EP3148560A4 - Utilisation de sécoïsolaricirésinol diglucosides (sdg) et composés associés pour la protection contre le rayonnement et les dommages chimiques - Google Patents

Utilisation de sécoïsolaricirésinol diglucosides (sdg) et composés associés pour la protection contre le rayonnement et les dommages chimiques Download PDF

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Publication number
EP3148560A4
EP3148560A4 EP15799095.3A EP15799095A EP3148560A4 EP 3148560 A4 EP3148560 A4 EP 3148560A4 EP 15799095 A EP15799095 A EP 15799095A EP 3148560 A4 EP3148560 A4 EP 3148560A4
Authority
EP
European Patent Office
Prior art keywords
sdgs
protection against
related compounds
chemical damage
against radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15799095.3A
Other languages
German (de)
English (en)
Other versions
EP3148560A2 (fr
Inventor
Melpo Christofidou-Solomidou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of EP3148560A2 publication Critical patent/EP3148560A2/fr
Publication of EP3148560A4 publication Critical patent/EP3148560A4/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
EP15799095.3A 2014-05-30 2015-06-01 Utilisation de sécoïsolaricirésinol diglucosides (sdg) et composés associés pour la protection contre le rayonnement et les dommages chimiques Withdrawn EP3148560A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462005330P 2014-05-30 2014-05-30
US201562101296P 2015-01-08 2015-01-08
PCT/US2015/033501 WO2015184441A2 (fr) 2014-05-30 2015-06-01 Utilisation de sécoïsolaricirésinol diglucosides (sdg) et composés associés pour la protection contre le rayonnement et les dommages chimiques

Publications (2)

Publication Number Publication Date
EP3148560A2 EP3148560A2 (fr) 2017-04-05
EP3148560A4 true EP3148560A4 (fr) 2018-04-25

Family

ID=54700083

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15799095.3A Withdrawn EP3148560A4 (fr) 2014-05-30 2015-06-01 Utilisation de sécoïsolaricirésinol diglucosides (sdg) et composés associés pour la protection contre le rayonnement et les dommages chimiques

Country Status (9)

Country Link
EP (1) EP3148560A4 (fr)
JP (2) JP2017520620A (fr)
KR (1) KR20170010019A (fr)
CN (2) CN107155304A (fr)
AU (2) AU2015266614A1 (fr)
CA (1) CA2950744A1 (fr)
IL (1) IL249219A0 (fr)
MA (1) MA39899A (fr)
WO (1) WO2015184441A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190067150A (ko) 2016-06-07 2019-06-14 더 트러스티즈 오브 더 유니버시티 오브 펜실베니아 이식과 관련된 허혈/재관류 손상으로부터 장기를 보호하기 위한 조성물 및 방법
CA3058943C (fr) * 2017-04-03 2023-10-17 Gusto Global, Llc Conception rationnelle d'agents biotherapeutiques d'origine microbienne
US20210128596A1 (en) * 2017-09-27 2021-05-06 University Of Pennsylvania Compositions and methods for treating septic cardiomyopathy
CA3077034A1 (fr) * 2017-09-27 2019-04-04 The Trustees Of The University Of Pennsylvania Utilisation de diglucosides de secoisolariciresinol (sdg) et composes apparentes dans la protection contre les dysfonctionnements cardiovasculaires induits par rayonnements
BR112021003813A2 (pt) * 2018-08-31 2021-05-18 Innophos, Inc. antioxidantes botânicos

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008147563A1 (fr) * 2007-05-25 2008-12-04 The Trustees Of The University Of Pennsylvania Complexe de lignane de graine de lin, procédés d'utilisation et compositions de celui-ci
WO2014200964A1 (fr) * 2013-06-10 2014-12-18 The Trustees Of The University Of Pennsylvania Préparation de (s,s)-sécoisolaricirésinol diglucoside et de (r,r)-sécoisolaricirésinol diglucoside

