JP2017522312A5 - - Google Patents

Download PDF

Info

Publication number
JP2017522312A5
JP2017522312A5 JP2017502194A JP2017502194A JP2017522312A5 JP 2017522312 A5 JP2017522312 A5 JP 2017522312A5 JP 2017502194 A JP2017502194 A JP 2017502194A JP 2017502194 A JP2017502194 A JP 2017502194A JP 2017522312 A5 JP2017522312 A5 JP 2017522312A5
Authority
JP
Japan
Prior art keywords
immunogenic composition
doses
antigen
combination
combination according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017502194A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017522312A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/040453 external-priority patent/WO2016011083A1/en
Publication of JP2017522312A publication Critical patent/JP2017522312A/ja
Publication of JP2017522312A5 publication Critical patent/JP2017522312A5/ja
Pending legal-status Critical Current

Links

JP2017502194A 2014-07-15 2015-07-14 Tlr4アゴニストアジュバント及びレンチウイルスベクターを用いたプライム・ブーストレジメン Pending JP2017522312A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462024797P 2014-07-15 2014-07-15
US201462024792P 2014-07-15 2014-07-15
US62/024,792 2014-07-15
US62/024,797 2014-07-15
PCT/US2015/040453 WO2016011083A1 (en) 2014-07-15 2015-07-14 Prime-boost regimens with a tlr4 agonist adjuvant and a lentiviral vector

Publications (2)

Publication Number Publication Date
JP2017522312A JP2017522312A (ja) 2017-08-10
JP2017522312A5 true JP2017522312A5 (enExample) 2018-08-23

Family

ID=53776968

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017502194A Pending JP2017522312A (ja) 2014-07-15 2015-07-14 Tlr4アゴニストアジュバント及びレンチウイルスベクターを用いたプライム・ブーストレジメン

Country Status (8)

