JP2017520620A - 放射線および化学損傷に対する保護のためのセコイソラリシレジノールジグルコシド（ｓｄｇ）および関連化合物の使用 - Google Patents

放射線および化学損傷に対する保護のためのセコイソラリシレジノールジグルコシド（ｓｄｇ）および関連化合物の使用 Download PDF

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JP2017520620A
JP2017520620A JP2017515874A JP2017515874A JP2017520620A JP 2017520620 A JP2017520620 A JP 2017520620A JP 2017515874 A JP2017515874 A JP 2017515874A JP 2017515874 A JP2017515874 A JP 2017515874A JP 2017520620 A JP2017520620 A JP 2017520620A
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sdg
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radiation
exposed
dna
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JP2017520620A5 (enExample
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メルポ クリストフィドウ−ソロミドウ，
メルポ クリストフィドウ−ソロミドウ，
Original Assignee
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2017515874A 2014-05-30 2015-06-01 放射線および化学損傷に対する保護のためのセコイソラリシレジノールジグルコシド（ｓｄｇ）および関連化合物の使用 Pending JP2017520620A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462005330P 2014-05-30 2014-05-30
US62/005,330 2014-05-30
US201562101296P 2015-01-08 2015-01-08
US62/101,296 2015-01-08
PCT/US2015/033501 WO2015184441A2 (en) 2014-05-30 2015-06-01 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE

Related Child Applications (1)

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JP2020068332A Division JP2020121987A (ja) 2014-05-30 2020-04-06 放射線および化学損傷に対する保護のためのセコイソラリシレジノールジグルコシド（ｓｄｇ）および関連化合物の使用

Publications (2)

Publication Number Publication Date
JP2017520620A true JP2017520620A (ja) 2017-07-27
JP2017520620A5 JP2017520620A5 (enExample) 2018-07-12

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JP2017515874A Pending JP2017520620A (ja) 2014-05-30 2015-06-01 放射線および化学損傷に対する保護のためのセコイソラリシレジノールジグルコシド（ｓｄｇ）および関連化合物の使用
JP2020068332A Pending JP2020121987A (ja) 2014-05-30 2020-04-06 放射線および化学損傷に対する保護のためのセコイソラリシレジノールジグルコシド（ｓｄｇ）および関連化合物の使用

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JP2020068332A Pending JP2020121987A (ja) 2014-05-30 2020-04-06 放射線および化学損傷に対する保護のためのセコイソラリシレジノールジグルコシド（ｓｄｇ）および関連化合物の使用

Country Status (9)

Country Link
EP (1) EP3148560A4 (enExample)
JP (2) JP2017520620A (enExample)
KR (1) KR20170010019A (enExample)
CN (2) CN112336736A (enExample)
AU (2) AU2015266614A1 (enExample)
CA (1) CA2950744A1 (enExample)
IL (1) IL249219A0 (enExample)
MA (1) MA39899A (enExample)
WO (1) WO2015184441A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11071746B2 (en) 2016-06-07 2021-07-27 The Trustees Of The University Of Pennsylvania Compositions and methods for protecting organs from ischemia/reperfusion injury associated with transplantation
CA3211208A1 (en) * 2017-04-03 2018-10-11 Gusto Global, Llc Rational design of microbial-based biotherapeutics
US20210128596A1 (en) * 2017-09-27 2021-05-06 University Of Pennsylvania Compositions and methods for treating septic cardiomyopathy
EP3687545A4 (en) * 2017-09-27 2021-06-09 The Trustees Of The University Of Pennsylvania USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION
CN112601462B (zh) * 2018-08-31 2023-10-31 伊诺弗斯公司 植物抗氧化剂
CN116850162A (zh) * 2023-08-08 2023-10-10 南通大学附属医院 肠二醇在制备治疗放射性肠炎药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
CA2312164C (en) * 1999-06-30 2009-12-15 University Of Saskatchewan Technologies Inc. Antioxidant activity in sdg metabolites
WO2001095901A1 (en) * 2000-06-14 2001-12-20 Alla Shapiro Radioprotective agents
CN100365005C (zh) * 2006-03-02 2008-01-30 江南大学 一种从亚麻籽中提取纯化开环异落叶松树脂酚二葡萄糖苷的方法
US20070293458A1 (en) * 2006-06-16 2007-12-20 Ip-6 Research Inc. Prevention of nuclear, solar, and other radiation-induced tissue damage
WO2010017332A2 (en) * 2008-08-07 2010-02-11 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Radioprotectants targeting thrombospondin-1 and cd47
CN101759731B (zh) * 2008-12-25 2011-10-19 中国科学院兰州化学物理研究所 亚麻籽胶和开环异落叶松树脂酚二葡萄糖苷的提取方法
SI3007557T1 (sl) * 2013-06-10 2018-12-31 The Trusees Of The University Of Pennsylvania Priprava (S,S)-sekoizolariciresinol diglukozida in (R,R)-sekoizolariciresinol diglukozida

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, JPN6019047663, 2 August 2013 (2013-08-02), pages 5325 - 5328, ISSN: 0004169015 *
BMC CANCER, vol. 13, JPN6019012469, 2013, ISSN: 0004169014 *

Also Published As

Publication number Publication date
IL249219A0 (en) 2017-02-28
EP3148560A4 (en) 2018-04-25
CA2950744A1 (en) 2015-12-03
AU2015266614A1 (en) 2016-12-15
JP2020121987A (ja) 2020-08-13
AU2020270469A1 (en) 2020-12-17
CN107155304A (zh) 2017-09-12
KR20170010019A (ko) 2017-01-25
WO2015184441A9 (en) 2016-01-21
WO2015184441A2 (en) 2015-12-03
MA39899A (fr) 2021-05-26
WO2015184441A3 (en) 2016-03-10
EP3148560A2 (en) 2017-04-05
CN112336736A (zh) 2021-02-09

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