JP2017519000A5 - - Google Patents

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Publication number
JP2017519000A5
JP2017519000A5 JP2016572403A JP2016572403A JP2017519000A5 JP 2017519000 A5 JP2017519000 A5 JP 2017519000A5 JP 2016572403 A JP2016572403 A JP 2016572403A JP 2016572403 A JP2016572403 A JP 2016572403A JP 2017519000 A5 JP2017519000 A5 JP 2017519000A5
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JP
Japan
Prior art keywords
pharmaceutical composition
compound
ocf
enyl
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016572403A
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English (en)
Japanese (ja)
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JP2017519000A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/035400 external-priority patent/WO2015191900A1/en
Publication of JP2017519000A publication Critical patent/JP2017519000A/ja
Publication of JP2017519000A5 publication Critical patent/JP2017519000A5/ja
Pending legal-status Critical Current

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JP2016572403A 2014-06-12 2015-06-11 グルカゴンアンタゴニスト Pending JP2017519000A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462011547P 2014-06-12 2014-06-12
US62/011,547 2014-06-12
US201462073916P 2014-10-31 2014-10-31
US62/073,916 2014-10-31
US201462078926P 2014-11-12 2014-11-12
US62/078,926 2014-11-12
PCT/US2015/035400 WO2015191900A1 (en) 2014-06-12 2015-06-11 Glucagon antagonists

Publications (2)

Publication Number Publication Date
JP2017519000A JP2017519000A (ja) 2017-07-13
JP2017519000A5 true JP2017519000A5 (enExample) 2018-07-19

Family

ID=54834341

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016572403A Pending JP2017519000A (ja) 2014-06-12 2015-06-11 グルカゴンアンタゴニスト

Country Status (4)

Country Link
US (2) US10076504B2 (enExample)
EP (1) EP3154956A4 (enExample)
JP (1) JP2017519000A (enExample)
WO (1) WO2015191900A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2615481T3 (es) 2008-08-13 2017-06-07 Metabasis Therapeutics, Inc. Antagonistas de glucagón
EP3154956A4 (en) 2014-06-12 2018-01-17 Ligand Pharmaceuticals, Inc. Glucagon antagonists
CN106336387A (zh) * 2015-07-10 2017-01-18 浙江海正药业股份有限公司 酰胺类衍生物、其制备方法及其在医药上的用途
BR112018076703A2 (pt) * 2016-06-27 2019-04-02 President And Fellows Of Harvard College compostos úteis para tratar distúrbios metabólicos
US12208071B2 (en) * 2018-02-13 2025-01-28 Ligand Pharmaceuticals Incorporated Glucagon receptor antagonists

