KR102584375B1 - 시드 트레인 공정 및 그 용도 - Google Patents

시드 트레인 공정 및 그 용도 Download PDF

Info

Publication number
KR102584375B1
KR102584375B1 KR1020227022305A KR20227022305A KR102584375B1 KR 102584375 B1 KR102584375 B1 KR 102584375B1 KR 1020227022305 A KR1020227022305 A KR 1020227022305A KR 20227022305 A KR20227022305 A KR 20227022305A KR 102584375 B1 KR102584375 B1 KR 102584375B1
Authority
KR
South Korea
Prior art keywords
cells
cell
days
culture medium
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020227022305A
Other languages
English (en)
Korean (ko)
Other versions
KR20220098051A (ko
Inventor
마이클 브루닝하우스
콘스탄틴 콘스탄티노브
벤자민 라이트
웨이창 주
Original Assignee
젠자임 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53477008&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102584375(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 젠자임 코포레이션 filed Critical 젠자임 코포레이션
Publication of KR20220098051A publication Critical patent/KR20220098051A/ko
Application granted granted Critical
Publication of KR102584375B1 publication Critical patent/KR102584375B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0031—Serum-free culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020227022305A 2014-06-09 2015-06-08 시드 트레인 공정 및 그 용도 Active KR102584375B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462009553P 2014-06-09 2014-06-09
US62/009,553 2014-06-09
PCT/US2015/034709 WO2015191462A1 (en) 2014-06-09 2015-06-08 Seed train processes and uses thereof
KR1020177000249A KR102416402B1 (ko) 2014-06-09 2015-06-08 시드 트레인 공정 및 그 용도

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020177000249A Division KR102416402B1 (ko) 2014-06-09 2015-06-08 시드 트레인 공정 및 그 용도

Publications (2)

Publication Number Publication Date
KR20220098051A KR20220098051A (ko) 2022-07-08
KR102584375B1 true KR102584375B1 (ko) 2023-09-27

Family

ID=53477008

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020227022305A Active KR102584375B1 (ko) 2014-06-09 2015-06-08 시드 트레인 공정 및 그 용도
KR1020177000249A Active KR102416402B1 (ko) 2014-06-09 2015-06-08 시드 트레인 공정 및 그 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020177000249A Active KR102416402B1 (ko) 2014-06-09 2015-06-08 시드 트레인 공정 및 그 용도

Country Status (18)