Country Link
US (1) US20170196954A1 (enExample)
EP (1) EP3169352A1 (enExample)
JP (1) JP2017522312A (enExample)
KR (1) KR20170032373A (enExample)
AU (1) AU2015289773A1 (enExample)
CA (1) CA2955015A1 (enExample)
MX (1) MX2017000630A (enExample)
WO (1) WO2016011083A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102764225B1 (ko) 2016-04-15 2025-02-07 알파인 이뮨 사이언시즈, 인코포레이티드 Cd80 변이체 면역조절 단백질 및 그의 용도
US10882914B2 (en) 2016-04-15 2021-01-05 Alpine Immune Sciences, Inc. ICOS ligand variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
WO2018022945A1 (en) 2016-07-28 2018-02-01 Alpine Immune Sciences, Inc. Cd112 variant immunomodulatory proteins and uses thereof
CA3032120A1 (en) 2016-07-28 2018-02-01 Alpine Immune Sciences, Inc. Cd155 variant immunomodulatory proteins and uses thereof
WO2018148180A2 (en) * 2017-02-07 2018-08-16 Immune Design Corp. Materials and methods for identifying and treating cancer patients
MX2019010887A (es) 2017-03-16 2019-10-15 Alpine Immune Sciences Inc Proteinas inmunomoduladoras de cb80 variante y usos de estas.
KR102692556B1 (ko) 2017-03-16 2024-08-09 알파인 이뮨 사이언시즈, 인코포레이티드 Pd-l1 변이체 면역조절 단백질 및 그의 용도
KR20190141146A (ko) 2017-03-16 2019-12-23 알파인 이뮨 사이언시즈, 인코포레이티드 Pd-l2 변이체 면역조절 단백질 및 그의 용도
EP4442268A3 (en) 2017-10-10 2025-04-02 Alpine Immune Sciences, Inc. Ctla-4 variant immunomodulatory proteins and uses thereof
WO2019079520A2 (en) 2017-10-18 2019-04-25 Alpine Immune Sciences, Inc. ICOS VARIANT LIGAND IMMUNOMODULATORY IMMUNOMODULATORY PROTEINS, COMPOSITIONS AND METHODS THEREOF
WO2019136179A1 (en) 2018-01-03 2019-07-11 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
US20210046130A1 (en) * 2018-01-24 2021-02-18 Virogin Biotech Canada Ltd Recombinant viral vaccines
US12065476B2 (en) 2018-06-15 2024-08-20 Alpine Immune Sciences, Inc. PD-1 variant immunomodulatory proteins and uses thereof
AU2019339332A1 (en) * 2018-09-10 2021-04-08 Torque Therapeutics, Inc. Antigen-specific T lymphocytes and methods of making and using the same
KR20210089146A (ko) 2018-09-19 2021-07-15 알파인 이뮨 사이언시즈, 인코포레이티드 변이체 cd80 단백질 및 관련 구축물의 방법 및 용도
EP3628735A1 (en) 2018-09-25 2020-04-01 Centre National De La Recherche Scientifique Antisense rna targeting pmp22 for the treatment of charcot-marie-tooth 1a disease
KR20210135987A (ko) 2018-11-30 2021-11-16 알파인 이뮨 사이언시즈, 인코포레이티드 Cd86 변이체 면역조절 단백질 및 그의 용도
WO2020131656A1 (en) * 2018-12-17 2020-06-25 Immune Design Corp. Pathogen-associated molecular pattern molecules and rna immunogenic compositions and methods of using the compositions for treating cancer
SG11202111033VA (en) 2019-04-17 2021-11-29 Alpine Immune Sciences Inc Methods and uses of variant icos ligand (icosl) fusion proteins
CN115812077A (zh) 2020-05-08 2023-03-17 高山免疫科学股份有限公司 April和baff抑制性免疫调节蛋白及其使用方法
AU2022269139A1 (en) 2021-05-07 2023-11-16 Alpine Immune Sciences, Inc. Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein
EP4490173A1 (en) 2022-03-07 2025-01-15 Alpine Immune Sciences, Inc. Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses
KR20250099778A (ko) 2022-10-04 2025-07-02 알파인 이뮨 사이언시즈, 인코포레이티드 자가항체-매개 질환의 치료에 사용하기 위한 돌연변이된 taci-fc 융합 단백질

