CN112336736A - 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途 - Google Patents

开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途 Download PDF

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Publication number
CN112336736A
CN112336736A CN202010760162.0A CN202010760162A CN112336736A CN 112336736 A CN112336736 A CN 112336736A CN 202010760162 A CN202010760162 A CN 202010760162A CN 112336736 A CN112336736 A CN 112336736A
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sdg
cells
dna
radiation
induced
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迈尔波·赫里斯托费多-所罗米多
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN202010760162.0A 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途 Pending CN112336736A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462005330P 2014-05-30 2014-05-30
US62/005,330 2014-05-30
US201562101296P 2015-01-08 2015-01-08
US62/101,296 2015-01-08
CN201580028874.0A CN107155304A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途

Related Parent Applications (1)

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CN201580028874.0A Division CN107155304A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途

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CN112336736A true CN112336736A (zh) 2021-02-09

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CN202010760162.0A Pending CN112336736A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途
CN201580028874.0A Pending CN107155304A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途

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EP (1) EP3148560A4 (enExample)
JP (2) JP2017520620A (enExample)
KR (1) KR20170010019A (enExample)
CN (2) CN112336736A (enExample)
AU (2) AU2015266614A1 (enExample)
CA (1) CA2950744A1 (enExample)
IL (1) IL249219A0 (enExample)
MA (1) MA39899A (enExample)
WO (1) WO2015184441A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116850162A (zh) * 2023-08-08 2023-10-10 南通大学附属医院 肠二醇在制备治疗放射性肠炎药物中的应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017214039A1 (en) * 2016-06-07 2017-12-14 University Of Pennsylvania Compositions and methods for protecting organs from ischemia/reperfusion injury associated with transplantation
WO2018187272A1 (en) * 2017-04-03 2018-10-11 Gusto Global, Llc Rational design of microbial-based biotherapeutics
CA3077034A1 (en) * 2017-09-27 2019-04-04 The Trustees Of The University Of Pennsylvania Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation-induced cardiovascular dysfunction
US20210128596A1 (en) * 2017-09-27 2021-05-06 University Of Pennsylvania Compositions and methods for treating septic cardiomyopathy
EP3843557B1 (en) * 2018-08-31 2023-09-20 Innophos, LLC An extract of anacardium occidentale for use in treating oxidation induced dna damage

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2312164A1 (en) * 1999-06-30 2000-12-30 University Of Saskatchewan Technologies Inc. Antioxidant activity in sdg metabolites
CN1447689A (zh) * 2000-06-14 2003-10-08 阿拉·夏皮罗 辐射保护剂
CN101759731A (zh) * 2008-12-25 2010-06-30 中国科学院兰州化学物理研究所 亚麻籽胶和开环异落叶松树脂酚二葡萄糖苷的提取方法
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100365005C (zh) * 2006-03-02 2008-01-30 江南大学 一种从亚麻籽中提取纯化开环异落叶松树脂酚二葡萄糖苷的方法
US20070293458A1 (en) * 2006-06-16 2007-12-20 Ip-6 Research Inc. Prevention of nuclear, solar, and other radiation-induced tissue damage
WO2010017332A2 (en) * 2008-08-07 2010-02-11 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Radioprotectants targeting thrombospondin-1 and cd47
TR201815423T4 (tr) * 2013-06-10 2018-11-21 Scripps Research Inst (s,s)-sekoi̇zolari̇si̇resi̇nol di̇glukozi̇d ve (r,r)-sekoi̇zolari̇si̇resi̇nol di̇glukozi̇d'i̇n hazirlanmasi.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2312164A1 (en) * 1999-06-30 2000-12-30 University Of Saskatchewan Technologies Inc. Antioxidant activity in sdg metabolites
CN1447689A (zh) * 2000-06-14 2003-10-08 阿拉·夏皮罗 辐射保护剂
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof
CN101759731A (zh) * 2008-12-25 2010-06-30 中国科学院兰州化学物理研究所 亚麻籽胶和开环异落叶松树脂酚二葡萄糖苷的提取方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OM P. MISHRA ET AL.: "Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)" *
张腾;张崇禧;黄建军;: "亚麻籽水解物化学成分研究及SDG含量测定" *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116850162A (zh) * 2023-08-08 2023-10-10 南通大学附属医院 肠二醇在制备治疗放射性肠炎药物中的应用

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Publication number Publication date
AU2020270469A1 (en) 2020-12-17
AU2015266614A1 (en) 2016-12-15
JP2017520620A (ja) 2017-07-27
EP3148560A4 (en) 2018-04-25
KR20170010019A (ko) 2017-01-25
MA39899A (fr) 2021-05-26
IL249219A0 (en) 2017-02-28
EP3148560A2 (en) 2017-04-05
JP2020121987A (ja) 2020-08-13
CN107155304A (zh) 2017-09-12
WO2015184441A2 (en) 2015-12-03
WO2015184441A9 (en) 2016-01-21
CA2950744A1 (en) 2015-12-03
WO2015184441A3 (en) 2016-03-10

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