JP2017514812A5 - - Google Patents
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- JP2017514812A5 JP2017514812A5 JP2016563404A JP2016563404A JP2017514812A5 JP 2017514812 A5 JP2017514812 A5 JP 2017514812A5 JP 2016563404 A JP2016563404 A JP 2016563404A JP 2016563404 A JP2016563404 A JP 2016563404A JP 2017514812 A5 JP2017514812 A5 JP 2017514812A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410174890.8 | 2014-04-29 | ||
| CN201410174890 | 2014-04-29 | ||
| PCT/CN2015/077887 WO2015165413A1 (zh) | 2014-04-29 | 2015-04-29 | 一种新型的稳定型抗体药物耦联物及其制备方法和用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019215918A Division JP7100617B2 (ja) | 2014-04-29 | 2019-11-29 | 新規安定型抗体薬物複合体の作製およびその応用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514812A JP2017514812A (ja) | 2017-06-08 |
| JP2017514812A5 true JP2017514812A5 (enExample) | 2017-07-20 |
| JP6666264B2 JP6666264B2 (ja) | 2020-03-13 |
Family
ID=54358190
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563404A Active JP6666264B2 (ja) | 2014-04-29 | 2015-04-29 | 新規安定型抗体薬物複合体の作製およびその応用 |
| JP2019215918A Active JP7100617B2 (ja) | 2014-04-29 | 2019-11-29 | 新規安定型抗体薬物複合体の作製およびその応用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019215918A Active JP7100617B2 (ja) | 2014-04-29 | 2019-11-29 | 新規安定型抗体薬物複合体の作製およびその応用 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US11040084B2 (enExample) |
| EP (2) | EP3517114A1 (enExample) |
| JP (2) | JP6666264B2 (enExample) |
| KR (1) | KR102511249B1 (enExample) |
| CN (2) | CN106856656B (enExample) |
| AU (2) | AU2015252518B2 (enExample) |
| ES (1) | ES2736505T3 (enExample) |
| WO (1) | WO2015165413A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3517114A1 (en) | 2014-04-29 | 2019-07-31 | Genequantum Healthcare (Suzhou) Co., Ltd. | New stable antibody-drug conjugate, preparation method and use thereof |
| BR112019000071A2 (pt) | 2016-07-07 | 2019-07-02 | Bolt Biotherapeutics Inc | conjugados adjuvantes de anticorpo |
| EP3937984A1 (en) | 2019-03-15 | 2022-01-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| CN114901694A (zh) * | 2019-12-31 | 2022-08-12 | 启德医药科技（苏州）有限公司 | 抗trop2抗体、抗体-药物缀合物及其应用 |
| WO2021136475A1 (en) * | 2019-12-31 | 2021-07-08 | Genequantum Healthcare (Suzhou) Co., Ltd. | A drug conjugate and applications thereof |
| US20230399616A1 (en) * | 2020-10-30 | 2023-12-14 | Westlake Therapeutics (Hangzhou) Co. Limited | Modified Red Blood Cells and Uses Thereof for Delivering Agents |
| AU2020482800B2 (en) * | 2020-12-23 | 2025-08-21 | Genequantum Healthcare (Suzhou) Co., Ltd. | Novel isomeric compounds comprising a ring-opened thiosuccinimide group, an oligopeptide fragment and a chiral moiety |
| KR20230147105A (ko) | 2021-01-28 | 2023-10-20 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 리가제 융합 단백질 및 그 응용 |
| WO2022188743A1 (en) * | 2021-03-08 | 2022-09-15 | Genequantum Healthcare (Suzhou) Co., Ltd. | Anti-her2 antibody-immune agonist conjugate and applications thereof |
| JP7844499B2 (ja) * | 2021-03-08 | 2026-04-13 | ジーンクアンタム ヘルスケア （スーチョウ） シーオー．， エルティーディー． | 抗体－免疫アゴニストコンジュゲート及びその使用 |
