JP2017510648A5 - - Google Patents
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- Publication number
- JP2017510648A5 JP2017510648A5 JP2017503081A JP2017503081A JP2017510648A5 JP 2017510648 A5 JP2017510648 A5 JP 2017510648A5 JP 2017503081 A JP2017503081 A JP 2017503081A JP 2017503081 A JP2017503081 A JP 2017503081A JP 2017510648 A5 JP2017510648 A5 JP 2017510648A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- carrier
- acetyl
- agent according
- donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 14
- 229940124597 therapeutic agent Drugs 0.000 claims 14
- 239000000126 substance Substances 0.000 claims 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 6
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 5
- FRPJTGXMTIIFIT-UHFFFAOYSA-N tetraacetylethylenediamine Chemical compound CC(=O)C(N)(C(C)=O)C(N)(C(C)=O)C(C)=O FRPJTGXMTIIFIT-UHFFFAOYSA-N 0.000 claims 5
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims 4
- 239000011859 microparticle Substances 0.000 claims 4
- 239000002105 nanoparticle Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- UAOKXEHOENRFMP-ZJIFWQFVSA-N [(2r,3r,4s,5r)-2,3,4,5-tetraacetyloxy-6-oxohexyl] acetate Chemical compound CC(=O)OC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C=O UAOKXEHOENRFMP-ZJIFWQFVSA-N 0.000 claims 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 2
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims 2
- 229920002988 biodegradable polymer Polymers 0.000 claims 2
- 239000004621 biodegradable polymer Substances 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims 2
- VPVSTMAPERLKKM-UHFFFAOYSA-N glycoluril Chemical compound N1C(=O)NC2NC(=O)NC21 VPVSTMAPERLKKM-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 229960001922 sodium perborate Drugs 0.000 claims 2
- 229940045872 sodium percarbonate Drugs 0.000 claims 2
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 claims 2
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims 2
- GMLREHXYJDLZOU-LEPYJNQMSA-N 3-Acetylmorphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GMLREHXYJDLZOU-LEPYJNQMSA-N 0.000 claims 1
- SKORSNZZDZSCKK-UHFFFAOYSA-N C(C)(=O)NC(N(C(C)=O)C(C)=O)=O Chemical compound C(C)(=O)NC(N(C(C)=O)C(C)=O)=O SKORSNZZDZSCKK-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- QISSLHPKTCLLDL-UHFFFAOYSA-N N-Acetylcaprolactam Chemical compound CC(=O)N1CCCCCC1=O QISSLHPKTCLLDL-UHFFFAOYSA-N 0.000 claims 1
- VIHYIVKEECZGOU-UHFFFAOYSA-N N-acetylimidazole Chemical compound CC(=O)N1C=CN=C1 VIHYIVKEECZGOU-UHFFFAOYSA-N 0.000 claims 1
- 239000012425 OXONE® Substances 0.000 claims 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 claims 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 claims 1
- 239000012346 acetyl chloride Substances 0.000 claims 1
- LIPOUNRJVLNBCD-UHFFFAOYSA-N acetyl dihydrogen phosphate Chemical compound CC(=O)OP(O)(O)=O LIPOUNRJVLNBCD-UHFFFAOYSA-N 0.000 claims 1
- 235000019395 ammonium persulphate Nutrition 0.000 claims 1
- ZJRXSAYFZMGQFP-UHFFFAOYSA-N barium peroxide Chemical compound [Ba+2].[O-][O-] ZJRXSAYFZMGQFP-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- LSXWFXONGKSEMY-UHFFFAOYSA-N di-tert-butyl peroxide Chemical compound CC(C)(C)OOC(C)(C)C LSXWFXONGKSEMY-UHFFFAOYSA-N 0.000 claims 1
- 229910001882 dioxygen Inorganic materials 0.000 claims 1
- BHDAXLOEFWJKTL-UHFFFAOYSA-L dipotassium;carboxylatooxy carbonate Chemical compound [K+].[K+].[O-]C(=O)OOC([O-])=O BHDAXLOEFWJKTL-UHFFFAOYSA-L 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 125000001976 hemiacetal group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- HPGPEWYJWRWDTP-UHFFFAOYSA-N lithium peroxide Chemical compound [Li+].[Li+].[O-][O-] HPGPEWYJWRWDTP-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- UJQLDFMZDSDZEY-UHFFFAOYSA-N n-(acetylcarbamoyl)acetamide Chemical compound CC(=O)NC(=O)NC(C)=O UJQLDFMZDSDZEY-UHFFFAOYSA-N 0.000 claims 1