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3524846A (en) 1967-06-02 1970-08-18 Syntex Corp Process for the didealkylation of phosphonate esters
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
US5091552A (en) 1986-06-30 1992-02-25 Board Of Regents, The University Of Texas System Novel antitumor aldophosphamide analogs
JPH0738070B2 (ja) 1986-07-25 1995-04-26 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
EP0284240B2 (en) 1987-03-09 1993-06-16 EASTMAN KODAK COMPANY (a New Jersey corporation) Photographic silver halide materials and process comprising a pyrazolotriazole coupler
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
AU651835B2 (en) 1990-06-13 1994-08-04 Arnold Glazier Phosphorous prodrugs
US5157027A (en) 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
EP0632048B1 (en) 1993-06-29 2001-03-21 Mitsubishi Chemical Corporation Phosphonate-nucleotide ester derivatives
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5780058A (en) 1995-07-21 1998-07-14 Alza Corporation Oral delivery of discrete units
US6132420A (en) 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
JPH09241284A (ja) 1996-03-08 1997-09-16 Koji Yamashita 新規なオキシアザホスホリン誘導体
MY125849A (en) 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
JPH1197740A (ja) 1997-09-19 1999-04-09 Showa Denko Kk GaP発光ダイオード用エピタキシャルウェーハおよびGaP発光ダイオード
ES2182379T3 (es) 1997-12-22 2003-03-01 Alza Corp Membrana de regulacion del regimen de liberacion para dispositivos de administracion controlada de farmacos.
WO1999033446A1 (en) 1997-12-29 1999-07-08 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
WO1999033513A1 (en) 1997-12-31 1999-07-08 Alza Corporation Osmotic drug delivery monitoring system and method
US6245357B1 (en) 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US6365185B1 (en) 1998-03-26 2002-04-02 University Of Cincinnati Self-destructing, controlled release peroral drug delivery system
CA2350246C (en) 1998-11-02 2010-04-27 Alza Corporation Controlled delivery of active agents
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US6503949B1 (en) 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
AU4537900A (en) 1999-05-17 2000-12-05 Agouron Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
CA2374650A1 (en) 1999-05-24 2000-11-30 Penglie Zhang Inhibitors of factor xa
ATE329920T1 (de) 1999-09-10 2006-07-15 Novo Nordisk As Modulatoren der protein tyrosin phosphatase (ptpases)
DE10008329A1 (de) 2000-02-23 2001-08-30 Merck Patent Gmbh Aminosulfonylbiphenylderivate
CA2411552A1 (en) 2000-06-23 2002-01-03 Novo Nordisk A/S Glucagon antagonists/inverse agonists
AU2002223501A1 (en) 2000-11-17 2002-05-27 Agouron Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
JP2005511683A (ja) 2001-12-03 2005-04-28 ノボ ノルディスク アクティーゼルスカブ 新規なグルカゴンアンタゴニスト
US6762318B2 (en) 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
US6881746B2 (en) 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
US20030212119A1 (en) 2001-12-20 2003-11-13 Jesper Lau Novel glucagon receptor antagonists/inverse agonists
AU2002347022A1 (en) 2001-12-20 2003-07-09 Novo Nordisk A/S Benzimidazols and indols as glucagon receptor antagonists/inverse agonisten
EP1519723A1 (en) 2002-06-27 2005-04-06 Novo Nordisk A/S Novel glucagon antagonists/inverse agonists
CA2508581A1 (en) 2002-12-04 2004-06-17 Merck & Co., Inc. Spirocyclic ureas, compositions containing such compounds and methods of use
US7132425B2 (en) 2002-12-12 2006-11-07 Hoffmann-La Roche Inc. 5-substituted-six-membered heteroaromatic glucokinase activators
US20040152750A1 (en) 2002-12-20 2004-08-05 Kodra Janos Tibor Novel glucagon antagonists
WO2004069158A2 (en) 2003-01-27 2004-08-19 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
US7138529B2 (en) 2003-04-16 2006-11-21 Hoffmann-La Roche Inc. Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists
EP1626717A4 (en) 2003-05-09 2009-09-09 Merck & Co Inc BENZIMIDAZOLE, COMPOSITIONS AND METHOD OF ADMINISTRATION CONTAINING SUCH COMPOUNDS
RU2422450C2 (ru) 2003-11-19 2011-06-27 Метабазис Терапеутикс, Инк. Новые фосфорсодержащие тиромиметики
JPWO2005054213A1 (ja) 2003-12-02 2007-12-06 塩野義製薬株式会社 ペルオキシソーム増殖活性化受容体アゴニスト活性を有するイソキサゾール誘導体
US20070015757A1 (en) 2003-12-19 2007-01-18 Novo Nordisk A/S Novel Glucagon Antagonists/Inverse Agonists
WO2005065680A1 (en) 2003-12-19 2005-07-21 Merck & Co., Inc. Cyclic guanidines, compositions containing such compounds and methods of use
ES2428538T3 (es) 2004-05-28 2013-11-08 Eli Lilly And Company Antagonistas del receptor de glucagón, preparación y usos terapéuticos
MXPA06014084A (es) 2004-06-04 2007-02-15 Merck & Co Inc Derivados de pirazol, composiciones que contienen dichos compuestos y metodos de uso.
MXPA06014426A (es) 2004-06-14 2007-03-01 Lilly Co Eli Antagonistas del receptor de glucagon, preparacion y usos therapeuticos.
EP1768954A4 (en) 2004-06-24 2008-05-28 Incyte Corp 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS
CN1980665A (zh) 2004-07-07 2007-06-13 默克公司 吡唑酰胺衍生物,包含这些化合物的组合物和使用方法
US7625938B2 (en) 2004-07-22 2009-12-01 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
ES2332470T3 (es) 2005-02-11 2010-02-05 Eli Lilly And Company Derivados de tiofeno sustituidos como antagonistas del receptor de glucagon, preparacion y usos terapeuticos.
CN101146762A (zh) 2005-03-21 2008-03-19 默克公司 取代的芳基和杂芳基衍生物
CA2600833A1 (en) 2005-03-30 2006-10-05 Merck & Co., Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US7709658B2 (en) 2005-07-26 2010-05-04 Merck Sharp & Dohme Corp. Process for synthesizing a substituted pyrazole
TW200745031A (en) 2005-10-13 2007-12-16 Merck & Co Inc Acyl indoles, compositions containing such compounds and methods of use
CA2629223C (en) 2005-11-17 2013-08-06 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
AU2006340002B2 (en) 2005-11-17 2011-12-22 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
CA2629321C (en) 2005-11-18 2013-08-06 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
EP1957068B1 (en) 2005-11-22 2014-08-13 Eli Lilly & Company Glucagon receptor antagonists, preparation and therapeutic uses
US7807702B2 (en) 2005-11-23 2010-10-05 Eli Lilly And Company Substituted thiophene carboxylic amide glucagon receptor antagonists, preparation and therapeutic uses
JP2009530381A (ja) 2006-03-23 2009-08-27 メルク エンド カムパニー インコーポレーテッド グルカゴン受容体アンタゴニスト化合物、この化合物を含む組成物及び使用方法
WO2007136577A2 (en) 2006-05-16 2007-11-29 Merck & Co., Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
WO2008001883A1 (en) 2006-06-29 2008-01-03 Nissan Chemical Industries, Ltd. α-AMINO ACID DERIVATIVE AND PHARMACEUTICAL COMPRISING THE SAME AS ACTIVE INGREDIENT
TW200821284A (en) 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
CN102584685A (zh) 2006-12-02 2012-07-18 财团法人首尔大学校产学协力财团 作为ppar配体的芳基化合物及其用途
DK2129654T3 (da) 2007-02-09 2014-08-25 Metabasis Therapeutics Inc Antagonister af glucagonreceptoren
ES2615481T3 (es) 2008-08-13 2017-06-07 Metabasis Therapeutics, Inc. Antagonistas de glucagón
EP2734207A4 (en) * 2011-07-18 2015-06-17 Tokai Pharmaceuticals Inc NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF PROSTATE CANCER
EP3154956A4 (en) 2014-06-12 2018-01-17 Ligand Pharmaceuticals, Inc. Glucagon antagonists
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
JP2017051900A (ja) 2015-09-08 2017-03-16 国立大学法人横浜国立大学 触媒とその製造方法
CN205117265U (zh) 2015-11-19 2016-03-30 北京美高科技发展有限公司 电缆式电液控制割管工具

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