JP2017514483A5 - - Google Patents
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- Publication number
- JP2017514483A5 JP2017514483A5 JP2016565257A JP2016565257A JP2017514483A5 JP 2017514483 A5 JP2017514483 A5 JP 2017514483A5 JP 2016565257 A JP2016565257 A JP 2016565257A JP 2016565257 A JP2016565257 A JP 2016565257A JP 2017514483 A5 JP2017514483 A5 JP 2017514483A5
- Authority
- JP
- Japan
- Prior art keywords
- adenovirus
- genome
- albumin binding
- protein
- adenoviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000701161 unidentified adenovirus Species 0.000 claims 20
- 102000009027 Albumins Human genes 0.000 claims 11
- 108010088751 Albumins Proteins 0.000 claims 11
- 101710094396 Hexon protein Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 210000000234 capsid Anatomy 0.000 claims 3
- 241000192016 Finegoldia magna Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108700011201 Streptococcus IgG Fc-binding Proteins 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000000174 oncolytic effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108700026758 Adenovirus hexon capsid Proteins 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 1
- 108700020796 Oncogene Proteins 0.000 claims 1
- 108091034131 VA RNA Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14382162.7 | 2014-04-30 | ||
| EP14382162.7A EP2940128A1 (en) | 2014-04-30 | 2014-04-30 | Adenovirus comprising an albumin-binding moiety |
| PCT/EP2015/059593 WO2015166082A1 (en) | 2014-04-30 | 2015-04-30 | Adenovirus comprising an albumin-binding moiety |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514483A JP2017514483A (ja) | 2017-06-08 |
| JP2017514483A5 true JP2017514483A5 (https=) | 2018-06-14 |
| JP6639412B2 JP6639412B2 (ja) | 2020-02-05 |
Family
ID=50774820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565257A Active JP6639412B2 (ja) | 2014-04-30 | 2015-04-30 | アルブミン結合部分を含んでなるアデノウイルス |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10604549B2 (https=) |
| EP (2) | EP2940128A1 (https=) |
| JP (1) | JP6639412B2 (https=) |
| KR (1) | KR102628234B1 (https=) |
| CN (1) | CN106471125B (https=) |
| AU (1) | AU2015254535B2 (https=) |
| BR (1) | BR112016025297B1 (https=) |
| CA (1) | CA2946650C (https=) |
| IL (1) | IL248590B (https=) |
| MX (1) | MX381286B (https=) |
| RU (1) | RU2711371C2 (https=) |
| WO (1) | WO2015166082A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
| EP2940128A1 (en) | 2014-04-30 | 2015-11-04 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Adenovirus comprising an albumin-binding moiety |
| KR102608590B1 (ko) | 2014-09-24 | 2023-12-01 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 종양 살상 바이러스 및 이의 사용방법 |
| WO2017147265A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| WO2017147269A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
| EP3532082A4 (en) | 2016-12-12 | 2020-08-26 | Salk Institute for Biological Studies | SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES |
| CN111164104A (zh) | 2017-08-09 | 2020-05-15 | 麻省理工学院 | 白蛋白结合肽缀合物及其方法 |
| WO2019074842A1 (en) * | 2017-10-09 | 2019-04-18 | Keith Black | ONCOLYTIC ANTICANCER IMMUNOTHERAPIES AND METHODS OF USE |
| SG11202004680UA (en) | 2017-11-22 | 2020-06-29 | Mesoblast Int Sarl | Cellular compositions and methods of treatment i |
| CN112292449A (zh) | 2018-04-09 | 2021-01-29 | 萨克生物研究学院 | 具有增强的复制特性的溶瘤腺病毒组合物 |
| US20210340279A1 (en) | 2018-08-31 | 2021-11-04 | Yale University | Compositions and methods of using cell-penetrating antibodies in combination with immune checkpoint modulators |
| WO2020052551A1 (en) * | 2018-09-10 | 2020-03-19 | Genesail Biotech (Shanghai) Co. Ltd. | A modified oncolytic virus, composition and use thereof |
| EP4079750A3 (en) * | 2018-11-21 | 2023-01-04 | Mayo Foundation for Medical Education and Research | Adenoviruses and methods for using adenoviruses |
| CN113710694A (zh) | 2019-04-29 | 2021-11-26 | 梅奥医学教育及研究基金会 | 用于治疗癌症的多价pd-l1结合化合物 |
| AU2020325825B2 (en) | 2019-08-05 | 2026-02-05 | Mesoblast International Sarl | Cellular compositions comprising viral vectors and methods of treatment |
