JP2017518352A5 - - Google Patents
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- JP2017518352A5 JP2017518352A5 JP2016574080A JP2016574080A JP2017518352A5 JP 2017518352 A5 JP2017518352 A5 JP 2017518352A5 JP 2016574080 A JP2016574080 A JP 2016574080A JP 2016574080 A JP2016574080 A JP 2016574080A JP 2017518352 A5 JP2017518352 A5 JP 2017518352A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- halogen
- composition
- substituted
- helminth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 150000002367 halogens Chemical class 0.000 claims 14
- 206010061217 Infestation Diseases 0.000 claims 9
- 108010034145 Helminth Proteins Proteins 0.000 claims 8
- 244000000013 helminth Species 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- -1 R 2 is H Chemical class 0.000 claims 5
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 4
- 125000006730 (C2-C5) alkynyl group Chemical group 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 150000002596 lactones Chemical class 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- 230000000507 anthelmentic effect Effects 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 244000078703 ectoparasite Species 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 2
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims 2
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims 2
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 claims 2
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims 2
- 239000005660 Abamectin Substances 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- 239000005894 Emamectin Substances 0.000 claims 2
- 241000242711 Fasciola hepatica Species 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 241000935974 Paralichthys dentatus Species 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 229950008167 abamectin Drugs 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- CMZOLQQGUABKKN-STGYROPVSA-N dimadectin Chemical compound O([C@H]1C[C@@H](C2)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C\C=C/[C@H](C)[C@@H](C(=C/C1)\C)OCOCCOC)[C@]12CC[C@H](C)[C@@H](C(C)C)O1 CMZOLQQGUABKKN-STGYROPVSA-N 0.000 claims 2
- 229950004439 dimadectin Drugs 0.000 claims 2
- QLFZZSKTJWDQOS-YDBLARSUSA-N doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 claims 2
- 229960003997 doramectin Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 claims 2
- WPNHOHPRXXCPRA-TVXIRPTOSA-N eprinomectin Chemical compound O1[C@@H](C)[C@@H](NC(C)=O)[C@H](OC)C[C@@H]1O[C@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C\C=C/[C@@H]2C)\C)O[C@H]1C WPNHOHPRXXCPRA-TVXIRPTOSA-N 0.000 claims 2
- 229960002346 eprinomectin Drugs 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 208000006275 fascioliasis Diseases 0.000 claims 2
- HICUREFSAIZXFQ-JOWPUVSESA-N i9z29i000j Chemical compound C1C[C@H](C)[C@@H](CC)O[C@@]21O[C@H](C\C=C(C)\[C@H](OC(=O)C(=N/OC)\C=1C=CC=CC=1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 HICUREFSAIZXFQ-JOWPUVSESA-N 0.000 claims 2
- 229960002418 ivermectin Drugs 0.000 claims 2
- 229950000961 latidectin Drugs 0.000 claims 2
- AFJYYKSVHJGXSN-KAJWKRCWSA-N selamectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C(/C)=C/C[C@@H](O[C@]2(O[C@@H]([C@@H](C)CC2)C2CCCCC2)C2)C[C@@H]2OC(=O)[C@@H]([C@]23O)C=C(C)C(=N\O)/[C@H]3OC\C2=C/C=C/[C@@H]1C AFJYYKSVHJGXSN-KAJWKRCWSA-N 0.000 claims 2
- 229960002245 selamectin Drugs 0.000 claims 2
- 229960001722 verapamil Drugs 0.000 claims 2
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 150000008378 aryl ethers Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000004832 aryl thioethers Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000005000 thioaryl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462014245P | 2014-06-19 | 2014-06-19 | |
| US62/014,245 | 2014-06-19 | ||
| PCT/US2015/036580 WO2015196014A1 (en) | 2014-06-19 | 2015-06-19 | Parasiticidal compositions comprising indole derivatives, methods and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518352A JP2017518352A (ja) | 2017-07-06 |