- GKRZNOGGALENQJ-UHFFFAOYSA-N n-carbamoylacetamide Chemical compound CC(=O)NC(N)=O GKRZNOGGALENQJ-UHFFFAOYSA-N 0.000 claims 1
- 229910021392 nanocarbon Inorganic materials 0.000 claims 1
- 150000002976 peresters Chemical class 0.000 claims 1
- 238000005502 peroxidation Methods 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- OKBMCNHOEMXPTM-UHFFFAOYSA-M potassium peroxymonosulfate Chemical compound [K+].OOS([O-])(=O)=O OKBMCNHOEMXPTM-UHFFFAOYSA-M 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229940083542 sodium Drugs 0.000 claims 1
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000002145 thermally induced phase separation Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1405874.7 | 2014-04-01 | ||
| GBGB1405874.7A GB201405874D0 (en) | 2014-04-01 | 2014-04-01 | A therapeutic agent for use in the treatment of infections |
| GB1415063.5 | 2014-08-26 | ||
| GBGB1415063.5A GB201415063D0 (en) | 2014-04-01 | 2014-08-26 | A therapeutic agent for use in the treatment of infections |
| PCT/GB2015/000100 WO2015150722A1 (en) | 2014-04-01 | 2015-03-24 | A therapeutic agent for use in the treatment of infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510648A JP2017510648A (ja) | 2017-04-13 |
| JP2017510648A5 true JP2017510648A5 (https=) | 2019-06-20 |
| JP6573286B2 JP6573286B2 (ja) | 2019-09-11 |
Family
ID=50737835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503081A Active JP6573286B2 (ja) | 2014-04-01 | 2015-03-24 | 感染の処置での使用のための治療剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9913805B2 (https=) |
| EP (2) | EP3125874B1 (https=) |
| JP (1) | JP6573286B2 (https=) |
| KR (2) | KR102482597B1 (https=) |
| CN (1) | CN106456557B (https=) |
| AU (1) | AU2015242495B2 (https=) |
| CA (1) | CA2943431C (https=) |
| DK (1) | DK3125874T3 (https=) |
| ES (2) | ES2953755T3 (https=) |
| GB (3) | GB201405874D0 (https=) |
| IL (1) | IL247969B (https=) |
| MX (1) | MX2016012757A (https=) |
| NZ (1) | NZ724298A (https=) |
| SG (2) | SG10201801524PA (https=) |
| WO (1) | WO2015150722A1 (https=) |
| ZA (1) | ZA201606387B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12551501B2 (en) | 2012-02-17 | 2026-02-17 | Wiab Water Innovation Ab | Compositions and methods for treating biofilms without inducing antimicrobial resistance |
| GB201405874D0 (en) * | 2014-04-01 | 2014-05-14 | Aga Nanotech Ltd | A therapeutic agent for use in the treatment of infections |
| CN107281220B (zh) * | 2016-03-31 | 2020-02-14 | 中国科学院上海硅酸盐研究所 | 一种介孔氧化硅基活性氧(ros)放疗增敏剂及其制备方法 |
| CN106860032B (zh) * | 2016-10-25 | 2021-04-09 | 咏达生医材料股份有限公司 | 一种气态皮肤供氧美白产品及其应用 |
| US12605403B2 (en) | 2016-12-22 | 2026-04-21 | Wiab Water Innovation Ab | Compositions and methods for treating transient biofilms |
| JP2019194162A (ja) * | 2018-05-01 | 2019-11-07 | ツァ ギャリー | 肌の酸素供給による美白及び加熱機能を備えた通気性材料 |
| CA3152075A1 (en) | 2019-10-10 | 2021-04-15 | Alpha Tau Medical Ltd. | Wet preparation of radiotherapy sources |
| GB2592911B (en) * | 2020-02-28 | 2023-06-28 | Aga Nanotech Ltd | A plasma-activatable wound dressing for treatment of infections |
| GB202005556D0 (en) | 2020-04-16 | 2020-06-03 | Aga Nanotech Ltd | Covid face mask |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5908614A (en) | 1995-08-15 | 1999-06-01 | Montgomery; Robert Eric | Peroxidase-activating oral compositions |
| EP1064910B1 (de) * | 1999-07-02 | 2005-09-14 | Cognis IP Management GmbH | Mikrokapseln - IV |
