JP2017514871A - Ｎｍｄａｒ調節化合物の組合せ - Google Patents

Ｎｍｄａｒ調節化合物の組合せ Download PDF

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JP2017514871A
JP2017514871A JP2016566909A JP2016566909A JP2017514871A JP 2017514871 A JP2017514871 A JP 2017514871A JP 2016566909 A JP2016566909 A JP 2016566909A JP 2016566909 A JP2016566909 A JP 2016566909A JP 2017514871 A JP2017514871 A JP 2017514871A
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nmdar antagonist
glyx
nmdar
group
antagonist
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JP2017514871A5 (cg-RX-API-DMAC7.html
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ジョーゼフ アール モスカル
ジョーゼフ アール モスカル
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ノースウェスタン ユニバーシティ
ノースウェスタン ユニバーシティ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016566909A 2014-05-06 2015-05-06 Ｎｍｄａｒ調節化合物の組合せ Pending JP2017514871A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989183P 2014-05-06 2014-05-06
US61/989,183 2014-05-06
PCT/US2015/029477 WO2015171770A1 (en) 2014-05-06 2015-05-06 Combinations of nmdar modulating compounds

Related Child Applications (1)

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JP2020083060A Division JP2020138973A (ja) 2014-05-06 2020-05-11 Ｎｍｄａｒ調節化合物の組合せ

Publications (2)

Publication Number Publication Date
JP2017514871A true JP2017514871A (ja) 2017-06-08
JP2017514871A5 JP2017514871A5 (cg-RX-API-DMAC7.html) 2018-06-14

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JP2016566909A Pending JP2017514871A (ja) 2014-05-06 2015-05-06 Ｎｍｄａｒ調節化合物の組合せ
JP2020083060A Pending JP2020138973A (ja) 2014-05-06 2020-05-11 Ｎｍｄａｒ調節化合物の組合せ
JP2022116942A Pending JP2022159322A (ja) 2014-05-06 2022-07-22 Ｎｍｄａｒ調節化合物の組合せ

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JP2022116942A Pending JP2022159322A (ja) 2014-05-06 2022-07-22 Ｎｍｄａｒ調節化合物の組合せ

Country Status (11)

Country Link
US (1) US20170072005A1 (cg-RX-API-DMAC7.html)
EP (1) EP3139943A4 (cg-RX-API-DMAC7.html)
JP (3) JP2017514871A (cg-RX-API-DMAC7.html)
KR (2) KR20220102662A (cg-RX-API-DMAC7.html)
CN (1) CN106659762A (cg-RX-API-DMAC7.html)
AU (1) AU2015256075B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016025910A8 (cg-RX-API-DMAC7.html)
CA (1) CA2947976A1 (cg-RX-API-DMAC7.html)
MX (1) MX2016014581A (cg-RX-API-DMAC7.html)
RU (1) RU2721948C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015171770A1 (cg-RX-API-DMAC7.html)

Cited By (2)

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JP2021519826A (ja) * 2018-04-04 2021-08-12 シャンハイ ジャンホー ファーマシューティカル アンド テクノロジー カンパニー リミテッド 芳香族化合物およびその製造方法と使用
JP2022520110A (ja) * 2019-02-14 2022-03-28 アルジャーノン・ファーマスーティカルズ・インコーポレイテッド 特発性肺線維症を治療するための組成物及び方法

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RU2017107558A (ru) 2014-09-15 2018-10-18 Руджен Холдингс (Кайман) Лимитед Производные пирролопиримидина в качестве антагонистов nmda-рецептора nr2b
US20180271869A1 (en) * 2014-09-22 2018-09-27 Jie Liu Treatment of anxiety disorders and autism spectrum disorders
WO2016126869A1 (en) 2015-02-04 2016-08-11 Rugen Holdings (Cayman) Limited 3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists
PL3297619T3 (pl) * 2015-05-22 2023-02-13 Vistagen Therapeutics, Inc. Terapeutyczne zastosowania L-4-chlorokinureniny
MX380424B (es) 2015-06-01 2025-03-12 Rugen Holdings Cayman Ltd Compuestos heterociclicos de 3,3-difluorpiperidina carbamato como antagonistas del receptor de n-metil-d-aspartato (nmda) nr2b.
BR112018007681A2 (pt) * 2015-10-16 2018-11-06 Univ Northwestern combinação farmacêutica de um antipsicótico atípico e um modulador de nmda para o tratamento de esquizofrenia, distúrbio bipolar, comprometimento cognitivo e distúrbio depressivo maior
JP2018534362A (ja) * 2015-10-16 2018-11-22 スキティアン バイオサイエンシーズ インコーポレーテッドＳｃｙｔｈｉａｎ Ｂｉｏｓｃｉｅｎｃｅｓ Ｉｎｃ． 外傷性脳損傷を処置するための方法および組成物
JP6967532B2 (ja) * 2016-05-25 2021-11-17 ナショナル ヘルス リサーチ インスティテューツNational Health Research Institutes 付加的抗うつ剤組成物及びその使用方法
US11000526B2 (en) 2016-11-22 2021-05-11 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
CN107550907A (zh) * 2017-08-29 2018-01-09 昆明医科大学 治疗精神分裂症的药物及验证药物的动物模型构建方法
WO2019113102A1 (en) * 2017-12-05 2019-06-13 Naurex Inc. Nmda receptor modulators (rapastinel) combination for use in combined treatment (sleep and cns disorder)
ES2907692T3 (es) 2017-12-29 2022-04-26 Celon Pharma Sa Composición de ketamina de polvo seco para su administración por vía pulmonar en la depresión resistente al tratamiento
CN109223785A (zh) * 2018-10-29 2019-01-18 中国药科大学 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用
WO2020146878A1 (en) * 2019-01-11 2020-07-16 Naurex Inc. Salt and crystalline forms of rapastinel
WO2021081624A1 (en) 2019-10-28 2021-05-06 Algernon Pharmaceuticals Inc. Use of glutamate 2b receptor antagonists and sigma receptor agonsists as antitussives
CN113234036B (zh) * 2021-05-12 2023-07-14 斯莱普泰(上海)生物医药科技有限公司 Nmda受体拮抗剂及其用途
KR20230056971A (ko) * 2021-10-21 2023-04-28 삼육대학교산학협력단 신규 케타민 유도체를 포함하는 우울증 예방 또는 치료용 약학적 조성물
KR20250065690A (ko) 2022-09-14 2025-05-13 더 보드 오브 트러스티스 오브 더 릴랜드 스탠포드 주니어 유니버시티 이보가 알칼로이드의 조성물 및 치료 방법
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