| JP2017518352A5 true JP2017518352A5 (enExample) | 2018-07-05 |
| JP6619756B2 JP6619756B2 (ja) | 2019-12-11 |
Family
ID=54868421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574080A Expired - Fee Related JP6619756B2 (ja) | 2014-06-19 | 2015-06-19 | インドール誘導体を含む殺寄生虫性組成物、寄生虫駆除方法及びこれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9776986B2 (enExample) |
| EP (2) | EP3157912B1 (enExample) |
| JP (1) | JP6619756B2 (enExample) |
| CN (1) | CN106536481B (enExample) |
| AU (2) | AU2015276941B2 (enExample) |
| BR (2) | BR112016029888B1 (enExample) |
| CA (1) | CA2952857A1 (enExample) |
| CL (3) | CL2016003258A1 (enExample) |
| CO (1) | CO2017000412A2 (enExample) |
| EA (1) | EA030459B1 (enExample) |
| ES (2) | ES2895826T3 (enExample) |
| MX (2) | MX383300B (enExample) |
| NZ (1) | NZ728102A (enExample) |
| PT (1) | PT3157912T (enExample) |
| WO (1) | WO2015196014A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10252977B2 (en) * | 2015-06-15 | 2019-04-09 | Bayer Cropscience Aktiengesellschaft | Halogen-substituted phenoxyphenylamidines and the use thereof as fungicides |
| CN107082758A (zh) * | 2016-02-15 | 2017-08-22 | 中山大学 | 一种合成吲哚衍生物的方法 |
| US10426772B2 (en) | 2016-05-16 | 2019-10-01 | Regents Of The University Of Minnesota | Use of ergot alkaloids as an anthelmintic agent |
| KR102204380B1 (ko) * | 2019-04-03 | 2021-01-19 | 영남대학교산학협력단 | 5-브로모인돌을 유효성분으로 함유하는 소나무재선충병 방제용 조성물 및 이의 용도 |
| CN112675850A (zh) * | 2020-12-23 | 2021-04-20 | 江苏广域化学有限公司 | 镍催化剂、其制备方法及嘧啶类衍生物的合成方法 |
| CN113109332A (zh) * | 2021-04-14 | 2021-07-13 | 山东商业职业技术学院 | 食盐中碘酸钾的快速检测试剂及方法 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1446368A (fr) * | 1965-06-08 | 1966-07-22 | Saint Gobain | Nouveaux composés de bis-(alcoylidène-2-indolinyl) et procédé de préparation de ces composés |
| GB1278464A (en) | 1968-10-15 | 1972-06-21 | Mitsubishi Chem Ind | Process and apparatus for the preparation of maleic anhydride |
| NL160809C (nl) | 1970-05-15 | 1979-12-17 | Duphar Int Res | Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen. |
| JPS4914624A (enExample) | 1972-06-08 | 1974-02-08 | ||
| US3950360A (en) | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| US3818047A (en) | 1972-08-07 | 1974-06-18 | C Henrick | Substituted pyrones |
| IE43725B1 (en) * | 1975-10-29 | 1981-05-06 | Lilly Co Eli | N-/2-(5-methoxy-6-halo-indol-3-yl)ethyl/-amides,methods for their preparation and their use |
| SE434277B (sv) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| CH604517A5 (enExample) | 1976-08-19 | 1978-09-15 | Ciba Geigy Ag | |
| US4134973A (en) | 1977-04-11 | 1979-01-16 | Merck & Co., Inc. | Carbohydrate derivatives of milbemycin and processes therefor |
| US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4144352A (en) | 1977-12-19 | 1979-03-13 | Merck & Co., Inc. | Milbemycin compounds as anthelmintic agents |
| US4203976A (en) | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| JPS57139012A (en) | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
| US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| JPS59199673A (ja) | 1983-04-25 | 1984-11-12 | Sumitomo Chem Co Ltd | 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤 |
| DE3580444D1 (en) | 1984-10-18 | 1990-12-13 | Ciba Geigy Ag | Benzoylphenylharnstoffe. |
| EP0192060B1 (de) | 1985-02-04 | 1991-09-18 | Nihon Bayer Agrochem K.K. | Heterocyclische Verbindungen |
| EP0237482A1 (de) | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen |
| EP0246739B1 (en) | 1986-03-25 | 1991-01-23 | Sankyo Company Limited | Macrolide compounds, their preparation and their use |
| DE3778768D1 (de) | 1986-07-02 | 1992-06-11 | Ciba Geigy Ag | Pestizide. |
| US4855317A (en) | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
| US4871719A (en) | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