| CN115197297B (zh) * | 2021-04-14 | 2023-08-01 | 启德医药科技（苏州）有限公司 | 连接子、缀合物及其应用 |
| US20240238440A1 (en) * | 2021-04-29 | 2024-07-18 | Hyslink Therapeutics | Preparation method for and application of antibody conjugated drug |
| US11814394B2 (en) * | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| US20250043005A1 (en) * | 2021-12-09 | 2025-02-06 | Genequantum Healthcare (Suzhou) Co., Ltd. | Antibody-cytokine fusion proteins and applications thereof |
| US20250213484A1 (en) * | 2022-03-29 | 2025-07-03 | Genequantum Healthcare (Suzhou) Co., Ltd. | A freeze-drying process for an adc |
| JP7893907B2 (ja) | 2022-06-02 | 2026-07-22 | ジーンクアンタム ヘルスケア （スーチョウ） シーオー．， エルティーディー． | オリゴ糖リンカー、オリゴ糖リンカーを含むリンカー－ペイロード、および糖鎖がリモデリングされた抗体薬物複合体、その製造方法と使用 |
| KR20250068592A (ko) * | 2022-06-28 | 2025-05-16 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 항-fgfr3 항체 접합체 및 이의 의학적 용도 |
| KR20250031198A (ko) | 2022-07-01 | 2025-03-06 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 고정화된 엔도글리코시다아제 융합 단백질 및 이의 적용 |
| AU2023305694A1 (en) * | 2022-07-15 | 2025-02-20 | Genequantum Healthcare (Suzhou) Co., Ltd. | Linkers, conjugates and applications thereof |
| WO2024012566A2 (en) | 2022-07-15 | 2024-01-18 | Genequantum Healthcare (Suzhou) Co., Ltd. | Antibody, linkers, payload, conjugates and applications thereof |
| AU2023328010A1 (en) | 2022-08-25 | 2025-03-20 | Genequantum Healthcare (Suzhou) Co., Ltd. | Pharmaceutical composition of antibody drug conjugate |
| WO2024078612A1 (en) * | 2022-10-14 | 2024-04-18 | Genequantum Healthcare (Suzhou) Co., Ltd. | Linker-payload compound, conjugates and applications thereof |
| WO2024193570A1 (en) * | 2023-03-21 | 2024-09-26 | Genequantum Healthcare (Suzhou) Co., Ltd. | Combination of antibody-drug conjugate and cancer therapy, and use thereof |
| CN120981487A (zh) * | 2023-03-30 | 2025-11-18 | 启德医药科技（苏州）有限公司 | 位点特异性正交生物偶联模式及其应用 |
| JP2026515759A (ja) | 2023-04-13 | 2026-05-19 | ジーンクオンタム ヘルスケア （スーチョウ） カンパニー リミテッド | 抗体－薬物コンジュゲートと抗ｐｄ－１抗体との組み合わせ、及びその使用 |
| WO2025113659A1 (zh) | 2023-12-01 | 2025-06-05 | 启德医药科技（苏州）有限公司 | 三糖连接子，包含三糖连接子的连接子-负载物和糖链重塑的抗体偶联药物，其制备方法和用途 |
| AR134906A1 (es) | 2024-01-12 | 2026-05-06 | Genequantum Healthcare Suzhou Co Ltd | Composición farmacéutica |
| WO2025255054A1 (en) * | 2024-06-03 | 2025-12-11 | Darbix Llc | Methods and compositions for oligonucleotide bioconjugation |
| WO2026133302A1 (en) | 2024-12-22 | 2026-06-25 | Biohaven Therapeutics Ltd. | Mouth wash for use with anti-trop2 antibody-drug conjugates |
| WO2026150353A2 (en) | 2025-01-11 | 2026-07-16 | Biohaven Therapeutics Ltd. | Antibody-drug conjugates for delivering cytotoxic agents |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6028056A (en) * | 1998-02-06 | 2000-02-22 | Diatide, Inc. | Pharmaceutical compositions for imaging and treating thrombi |
| ES2605443T3 (es) | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| US7241020B2 (en) * | 2003-11-20 | 2007-07-10 | Mirror Lite | High definition vehicular mirror |
