ADM) 항체 또는 항-ADM 항체 단편 또는 항-ADM 비-Ig 스캐폴드 |
| CN120359042A (zh) | 2022-12-15 | 2025-07-22 | 4Teen4制药有限公司 | 改善危重病患者肺功能的dpp3抑制剂 |
| CN115804836A (zh) * | 2022-12-27 | 2023-03-17 | 中国人民解放军海军特色医学中心 | 一种中枢小分子蛋白dpp3在制备降压药物中的应用 |
| CN120857945A (zh) | 2023-03-29 | 2025-10-28 | 4Teen4制药有限公司 | 用于在血压下降的危重病患者中保护心肌和预防心肌损伤的dpp3抑制剂 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| JPS6188884A (ja) | 1984-10-04 | 1986-05-07 | Sankyo Co Ltd | エンケフアリナ−ゼｂ阻害物質およびその製法 |
| AU634716B2 (en) | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0746609A4 (en) | 1991-12-17 | 1997-12-17 | Genpharm Int | NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES |
| JPH06219989A (ja) * | 1993-01-27 | 1994-08-09 | Microbial Chem Res Found | 新規生理活性物質フルオスタチンａおよびｂ、その製造法およびその用途 |
| GB9312324D0 (en) * | 1993-06-15 | 1993-07-28 | Pitman Moore Inc | Vaccine |
| US5612186A (en) | 1994-06-22 | 1997-03-18 | Food Industry Research And Development Institute | Enzyme-capture assay (ECA) for the identification of Escherichia coli in clinical samples |
| US5601986A (en) | 1994-07-14 | 1997-02-11 | Amgen Inc. | Assays and devices for the detection of extrahepatic biliary atresia |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| WO2001016334A2 (en) | 1999-09-01 | 2001-03-08 | Incyte Genomics, Inc. | Human hydrolytic enzymes |
| US6864363B2 (en) * | 2000-11-08 | 2005-03-08 | University Of Georgia Research Foundation, Inc. | Dipeptidylpeptidases and methods of use |
| WO2003020746A1 (en) | 2001-08-30 | 2003-03-13 | Biorexis Pharmaceutical Corporation | Modified transferrin fusion proteins |
| EP2298278B1 (en) | 2002-06-07 | 2015-11-11 | Dyax Corp. | Prevention and reduction of blood loss and inflammatory response |
| CN1852974A (zh) * | 2003-06-09 | 2006-10-25 | 密歇根大学董事会 | 用于治疗和诊断癌症的组合物和方法 |
| EP1675878A2 (en) | 2003-10-24 | 2006-07-05 | Avidia, Inc. | Ldl receptor class a and egf domain monomers and multimers |
| US20100028995A1 (en) | 2004-02-23 | 2010-02-04 | Anaphore, Inc. | Tetranectin Trimerizing Polypeptides |
| WO2005106486A2 (en) * | 2004-04-28 | 2005-11-10 | Bayer Healthcare Ag | Diagnostic and therapeutics for diseases associated with dipeptidyl-peptidase 3(dpp3) |
| WO2005118842A1 (ja) * | 2004-06-01 | 2005-12-15 | Sysmex Corporation | 酵素活性測定方法および酵素活性測定用カラム |
| EP1793847A2 (en) | 2004-09-21 | 2007-06-13 | NascaCell IP GmbH | Use of microproteins as tryptase inhibitors |
| JP2006230318A (ja) | 2005-02-25 | 2006-09-07 | Maruishi Pharmaceutical Co Ltd | 関節リウマチの診断方法 |
| CN100420947C (zh) * | 2005-05-30 | 2008-09-24 | 孙东旭 | 用单一捕获剂定量检测特异性分析物的方法及其试剂盒 |
| WO2007055979A2 (en) * | 2005-11-02 | 2007-05-18 | Meyer Pharmaceuticals Llc | Native trre: protein implicated in tnf receptor shedding for treating arthritis and inflammation |
| JP5410955B2 (ja) | 2006-03-13 | 2014-02-05 | ベクトン・ディキンソン・アンド・カンパニー | ジペプチジルペプチダーゼ関連の疾患状態の診断および予後 |
| EP2302395B1 (en) | 2006-06-07 | 2015-04-15 | Health Diagnostic Laboratory, Inc. | Markers associated with arteriovascular events and methods of use thereof |
| EP2231860B1 (en) | 2007-12-19 | 2011-10-05 | Affibody AB | Polypeptide derived from protein a and able to bind pdgf |
