CN106856656B - 一种稳定型抗体药物耦联物及其制备方法和用途 - Google Patents

一种稳定型抗体药物耦联物及其制备方法和用途 Download PDF

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CN106856656B
CN106856656B CN201580023609.3A CN201580023609A CN106856656B CN 106856656 B CN106856656 B CN 106856656B CN 201580023609 A CN201580023609 A CN 201580023609A CN 106856656 B CN106856656 B CN 106856656B
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compound
group
formula
antibody
glycine
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CN106856656A (zh
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秦刚
袁金铎
姜鹭
谭初兵
时丽丽
吕操
陈蕾蕾
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Genequantum Healthcare Suzhou Co Ltd
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    • A61K38/07—Tetrapeptides
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN201580023609.3A 2014-04-29 2015-04-29 一种稳定型抗体药物耦联物及其制备方法和用途 Active CN106856656B (zh)

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US (5) US11040084B2 (enExample)
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Cited By (3)

* Cited by examiner, † Cited by third party
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WO2023232144A1 (zh) 2022-06-02 2023-12-07 启德医药科技（苏州）有限公司 寡糖连接子，包含寡糖连接子的连接子-负载物和糖链重塑的抗体偶联药物，其制备方法和用途
WO2024002330A1 (zh) 2022-07-01 2024-01-04 启德医药科技（苏州）有限公司 固定化的内切糖苷酶融合蛋白及其应用
WO2025113659A1 (zh) 2023-12-01 2025-06-05 启德医药科技（苏州）有限公司 三糖连接子，包含三糖连接子的连接子-负载物和糖链重塑的抗体偶联药物，其制备方法和用途

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EP3517114A1 (en) 2014-04-29 2019-07-31 Genequantum Healthcare (Suzhou) Co., Ltd. New stable antibody-drug conjugate, preparation method and use thereof
BR112019000071A2 (pt) 2016-07-07 2019-07-02 Bolt Biotherapeutics Inc conjugados adjuvantes de anticorpo
EP3937984A1 (en) 2019-03-15 2022-01-19 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
CN114901694A (zh) * 2019-12-31 2022-08-12 启德医药科技（苏州）有限公司 抗trop2抗体、抗体-药物缀合物及其应用
WO2021136475A1 (en) * 2019-12-31 2021-07-08 Genequantum Healthcare (Suzhou) Co., Ltd. A drug conjugate and applications thereof
US20230399616A1 (en) * 2020-10-30 2023-12-14 Westlake Therapeutics (Hangzhou) Co. Limited Modified Red Blood Cells and Uses Thereof for Delivering Agents
AU2020482800B2 (en) * 2020-12-23 2025-08-21 Genequantum Healthcare (Suzhou) Co., Ltd. Novel isomeric compounds comprising a ring-opened thiosuccinimide group, an oligopeptide fragment and a chiral moiety
KR20230147105A (ko) 2021-01-28 2023-10-20 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. 리가제 융합 단백질 및 그 응용
WO2022188743A1 (en) * 2021-03-08 2022-09-15 Genequantum Healthcare (Suzhou) Co., Ltd. Anti-her2 antibody-immune agonist conjugate and applications thereof
JP7844499B2 (ja) * 2021-03-08 2026-04-13 ジーンクアンタム ヘルスケア （スーチョウ） シーオー．， エルティーディー． 抗体－免疫アゴニストコンジュゲート及びその使用
CN115197297B (zh) * 2021-04-14 2023-08-01 启德医药科技（苏州）有限公司 连接子、缀合物及其应用
US20240238440A1 (en) * 2021-04-29 2024-07-18 Hyslink Therapeutics Preparation method for and application of antibody conjugated drug
US11814394B2 (en) * 2021-11-16 2023-11-14 Genequantum Healthcare (Suzhou) Co., Ltd. Exatecan derivatives, linker-payloads, and conjugates and thereof
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