CA2950744A1 - Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation and chemical damage - Google Patents

Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation and chemical damage Download PDF

Info

Publication number
CA2950744A1
CA2950744A1 CA2950744A CA2950744A CA2950744A1 CA 2950744 A1 CA2950744 A1 CA 2950744A1 CA 2950744 A CA2950744 A CA 2950744A CA 2950744 A CA2950744 A CA 2950744A CA 2950744 A1 CA2950744 A1 CA 2950744A1
Authority
CA
Canada
Prior art keywords
sdg
subject
radiation
exposed
bioactive ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2950744A
Other languages
English (en)
French (fr)
Inventor
Melpo Christofidou-Solomidou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of CA2950744A1 publication Critical patent/CA2950744A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CA2950744A 2014-05-30 2015-06-01 Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation and chemical damage Abandoned CA2950744A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462005330P 2014-05-30 2014-05-30
US62/005,330 2014-05-30
US201562101296P 2015-01-08 2015-01-08
US62/101,296 2015-01-08
PCT/US2015/033501 WO2015184441A2 (en) 2014-05-30 2015-06-01 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE

Publications (1)

Publication Number Publication Date
CA2950744A1 true CA2950744A1 (en) 2015-12-03

Family

ID=54700083

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2950744A Abandoned CA2950744A1 (en) 2014-05-30 2015-06-01 Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation and chemical damage

Country Status (9)

Country Link
EP (1) EP3148560A4 (enExample)
JP (2) JP2017520620A (enExample)
KR (1) KR20170010019A (enExample)
CN (2) CN112336736A (enExample)
AU (2) AU2015266614A1 (enExample)
CA (1) CA2950744A1 (enExample)
IL (1) IL249219A0 (enExample)
MA (1) MA39899A (enExample)
WO (1) WO2015184441A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017214039A1 (en) 2016-06-07 2017-12-14 University Of Pennsylvania Compositions and methods for protecting organs from ischemia/reperfusion injury associated with transplantation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3211208A1 (en) * 2017-04-03 2018-10-11 Gusto Global, Llc Rational design of microbial-based biotherapeutics
US20210128596A1 (en) * 2017-09-27 2021-05-06 University Of Pennsylvania Compositions and methods for treating septic cardiomyopathy
EP3687545A4 (en) * 2017-09-27 2021-06-09 The Trustees Of The University Of Pennsylvania USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION
CN112601462B (zh) * 2018-08-31 2023-10-31 伊诺弗斯公司 植物抗氧化剂
CN116850162A (zh) * 2023-08-08 2023-10-10 南通大学附属医院 肠二醇在制备治疗放射性肠炎药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2312164C (en) * 1999-06-30 2009-12-15 University Of Saskatchewan Technologies Inc. Antioxidant activity in sdg metabolites
WO2001095901A1 (en) * 2000-06-14 2001-12-20 Alla Shapiro Radioprotective agents
CN100365005C (zh) * 2006-03-02 2008-01-30 江南大学 一种从亚麻籽中提取纯化开环异落叶松树脂酚二葡萄糖苷的方法
US20070293458A1 (en) * 2006-06-16 2007-12-20 Ip-6 Research Inc. Prevention of nuclear, solar, and other radiation-induced tissue damage
US10449224B2 (en) * 2007-05-25 2019-10-22 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using and compositions thereof
WO2010017332A2 (en) * 2008-08-07 2010-02-11 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Radioprotectants targeting thrombospondin-1 and cd47
CN101759731B (zh) * 2008-12-25 2011-10-19 中国科学院兰州化学物理研究所 亚麻籽胶和开环异落叶松树脂酚二葡萄糖苷的提取方法
SI3007557T1 (sl) * 2013-06-10 2018-12-31 The Trusees Of The University Of Pennsylvania Priprava (S,S)-sekoizolariciresinol diglukozida in (R,R)-sekoizolariciresinol diglukozida

