RU2721948C2 - Комбинации соединений, модулирующих nmda-рецептор - Google Patents
Комбинации соединений, модулирующих nmda-рецептор Download PDFInfo
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- RU2721948C2 RU2721948C2 RU2016146714A RU2016146714A RU2721948C2 RU 2721948 C2 RU2721948 C2 RU 2721948C2 RU 2016146714 A RU2016146714 A RU 2016146714A RU 2016146714 A RU2016146714 A RU 2016146714A RU 2721948 C2 RU2721948 C2 RU 2721948C2
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- nmda receptor
- receptor antagonist
- glyx
- ketamine
- effective amount
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US20180271869A1 (en) * | 2014-09-22 | 2018-09-27 | Jie Liu | Treatment of anxiety disorders and autism spectrum disorders |
| WO2016126869A1 (en) | 2015-02-04 | 2016-08-11 | Rugen Holdings (Cayman) Limited | 3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists |
| PL3297619T3 (pl) * | 2015-05-22 | 2023-02-13 | Vistagen Therapeutics, Inc. | Terapeutyczne zastosowania L-4-chlorokinureniny |
| MX380424B (es) | 2015-06-01 | 2025-03-12 | Rugen Holdings Cayman Ltd | Compuestos heterociclicos de 3,3-difluorpiperidina carbamato como antagonistas del receptor de n-metil-d-aspartato (nmda) nr2b. |
| BR112018007681A2 (pt) * | 2015-10-16 | 2018-11-06 | Univ Northwestern | combinação farmacêutica de um antipsicótico atípico e um modulador de nmda para o tratamento de esquizofrenia, distúrbio bipolar, comprometimento cognitivo e distúrbio depressivo maior |
| JP2018534362A (ja) * | 2015-10-16 | 2018-11-22 | スキティアン バイオサイエンシーズ インコーポレーテッドＳｃｙｔｈｉａｎ Ｂｉｏｓｃｉｅｎｃｅｓ Ｉｎｃ． | 外傷性脳損傷を処置するための方法および組成物 |
| JP6967532B2 (ja) * | 2016-05-25 | 2021-11-17 | ナショナル ヘルス リサーチ インスティテューツNational Health Research Institutes | 付加的抗うつ剤組成物及びその使用方法 |
| US11000526B2 (en) | 2016-11-22 | 2021-05-11 | Rugen Holdings (Cayman) Limited | Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders |
| CN107550907A (zh) * | 2017-08-29 | 2018-01-09 | 昆明医科大学 | 治疗精神分裂症的药物及验证药物的动物模型构建方法 |
| WO2019113102A1 (en) * | 2017-12-05 | 2019-06-13 | Naurex Inc. | Nmda receptor modulators (rapastinel) combination for use in combined treatment (sleep and cns disorder) |
| ES2907692T3 (es) | 2017-12-29 | 2022-04-26 | Celon Pharma Sa | Composición de ketamina de polvo seco para su administración por vía pulmonar en la depresión resistente al tratamiento |
| CN110343050B (zh) * | 2018-04-04 | 2021-09-24 | 上海键合医药科技有限公司 | 芳香类化合物及其制备方法和用途 |
| CN109223785A (zh) * | 2018-10-29 | 2019-01-18 | 中国药科大学 | 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用 |
| WO2020146878A1 (en) * | 2019-01-11 | 2020-07-16 | Naurex Inc. | Salt and crystalline forms of rapastinel |
| WO2020163966A1 (en) | 2019-02-14 | 2020-08-20 | Algernon Pharmaceuticals Inc. | Compositions and methods for treating idiopathic pulmonary fibrosis |
| WO2021081624A1 (en) | 2019-10-28 | 2021-05-06 | Algernon Pharmaceuticals Inc. | Use of glutamate 2b receptor antagonists and sigma receptor agonsists as antitussives |
| CN113234036B (zh) * | 2021-05-12 | 2023-07-14 | 斯莱普泰(上海)生物医药科技有限公司 | Nmda受体拮抗剂及其用途 |
| KR20230056971A (ko) * | 2021-10-21 | 2023-04-28 | 삼육대학교산학협력단 | 신규 케타민 유도체를 포함하는 우울증 예방 또는 치료용 약학적 조성물 |
| KR20250065690A (ko) | 2022-09-14 | 2025-05-13 | 더 보드 오브 트러스티스 오브 더 릴랜드 스탠포드 주니어 유니버시티 | 이보가 알칼로이드의 조성물 및 치료 방법 |
| WO2025065271A1 (en) * | 2023-09-26 | 2025-04-03 | Liangzhu Laboratory | Methods and devices for treating depression |
| WO2025124571A1 (zh) * | 2023-12-14 | 2025-06-19 | 斯莱普泰(上海)生物医药科技有限公司 | Nmda受体拮抗剂及其用途 |
| CN119174765A (zh) * | 2024-09-04 | 2024-12-24 | 复旦大学附属中山医院 | Gsdme蛋白的小分子抑制剂在肿瘤及其免疫治疗中的作用 |
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| US20130310323A1 (en) * | 2009-10-05 | 2013-11-21 | Northwestern University | Methods of Treating Depression and Other Related Diseases |
| EA019351B1 (ru) * | 2008-07-03 | 2014-03-31 | ПАНМИРА ФАРМАСЬЮТИКАЛС, ЭлЭлСи | Антагонисты рецепторов простагландина d |
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| GB0523998D0 (en) * | 2005-11-25 | 2006-01-04 | Merck Sharp & Dohme | Therapeutic agents |
| US20090275597A1 (en) * | 2008-05-02 | 2009-11-05 | Forest Laboratories Holdings Limited | Methods of treating cns disorders |
| EP2381941A4 (en) * | 2008-12-29 | 2012-08-01 | Univ Vanderbilt | 3.1.0 BICYCLIC GLYTI INHIBITORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| PL2582366T3 (pl) * | 2010-06-15 | 2016-04-29 | Gruenenthal Gmbh | Kombinacja farmaceutyczna do leczenia bólu |
| US9737531B2 (en) * | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| MX2014010939A (es) * | 2012-03-12 | 2014-11-13 | Janssen Pharmaceutica Nv | Esketamina para el tratamiento de la depresion refractaria al tratamiento o resistente al tratamiento. |
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| EA019351B1 (ru) * | 2008-07-03 | 2014-03-31 | ПАНМИРА ФАРМАСЬЮТИКАЛС, ЭлЭлСи | Антагонисты рецепторов простагландина d |
| US20130310323A1 (en) * | 2009-10-05 | 2013-11-21 | Northwestern University | Methods of Treating Depression and Other Related Diseases |
Non-Patent Citations (1)
| Title |
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| ZHANG X L ET AL., "A NMDA RECEPTOR GLYCINE SITE PARTIAL AGONIST, GLYX-13, SIMULTANEOUSLY ENCHANCES LTP AND REDUCES LTD AT SCHAFFER COLLATERAL-CA1 SYNAPSES IN HIPPOCAMPUS", NEUROPHARMACOLOGY, PERGAMON PRESS, VOL. 55, NO. 7, 01.12.1988. * |
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| EP3139943A1 (en) | 2017-03-15 |
| KR20170013890A (ko) | 2017-02-07 |
| EP3139943A4 (en) | 2018-07-18 |
| CA2947976A1 (en) | 2015-11-12 |
| CN106659762A (zh) | 2017-05-10 |
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