| WO2001078687A1 (en) * | 2000-04-18 | 2001-10-25 | Peptron Inc. | Injectable sustained release pharmaceutical composition and processes for preparing the same |
| KR100342746B1 (ko) * | 2000-06-27 | 2002-07-03 | 김찬화 | 인슐린의 방출제어제제 및 그 방법 |
| GB0411304D0 (en) * | 2004-05-21 | 2004-06-23 | Fellows Adrian N | An antimicrobial composition |
| US20060088498A1 (en) * | 2004-10-27 | 2006-04-27 | Truox, Inc. | Anti-microbial composition using in-situ generation of an oxidizing agent |
| EP1919507A2 (en) * | 2005-08-04 | 2008-05-14 | Thomas William Rademacher | Nanoparticles comprising antibacterial ligands |
| KR20070071225A (ko) * | 2005-12-29 | 2007-07-04 | 애경산업(주) | 치아 미백용 조성물 |
| GB0711952D0 (en) * | 2007-06-20 | 2007-08-01 | King S College London | Microspheres |
| US20110218140A1 (en) * | 2008-02-25 | 2011-09-08 | Gonsalves Kenneth E | Biodegradable therapeutic nanoparticles containing an antimicrobial agent |
| EP2313122B1 (en) * | 2008-07-17 | 2019-03-06 | Micell Technologies, Inc. | Drug delivery medical device |
| US8969282B2 (en) * | 2009-02-05 | 2015-03-03 | American Sterilizer Company | Low odor, hard surface sporicide |
| US8889161B2 (en) * | 2009-04-27 | 2014-11-18 | Premier Dental Products Company | Microencapsulated compositions and methods for tissue mineralization |
| KR101136028B1 (ko) * | 2009-04-27 | 2012-04-18 | 한양대학교 산학협력단 | 다공성 마이크로스피어의 제조방법 |
| NZ600269A (en) * | 2009-05-20 | 2014-02-28 | Dec Int Nz Ltd | Delivery device for treatment of mastitis |
| US9187594B2 (en) * | 2010-02-09 | 2015-11-17 | The Regents Of The University Of Michigan | Nano-fibrous microspheres and methods for making the same |
| HUE033386T2 (en) * | 2010-07-09 | 2017-11-28 | Innocore Tech B V | Release of Biodegradable Phase Separated Segmented Multiblock Copolymers and Biologically Active Polypeptides |
| CN103221070B (zh) * | 2010-08-30 | 2019-07-12 | 哈佛大学校长及研究员协会 | 用于狭窄病变和溶解血栓疗法的切变控制释放 |
| GB201405874D0 (en) * | 2014-04-01 | 2014-05-14 | Aga Nanotech Ltd | A therapeutic agent for use in the treatment of infections |
-
2014
- 2014-04-01 GB GBGB1405874.7A patent/GB201405874D0/en not_active Ceased
- 2014-08-26 GB GBGB1415063.5A patent/GB201415063D0/en not_active Ceased
-
2015
- 2015-03-24 KR KR1020227003691A patent/KR102482597B1/ko active Active
- 2015-03-24 EP EP15714598.8A patent/EP3125874B1/en active Active
- 2015-03-24 CA CA2943431A patent/CA2943431C/en active Active
- 2015-03-24 WO PCT/GB2015/000100 patent/WO2015150722A1/en not_active Ceased
- 2015-03-24 JP JP2017503081A patent/JP6573286B2/ja active Active
- 2015-03-24 GB GB1617053.2A patent/GB2538923B/en active Active
- 2015-03-24 NZ NZ724298A patent/NZ724298A/en not_active IP Right Cessation
- 2015-03-24 SG SG10201801524PA patent/SG10201801524PA/en unknown
- 2015-03-24 MX MX2016012757A patent/MX2016012757A/es active IP Right Grant
- 2015-03-24 CN CN201580018976.4A patent/CN106456557B/zh active Active
- 2015-03-24 AU AU2015242495A patent/AU2015242495B2/en active Active
- 2015-03-24 EP EP20215977.8A patent/EP3848022B1/en active Active
- 2015-03-24 SG SG11201608093WA patent/SG11201608093WA/en unknown
- 2015-03-24 ES ES20215977T patent/ES2953755T3/es active Active
- 2015-03-24 KR KR1020167030614A patent/KR102359855B1/ko active Active
- 2015-03-24 ES ES15714598T patent/ES2855985T3/es active Active
- 2015-03-24 US US15/126,511 patent/US9913805B2/en active Active
- 2015-03-24 DK DK15714598.8T patent/DK3125874T3/da active
-
2016
- 2016-09-15 ZA ZA2016/06387A patent/ZA201606387B/en unknown
- 2016-09-22 IL IL247969A patent/IL247969B/en active IP Right Grant
-
2018
- 2018-01-18 US US15/874,552 patent/US10933026B2/en active Active
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