Country Link
US (2) US10570367B2 (https=)
EP (3) EP3152299B1 (https=)
JP (3) JP6784600B2 (https=)
KR (2) KR102584375B1 (https=)
CN (2) CN111575225B (https=)
AU (3) AU2015274897B2 (https=)
BR (1) BR112016028891B1 (https=)
CA (1) CA2951551C (https=)
CY (1) CY1122803T1 (https=)
DK (1) DK3152299T3 (https=)
ES (2) ES2773630T3 (https=)
HU (1) HUE047683T2 (https=)
IL (3) IL290096B2 (https=)
MX (2) MX373323B (https=)
RU (1) RU2694327C2 (https=)
SG (1) SG11201610216UA (https=)
TW (3) TWI776235B (https=)
WO (1) WO2015191462A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2958988A2 (en) 2013-02-22 2015-12-30 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
CN105143443A (zh) 2013-02-22 2015-12-09 建新公司 微载体灌注培养方法及其用途
TW202204596A (zh) 2014-06-06 2022-02-01 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
KR20250025516A (ko) 2014-12-22 2025-02-21 젠자임 코포레이션 포유류 세포의 배양 방법
CA3001761A1 (en) * 2015-10-26 2017-05-04 Lonza Limited A manufacturing facility for the production of biopharmaceuticals
CN110072961B (zh) * 2016-12-22 2022-02-08 东亚合成株式会社 粘合剂组合物以及使用其的覆盖膜、粘合片、覆铜层压板和电磁波屏蔽材料
EP3681989A1 (en) * 2017-09-15 2020-07-22 Bristol-Myers Squibb Company Online biomass capacitance monitoring during large scale production of polypeptides of interest
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
EP3650528A1 (en) * 2018-11-08 2020-05-13 Aglaris Ltd Cell culture system and method
WO2020152509A1 (en) * 2019-01-25 2020-07-30 Enzene Biosciences Limited Automated integrated continuous system and bioprocess for producing therapeutic protein
JP2022520793A (ja) * 2019-02-15 2022-04-01 ジャスト－エヴォテック バイオロジックス、インコーポレイテッド 自動バイオ製造システム、施設、及びプロセス
EP3976762A1 (en) * 2019-05-24 2022-04-06 Rubius Therapeutics, Inc. Methods of generating enucleated erythroid cells
CN114144510A (zh) * 2019-06-17 2022-03-04 德卡产品有限公司 用于集中式流体管理和培养控制的系统和方法
GB201908612D0 (en) * 2019-06-17 2019-07-31 Ge Healthcare Bio Sciences Ab A method for separating biomolecules
CA3144125A1 (en) * 2019-07-16 2021-01-21 Haihong Sun Cell culture method based on high-density and continuous inoculation and use thereof
EP3831924A1 (en) * 2019-12-03 2021-06-09 Sartorius Stedim Data Analytics AB Adapting control of a cell culture in a production scale vessel with regard to a starting medium
CA3257876A1 (en) * 2022-06-28 2024-01-04 Amgen Inc. ADAPTIVE FACILITY CONFIGURATIONS FOR THE MANUFACTURING THERAPEUTIC PRODUCTS
AU2023338692A1 (en) * 2022-09-06 2025-02-20 Amgen Inc. Large scale bioreactor system and method
AU2024235838A1 (en) * 2023-03-13 2025-09-11 Amgen Inc. Systems and methods for seed train optimization
WO2026033566A2 (en) 2024-08-09 2026-02-12 Omnibrx Biotechnologies Private Limited A multistage bioreactor system and method thereof
GB202414239D0 (en) * 2024-09-27 2024-11-13 St Andrews Pharmaceutical Tech Limited Method and/or apparatus for producing a cell inoculum for use in a biomanufacturing or cell culture process

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030113915A1 (en) * 2001-12-18 2003-06-19 Bayer Corporation (An Indiana Corporation) Device and method for seed-train expansion of mammalian cells
JP2005509406A (ja) 2001-05-09 2005-04-14 バイエル・フアーマシユーチカルズ・コーポレーシヨン 哺乳動物細胞株のための低温保存袋アセンブリー

