JP2017521057A5 - - Google Patents
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- JP2017521057A5 JP2017521057A5 JP2016572251A JP2016572251A JP2017521057A5 JP 2017521057 A5 JP2017521057 A5 JP 2017521057A5 JP 2016572251 A JP2016572251 A JP 2016572251A JP 2016572251 A JP2016572251 A JP 2016572251A JP 2017521057 A5 JP2017521057 A5 JP 2017521057A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- culture
- cell culture
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 25
- 238000004519 manufacturing process Methods 0.000 claims description 16
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 7
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims 49
- 238000004113 cell culture Methods 0.000 claims 28
- 239000001963 growth medium Substances 0.000 claims 18
- 210000004962 mammalian cell Anatomy 0.000 claims 13
- 230000010412 perfusion Effects 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 4
- 238000010257 thawing Methods 0.000 claims 4
- 238000003306 harvesting Methods 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000011437 continuous method Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 description 8
- 239000012528 membrane Substances 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000000164 protein isolation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009553P | 2014-06-09 | 2014-06-09 | |
| US62/009,553 | 2014-06-09 | ||
| PCT/US2015/034709 WO2015191462A1 (en) | 2014-06-09 | 2015-06-08 | Seed train processes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177043A Division JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521057A JP2017521057A (ja) | 2017-08-03 |
| JP2017521057A5 true JP2017521057A5 (https=) | 2018-07-12 |
| JP6784600B2 JP6784600B2 (ja) | 2020-11-11 |
Family
ID=53477008
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572251A Active JP6784600B2 (ja) | 2014-06-09 | 2015-06-08 | シードトレイン法およびその使用 |
| JP2020177043A Active JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
| JP2022092635A Active JP7360504B2 (ja) | 2014-06-09 | 2022-06-08 | シードトレイン法およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177043A Active JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
| JP2022092635A Active JP7360504B2 (ja) | 2014-06-09 | 2022-06-08 | シードトレイン法およびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10570367B2 (https=) |
| EP (3) | EP3152299B1 (https=) |
| JP (3) | JP6784600B2 (https=) |
| KR (2) | KR102584375B1 (https=) |
| CN (2) | CN111575225B (https=) |
| AU (3) | AU2015274897B2 (https=) |
| BR (1) | BR112016028891B1 (https=) |
| CA (1) | CA2951551C (https=) |
| CY (1) | CY1122803T1 (https=) |
| DK (1) | DK3152299T3 (https=) |
| ES (2) | ES2773630T3 (https=) |
| HU (1) | HUE047683T2 (https=) |
| IL (3) | IL290096B2 (https=) |
| MX (2) | MX373323B (https=) |
| RU (1) | RU2694327C2 (https=) |
| SG (1) | SG11201610216UA (https=) |
| TW (3) | TWI776235B (https=) |
| WO (1) | WO2015191462A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| CN105143443A (zh) | 2013-02-22 | 2015-12-09 | 建新公司 | 微载体灌注培养方法及其用途 |
| TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| KR20250025516A (ko) | 2014-12-22 | 2025-02-21 | 젠자임 코포레이션 | 포유류 세포의 배양 방법 |
| CA3001761A1 (en) * | 2015-10-26 | 2017-05-04 | Lonza Limited | A manufacturing facility for the production of biopharmaceuticals |
| CN110072961B (zh) * | 2016-12-22 | 2022-02-08 | 东亚合成株式会社 | 粘合剂组合物以及使用其的覆盖膜、粘合片、覆铜层压板和电磁波屏蔽材料 |
| EP3681989A1 (en) * | 2017-09-15 | 2020-07-22 | Bristol-Myers Squibb Company | Online biomass capacitance monitoring during large scale production of polypeptides of interest |
| TWI846694B (zh) * | 2018-05-04 | 2024-07-01 | 美商健臻公司 | 具有過濾系統的灌注式生物反應器 |
| US12071607B2 (en) * | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| EP3650528A1 (en) * | 2018-11-08 | 2020-05-13 | Aglaris Ltd | Cell culture system and method |
| WO2020152509A1 (en) * | 2019-01-25 | 2020-07-30 | Enzene Biosciences Limited | Automated integrated continuous system and bioprocess for producing therapeutic protein |
| JP2022520793A (ja) * | 2019-02-15 | 2022-04-01 | ジャスト－エヴォテック バイオロジックス、インコーポレイテッド | 自動バイオ製造システム、施設、及びプロセス |
| EP3976762A1 (en) * | 2019-05-24 | 2022-04-06 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells |
| CN114144510A (zh) * | 2019-06-17 | 2022-03-04 | 德卡产品有限公司 | 用于集中式流体管理和培养控制的系统和方法 |
| GB201908612D0 (en) * | 2019-06-17 | 2019-07-31 | Ge Healthcare Bio Sciences Ab | A method for separating biomolecules |
| CA3144125A1 (en) * | 2019-07-16 | 2021-01-21 | Haihong Sun | Cell culture method based on high-density and continuous inoculation and use thereof |
| EP3831924A1 (en) * | 2019-12-03 | 2021-06-09 | Sartorius Stedim Data Analytics AB | Adapting control of a cell culture in a production scale vessel with regard to a starting medium |
| CA3257876A1 (en) * | 2022-06-28 | 2024-01-04 | Amgen Inc. | ADAPTIVE FACILITY CONFIGURATIONS FOR THE MANUFACTURING THERAPEUTIC PRODUCTS |
| AU2023338692A1 (en) * | 2022-09-06 | 2025-02-20 | Amgen Inc. | Large scale bioreactor system and method |
| AU2024235838A1 (en) * | 2023-03-13 | 2025-09-11 | Amgen Inc. | Systems and methods for seed train optimization |
| WO2026033566A2 (en) | 2024-08-09 | 2026-02-12 | Omnibrx Biotechnologies Private Limited | A multistage bioreactor system and method thereof |
| GB202414239D0 (en) * | 2024-09-27 | 2024-11-13 | St Andrews Pharmaceutical Tech Limited | Method and/or apparatus for producing a cell inoculum for use in a biomanufacturing or cell culture process |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| RU2058992C1 (ru) | 1993-07-14 | 1996-04-27 | Антипин Георгий Васильевич | Способ получения кормового белка и устройство для его осуществления |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| RU2215748C2 (ru) * | 1999-04-09 | 2003-11-10 | Сентро Де Инмунология Молекулар | Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция |
| US6585971B1 (en) | 1999-11-12 | 2003-07-01 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
| CA2431230C (en) * | 2000-12-20 | 2011-02-22 | Bayer Pharmaceuticals Corporation | A device and method for seed-train expansion of mammalian cells |
| JP2005509406A (ja) | 2001-05-09 | 2005-04-14 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 哺乳動物細胞株のための低温保存袋アセンブリー |
| KR100909316B1 (ko) | 2001-08-31 | 2009-07-24 | 바이엘 헬스케어 아게 | 고세포밀도 발효를 수행하기 위한 유닛 및 방법 |
| EP1434857B1 (en) | 2001-10-02 | 2007-08-01 | Novo Nordisk Health Care AG | Method for production of recombinant proteins in eukaryote cells |
| AU2002348151A1 (en) | 2001-11-05 | 2003-05-19 | Genvec, Inc. | Viral vector production methods and compositions |
| US6953692B2 (en) * | 2001-12-18 | 2005-10-11 | Bayer Pharmaceuticals Corporation | Device and method for seed-train expansion of mammalian cells |
| US20050019914A1 (en) * | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| BE1016538A3 (fr) | 2004-02-20 | 2007-01-09 | Cesco Bioengineering Co Ltd | Appareil et procede pour la preparation et la mise en culture de cellules. |
| TWI384069B (zh) * | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| EP1789528A4 (en) | 2004-09-16 | 2011-07-20 | Becton Dickinson Co | BIOREACTOR FOR CULTIVATION OF CELLS UNDER PERFUSION |
| WO2006039588A2 (en) | 2004-09-30 | 2006-04-13 | Bayer Healthcare Llc | Devices and methods for integrated continuous manufacturing of biological molecules |
| ES2662589T3 (es) | 2005-06-15 | 2018-04-09 | Zhejiang Jinyishengshi Bioengineering Co., Ltd. | Recipientes para cultivo en suspensión |
| WO2006138143A1 (en) | 2005-06-15 | 2006-12-28 | Amprotein Corporation | Suspension culture vessels |
| US20080206819A1 (en) | 2006-08-21 | 2008-08-28 | Mary Tsao | Intensified Perfusion Production Method |
| WO2008073620A2 (en) | 2006-11-02 | 2008-06-19 | Neose Technologies, Inc. | Manufacturing process for the production of polypeptides expressed in insect cell-lines |
| US8501462B2 (en) | 2007-02-27 | 2013-08-06 | The Board Of Trustees Of The University Of Illinois | Insert device for multiwell plate |
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| WO2009034186A2 (en) | 2007-09-13 | 2009-03-19 | Helmholtz-Zentrum für Infektionsforschung GmbH | Process for cell cultivation |
| US20090233334A1 (en) | 2008-03-11 | 2009-09-17 | Excellgene Sa | Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale |
| DE102008019691A1 (de) | 2008-04-15 | 2009-10-29 | Technische Universität Ilmenau | Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion |
| CN101821378B (zh) | 2008-06-16 | 2015-07-08 | 浙江金仪盛世生物工程有限公司 | 生物反应器 |