| US4874749A (en) | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| DE3888936T2 (de) | 1987-11-03 | 1994-07-21 | Beecham Group Plc | Zwischenprodukte für die Herstellung makrolider Antibiotika mit anthelmintischer Wirkung. |
| MA21697A1 (fr) | 1988-12-19 | 1990-07-01 | Dow Agrosciences Llc | Composes de macrolides. |
| NZ232422A (en) | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
| IE904606A1 (en) | 1989-12-21 | 1991-07-03 | Beecham Group Plc | Novel products |
| NZ247278A (en) | 1991-02-12 | 1995-03-28 | Ancare Distributors | Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier |
| WO1992022555A1 (en) | 1991-06-17 | 1992-12-23 | Beecham Group Plc | Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents |
| US5202242A (en) | 1991-11-08 | 1993-04-13 | Dowelanco | A83543 compounds and processes for production thereof |
| US5345377A (en) | 1992-10-30 | 1994-09-06 | Electric Power Research Institute, Inc. | Harmonic controller for an active power line conditioner |
| US5591606A (en) | 1992-11-06 | 1997-01-07 | Dowelanco | Process for the production of A83543 compounds with Saccharopolyspora spinosa |
| GB9300883D0 (en) | 1993-01-18 | 1993-03-10 | Pfizer Ltd | Antiparasitic agents |
| ES2099604T3 (es) | 1993-03-12 | 1997-05-16 | Dowelanco | Nuevos compuestos a83543 y procedimiento para su produccion. |
| US5399582A (en) | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
| DE19515371C2 (de) * | 1994-04-29 | 2000-06-15 | Rodenstock Optik G | Photochrome Spirooxazinverbindungen |
| US5502071A (en) * | 1994-08-19 | 1996-03-26 | American Cyanamid Company | Indoles as insecticides and acaricides |
| AUPM969994A0 (en) | 1994-11-28 | 1994-12-22 | Virbac S.A. | Equine anthelmintic formulations |
| US5962499A (en) | 1995-03-20 | 1999-10-05 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| US6221894B1 (en) | 1995-03-20 | 2001-04-24 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| MY113806A (en) | 1995-07-21 | 2002-05-31 | Upjohn Co | Antiparasitic marcfortines and paraherquamides |
| US6010710A (en) | 1996-03-29 | 2000-01-04 | Merial | Direct pour-on skin solution for antiparasitic use in cattle and sheep |
| US5885607A (en) | 1996-03-29 | 1999-03-23 | Rhone Merieux | N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs |
| FR2752525B1 (fr) | 1996-08-20 | 2000-05-05 | Rhone Merieux | Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede |
| IE80657B1 (en) | 1996-03-29 | 1998-11-04 | Merial Sas | Insecticidal combination to control mammal fleas in particular fleas on cats and dogs |
| US6001981A (en) | 1996-06-13 | 1999-12-14 | Dow Agrosciences Llc | Synthetic modification of Spinosyn compounds |
| US6998131B2 (en) | 1996-09-19 | 2006-02-14 | Merial Limited | Spot-on formulations for combating parasites |
| US6207647B1 (en) | 1997-07-18 | 2001-03-27 | Smithkline Beecham Corporation | RatA |
| US6174540B1 (en) | 1998-09-14 | 2001-01-16 | Merck & Co., Inc. | Long acting injectable formulations containing hydrogenated caster oil |
| PE20011289A1 (es) | 2000-04-07 | 2001-12-21 | Upjohn Co | Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles |
| US6399786B1 (en) | 2000-07-14 | 2002-06-04 | Merck & Co., Inc. | Nonacyclic nodulisporic acid derivatives |
| AU2001279938B2 (en) * | 2000-08-09 | 2007-01-25 | Astrazeneca Ab | Indole, azaindole and indazole derivatives having VEGF inhibiting activity |
| WO2002016348A1 (en) * | 2000-08-09 | 2002-02-28 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| TW200300140A (en) * | 2001-11-14 | 2003-05-16 | Novartis Ag | Organic compounds |
| AR042420A1 (es) | 2002-09-11 | 2005-06-22 | Novartis Ag | Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica |
| KR101197482B1 (ko) | 2004-03-05 | 2012-11-09 | 닛산 가가쿠 고교 가부시키 가이샤 | 이속사졸린 치환 벤즈아미드 화합물 및 유해생물 방제제 |
| EP1783114A1 (en) | 2005-11-03 | 2007-05-09 | Novartis AG | N-(hetero)aryl indole derivatives as pesticides |
