JP2017514467A - 核酸キャリパーを用いた高スループット構造決定 - Google Patents

核酸キャリパーを用いた高スループット構造決定 Download PDF

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Publication number
JP2017514467A
JP2017514467A JP2016562759A JP2016562759A JP2017514467A JP 2017514467 A JP2017514467 A JP 2017514467A JP 2016562759 A JP2016562759 A JP 2016562759A JP 2016562759 A JP2016562759 A JP 2016562759A JP 2017514467 A JP2017514467 A JP 2017514467A
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JP
Japan
Prior art keywords
target
nucleic acid
caliper
sequence
bound
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JP2016562759A
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English (en)
Japanese (ja)
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JP2017514467A5 (enExample
Inventor
シー，ウィリアム，エム．
ウォン，ウェスレー，フィリップ
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Boston Childrens Hospital
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Boston Childrens Hospital
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Publication of JP2017514467A publication Critical patent/JP2017514467A/ja
Publication of JP2017514467A5 publication Critical patent/JP2017514467A5/ja
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Bioinformatics & Computational Biology (AREA)
JP2016562759A 2014-04-23 2015-04-23 核酸キャリパーを用いた高スループット構造決定 Ceased JP2017514467A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461982914P 2014-04-23 2014-04-23
US61/982,914 2014-04-23
PCT/US2015/027290 WO2015164602A2 (en) 2014-04-23 2015-04-23 High-throughput structure determination using nucleic acid calipers

Publications (2)

Publication Number Publication Date
JP2017514467A true JP2017514467A (ja) 2017-06-08
JP2017514467A5 JP2017514467A5 (enExample) 2018-06-07

Family

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Family Applications (1)

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JP2016562759A Ceased JP2017514467A (ja) 2014-04-23 2015-04-23 核酸キャリパーを用いた高スループット構造決定

Country Status (5)

Country Link
US (2) US9897597B2 (enExample)
EP (2) EP3134550B1 (enExample)
JP (1) JP2017514467A (enExample)
CN (1) CN106661616A (enExample)
WO (1) WO2015164602A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8491454B2 (en) 2008-12-02 2013-07-23 President And Fellows Of Harvard College Spinning force apparatus
WO2015164602A2 (en) 2014-04-23 2015-10-29 Children's Medical Center Corporation High-throughput structure determination using nucleic acid calipers
WO2016089588A1 (en) 2014-12-06 2016-06-09 Children's Medical Center Corporation Nucleic acid-based linkers for detecting and measuring interactions
KR20160100175A (ko) * 2015-02-13 2016-08-23 주식회사 삼홍사 높낮이 조절이 가능한 책상
WO2016196824A1 (en) 2015-06-02 2016-12-08 Children's Medical Center Corporation Nucleic acid complexes for screening barcoded compounds
WO2017003950A2 (en) 2015-06-27 2017-01-05 Children's Medical Center Corporation Compositions and methods for analyte detection using nanoswitches
US11713483B2 (en) 2016-02-09 2023-08-01 Children's Medical Center Corporation Method for detection of analytes via polymer complexes
WO2017147398A1 (en) 2016-02-25 2017-08-31 Children's Medical Center Corporation Spinning apparatus for measurement of characteristics relating to molecules
WO2017151062A1 (en) * 2016-03-03 2017-09-08 National University Of Singapore A method of determining a presence of interaction between a substance molecule and a substrate molecule
US12123869B2 (en) 2016-03-23 2024-10-22 Children's Medical Center Corporation Rapid and sensitive detection and quantification of analytes in complex samples using polymer-based methods
CN109563539A (zh) 2016-06-15 2019-04-02 慕尼黑路德维希马克西米利安斯大学 使用dna纳米技术的单分子检测或定量
TWM549567U (zh) * 2016-12-30 2017-10-01 Kelly Int Corp 薄型升降台
US11591636B2 (en) 2017-11-20 2023-02-28 Children's Medical Center Corporation Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids
CN109961144A (zh) * 2019-03-08 2019-07-02 华北电力大学 一种基于dna核酶的dna分子逻辑门
CN112998395A (zh) * 2021-04-22 2021-06-22 宁波翘楚智能设备科技有限公司 可升降桌上桌

