EP3148560A4 - USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE - Google Patents

USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE Download PDF

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Publication number
EP3148560A4
EP3148560A4 EP15799095.3A EP15799095A EP3148560A4 EP 3148560 A4 EP3148560 A4 EP 3148560A4 EP 15799095 A EP15799095 A EP 15799095A EP 3148560 A4 EP3148560 A4 EP 3148560A4
Authority
EP
European Patent Office
Prior art keywords
sdgs
protection against
related compounds
chemical damage
against radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15799095.3A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3148560A2 (en
Inventor
Melpo Christofidou-Solomidou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of EP3148560A2 publication Critical patent/EP3148560A2/en
Publication of EP3148560A4 publication Critical patent/EP3148560A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
EP15799095.3A 2014-05-30 2015-06-01 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE Withdrawn EP3148560A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462005330P 2014-05-30 2014-05-30
US201562101296P 2015-01-08 2015-01-08
PCT/US2015/033501 WO2015184441A2 (en) 2014-05-30 2015-06-01 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE

Publications (2)

Publication Number Publication Date
EP3148560A2 EP3148560A2 (en) 2017-04-05
EP3148560A4 true EP3148560A4 (en) 2018-04-25

Family

ID=54700083

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15799095.3A Withdrawn EP3148560A4 (en) 2014-05-30 2015-06-01 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE

Country Status (9)

Country Link
EP (1) EP3148560A4 (enExample)
JP (2) JP2017520620A (enExample)
KR (1) KR20170010019A (enExample)
CN (2) CN112336736A (enExample)
AU (2) AU2015266614A1 (enExample)
CA (1) CA2950744A1 (enExample)
IL (1) IL249219A0 (enExample)
MA (1) MA39899A (enExample)
WO (1) WO2015184441A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11071746B2 (en) 2016-06-07 2021-07-27 The Trustees Of The University Of Pennsylvania Compositions and methods for protecting organs from ischemia/reperfusion injury associated with transplantation
CA3211208A1 (en) * 2017-04-03 2018-10-11 Gusto Global, Llc Rational design of microbial-based biotherapeutics
US20210128596A1 (en) * 2017-09-27 2021-05-06 University Of Pennsylvania Compositions and methods for treating septic cardiomyopathy
EP3687545A4 (en) * 2017-09-27 2021-06-09 The Trustees Of The University Of Pennsylvania USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION
CN112601462B (zh) * 2018-08-31 2023-10-31 伊诺弗斯公司 植物抗氧化剂
CN116850162A (zh) * 2023-08-08 2023-10-10 南通大学附属医院 肠二醇在制备治疗放射性肠炎药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008147563A1 (en) * 2007-05-25 2008-12-04 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using and compositions thereof
WO2014200964A1 (en) * 2013-06-10 2014-12-18 The Trustees Of The University Of Pennsylvania Preparation of (s,s)-secoisolariciresinol diglucoside and (r,r)-secoisolariciresinol diglucoside

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2312164C (en) * 1999-06-30 2009-12-15 University Of Saskatchewan Technologies Inc. Antioxidant activity in sdg metabolites
WO2001095901A1 (en) * 2000-06-14 2001-12-20 Alla Shapiro Radioprotective agents
CN100365005C (zh) * 2006-03-02 2008-01-30 江南大学 一种从亚麻籽中提取纯化开环异落叶松树脂酚二葡萄糖苷的方法
US20070293458A1 (en) * 2006-06-16 2007-12-20 Ip-6 Research Inc. Prevention of nuclear, solar, and other radiation-induced tissue damage
WO2010017332A2 (en) * 2008-08-07 2010-02-11 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Radioprotectants targeting thrombospondin-1 and cd47
CN101759731B (zh) * 2008-12-25 2011-10-19 中国科学院兰州化学物理研究所 亚麻籽胶和开环异落叶松树脂酚二葡萄糖苷的提取方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008147563A1 (en) * 2007-05-25 2008-12-04 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using and compositions thereof
WO2014200964A1 (en) * 2013-06-10 2014-12-18 The Trustees Of The University Of Pennsylvania Preparation of (s,s)-secoisolariciresinol diglucoside and (r,r)-secoisolariciresinol diglucoside