| AU2006326449A1 (en) | 2005-12-14 | 2007-06-21 | E. I. Du Pont De Nemours And Company | Isoxazolines for controlling invertebrate pests |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| AU2007269584B2 (en) | 2006-07-05 | 2012-05-03 | Boehringer Ingelheim Animal Health USA Inc. | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof |
| JP4948074B2 (ja) * | 2006-08-01 | 2012-06-06 | 東ソー株式会社 | ２−トリフルオロメチルインドール類の製造方法 |
| WO2008050207A1 (en) * | 2006-10-25 | 2008-05-02 | Pfizer Limited | Heterocyclic compounds useful as anabolic agents for livestock animals |
| JP2008179621A (ja) * | 2006-12-28 | 2008-08-07 | Taisho Pharmaceutical Co Ltd | 含窒素飽和複素環化合物 |
| WO2008122375A2 (en) | 2007-04-10 | 2008-10-16 | Bayer Cropscience Ag | Insecticidal aryl isoxazoline derivatives |
| SI3088384T1 (sl) | 2007-05-15 | 2019-04-30 | Merial, Inc. | Ariloazol-2-il cianoetilamino spojine, postopek njihove izdelave in njihova uporaba |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| CA2971008A1 (en) | 2007-06-27 | 2008-12-31 | E. I. Du Pont De Nemours And Company | Animal pest control method |
| ES2423505T3 (es) | 2007-06-29 | 2013-09-20 | Zoetis Llc | Combinación antihelmíntica |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| EP2300460A1 (en) | 2008-05-28 | 2011-03-30 | Wyeth LLC | 3-substituted-1h-indole compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| KR101022649B1 (ko) * | 2008-08-07 | 2011-03-22 | 삼성모바일디스플레이주식회사 | 헤테로고리 화합물 및 이를 이용한 유기 전계 발광 장치 |
| US20110212031A1 (en) * | 2008-10-31 | 2011-09-01 | Cyrille Sur | Novel substituted azabenzoxazoles |
| CN102070618B (zh) * | 2009-11-23 | 2013-08-21 | 和记黄埔医药（上海）有限公司 | 一种化合物及其晶体 |
| CN102153544B (zh) * | 2010-02-12 | 2015-04-29 | 上海阳帆医药科技有限公司 | 一类酪氨酸激酶抑制剂的制备及用途 |
| EP2455378A1 (en) | 2010-11-03 | 2012-05-23 | Philip Morris Products S.A. | Carbazole and carboline derivatives, and preparation and therapeutic applications thereof |
| AR084433A1 (es) * | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
| WO2012088431A1 (en) | 2010-12-23 | 2012-06-28 | Ironwood Pharmaceuticals, Inc. | Faah inhibitors |
| EP2669271A4 (en) * | 2011-01-25 | 2014-08-13 | Kissei Pharmaceutical | INDOLE DERIVATIVE AND PHARMACEUTICAL ACCEPTABLE SALT THEREOF |
| US20140005174A1 (en) | 2011-03-17 | 2014-01-02 | Anilkumar G. Nair | Indole derivatives useful as ccr2 antagonists |
| WO2013158894A1 (en) * | 2012-04-20 | 2013-10-24 | Merial Limited | Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof |
| CN103641767B (zh) * | 2013-11-22 | 2017-01-11 | 沈阳药科大学 | 取代苯基吲哚基硒醚、硒亚砜、硒砜及其作为肿瘤细胞增殖抑制剂的用途 |
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2015
- 2015-06-19 MX MX2019012952A patent/MX383300B/es unknown
- 2015-06-19 US US14/744,166 patent/US9776986B2/en active Active
- 2015-06-19 BR BR112016029888-8A patent/BR112016029888B1/pt not_active IP Right Cessation
- 2015-06-19 EA EA201790040A patent/EA030459B1/ru unknown
- 2015-06-19 PT PT15738519T patent/PT3157912T/pt unknown
- 2015-06-19 EP EP15738519.6A patent/EP3157912B1/en active Active
- 2015-06-19 ES ES18212461T patent/ES2895826T3/es active Active
- 2015-06-19 CN CN201580040216.3A patent/CN106536481B/zh active Active
- 2015-06-19 CA CA2952857A patent/CA2952857A1/en not_active Abandoned
- 2015-06-19 JP JP2016574080A patent/JP6619756B2/ja not_active Expired - Fee Related
- 2015-06-19 MX MX2016016928A patent/MX2016016928A/es active IP Right Grant
- 2015-06-19 WO PCT/US2015/036580 patent/WO2015196014A1/en not_active Ceased
- 2015-06-19 AU AU2015276941A patent/AU2015276941B2/en active Active
- 2015-06-19 ES ES15738519T patent/ES2723969T3/es active Active
- 2015-06-19 EP EP18212461.0A patent/EP3517524B1/en active Active
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2016
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2017
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2018
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2019
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2020
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