JP2017521374A5 - - Google Patents
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- JP2017521374A5 JP2017521374A5 JP2016569875A JP2016569875A JP2017521374A5 JP 2017521374 A5 JP2017521374 A5 JP 2017521374A5 JP 2016569875 A JP2016569875 A JP 2016569875A JP 2016569875 A JP2016569875 A JP 2016569875A JP 2017521374 A5 JP2017521374 A5 JP 2017521374A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- kidney
- inhibitors
- use according
- donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000003112 inhibitor Substances 0.000 claims 44
- 210000003734 kidney Anatomy 0.000 claims 17
- 238000002054 transplantation Methods 0.000 claims 10
- 206010063837 Reperfusion injury Diseases 0.000 claims 9
- 238000000502 dialysis Methods 0.000 claims 9
- 238000001990 intravenous administration Methods 0.000 claims 9
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 9
- 125000002652 ribonucleotide group Chemical group 0.000 claims 9
- 230000002265 prevention Effects 0.000 claims 8
- 230000001052 transient effect Effects 0.000 claims 6
- 108020004459 Small interfering RNA Proteins 0.000 claims 5
- 108700025694 p53 Genes Proteins 0.000 claims 5
- 108091028664 Ribonucleotide Proteins 0.000 claims 4
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 4
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 4
- 230000000692 anti-sense effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000003018 immunosuppressive agent Substances 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 4
- 239000002336 ribonucleotide Substances 0.000 claims 4
- 229960001967 tacrolimus Drugs 0.000 claims 4
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 4
- HYCSHFLKPSMPGO-UHFFFAOYSA-N 3-hydroxypropyl dihydrogen phosphate Chemical compound OCCCOP(O)(O)=O HYCSHFLKPSMPGO-UHFFFAOYSA-N 0.000 claims 3
- 229910019142 PO4 Inorganic materials 0.000 claims 3
- 108091081021 Sense strand Proteins 0.000 claims 3
- 208000020832 chronic kidney disease Diseases 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 201000000523 end stage renal failure Diseases 0.000 claims 3
- 229940124589 immunosuppressive drug Drugs 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims 2
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 2
- 239000007972 injectable composition Substances 0.000 claims 2
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims 2
- 229940014456 mycophenolate Drugs 0.000 claims 2
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 2
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 2
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000010410 reperfusion Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229940104230 thymidine Drugs 0.000 claims 2
- 230000026683 transduction Effects 0.000 claims 2
- 238000010361 transduction Methods 0.000 claims 2
- 208000007204 Brain death Diseases 0.000 claims 1
- 229940122739 Calcineurin inhibitor Drugs 0.000 claims 1
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims 1
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000001494 anti-thymocyte effect Effects 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229940109239 creatinine Drugs 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000009093 first-line therapy Methods 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000004768 organ dysfunction Effects 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 238000005057 refrigeration Methods 0.000 claims 1
- 229920002477 rna polymer Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 159000000000 sodium salts Chemical group 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462004239P | 2014-05-29 | 2014-05-29 | |
| US62/004,239 | 2014-05-29 | ||