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
RU2058992C1 (ru) 1993-07-14 1996-04-27 Антипин Георгий Васильевич Способ получения кормового белка и устройство для его осуществления
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
RU2215748C2 (ru) * 1999-04-09 2003-11-10 Сентро Де Инмунология Молекулар Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция
US6585971B1 (en) 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
CA2431230C (en) * 2000-12-20 2011-02-22 Bayer Pharmaceuticals Corporation A device and method for seed-train expansion of mammalian cells
KR100909316B1 (ko) 2001-08-31 2009-07-24 바이엘 헬스케어 아게 고세포밀도 발효를 수행하기 위한 유닛 및 방법
EP1434857B1 (en) 2001-10-02 2007-08-01 Novo Nordisk Health Care AG Method for production of recombinant proteins in eukaryote cells
AU2002348151A1 (en) 2001-11-05 2003-05-19 Genvec, Inc. Viral vector production methods and compositions
US20050019914A1 (en) * 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
BE1016538A3 (fr) 2004-02-20 2007-01-09 Cesco Bioengineering Co Ltd Appareil et procede pour la preparation et la mise en culture de cellules.
TWI384069B (zh) * 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
EP1789528A4 (en) 2004-09-16 2011-07-20 Becton Dickinson Co BIOREACTOR FOR CULTIVATION OF CELLS UNDER PERFUSION
WO2006039588A2 (en) 2004-09-30 2006-04-13 Bayer Healthcare Llc Devices and methods for integrated continuous manufacturing of biological molecules
ES2662589T3 (es) 2005-06-15 2018-04-09 Zhejiang Jinyishengshi Bioengineering Co., Ltd. Recipientes para cultivo en suspensión
WO2006138143A1 (en) 2005-06-15 2006-12-28 Amprotein Corporation Suspension culture vessels
US20080206819A1 (en) 2006-08-21 2008-08-28 Mary Tsao Intensified Perfusion Production Method
WO2008073620A2 (en) 2006-11-02 2008-06-19 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
US8501462B2 (en) 2007-02-27 2013-08-06 The Board Of Trustees Of The University Of Illinois Insert device for multiwell plate
EP2522729A1 (en) * 2007-03-02 2012-11-14 Boehringer Ingelheim Pharma GmbH & Co. KG Improvement of protein production
JP5140721B2 (ja) 2007-04-17 2013-02-13 イクスエンド、ホールディング、ベスローテン、フェンノートシャップ 連続メンブレン吸着方法および装置
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
WO2009023562A2 (en) 2007-08-09 2009-02-19 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
WO2009034186A2 (en) 2007-09-13 2009-03-19 Helmholtz-Zentrum für Infektionsforschung GmbH Process for cell cultivation
US20090233334A1 (en) 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
DE102008019691A1 (de) 2008-04-15 2009-10-29 Technische Universität Ilmenau Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion
CN101821378B (zh) 2008-06-16 2015-07-08 浙江金仪盛世生物工程有限公司 生物反应器
US8728479B2 (en) 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
CA2766902C (en) 2009-07-06 2021-07-06 Genentech, Inc. Method of culturing eukaryotic cells
KR102027596B1 (ko) 2010-12-06 2019-10-01 타폰 바이오시스템즈, 인코포레이티드 생물학적 산물을 위한 연속 처리 방법
PL2665806T3 (pl) 2011-01-17 2021-12-27 F.Hoffmann-La Roche Ag Urządzenie rozdzielające
DK2707488T3 (en) 2011-05-12 2017-12-11 Probiogen Ag IMPROVEMENT OF PROTEIN PREPARATION YIELD MEDIATED BY CDC42 GTPASE ON FAST CYCLES
DK2726600T3 (en) 2011-07-01 2017-05-15 Amgen Inc Mammalian Cell Culture
AR089231A1 (es) * 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
WO2013116449A1 (en) 2012-02-02 2013-08-08 Corning Incorporated Automatic continuous perfusion cell culture microplate consumables
CN106399094A (zh) 2012-04-01 2017-02-15 Emd密理博公司 细胞培养和梯度迁移化验方法和装置
CN104903436B (zh) * 2012-10-23 2018-03-30 建新公司 灌注培养方法及其用途
EP2958988A2 (en) 2013-02-22 2015-12-30 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
CN105143443A (zh) 2013-02-22 2015-12-09 建新公司 微载体灌注培养方法及其用途
SG10201709131UA (en) 2013-03-08 2017-12-28 Genzyme Corp Continuous purification of therapeutic proteins
KR20210095233A (ko) 2013-03-15 2021-07-30 젠자임 코포레이션 고-밀도 세포 뱅킹 방법
BR122021001466B1 (pt) 2013-09-16 2021-10-13 Genzyme Corporation Sistema de filtração de circuito aberto
DK3083933T3 (da) * 2013-12-20 2026-03-16 Biogen Ma Inc Anvendelse af perfusionssåningskulturer til forbedring af biofarmaceutisk fed-batch-produktionskapacitet og -produktkvalitet
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
PT3152317T (pt) 2014-06-04 2019-04-18 Amgen Inc Métodos de colheita de culturas de células de mamíferos
TW202204596A (zh) 2014-06-06 2022-02-01 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
CN104450597B (zh) 2014-12-10 2020-07-28 青岛农业大学 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法
KR20250025516A (ko) 2014-12-22 2025-02-21 젠자임 코포레이션 포유류 세포의 배양 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005509406A (ja) 2001-05-09 2005-04-14 バイエル・フアーマシユーチカルズ・コーポレーシヨン 哺乳動物細胞株のための低温保存袋アセンブリー
US20030113915A1 (en) * 2001-12-18 2003-06-19 Bayer Corporation (An Indiana Corporation) Device and method for seed-train expansion of mammalian cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Shukla 등. Single-use disposable technologies for biopharmaceutical manufacturing. Trends in biotechnology. 2013. vol.31, no.3, pp.147-154 1부.*
Tao 등. Development and implementation of a perfusion-based high cell density cell banking process. American Institute of Chemical Engineers. 2011. vol.27, no.3, pp.824-829 1부.*