| US8728479B2 (en) | 2009-03-31 | 2014-05-20 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| CA2766902C (en) | 2009-07-06 | 2021-07-06 | Genentech, Inc. | Method of culturing eukaryotic cells |
| KR102027596B1 (ko) | 2010-12-06 | 2019-10-01 | 타폰 바이오시스템즈, 인코포레이티드 | 생물학적 산물을 위한 연속 처리 방법 |
| PL2665806T3 (pl) | 2011-01-17 | 2021-12-27 | F.Hoffmann-La Roche Ag | Urządzenie rozdzielające |
| DK2707488T3 (en) | 2011-05-12 | 2017-12-11 | Probiogen Ag | IMPROVEMENT OF PROTEIN PREPARATION YIELD MEDIATED BY CDC42 GTPASE ON FAST CYCLES |
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| WO2013116449A1 (en) | 2012-02-02 | 2013-08-08 | Corning Incorporated | Automatic continuous perfusion cell culture microplate consumables |
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| CN104903436B (zh) * | 2012-10-23 | 2018-03-30 | 建新公司 | 灌注培养方法及其用途 |
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| CN105143443A (zh) | 2013-02-22 | 2015-12-09 | 建新公司 | 微载体灌注培养方法及其用途 |
| SG10201709131UA (en) | 2013-03-08 | 2017-12-28 | Genzyme Corp | Continuous purification of therapeutic proteins |
| KR20210095233A (ko) | 2013-03-15 | 2021-07-30 | 젠자임 코포레이션 | 고-밀도 세포 뱅킹 방법 |
| BR122021001466B1 (pt) | 2013-09-16 | 2021-10-13 | Genzyme Corporation | Sistema de filtração de circuito aberto |
| DK3083933T3 (da) * | 2013-12-20 | 2026-03-16 | Biogen Ma Inc | Anvendelse af perfusionssåningskulturer til forbedring af biofarmaceutisk fed-batch-produktionskapacitet og -produktkvalitet |
| TWI671312B (zh) | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| PT3152317T (pt) | 2014-06-04 | 2019-04-18 | Amgen Inc | Métodos de colheita de culturas de células de mamíferos |
| TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CN104450597B (zh) | 2014-12-10 | 2020-07-28 | 青岛农业大学 | 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法 |
| KR20250025516A (ko) | 2014-12-22 | 2025-02-21 | 젠자임 코포레이션 | 포유류 세포의 배양 방법 |
-
2015
- 2015-06-05 TW TW109131864A patent/TWI776235B/zh active
- 2015-06-05 TW TW111129481A patent/TW202246486A/zh unknown
- 2015-06-05 TW TW104118240A patent/TWI707949B/zh active
- 2015-06-08 JP JP2016572251A patent/JP6784600B2/ja active Active
- 2015-06-08 WO PCT/US2015/034709 patent/WO2015191462A1/en not_active Ceased
- 2015-06-08 BR BR112016028891-2A patent/BR112016028891B1/pt active IP Right Grant
- 2015-06-08 CA CA2951551A patent/CA2951551C/en active Active
- 2015-06-08 IL IL290096A patent/IL290096B2/en unknown
- 2015-06-08 KR KR1020227022305A patent/KR102584375B1/ko active Active
- 2015-06-08 CN CN202010299662.9A patent/CN111575225B/zh active Active
- 2015-06-08 ES ES15730933T patent/ES2773630T3/es active Active
- 2015-06-08 US US14/733,630 patent/US10570367B2/en active Active
- 2015-06-08 RU RU2016151316A patent/RU2694327C2/ru active
- 2015-06-08 EP EP15730933.7A patent/EP3152299B1/en not_active Revoked
- 2015-06-08 MX MX2016016301A patent/MX373323B/es active IP Right Grant
- 2015-06-08 HU HUE15730933A patent/HUE047683T2/hu unknown
- 2015-06-08 DK DK15730933.7T patent/DK3152299T3/da active
- 2015-06-08 KR KR1020177000249A patent/KR102416402B1/ko active Active
- 2015-06-08 CN CN201580042488.7A patent/CN106574249B/zh active Active
- 2015-06-08 AU AU2015274897A patent/AU2015274897B2/en active Active
- 2015-06-08 SG SG11201610216UA patent/SG11201610216UA/en unknown
- 2015-06-08 ES ES21161811T patent/ES3043610T3/es active Active
- 2015-06-08 EP EP19209942.2A patent/EP3628730A1/en active Pending
- 2015-06-08 EP EP21161811.1A patent/EP3858983B1/en active Active
-
2016
- 2016-12-08 IL IL249452A patent/IL249452B/en active IP Right Grant
- 2016-12-08 MX MX2020004073A patent/MX2020004073A/es unknown
-
2020
- 2020-02-19 CY CY20201100157T patent/CY1122803T1/el unknown
- 2020-02-24 US US16/799,592 patent/US20200377850A1/en not_active Abandoned
- 2020-10-22 JP JP2020177043A patent/JP7089000B2/ja active Active
-
2021
- 2021-03-18 IL IL281626A patent/IL281626B/en unknown
- 2021-10-05 AU AU2021245116A patent/AU2021245116B2/en active Active
-
2022
- 2022-06-08 JP JP2022092635A patent/JP7360504B2/ja active Active
-
2023
- 2023-06-15 AU AU2023203734A patent/AU2023203734A1/en not_active Abandoned
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