| PCT/US2015/032499 WO2015183842A1 (en) | 2014-05-29 | 2015-05-27 | Methods and compositions for preventing ischemia reperfusion injury in organs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020074549A Division JP2020128383A (ja) | 2014-05-29 | 2020-04-20 | 臓器の虚血再灌流傷害を予防するための方法及び組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017521374A JP2017521374A (ja) | 2017-08-03 |
| JP2017521374A5 true JP2017521374A5 (enExample) | 2018-06-28 |
Family
ID=53398201
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016569875A Withdrawn JP2017521374A (ja) | 2014-05-29 | 2015-05-27 | 臓器の虚血再灌流傷害を予防するための方法及び組成物 |
| JP2020074549A Pending JP2020128383A (ja) | 2014-05-29 | 2020-04-20 | 臓器の虚血再灌流傷害を予防するための方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020074549A Pending JP2020128383A (ja) | 2014-05-29 | 2020-04-20 | 臓器の虚血再灌流傷害を予防するための方法及び組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20170081665A1 (enExample) |
| EP (2) | EP3149172B1 (enExample) |
| JP (2) | JP2017521374A (enExample) |
| KR (1) | KR20170007492A (enExample) |
| CN (2) | CN112410336A (enExample) |
| AU (1) | AU2015267160B2 (enExample) |
| BR (1) | BR112016028009A2 (enExample) |
| CA (1) | CA2949109A1 (enExample) |
| DK (2) | DK3149172T3 (enExample) |
| ES (2) | ES2862185T3 (enExample) |
| HU (2) | HUE040092T2 (enExample) |
| IL (2) | IL248912A0 (enExample) |
| LT (2) | LT3149172T (enExample) |
| MX (2) | MX373950B (enExample) |
| PL (2) | PL3444349T3 (enExample) |
| PT (2) | PT3444349T (enExample) |
| SI (2) | SI3444349T1 (enExample) |
| WO (1) | WO2015183842A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| US12091664B2 (en) | 2018-01-12 | 2024-09-17 | University Of Massachusetts | Methods for preventing graft ischemia reperfusion injury during ex vivo machine perfusion preservation |
| GB202016863D0 (en) * | 2020-10-23 | 2020-12-09 | Causeway Therapeutics Ltd | Microrna-29 compounds, compositions and uses in therapy |
| AU2022418939A1 (en) * | 2021-12-22 | 2024-03-21 | Na Vaccine Institute | Composition for preventing or treating ischemia-reperfusion injury and use thereof |
| KR20240154159A (ko) * | 2023-04-17 | 2024-10-25 | 재단법인 아산사회복지재단 | miR-223을 유효성분으로 포함하는 간 손상 예방 또는 치료용 조성물 |
| CN118460648B (zh) * | 2024-07-10 | 2025-01-28 | 凯莱英医药集团（天津）股份有限公司 | 一种qpi-1002的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5861254A (en) | 1997-01-31 | 1999-01-19 | Nexstar Pharmaceuticals, Inc. | Flow cell SELEX |
| IE920562A1 (en) | 1991-02-21 | 1992-08-26 | Gilead Sciences | Aptamer specific for biomolecules and method of making |
| US5756291A (en) | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
| DE69427974T2 (de) | 1993-04-29 | 2001-12-06 | Unilever N.V., Rotterdam | Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae |
| WO2000044364A2 (en) | 1999-01-29 | 2000-08-03 | The Board Of Trustees Of The University Of Illinois | P53 inhibitors and their use for the treatment of cancer, hyperthermia, hypoxia, a burn, trauma to the central nervous system, a seizure, acute inflammation, tissue ageing, preservation of organs for transplant and preparation of a host for bone marrow transplant |
| US6376190B1 (en) | 2000-09-22 | 2002-04-23 | Somalogic, Inc. | Modified SELEX processes without purified protein |
| US20060105975A1 (en) | 2004-04-19 | 2006-05-18 | Shannon Pendergrast | Aptamer-mediated intracellular delivery of therapeutic oligonucleotides |
| JP4991547B2 (ja) * | 2004-09-28 | 2012-08-01 | クアーク・ファーマスーティカルス、インコーポレイテッド | 脱毛症、急性腎不全および他の疾患の治療のためのオリゴリボヌクレオチドおよびその使用の方法 |
| US8362229B2 (en) | 2006-02-08 | 2013-01-29 | Quark Pharmaceuticals, Inc. | Tandem siRNAS |
| US7910566B2 (en) * | 2006-03-09 | 2011-03-22 | Quark Pharmaceuticals Inc. | Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA |
| WO2009001359A2 (en) | 2007-06-27 | 2008-12-31 | Quark Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of pro-apoptotic genes |
| CA2701845A1 (en) * | 2007-10-03 | 2009-04-09 | Quark Pharmaceuticals, Inc. | Novel sirna structures |
| WO2009155504A2 (en) * | 2008-06-20 | 2009-12-23 | The Children's Medical Center Corporation | Methods for the modulation of angiogenesis |
| US8637482B2 (en) * | 2009-06-08 | 2014-01-28 | Quark Pharmaceuticals, Inc. | Methods for treating chronic kidney disease |
| AU2010324658A1 (en) | 2009-11-26 | 2012-05-03 | Quark Pharmaceuticals, Inc. | siRNA compounds comprising terminal substitutions |
| WO2011084193A1 (en) | 2010-01-07 | 2011-07-14 | Quark Pharmaceuticals, Inc. | Oligonucleotide compounds comprising non-nucleotide overhangs |
| JPWO2011138966A1 (ja) | 2010-05-06 | 2013-07-22 | ダイヤニトリックス株式会社 | 微生物触媒を用いたアクリルアミドの製造方法 |
| US9808461B2 (en) * | 2010-11-17 | 2017-11-07 | The University Of North Carolina At Chapel Hill | Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6 |
| EP2649181B1 (en) | 2010-12-06 | 2016-04-27 | Quark Pharmaceuticals, Inc. | Double stranded oligonucleotide compounds comprising positional modifications |
| US9176487B2 (en) * | 2011-10-24 | 2015-11-03 | Mayo Foundation For Medical Education And Research | Methods and materials for reducing the risk of infections |
| ES2704855T3 (es) * | 2012-09-12 | 2019-03-20 | Quark Pharmaceuticals Inc | Moléculas de oligonucleótido de doble cadena para p53 y métodos de uso de las mismas |
-
2015
- 2015-05-27 SI SI201531563T patent/SI3444349T1/sl unknown
- 2015-05-27 EP EP15729289.7A patent/EP3149172B1/en not_active Not-in-force
- 2015-05-27 KR KR1020167037012A patent/KR20170007492A/ko not_active Withdrawn
- 2015-05-27 US US15/312,425 patent/US20170081665A1/en not_active Abandoned
- 2015-05-27 HU HUE15729289A patent/HUE040092T2/hu unknown
- 2015-05-27 CA CA2949109A patent/CA2949109A1/en not_active Abandoned
- 2015-05-27 PT PT181837352T patent/PT3444349T/pt unknown
- 2015-05-27 SI SI201530342T patent/SI3149172T1/sl unknown
- 2015-05-27 LT LTEP15729289.7T patent/LT3149172T/lt unknown
- 2015-05-27 DK DK15729289.7T patent/DK3149172T3/en active
- 2015-05-27 EP EP18183735.2A patent/EP3444349B1/en active Active
- 2015-05-27 LT LTEP18183735.2T patent/LT3444349T/lt unknown
- 2015-05-27 WO PCT/US2015/032499 patent/WO2015183842A1/en not_active Ceased
- 2015-05-27 PL PL18183735T patent/PL3444349T3/pl unknown
- 2015-05-27 CN CN202011264844.9A patent/CN112410336A/zh active Pending
- 2015-05-27 MX MX2016015635A patent/MX373950B/es active IP Right Grant
- 2015-05-27 BR BR112016028009A patent/BR112016028009A2/pt active Search and Examination
- 2015-05-27 PT PT15729289T patent/PT3149172T/pt unknown
- 2015-05-27 CN CN201580041391.4A patent/CN106661579B/zh not_active Expired - Fee Related
- 2015-05-27 ES ES18183735T patent/ES2862185T3/es active Active
- 2015-05-27 HU HUE18183735A patent/HUE054226T2/hu unknown
- 2015-05-27 PL PL15729289T patent/PL3149172T3/pl unknown
- 2015-05-27 ES ES15729289.7T patent/ES2683869T3/es active Active
- 2015-05-27 JP JP2016569875A patent/JP2017521374A/ja not_active Withdrawn
- 2015-05-27 DK DK18183735.2T patent/DK3444349T3/da active
- 2015-05-27 AU AU2015267160A patent/AU2015267160B2/en not_active Expired - Fee Related
-
2016
- 2016-11-11 IL IL248912A patent/IL248912A0/en active IP Right Grant
- 2016-11-28 MX MX2020005794A patent/MX2020005794A/es unknown
-
2017
- 2017-07-14 US US15/650,297 patent/US9868953B2/en active Active
- 2017-12-05 US US15/832,334 patent/US20180305696A1/en not_active Abandoned
-
2020
- 2020-04-20 JP JP2020074549A patent/JP2020128383A/ja active Pending
- 2020-10-19 IL IL278144A patent/IL278144B/en unknown
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