| US20240293487A1 (en) * | 2020-03-25 | 2024-09-05 | Jin-Woo Choi | Immunoevasive anti-tumor adenovirus |
| CA3188492A1 (en) | 2020-08-10 | 2022-02-17 | Silviu Itescu | Cellular compositions and methods of treatment |
| CN116271066B (zh) * | 2021-12-13 | 2026-02-06 | 康希诺生物股份公司 | 一种重组腺病毒载体疫苗吸入给药递送系统 |
| CN114159556B (zh) * | 2021-12-14 | 2023-06-16 | 中国人民解放军军事科学院军事医学研究院 | 一种用于腺病毒载体疫苗免疫增强的蛋白质纳米递送载体 |
| WO2023120762A1 (ko) * | 2021-12-21 | 2023-06-29 | (주)큐리진 | 면역 회피성 항종양 아데노바이러스 |
| EP4458973A4 (en) * | 2021-12-21 | 2026-02-18 | Curigin Co Ltd | IMMUNE-MASKING ANTITUMORAL ADENOVIRUS |
| EP4602078A2 (en) | 2022-10-11 | 2025-08-20 | Yale University | Compositions and methods of using cell-penetrating antibodies |
| CN115624524B (zh) * | 2022-10-25 | 2023-10-27 | 中国医科大学附属第一医院 | Peg化白蛋白修饰的溶瘤病毒静脉递送制剂的制备及其应用 |
| WO2026042009A1 (en) * | 2024-08-19 | 2026-02-26 | Theriva Biologics S.L. | Modified adenovirus by hexon hypervariable region 7 (hvr7) gene insertion |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU561343B2 (en) | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| DE3377363D1 (en) | 1982-03-31 | 1988-08-18 | Ajinomoto Kk | Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells |
| US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
| US5391485A (en) | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
| US5328988A (en) | 1987-10-26 | 1994-07-12 | Immunex Corporation | Interleukin-7 |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US5457038A (en) | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
| KR970005042B1 (ko) | 1993-02-09 | 1997-04-11 | 한일합성섬유공업 주식회사 | 종양괴사인자-알파 뮤테인 |
| US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5641665A (en) | 1994-11-28 | 1997-06-24 | Vical Incorporated | Plasmids suitable for IL-2 expression |
| US5998205A (en) | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
| EP1240337B1 (en) * | 1999-12-24 | 2006-08-23 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US7445929B2 (en) | 2000-05-26 | 2008-11-04 | Dainippon Sumitomo Pharma Co., Ltd. | Recombinant adenovirus vector having a reduced side effect |
| GB0017720D0 (en) | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
| WO2007050128A2 (en) | 2005-05-31 | 2007-05-03 | Vectorlogics, Inc. | Shielded adenoviral vectors and methods of use |
| EP2012822B1 (en) | 2006-04-28 | 2010-01-20 | The Trustees of the University of Pennsylvania | Modified adenovirus hexon protein and uses thereof |
| EP2176295B1 (en) * | 2007-07-16 | 2014-11-19 | Genentech, Inc. | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| CN101781636A (zh) * | 2009-01-19 | 2010-07-21 | 中国人民解放军第二军医大学东方肝胆外科医院 | 一种含11型腺病毒纤毛蛋白基因的增殖型重组溶瘤腺病毒、其构建方法及其用途 |
| ES2385251B1 (es) * | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
| EP2558481B1 (en) | 2010-04-14 | 2017-12-20 | Mogam Biotechnology Research Institute | Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same |
| EP2940128A1 (en) | 2014-04-30 | 2015-11-04 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Adenovirus comprising an albumin-binding moiety |
-
2014
- 2014-04-30 EP EP14382162.7A patent/EP2940128A1/en not_active Withdrawn
-
2015
- 2015-04-30 KR KR1020167033433A patent/KR102628234B1/ko active Active
- 2015-04-30 US US15/307,408 patent/US10604549B2/en active Active
- 2015-04-30 WO PCT/EP2015/059593 patent/WO2015166082A1/en not_active Ceased
- 2015-04-30 EP EP15720960.2A patent/EP3137599A1/en active Pending
- 2015-04-30 AU AU2015254535A patent/AU2015254535B2/en active Active
- 2015-04-30 JP JP2016565257A patent/JP6639412B2/ja active Active
- 2015-04-30 RU RU2016146664A patent/RU2711371C2/ru active
- 2015-04-30 CN CN201580023575.8A patent/CN106471125B/zh active Active
- 2015-04-30 CA CA2946650A patent/CA2946650C/en active Active
- 2015-04-30 BR BR112016025297-7A patent/BR112016025297B1/pt active IP Right Grant
- 2015-04-30 MX MX2016014187A patent/MX381286B/es unknown
-
2016
- 2016-10-29 IL IL248590A patent/IL248590B/en active IP Right Grant
-
2020
- 2020-02-19 US US16/795,478 patent/US11578104B2/en active Active
-
2023
- 2023-01-10 US US18/152,562 patent/US20230331786A1/en active Pending
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