| MX359570B (es) | 2008-11-03 | 2018-10-01 | Molecular Partners Ag | Proteinas de union que inhiben la interaccion en el receptor de vegf-a. |
| US8715928B2 (en) * | 2009-02-13 | 2014-05-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Molecular-based method of cancer diagnosis and prognosis |
| US9376477B2 (en) | 2009-08-27 | 2016-06-28 | Covagen Ag | IL-17 binding compounds and medical uses thereof |
| WO2011073214A2 (en) | 2009-12-14 | 2011-06-23 | Scil Proteins Gmbh | A method for identifying hetero-multimeric modified ubiquitin proteins with binding capability to ligands |
| KR101234352B1 (ko) * | 2010-03-18 | 2013-02-15 | 권동락 | 선택적 면역 세포 분리 반출장치 |
| JP5902679B2 (ja) | 2010-06-08 | 2016-04-13 | ピエリス アーゲーＰｉｅｒｉｓ Ａｇ | ＩＬ−４Ｒαに結合する涙液リポカリンムテイン |
| US20190145981A1 (en) * | 2016-04-21 | 2019-05-16 | Sphingotec Therapeutics Gmbh | Methods for determining dpp3 and therapeutic methods |
-
2017
- 2017-04-20 US US16/095,563 patent/US20190145981A1/en active Pending
- 2017-04-20 EP EP21153574.5A patent/EP3854817A1/en active Pending
- 2017-04-20 SG SG11201809252YA patent/SG11201809252YA/en unknown
- 2017-04-20 BR BR112018071583-2A patent/BR112018071583A2/pt unknown
- 2017-04-20 MY MYPI2018703855A patent/MY200300A/en unknown
- 2017-04-20 AU AU2017252212A patent/AU2017252212B2/en active Active
- 2017-04-20 KR KR1020237026743A patent/KR102886883B1/ko active Active
- 2017-04-20 KR KR1020187033194A patent/KR102565453B1/ko active Active
- 2017-04-20 WO PCT/EP2017/059377 patent/WO2017182561A1/en not_active Ceased
- 2017-04-20 CN CN201780039077.1A patent/CN110168372A/zh active Pending
- 2017-04-20 EP EP24178574.0A patent/EP4417218A3/en active Pending
- 2017-04-20 CN CN202510254123.6A patent/CN120093910A/zh active Pending
- 2017-04-20 CH CH001280/2018A patent/CH713803B1/de unknown
- 2017-04-20 CN CN202511191873.XA patent/CN120992960A/zh active Pending
- 2017-04-20 DE DE112017002105.7T patent/DE112017002105T5/de active Pending
- 2017-04-20 IL IL262472A patent/IL262472B2/en unknown
- 2017-04-20 KR KR1020247025458A patent/KR102886863B1/ko active Active
- 2017-04-20 JP JP2018555652A patent/JP2019520550A/ja active Pending
- 2017-04-20 EP EP17720047.4A patent/EP3446125B1/en active Active
- 2017-04-20 MX MX2018012856A patent/MX2018012856A/es unknown
- 2017-04-20 EP EP21153560.4A patent/EP3896450A1/en active Pending
- 2017-04-20 EP EP24178565.8A patent/EP4417217A3/en active Pending
- 2017-04-20 CA CA3021252A patent/CA3021252A1/en active Pending
-
2018
- 2018-10-19 MX MX2025006655A patent/MX2025006655A/es unknown
- 2018-10-19 MX MX2020001193A patent/MX2020001193A/es unknown
-
2020
- 2020-04-23 JP JP2020076521A patent/JP7219737B2/ja active Active
- 2020-07-02 US US16/919,449 patent/US11726094B2/en active Active
-
2022
- 2022-07-08 JP JP2022110620A patent/JP2022163014A/ja active Pending
-
2023
- 2023-06-21 US US18/338,805 patent/US20240385197A1/en active Pending
- 2023-11-02 AU AU2023258417A patent/AU2023258417A1/en active Pending
-
2024
- 2024-10-11 JP JP2024178873A patent/JP2025011237A/ja active Pending
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