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
AYELLA A ET AL: "Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside", NUTRITION RESEARCH, ELSEVIER INC, XX, vol. 30, no. 11, 1 November 2010 (2010-11-01), pages 762 - 769, XP027543571, ISSN: 0271-5317, [retrieved on 20101101] *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; LI, XIANWEI ET AL: "Inhibition of secoisolariciresinol diglucoside on lung cancer cell line A549 and its mechanism", XP002776405, retrieved from STN Database accession no. 2011:728760 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1996, THOMPSON L U ET AL: "Antitumorigenic effect of a mammalian lignan precursor from flaxseed.", XP002776404, Database accession no. NLM8875553 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; December 2012 (2012-12-01), CHRISTOFIDOU-SOLOMIDOU MELPO ET AL: "Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG).", XP002776406, Database accession no. NLM23106213 *
DONGHUA LI ET AL: "Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice", CANCER LETTERS, vol. 142, no. 1, 1 July 1999 (1999-07-01), US, pages 91 - 96, XP055431283, ISSN: 0304-3835, DOI: 10.1016/S0304-3835(99)00158-5 *
J. CHEN ET AL: "Flaxseed and Pure Secoisolariciresinol Diglucoside, but Not Flaxseed Hull, Reduce Human Breast Tumor Growth (MCF-7) in Athymic Mice", THE JOURNAL OF NUTRITION, vol. 139, no. 11, 23 September 2009 (2009-09-23), US, pages 2061 - 2066, XP055431301, ISSN: 0022-3166, DOI: 10.3945/jn.109.112508 *
JAMES C LEE ET AL: "Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury", CANCER BIOLOGY & THERAPY, vol. 8, no. 1, 1 January 2009 (2009-01-01), US, pages 47 - 53, XP055431297, ISSN: 1538-4047, DOI: 10.4161/cbt.8.1.7092 *
MASSIMO BAMBAGIOTTI-ALBERTI ET AL: "Investigation of mammalian lignan precursors in flax seed: First evidence of secoisolariciresinol diglucoside in two isomeric forms by liquid chromatography/mass spectrometry", RAPID COMMUNICATIONS IN MASS SPECTROMETRY., vol. 8, no. 12, 1 December 1994 (1994-12-01), GB, pages 929 - 932, XP055697483, ISSN: 0951-4198, DOI: 10.1002/rcm.1290081204 *
MISHRA, OM P. ET AL: "Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA from gamma radiation damage", RADIATION RESEARCH ( 2014 ), 182(1), 102-110 CODEN: RAREAE; ISSN: 0033-7587, 19 June 2014 (2014-06-19), XP009502086, DOI: 10.1667/RR13635.1 10.1667/RR13635.1 *
RADIATION RESEARCH DEC 2012, vol. 178, no. 6, December 2012 (2012-12-01), pages 568 - 580, ISSN: 1938-5404 *
RALPH PIETROFESA ET AL: "Radiation mitigating properties of the lignan component in flaxseed", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 4 April 2013 (2013-04-04), pages 179, XP021145252, ISSN: 1471-2407, DOI: 10.1186/1471-2407-13-179 *
THOMPSON L U ET AL: "Antitumorigenic effect of a mammalian lignan precursor from flaxseed.", NUTRITION AND CANCER 1996, vol. 26, no. 2, 1996, pages 159 - 165, ISSN: 0163-5581 *

Also Published As

Publication number Publication date
IL249219A0 (en) 2017-02-28
CA2950744A1 (en) 2015-12-03
JP2017520620A (ja) 2017-07-27
AU2015266614A1 (en) 2016-12-15
JP2020121987A (ja) 2020-08-13
AU2020270469A1 (en) 2020-12-17
CN107155304A (zh) 2017-09-12
KR20170010019A (ko) 2017-01-25
WO2015184441A9 (en) 2016-01-21
WO2015184441A2 (en) 2015-12-03
MA39899A (fr) 2021-05-26
WO2015184441A3 (en) 2016-03-10
EP3148560A2 (en) 2017-04-05
CN112336736A (zh) 2021-02-09

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