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4411993A (en) 1981-04-29 1983-10-25 Steven Gillis Hybridoma antibody which inhibits interleukin 2 activity
US7045313B1 (en) 1982-11-30 2006-05-16 The United States Of America As Represented By The Department Of Health And Human Services Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
US4543439A (en) 1982-12-13 1985-09-24 Massachusetts Institute Of Technology Production and use of monoclonal antibodies to phosphotyrosine-containing proteins
US4703004A (en) 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4902614A (en) 1984-12-03 1990-02-20 Teijin Limited Monoclonal antibody to human protein C
US4569794A (en) 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5352449A (en) 1986-05-30 1994-10-04 Cambridge Biotech Corporation Vaccine comprising recombinant feline leukemia antigen and saponin adjuvant
US5011912A (en) 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US5443964A (en) 1987-08-10 1995-08-22 Duke University Poxvirus insertion/expression vector
US4937190A (en) 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
ATE112314T1 (de) 1988-05-17 1994-10-15 Lubrizol Genetics Inc Pflanzliches ubiquitinpromotorsystem.
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
CA2017507C (en) 1989-05-25 1996-11-12 Gary Van Nest Adjuvant formulation comprising a submicron oil droplet emulsion
US5256643A (en) 1990-05-29 1993-10-26 The Government Of The United States Human cripto protein
US6410010B1 (en) 1992-10-13 2002-06-25 Board Of Regents, The University Of Texas System Recombinant P53 adenovirus compositions
DE69233186T2 (de) 1991-05-06 2004-06-03 The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer Karcinoembryonale antigen expremierende rekombinante viren und methoden ihrer anwendung
US5273965A (en) 1992-07-02 1993-12-28 Cambridge Biotech Corporation Methods for enhancing drug delivery with modified saponins
TNSN93075A1 (fr) 1992-07-08 1994-03-17 Schering Corp Utilisation de gm-csf comme adjuvant pour vaccin
US5786148A (en) 1996-11-05 1998-07-28 Incyte Pharmaceuticals, Inc. Polynucleotides encoding a novel prostate-specific kallikrein
EP0786522A2 (en) 1992-07-17 1997-07-30 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecules for treatment of stenotic conditions
DE9319879U1 (de) 1993-12-23 1994-03-17 Ems-Inventa AG, Zürich Sequentiell Coextrudierte Kühlflüssigkeitsleitung
US5688506A (en) 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
EP1167378B1 (en) 1994-07-15 2011-05-11 University of Iowa Research Foundation Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
WO1996009380A1 (en) 1994-09-23 1996-03-28 The University Of British Columbia Method of enhancing expression of mhc class i molecules bearing endogenous peptides
PT784483E (pt) 1994-10-03 2001-05-31 Us Gov Health & Human Serv Composicao que compreende um virus recombinante que exprime um antigenio e um virus recombinante que exprime uma molecula imunoestimuladora
US5981215A (en) 1995-06-06 1999-11-09 Human Genome Sciences, Inc. Human criptin growth factor
US5955306A (en) 1996-09-17 1999-09-21 Millenium Pharmaceuticals, Inc. Genes encoding proteins that interact with the tub protein
US5840871A (en) 1997-01-29 1998-11-24 Incyte Pharmaceuticals, Inc. Prostate-associated kallikrein
EP0961830A1 (en) 1997-01-29 1999-12-08 Neurosearch A/S EXPRESSION VECTORS AND METHODS FOR $i(IN VIVO) EXPRESSION OF THERAPEUTIC POLYPEPTIDES
US6887660B2 (en) 1997-02-25 2005-05-03 Corixa Corporation Compounds for immunodiagnosis of prostate cancer and methods for their use
US6395713B1 (en) 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
EP1044021B1 (en) 1998-01-05 2009-09-23 The University of Washington Enhanced transport using membrane disruptive agents
CZ298364B6 (cs) 1998-02-05 2007-09-05 Smithkline Beecham Biologicals S. A. Deriváty antigenu asociovaných s nádory z MAGE rodiny a sekvence nukleových kyselin kodující tyto deriváty, jejich použití pro prípravu fúzních proteinu a prostredku pro vakcinaci
JP2002511266A (ja) 1998-04-15 2002-04-16 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ 腫瘍関連核酸及びその使用
GB2337755B (en) 1998-05-29 2003-10-29 Secr Defence Virus vaccine
AU762812B2 (en) 1998-07-14 2003-07-03 Corixa Corporation Compositions and methods for therapy and diagnosis of prostate cancer
IL141044A0 (en) 1998-08-07 2002-02-10 Univ Washington Innunological herpes simplex virus antigens and methods for use thereof
MXPA01009073A (es) 1999-03-10 2002-05-06 Phogen Ltd Suministro de acidos nucleicos y proteinas a las celulas.
DE60014076T2 (de) 1999-04-19 2005-10-13 Glaxosmithkline Biologicals S.A. Adjuvans-zusammensetzung, enthaltend saponin und ein immunstimulatorisches oligonukleotid
CA2379166C (en) 1999-08-09 2013-03-26 Targeted Genetics Corporation Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs
US20020130430A1 (en) 2000-12-29 2002-09-19 Castor Trevor Percival Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
US20030077829A1 (en) 2001-04-30 2003-04-24 Protiva Biotherapeutics Inc.. Lipid-based formulations
US7060498B1 (en) 2001-11-28 2006-06-13 Genta Salus Llc Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
US7247615B2 (en) 2001-11-30 2007-07-24 United States Of America, Represented By The Secretary, Department Of Health And Human Services Peptide agonists of prostate-specific antigen and uses therefor
US7141540B2 (en) 2001-11-30 2006-11-28 Genta Salus Llc Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
WO2006060314A2 (en) 2004-12-01 2006-06-08 Bayer Schering Pharma Aktiengesellschaft Generation of replication competent viruses for therapeutic use
DK2468300T3 (da) 2006-09-26 2018-01-29 Infectious Disease Res Inst Vaccinesammensætning indeholdende syntetisk adjuvant
CA2698668A1 (en) 2007-09-07 2009-03-19 University Of Georgia Research Foundation, Inc. Synthetic lipid a derivative
ES2664988T3 (es) 2007-12-11 2018-04-24 The University Of North Carolina At Chapel Hill Vectores retrovirales modificados del tracto de polipurinas
JP5830015B2 (ja) 2009-06-05 2015-12-09 インフェクシャス ディズィーズ リサーチ インスティチュート 合成グルコピラノシル脂質アジュバント
SMT201800656T1 (it) 2009-07-24 2019-01-11 Immune Design Corp Vettori lentivirali non integranti
BR112013025799A2 (pt) 2011-04-08 2016-12-20 Immune Design Corp método para induzir uma resposta imune em um sujeito, e, preparação
AU2013237900B2 (en) * 2012-03-30 2017-07-27 Immune Design Corp. Lentiviral vector particles having improved transduction efficiency for cells expressing DC- SIGN
US8323662B1 (en) 2012-03-30 2012-12-04 Immune Design Corp. Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein

Similar Documents

Publication Publication Date Title
JP2017522312A5 (enExample)
JP6921750B2 (ja) ペプチドミニ遺伝子発現系を含むリステリアベースの組成物およびその使用方法
JP6895975B2 (ja) 組換えt細胞受容体を含む組成物及びライブラリー並びに組換えt細胞受容体を使用する方法
JP2019503186A (ja) 個別化された送達ベクターベースの免疫療法およびその使用
CA3212964A1 (en) Tumor neoantigenic peptides
TW201639594A (zh) 利用重組李斯特菌菌株之組合療法
Xiao et al. Dendritic cell-directed vaccination with a lentivector encoding PSCA for prostate cancer in mice
JP2018515588A (ja) 個別化送達ベクターに基づく免疫療法とその使用
Dai et al. PD-1/PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines
RU2013103335A (ru) Конструкции гомодимерных белков
JP7384896B2 (ja) 主要組織適合遺伝子複合(mhc)クラスii-発現癌細胞ワクチン、及び統合免疫応答を生じさせるための使用方法
US20230293650A1 (en) Individualized therapeutic anticancer vaccine
Neukirch et al. Adenovirus based virus-like-vaccines targeting endogenous retroviruses can eliminate growing colorectal cancers in mice
Wang et al. The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC‐205/CD205 receptor on dendritic cells
Kilpeläinen et al. Priming with recombinant BCG expressing novel HIV-1 conserved mosaic immunogens and boosting with recombinant ChAdOx1 is safe, stable, and elicits HIV-1-specific T-cell responses in BALB/c mice
JP2022071130A (ja) ワクチンとして使用するためのエキソソームアンカータンパク質を発現するヌクレオチド配列
Li et al. Antigen-clustered nanovaccine achieves long-term tumor remission by promoting B/CD 4 T cell crosstalk
Chen et al. Induction of HCA587-specific antitumor immunity with HCA587 protein formulated with CpG and ISCOM in mice
Wang et al. DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice
JP2017516462A5 (enExample)
Hart et al. Stable expression of lentiviral antigens by quality-controlled recombinant Mycobacterium bovis BCG vectors
Kim et al. Single chain MHC I trimer-based DNA vaccines for protection against Listeria monocytogenes infection
RU2020100072A (ru) Иммуногенные композиции, содержащие cea, muc1 и tert
Lowe et al. Tumor immunity against a simian virus 40 oncoprotein requires CD8+ T lymphocytes in the effector immune phase
Chen et al. Induction of humoral and cellular immune responses in mice by multiepitope vaccines composing of both T and B lymphocyte epitopes of MAGE-A3 which are recombined into HBcAg