JP2018510206A5 - - Google Patents
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- Publication number
- JP2018510206A5 JP2018510206A5 JP2017552093A JP2017552093A JP2018510206A5 JP 2018510206 A5 JP2018510206 A5 JP 2018510206A5 JP 2017552093 A JP2017552093 A JP 2017552093A JP 2017552093 A JP2017552093 A JP 2017552093A JP 2018510206 A5 JP2018510206 A5 JP 2018510206A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- appendix
- subject
- compound
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 31
- 239000008194 pharmaceutical composition Substances 0.000 claims description 31
- 102000030169 Apolipoprotein C-III Human genes 0.000 claims description 27
- 108010056301 Apolipoprotein C-III Proteins 0.000 claims description 27
- 150000002148 esters Chemical class 0.000 claims description 19
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 14
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- VOGXDRFFBBLZBT-AAQCHOMXSA-N 2-[(5z,8z,11z,14z,17z)-icosa-5,8,11,14,17-pentaenoxy]butanoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCOC(CC)C(O)=O VOGXDRFFBBLZBT-AAQCHOMXSA-N 0.000 claims description 7
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 5
- 230000003078 antioxidant effect Effects 0.000 claims description 5
- 125000004494 ethyl ester group Chemical group 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000001258 dyslipidemic effect Effects 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 108020004999 messenger RNA Proteins 0.000 claims description 4
- 125000004492 methyl ester group Chemical group 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 3
- 208000032928 Dyslipidaemia Diseases 0.000 claims description 3
- 208000035150 Hypercholesterolemia Diseases 0.000 claims description 3
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 125000005456 glyceride group Chemical group 0.000 claims description 3
- 208000006575 hypertriglyceridemia Diseases 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 description 42
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 229940126062 Compound A Drugs 0.000 description 3
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 3
- 238000008214 LDL Cholesterol Methods 0.000 description 2
- 108010028554 LDL Cholesterol Proteins 0.000 description 2
- 125000005907 alkyl ester group Chemical group 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- -1 isopropyl ester Chemical class 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 229960001295 tocopherol Drugs 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- 125000002640 tocopherol group Chemical group 0.000 description 2
- 125000005457 triglyceride group Chemical group 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020017712A JP7341916B2 (ja) | 2015-04-01 | 2020-02-05 | アポｃ３を低下させるためのチアオキソ化合物の使用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2015/001316 WO2016156912A1 (en) | 2015-04-01 | 2015-04-01 | Use of thia oxo compounds for lowering apo c3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020017712A Division JP7341916B2 (ja) | 2015-04-01 | 2020-02-05 | アポｃ３を低下させるためのチアオキソ化合物の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510206A JP2018510206A (ja) | 2018-04-12 |
| JP2018510206A5 true JP2018510206A5 (enExample) | 2018-05-31 |
Family
ID=53879725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552093A Pending JP2018510206A (ja) | 2015-04-01 | 2015-04-01 | アポｃ３を低下させるためのチアオキソ化合物の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20180110747A1 (enExample) |
| JP (1) | JP2018510206A (enExample) |
| KR (1) | KR20180010181A (enExample) |
| AU (1) | AU2015389862B2 (enExample) |
| MX (1) | MX388141B (enExample) |
| RU (1) | RU2705991C2 (enExample) |
| WO (1) | WO2016156912A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180104201A1 (en) | 2015-04-28 | 2018-04-19 | Pronova Biopharma Norge As | Use of structurally enhanced fatty acids containing sulphur for preventing and or treating non alcoholic steatohepatitis |
| PT3720431T (pt) | 2017-12-06 | 2024-12-05 | Basf As | Derivados de ácidos gordos para o tratamento da esteato-hepatite não alcoólica |
| CN112351775A (zh) | 2018-05-23 | 2021-02-09 | 北海医疗私人有限公司 | 用于改善血糖控制和治疗炎性肠病的结构修饰的脂肪酸 |
| CN116829139A (zh) | 2020-12-22 | 2023-09-29 | 北海医疗私人有限公司 | 用于治疗非酒精性脂肪性肝炎的包含含氧的结构增强的脂肪酸的联合治疗剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5843755B2 (ja) * | 2009-05-08 | 2016-01-13 | プロノヴァ・バイオファーマ・ノルゲ・アーエスＰｒｏｎｏｖａ ＢｉｏＰｈａｒｍａ Ｎｏｒｇｅ ＡＳ | 心血管性、代謝性および炎症性疾患領域に関する疾患の処置のための多価不飽和脂肪酸 |
| NZ610705A (en) * | 2010-11-05 | 2014-10-31 | Pronova Biopharma Norge As | Methods of treatment using lipid compounds |
| EP2846779A4 (en) * | 2012-05-07 | 2015-12-16 | Omthera Pharmaceuticals Inc | STATIN AND OMEGA-3 FATTY ACID COMPOSITIONS |
| AU2014222389B2 (en) * | 2013-02-28 | 2018-11-29 | Pronova Biopharma Norge As | A composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same |
-
2015
- 2015-04-01 JP JP2017552093A patent/JP2018510206A/ja active Pending
- 2015-04-01 MX MX2017012641A patent/MX388141B/es unknown
- 2015-04-01 KR KR1020177031665A patent/KR20180010181A/ko not_active Ceased
- 2015-04-01 RU RU2017137960A patent/RU2705991C2/ru active
- 2015-04-01 WO PCT/IB2015/001316 patent/WO2016156912A1/en not_active Ceased
- 2015-04-01 AU AU2015389862A patent/AU2015389862B2/en active Active
- 2015-04-01 US US15/562,554 patent/US20180110747A1/en not_active Abandoned
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