JP2017511129A - 遺伝子操作された光活性化アニオンチャネルタンパク質及びその使用方法 - Google Patents

遺伝子操作された光活性化アニオンチャネルタンパク質及びその使用方法 Download PDF

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JP2017511129A
JP2017511129A JP2016559160A JP2016559160A JP2017511129A JP 2017511129 A JP2017511129 A JP 2017511129A JP 2016559160 A JP2016559160 A JP 2016559160A JP 2016559160 A JP2016559160 A JP 2016559160A JP 2017511129 A JP2017511129 A JP 2017511129A
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amino acid
seq
residue
acid sequence
polypeptide
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JP2017511129A5 (cg-RX-API-DMAC7.html
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カール エイ． ダイセロス
カール エイ． ダイセロス
スー ユァン リー
スー ユァン リー
チャル ラマクリシュナン
チャル ラマクリシュナン
アンドレ バーント
アンドレ バーント
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Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2016559160A 2014-03-28 2015-03-27 遺伝子操作された光活性化アニオンチャネルタンパク質及びその使用方法 Ceased JP2017511129A (ja)

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US201461972182P 2014-03-28 2014-03-28
US61/972,182 2014-03-28
PCT/US2015/023087 WO2015148974A2 (en) 2014-03-28 2015-03-27 Engineered light-activated anion channel proteins and methods of use thereof

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JP2017511129A true JP2017511129A (ja) 2017-04-20
JP2017511129A5 JP2017511129A5 (cg-RX-API-DMAC7.html) 2018-05-10

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US (3) US10052383B2 (cg-RX-API-DMAC7.html)
EP (2) EP3122761B1 (cg-RX-API-DMAC7.html)
JP (1) JP2017511129A (cg-RX-API-DMAC7.html)
CN (1) CN106459138A (cg-RX-API-DMAC7.html)
AU (1) AU2015237265A1 (cg-RX-API-DMAC7.html)
CA (1) CA2943367A1 (cg-RX-API-DMAC7.html)
ES (1) ES2725951T3 (cg-RX-API-DMAC7.html)
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WO2007024391A2 (en) 2005-07-22 2007-03-01 The Board Of Trustees Of The Leland Stanford Junior University Light-activated cation channel and uses thereof
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
MX2010011657A (es) 2008-04-23 2011-01-21 Univ Leland Stanford Junior Sistemas, metodos y composiciones para la estimulacion optica de celulas objetivo.
BRPI0915583A2 (pt) 2008-06-17 2016-01-26 Univ Leland Stanford Junior aparelho e métodos para controle do desenvolvimento celular
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
CN106947741A (zh) 2010-11-05 2017-07-14 斯坦福大学托管董事会 光活化嵌合视蛋白及其使用方法
CA2816990A1 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CA3036859A1 (en) 2011-12-16 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
US20140024701A1 (en) 2012-02-21 2014-01-23 Circuit Therapeutics, Inc. Compositions and Methods for Treating Neurogenic Disorders of the Pelvic Floor
WO2016209654A1 (en) 2015-06-22 2016-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
KR102644929B1 (ko) 2015-07-21 2024-03-08 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 자기 공명 영상 호환 가능한 광유전학을 위한 탄소 섬유 광단자
JP2018529335A (ja) 2015-09-15 2018-10-11 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 光応答性ポリペプチド及びその使用方法
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
US10961296B2 (en) * 2017-11-10 2021-03-30 Howard Hughes Medical Institute Modified ligand-gated ion channels and methods of use
CN108192896B (zh) * 2018-02-10 2021-05-07 中国烟草总公司郑州烟草研究院 一个烟草慢阴离子通道蛋白NtSLAH1及其应用
WO2020061079A1 (en) * 2018-09-18 2020-03-26 California Institute Of Technology Engineered light-sensitive proteins
WO2020059675A1 (ja) 2018-09-20 2020-03-26 国立大学法人岩手大学 改変チャネルロドプシン
CN111263086A (zh) * 2020-02-10 2020-06-09 江南大学 细胞融合的光电传感器的制作方法及其成像系统的工作方法
US11921271B2 (en) 2020-05-22 2024-03-05 The Board Of Trustees Of The Leland Stanford Junior Univeristy Multifocal macroscope for large field of view imaging of dynamic specimens

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ES2725951T3 (es) 2019-09-30
WO2015148974A3 (en) 2015-12-23
US20180344851A1 (en) 2018-12-06
US20200030446A1 (en) 2020-01-30
WO2015148974A2 (en) 2015-10-01
EP3122761A2 (en) 2017-02-01
AU2015237265A1 (en) 2016-10-13
EP3122761B1 (en) 2019-03-06
CA2943367A1 (en) 2015-10-01
CN106459138A (zh) 2017-02-22
US10052383B2 (en) 2018-08-21
EP3122761A4 (en) 2017-12-06
EP3581580A1 (en) 2019-12-18
US20170095556A1 (en) 2017-04-06
US10478499B2 (en) 2019-11-19

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