Also Published As

Publication number Publication date
JP2017521057A (ja) 2017-08-03
CY1122803T1 (el) 2021-05-05
IL281626B (en) 2022-03-01
HUE047683T2 (hu) 2020-05-28
IL290096A (en) 2022-03-01
US10570367B2 (en) 2020-02-25
CA2951551C (en) 2023-02-28
ES3043610T3 (en) 2025-11-25
JP7089000B2 (ja) 2022-06-21
JP6784600B2 (ja) 2020-11-11
EP3858983A1 (en) 2021-08-04
US20200377850A1 (en) 2020-12-03
CA2951551A1 (en) 2015-12-17
JP7360504B2 (ja) 2023-10-12
JP2021019621A (ja) 2021-02-18
BR112016028891B1 (pt) 2023-04-11
AU2021245116A1 (en) 2021-10-28
JP2022120031A (ja) 2022-08-17
KR20220098051A (ko) 2022-07-08
EP3152299B1 (en) 2019-11-20
BR112016028891A2 (pt) 2017-08-22
IL281626A (en) 2021-05-31
EP3858983C0 (en) 2025-07-16
MX2020004073A (es) 2020-07-29
RU2019119708A (ru) 2019-07-03
EP3152299A1 (en) 2017-04-12
IL249452B (en) 2021-04-29
TW202102658A (zh) 2021-01-16
IL290096B2 (en) 2024-04-01
TW201610148A (zh) 2016-03-16
MX2016016301A (es) 2017-04-06
KR102416402B1 (ko) 2022-07-04
DK3152299T3 (da) 2020-02-24
TWI707949B (zh) 2020-10-21
EP3628730A1 (en) 2020-04-01
RU2016151316A3 (https=) 2018-11-15
RU2694327C2 (ru) 2019-07-11
MX373323B (es) 2020-05-04
TWI776235B (zh) 2022-09-01
WO2015191462A1 (en) 2015-12-17
IL290096B1 (en) 2023-12-01
AU2021245116B2 (en) 2023-07-27
ES2773630T3 (es) 2020-07-13
SG11201610216UA (en) 2017-01-27
CN111575225A (zh) 2020-08-25
AU2023203734A1 (en) 2023-07-06
AU2015274897A1 (en) 2017-01-12
RU2016151316A (ru) 2018-07-10
US20150353896A1 (en) 2015-12-10
AU2015274897B2 (en) 2021-11-04
CN106574249B (zh) 2020-05-08
KR20170015472A (ko) 2017-02-08
CN106574249A (zh) 2017-04-19
IL249452A0 (en) 2017-02-28
EP3858983B1 (en) 2025-07-16
TW202246486A (zh) 2022-12-01
CN111575225B (zh) 2023-09-08

Similar Documents

Publication Publication Date Title
AU2021245116B2 (en) Seed train processes and uses thereof
RU2768003C2 (ru) Интегрированное непрерывное производство терапевтических белковых лекарственных веществ
HK40058623A (en) Seed train processes and uses thereof
HK40058623B (en) Seed train processes and uses thereof
HK40026945A (en) Seed train processes and uses thereof
HK1236567B (en) Seed train processes and uses thereof
HK1236567A1 (en) Seed train processes and uses thereof
RU2786997C2 (ru) Процессы культивирования в системе посевных ферментеров и способы их применения

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20220629

Application number text: 1020177000249

Filing date: 20170104

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20220729

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20221019

Patent event code: PE09021S01D

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20230426

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20230820

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20230925

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20230925

End annual number: 3

Start annual number: 1

PG1601 Publication of registration