| NZ551180A (en) | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
| UA108598C2 (xx) * | 2008-04-30 | 2015-05-25 | Високоефективні кон'югати та гідрофільні зшиваючі агенти (лінкери) | |
| US8940501B2 (en) | 2009-01-30 | 2015-01-27 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
| US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| EP2904089A4 (en) * | 2012-10-04 | 2016-05-25 | Immunogen Inc | USE OF A PVDF MEMBRANE FOR PURIFYING CELL BINDING AGENT-CYTOTOXIC AGENT CONJUGATES |
| EP2777714A1 (en) | 2013-03-15 | 2014-09-17 | NBE-Therapeutics LLC | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
| EP2988786A4 (en) * | 2013-04-22 | 2016-12-21 | Avelas Biosciences Inc | COMPOSITIONS FOR SELECTIVE DRUG ADMINISTRATION AND METHOD OF USE |
| GB2529356B (en) * | 2013-04-28 | 2020-12-23 | Genequantum Healthcare Co Ltd | Novel linkers, coupling intermediates, conjugates, preparation method and application thereof |
| EP3517114A1 (en) | 2014-04-29 | 2019-07-31 | Genequantum Healthcare (Suzhou) Co., Ltd. | New stable antibody-drug conjugate, preparation method and use thereof |
| CN107828351B (zh) | 2016-09-15 | 2021-07-27 | E·I·内穆尔杜邦公司 | 用于粘合的导电糊料 |
| JP2021531826A (ja) | 2018-07-09 | 2021-11-25 | ジーンクアンタム ヘルスケア (スーチョウ) シーオー., エルティーディー.Genequantum Healthcare (Suzhou)Co., Ltd. | 栄養膜細胞表面抗原２（ｔｒｏｐ２）に対する特異的な抗体 |
| CN114901694A (zh) | 2019-12-31 | 2022-08-12 | 启德医药科技（苏州）有限公司 | 抗trop2抗体、抗体-药物缀合物及其应用 |
| KR20230147105A (ko) | 2021-01-28 | 2023-10-20 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 리가제 융합 단백질 및 그 응용 |
| ES3031876T3 (en) | 2021-02-09 | 2025-07-11 | Genequantum Healthcare Suzhou Co Ltd | Conjugation device and method for producing conjugates |
| JP7844499B2 (ja) | 2021-03-08 | 2026-04-13 | ジーンクアンタム ヘルスケア （スーチョウ） シーオー．， エルティーディー． | 抗体－免疫アゴニストコンジュゲート及びその使用 |
| CN115197297B (zh) | 2021-04-14 | 2023-08-01 | 启德医药科技（苏州）有限公司 | 连接子、缀合物及其应用 |
-
2015
- 2015-04-29 EP EP19157398.9A patent/EP3517114A1/en not_active Withdrawn
- 2015-04-29 JP JP2016563404A patent/JP6666264B2/ja active Active
- 2015-04-29 WO PCT/CN2015/077887 patent/WO2015165413A1/zh not_active Ceased
- 2015-04-29 KR KR1020167033391A patent/KR102511249B1/ko active Active
- 2015-04-29 AU AU2015252518A patent/AU2015252518B2/en active Active
- 2015-04-29 CN CN201580023609.3A patent/CN106856656B/zh active Active
- 2015-04-29 US US15/307,738 patent/US11040084B2/en active Active
- 2015-04-29 EP EP15786402.6A patent/EP3138568B1/en active Active
- 2015-04-29 ES ES15786402T patent/ES2736505T3/es active Active
- 2015-10-09 CN CN202110225700.0A patent/CN112999362B/zh active Active
-
2019
- 2019-11-29 JP JP2019215918A patent/JP7100617B2/ja active Active
-
2020
- 2020-02-11 AU AU2020200975A patent/AU2020200975B2/en active Active
-
2021
- 2021-02-19 US US17/180,645 patent/US11911435B2/en active Active
- 2021-02-19 US US17/180,412 patent/US11911434B2/en active Active
-
2024
- 2024-01-10 US US18/408,826 patent/US20240156894A1/en active Pending
- 2024-01-11 US US18/410,200 patent/US20240165192A1/en active Pending
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