Citations (1)

* Cited by examiner, † Cited by third party
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US20120149129A1 (en) * 2009-03-06 2012-06-14 California Institute Of Technology Low cost, portable sensor for molecular assays

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US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5023243A (en) 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
DE3280400D1 (de) 1981-10-23 1992-06-04 Molecular Biosystems Inc Oligonukleotides heilmittel und dessen herstellungsverfahren.
WO1997023647A1 (en) * 1995-12-22 1997-07-03 Behringwerke Aktiengesellschaft Homogeneous amplification and detection of nucleic acids
US20040054162A1 (en) * 2001-10-30 2004-03-18 Hanna Michelle M. Molecular detection systems utilizing reiterative oligonucleotide synthesis
WO2005092038A2 (en) * 2004-03-22 2005-10-06 The Johns Hopkins University Methods for the detection of nucleic acid differences
US7842793B2 (en) 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
US7745594B2 (en) 2005-07-21 2010-06-29 California Institute Of Technology Nucleic acid-based logic circuits
CN102083998B (zh) * 2007-06-19 2016-08-03 斯特拉托斯基因公司 通过展开进行高通量核酸测序
US9102520B2 (en) 2008-08-13 2015-08-11 California Institute Of Technology Nanocomposite structures and related methods and systems
US8491454B2 (en) 2008-12-02 2013-07-23 President And Fellows Of Harvard College Spinning force apparatus
AU2010336137B2 (en) * 2009-12-21 2015-08-06 Seegene, Inc. TSG primer target detection
US20120238738A1 (en) 2010-07-19 2012-09-20 New England Biolabs, Inc. Oligonucleotide Adapters: Compositions and Methods of Use
CA2818556A1 (en) * 2010-11-24 2012-05-31 The Regents Of The University Of California Nucleotide-based probes and methods for the detection and quantification of macromolecules and other analytes
US20130005049A1 (en) * 2011-06-30 2013-01-03 Kent State University Devices and methods for detecting single nucleotide polymorphisms
US9428799B2 (en) * 2011-07-25 2016-08-30 Bioinventors & Entrepreneurs Network Llc Method for determining an allele profile of nucleic acid
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US20120149129A1 (en) * 2009-03-06 2012-06-14 California Institute Of Technology Low cost, portable sensor for molecular assays

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HALVORSEN ET AL., NANOTECHNOLOGY, vol. 2011, vol.22, JPN6019006184, pages 1 - 7, ISSN: 0004329366 *
KIM ET AL., NUCLEIC ACIDS RESEARCH, vol. 2009, vol.37, JPN7019000515, pages 136 - 1, ISSN: 0004329364 *
KOUSSA ET AL, METHODS, vol. 2014, vol.67, JPN6019006185, pages 134 - 141, ISSN: 0004329367 *
KOUSSA ET AL., NATURE METHODS, vol. 2015, vol.12, JPN6019006186, pages 123 - 126, ISSN: 0004329368 *
PFITZNER ET AL., ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 2013, vol.52, JPN6019006183, pages 7766 - 7771, ISSN: 0004329365 *

Also Published As

Publication number Publication date
WO2015164602A3 (en) 2015-12-23
US20170045506A1 (en) 2017-02-16
US20180306783A1 (en) 2018-10-25
US9897597B2 (en) 2018-02-20
WO2015164602A2 (en) 2015-10-29
EP3594363A1 (en) 2020-01-15
EP3134550B1 (en) 2019-09-04
EP3134550A2 (en) 2017-03-01
US10914733B2 (en) 2021-02-09
CN106661616A (zh) 2017-05-10
EP3134550A4 (en) 2017-12-13

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