CA3021252A1 - Methods for determining dpp3 and therapeutic methods - Google Patents

Methods for determining dpp3 and therapeutic methods Download PDF

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Publication number
CA3021252A1
CA3021252A1 CA3021252A CA3021252A CA3021252A1 CA 3021252 A1 CA3021252 A1 CA 3021252A1 CA 3021252 A CA3021252 A CA 3021252A CA 3021252 A CA3021252 A CA 3021252A CA 3021252 A1 CA3021252 A1 CA 3021252A1
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Canada
Prior art keywords
dpp3
subject
disease
antibody
condition
Prior art date
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Pending
Application number
CA3021252A
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English (en)
French (fr)
Inventor
Andreas Bergmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
4Teen4 Pharmaceuticals GmbH
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Sphingotec Therapeutics GmbH
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Publication of CA3021252A1 publication Critical patent/CA3021252A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
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CA3021252A 2016-04-21 2017-04-20 Methods for determining dpp3 and therapeutic methods Pending CA3021252A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16166476.8 2016-04-21
EP16166476 2016-04-21
PCT/EP2017/059377 WO2017182561A1 (en) 2016-04-21 2017-04-20 Methods for determining dpp3 and therapeutic methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3264486A Division CA3264486A1 (en) 2016-04-21 2017-04-20 Methods for determining dpp3 and therapeutic methods

Publications (1)

Publication Number Publication Date
CA3021252A1 true CA3021252A1 (en) 2017-10-26

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CA3021252A Pending CA3021252A1 (en) 2016-04-21 2017-04-20 Methods for determining dpp3 and therapeutic methods

Country Status (15)

Country Link
US (3) US20190145981A1 (cg-RX-API-DMAC7.html)
EP (5) EP3854817A1 (cg-RX-API-DMAC7.html)
JP (4) JP2019520550A (cg-RX-API-DMAC7.html)
KR (3) KR102886883B1 (cg-RX-API-DMAC7.html)
CN (3) CN110168372A (cg-RX-API-DMAC7.html)
AU (2) AU2017252212B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018071583A2 (cg-RX-API-DMAC7.html)
CA (1) CA3021252A1 (cg-RX-API-DMAC7.html)
CH (1) CH713803B1 (cg-RX-API-DMAC7.html)
DE (1) DE112017002105T5 (cg-RX-API-DMAC7.html)
IL (1) IL262472B2 (cg-RX-API-DMAC7.html)
MX (3) MX2018012856A (cg-RX-API-DMAC7.html)
MY (1) MY200300A (cg-RX-API-DMAC7.html)
SG (1) SG11201809252YA (cg-RX-API-DMAC7.html)
WO (1) WO2017182561A1 (cg-RX-API-DMAC7.html)

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US20190145981A1 (en) * 2016-04-21 2019-05-16 Sphingotec Therapeutics Gmbh Methods for determining dpp3 and therapeutic methods
US11530276B2 (en) * 2017-10-25 2022-12-20 4TEEN4 Pharmaceuticals GmbH DPP3 binder directed to and binding to specific DPP3-epitopes and its use in the prevention or treatment of diseases / acute conditions that are associated with oxidative stress
CN113557031A (zh) * 2018-12-21 2021-10-26 4Teen4制药有限公司 使用血管紧张肽受体激动剂和/或其前体的治疗的疗法指导和/或疗法监测
EP4552649A3 (en) * 2019-08-30 2025-06-25 4TEEN4 Pharmaceuticals GmbH Therapy guidance and/or therapy monitoring for treatment of shock
IL295728A (en) 2020-02-27 2022-10-01 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock
AU2021228207A1 (en) * 2020-02-27 2022-10-20 4TEEN4 Pharmaceuticals GmbH DPP3 for therapy guidance, monitoring and stratification of nt-ADM antibodies in patients with shock
IL295951A (en) 2020-02-27 2022-10-01 Adrenomed Ag Anti-adrenomedullin (adm) binder for use in therapy of patients in shock
EP4121763A1 (en) * 2020-03-16 2023-01-25 4TEEN4 Pharmaceuticals GmbH Dpp3 in patients infected with coronavirus
EP3922993A1 (en) * 2020-06-12 2021-12-15 4TEEN4 Pharmaceuticals GmbH Dpp3 in patients infected with coronavirus
WO2023175035A1 (en) 2022-03-15 2023-09-21 Adrenomed Ag Stable aqueous formulation of an anti-adrenomedullin (adm) antibody or anti-adm antibody fragment
CN117186177B (zh) * 2022-05-31 2024-08-23 中国农业大学 一种具有降尿酸活性的鸭血球蛋白肽及其制备方法
CN119630969A (zh) 2022-07-29 2025-03-14 4Teen4制药有限公司 预测患有败血症性休克的患者中的dpp3增加
KR20250042158A (ko) 2022-07-29 2025-03-26 아드레노메드 아게 쇼크의 요법 또는 예방에 사용하기 위한 항-아드레노메둘린 (ADM) 항체 또는 항-ADM 항체 단편 또는 항-ADM 비-Ig 스캐폴드
CN120359042A (zh) 2022-12-15 2025-07-22 4Teen4制药有限公司 改善危重病患者肺功能的dpp3抑制剂
CN115804836A (zh) * 2022-12-27 2023-03-17 中国人民解放军海军特色医学中心 一种中枢小分子蛋白dpp3在制备降压药物中的应用
CN120857945A (zh) 2023-03-29 2025-10-28 4Teen4制药有限公司 用于在血压下降的危重病患者中保护心肌和预防心肌损伤的dpp3抑制剂

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