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486126B1 (en) * 1999-06-30 2002-11-26 University Of Saskatchewan Technologies Incorporated Antioxidant activity in SDG metabolites
AU2001271296A1 (en) * 2000-06-14 2001-12-24 Alla Shapiro Radioprotective agents
CN100365005C (zh) * 2006-03-02 2008-01-30 江南大学 一种从亚麻籽中提取纯化开环异落叶松树脂酚二葡萄糖苷的方法
US20070293458A1 (en) * 2006-06-16 2007-12-20 Ip-6 Research Inc. Prevention of nuclear, solar, and other radiation-induced tissue damage
EP2340034B2 (fr) * 2008-08-07 2019-02-13 The United States Of America, As Represented By The Secretary, Department of Health and Human Services Radioprotecteurs ciblant la thrombospondine-1 et cd47
CN101759731B (zh) * 2008-12-25 2011-10-19 中国科学院兰州化学物理研究所 亚麻籽胶和开环异落叶松树脂酚二葡萄糖苷的提取方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008147563A1 (fr) * 2007-05-25 2008-12-04 The Trustees Of The University Of Pennsylvania Complexe de lignane de graine de lin, procédés d'utilisation et compositions de celui-ci
WO2014200964A1 (fr) * 2013-06-10 2014-12-18 The Trustees Of The University Of Pennsylvania Préparation de (s,s)-sécoisolaricirésinol diglucoside et de (r,r)-sécoisolaricirésinol diglucoside

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AYELLA A ET AL: "Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside", NUTRITION RESEARCH, ELSEVIER INC, XX, vol. 30, no. 11, 1 November 2010 (2010-11-01), pages 762 - 769, XP027543571, ISSN: 0271-5317, [retrieved on 20101101] *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; LI, XIANWEI ET AL: "Inhibition of secoisolariciresinol diglucoside on lung cancer cell line A549 and its mechanism", XP002776405, retrieved from STN Database accession no. 2011:728760 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1996, THOMPSON L U ET AL: "Antitumorigenic effect of a mammalian lignan precursor from flaxseed.", XP002776404, Database accession no. NLM8875553 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; December 2012 (2012-12-01), CHRISTOFIDOU-SOLOMIDOU MELPO ET AL: "Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG).", XP002776406, Database accession no. NLM23106213 *
DONGHUA LI ET AL: "Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice", CANCER LETTERS, vol. 142, no. 1, 1 July 1999 (1999-07-01), US, pages 91 - 96, XP055431283, ISSN: 0304-3835, DOI: 10.1016/S0304-3835(99)00158-5 *
J. CHEN ET AL: "Flaxseed and Pure Secoisolariciresinol Diglucoside, but Not Flaxseed Hull, Reduce Human Breast Tumor Growth (MCF-7) in Athymic Mice", THE JOURNAL OF NUTRITION, vol. 139, no. 11, 23 September 2009 (2009-09-23), US, pages 2061 - 2066, XP055431301, ISSN: 0022-3166, DOI: 10.3945/jn.109.112508 *
JAMES C LEE ET AL: "Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury", CANCER BIOLOGY & THERAPY, vol. 8, no. 1, 1 January 2009 (2009-01-01), US, pages 47 - 53, XP055431297, ISSN: 1538-4047, DOI: 10.4161/cbt.8.1.7092 *
MISHRA, OM P. ET AL: "Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA from gamma radiation damage", RADIATION RESEARCH ( 2014 ), 182(1), 102-110 CODEN: RAREAE; ISSN: 0033-7587, 19 June 2014 (2014-06-19), XP009502086, DOI: 10.1667/RR13635.1 10.1667/RR13635.1 *
RADIATION RESEARCH DEC 2012, vol. 178, no. 6, December 2012 (2012-12-01), pages 568 - 580, ISSN: 1938-5404 *
RALPH PIETROFESA ET AL: "Radiation mitigating properties of the lignan component in flaxseed", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 4 April 2013 (2013-04-04), pages 179, XP021145252, ISSN: 1471-2407, DOI: 10.1186/1471-2407-13-179 *
THOMPSON L U ET AL: "Antitumorigenic effect of a mammalian lignan precursor from flaxseed.", NUTRITION AND CANCER 1996, vol. 26, no. 2, 1996, pages 159 - 165, ISSN: 0163-5581 *

Also Published As

Publication number Publication date
JP2017520620A (ja) 2017-07-27
AU2020270469A1 (en) 2020-12-17
WO2015184441A9 (fr) 2016-01-21
EP3148560A2 (fr) 2017-04-05
WO2015184441A2 (fr) 2015-12-03
MA39899A (fr) 2021-05-26
CA2950744A1 (fr) 2015-12-03
AU2015266614A1 (en) 2016-12-15
JP2020121987A (ja) 2020-08-13
KR20170010019A (ko) 2017-01-25
CN112336736A (zh) 2021-02-09
CN107155304A (zh) 2017-09-12
IL249219A0 (en) 2017-02-28
WO2015184441A3 (fr) 2016-03-10

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