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017214039A1 (en) 2016-06-07 2017-12-14 University Of Pennsylvania Compositions and methods for protecting organs from ischemia/reperfusion injury associated with transplantation
EP3463334A4 (en) * 2016-06-07 2020-01-22 University Of Pennsylvania COMPOSITIONS AND METHODS FOR PROTECTING ORGANS FROM ISCHEMIC / PERFUSION LESION IN RELATION TO TRANSPLANTATION

Also Published As

Publication number Publication date
IL249219A0 (en) 2017-02-28
EP3148560A4 (en) 2018-04-25
JP2017520620A (ja) 2017-07-27
AU2015266614A1 (en) 2016-12-15
JP2020121987A (ja) 2020-08-13
AU2020270469A1 (en) 2020-12-17
CN107155304A (zh) 2017-09-12
KR20170010019A (ko) 2017-01-25
WO2015184441A9 (en) 2016-01-21
WO2015184441A2 (en) 2015-12-03
MA39899A (fr) 2021-05-26
WO2015184441A3 (en) 2016-03-10
EP3148560A2 (en) 2017-04-05
CN112336736A (zh) 2021-02-09

Similar Documents

Publication Publication Date Title
AU2020270469A1 (en) Use of secoisolariciresinol diglucosides (SDGs) and related compounds for protection against radiation and chemical damage
Zhou et al. Rhein regulates redox‐mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage‐activated crosstalk
Antkiewicz-Michaluk et al. Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: behavioral and neurochemical studies in the rat
Ghasemi-Pirbaluti et al. The effect of menthol on acute experimental colitis in rats
Wu et al. Protective effects of Flagellin a N/C against radiation-induced NLR Pyrin domain containing 3 Inflammasome-dependent Pyroptosis in intestinal cells
Moussa et al. A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease
US10966995B2 (en) Use of secoisolariciresinol diglucosides (SDGS) and related compounds for protection against radiation and chemical damage
Selvakumar et al. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson׳ s disease
JP5620443B2 (ja) 抗ｅｇｆｒ療法に二次的な皮疹の予防および処置のためのビタミンｋ
Djordjevic et al. Fluoxetine affects antioxidant system and promotes apoptotic signaling in Wistar rat liver
Aldbass et al. Protective and therapeutic potency of N-acetyl-cysteine on propionic acid-induced biochemical autistic features in rats
JP2025119055A (ja) 癌治療
Pietrofesa et al. The synthetic lignan secoisolariciresinol diglucoside prevents asbestos‐induced NLRP3 inflammasome activation in murine macrophages
WO2015069562A1 (en) Genistein cancer treatment regimen maximizing cancer radiation therapy benefits
Alharthi Chicoric acid enhances the antioxidative defense system and protects against inflammation and apoptosis associated with the colitis model induced by dextran sulfate sodium in rats
Sun et al. Targeting MCL1 with Sanggenon C overcomes MCL1-driven adaptive chemoresistance via dysregulation of autophagy and endoplasmic reticulum stress in cervical cancer
Zhao et al. Epimedium polysaccharides ameliorate ulcerative colitis by inhibiting oxidative stress and regulating autophagy
Cuzzocrea et al. Synergistic interaction between methotrexate and a superoxide dismutase mimetic: pharmacologic and potential clinical significance
US20230310359A1 (en) Anti-Oncogenic Phytochemicals and Methods and Uses for Treating Cancer
HK1240082A1 (en) Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation and chemical damage
JP2020512408A (ja) 肺がんの治療に使用するための組み合わせ
Mukawa et al. Inhibitory effects of the cyclooxygenase-2 inhibitor, etodolac, on colitis-associated tumorigenesis in p53-deficient mice treated with dextran sulfate sodium
Srivastava et al. Chronic kidney disease amplifies severe kidney injury and mortality in a mouse model of skin arsenical exposure
Sardar et al. Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice
Ma et al. Penicillamine ameliorates intestinal barrier damage in dextran sulfate sodium-induced experimental colitis mice by inhibiting cuproptosis

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20200601

FZDE Discontinued

Effective date: 20221028

FZDE Discontinued

Effective date: 20221028