|
GB1524747A
(en)
|
1976-05-11 |
1978-09-13 |
Ici Ltd |
Polypeptide
|
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
|
EP0100172B1
(en)
|
1982-07-23 |
1987-08-12 |
Imperial Chemical Industries Plc |
Amide derivatives
|
|
GB8327256D0
(en)
|
1983-10-12 |
1983-11-16 |
Ici Plc |
Steroid derivatives
|
|
US5093330A
(en)
|
1987-06-15 |
1992-03-03 |
Ciba-Geigy Corporation |
Staurosporine derivatives substituted at methylamino nitrogen
|
|
US5010099A
(en)
|
1989-08-11 |
1991-04-23 |
Harbor Branch Oceanographic Institution, Inc. |
Discodermolide compounds, compositions containing same and method of preparation and use
|
|
NZ243082A
(en)
|
1991-06-28 |
1995-02-24 |
Ici Plc |
4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
|
|
GB9127376D0
(en)
|
1991-12-24 |
1992-02-19 |
Wellcome Found |
Amidino derivatives
|
|
GB9300059D0
(en)
|
1992-01-20 |
1993-03-03 |
Zeneca Ltd |
Quinazoline derivatives
|
|
NZ251092A
(en)
|
1992-04-02 |
1996-12-20 |
Smithkline Beecham Corp |
4-cyano-cyclohexane derivatives; medicaments; used in treating asthma
|
|
TW225528B
(en:Method)
|
1992-04-03 |
1994-06-21 |
Ciba Geigy Ag |
|
|
GB9314893D0
(en)
|
1993-07-19 |
1993-09-01 |
Zeneca Ltd |
Quinazoline derivatives
|
|
PT957087E
(pt)
|
1994-06-15 |
2003-04-30 |
Wellcome Found |
Intermediarios uteis na preparacao de inibidores de enzimas
|
|
EP0817775B1
(en)
|
1995-03-30 |
2001-09-12 |
Pfizer Inc. |
Quinazoline derivatives
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5843901A
(en)
|
1995-06-07 |
1998-12-01 |
Advanced Research & Technology Institute |
LHRH antagonist peptides
|
|
CA2224435C
(en)
|
1995-07-06 |
2008-08-05 |
Novartis Ag |
Pyrrolopyrimidines and processes for the preparation thereof
|
|
US5760041A
(en)
|
1996-02-05 |
1998-06-02 |
American Cyanamid Company |
4-aminoquinazoline EGFR Inhibitors
|
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
|
PL190489B1
(pl)
|
1996-04-12 |
2005-12-30 |
Warner Lambert Co |
Nieodwracalne inhibitory kinaz tyrozyny, kompozycja farmaceutyczna je zawierająca i ich zastosowanie
|
|
JP2000512990A
(ja)
|
1996-06-24 |
2000-10-03 |
ファイザー・インク |
過増殖性疾患を処置するためのフェニルアミノ置換三環式誘導体
|
|
AU716610B2
(en)
|
1996-08-30 |
2000-03-02 |
Novartis Ag |
Method for producing epothilones, and intermediate products obtained during the production process
|
|
DE69724269T2
(de)
|
1996-09-06 |
2004-06-09 |
Obducat Ab |
Verfahren für das anisotrope ätzen von strukturen in leitende materialien
|
|
AU4342997A
(en)
|
1996-09-13 |
1998-04-02 |
Sugen, Inc. |
Use of quinazoline derivatives for the manufacture of a medicament in the reatment of hyperproliferative skin disorders
|
|
EP0837063A1
(en)
|
1996-10-17 |
1998-04-22 |
Pfizer Inc. |
4-Aminoquinazoline derivatives
|
|
WO1998022461A1
(de)
|
1996-11-18 |
1998-05-28 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Epothilone c, d, e und f, deren herstellung und deren verwendung als cytostatische mittel bzw. als pflanzenschutzmittel
|
|
US6441186B1
(en)
|
1996-12-13 |
2002-08-27 |
The Scripps Research Institute |
Epothilone analogs
|
|
MY117948A
(en)
|
1997-01-13 |
2004-08-30 |
Glaxo Group Ltd |
Nitride oxide synthase inhibitors.
|
|
DE19723722A1
(de)
|
1997-05-30 |
1998-12-10 |
Schering Ag |
Nichtsteroidale Gestagene
|
|
CO4940418A1
(es)
|
1997-07-18 |
2000-07-24 |
Novartis Ag |
Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
|
|
GB9721069D0
(en)
|
1997-10-03 |
1997-12-03 |
Pharmacia & Upjohn Spa |
Polymeric derivatives of camptothecin
|
|
US6350458B1
(en)
|
1998-02-10 |
2002-02-26 |
Generex Pharmaceuticals Incorporated |
Mixed micellar drug deliver system and method of preparation
|
|
US6506766B1
(en)
|
1998-02-13 |
2003-01-14 |
Abbott Laboratories |
Glucocortiocoid-selective antinflammatory agents
|
|
US6194181B1
(en)
|
1998-02-19 |
2001-02-27 |
Novartis Ag |
Fermentative preparation process for and crystal forms of cytostatics
|
|
EP1058679B1
(en)
|
1998-02-25 |
2005-10-19 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues therof
|
|
GB9811599D0
(en)
|
1998-05-30 |
1998-07-29 |
Glaxo Group Ltd |
Nitric oxide synthase inhibitors
|
|
CA2339961C
(en)
|
1998-08-11 |
2009-01-20 |
Novartis Ag |
Isoquinoline derivatives with angiogenesis inhibiting activity
|
|
CA2350189A1
(en)
|
1998-11-20 |
2000-06-02 |
Kosan Biosciences, Inc. |
Recombinant methods and materials for producing epothilone and epothilone derivatives
|
|
AU4501800A
(en)
|
1999-05-04 |
2000-11-17 |
American Home Products Corporation |
Tetracyclic progesterone receptor modulator compounds and methods
|
|
ES2165768B1
(es)
|
1999-07-14 |
2003-04-01 |
Almirall Prodesfarma Sa |
Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
CO5180649A1
(es)
|
1999-09-01 |
2002-07-30 |
Abbott Lab |
Antagonistas de los receptores de los glucocorticoides para el tratamiento de la diabetes para el tratamiento de la diabetes
|
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
|
IL155093A0
(en)
|
2000-09-29 |
2003-10-31 |
Glaxo Group Ltd |
Morpholin-acetamide derivatives for the treatment on inflammatory diseases
|
|
SG159378A1
(en)
|
2000-11-07 |
2010-03-30 |
Novartis Ag |
Indolylmaleimide derivatives as protein kinase c inhibitors
|
|
GB0031179D0
(en)
|
2000-12-21 |
2001-01-31 |
Glaxo Group Ltd |
Nitric oxide synthase inhibitors
|
|
WO2002059111A2
(en)
|
2000-12-21 |
2002-08-01 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6484903B2
(en)
|
2001-01-09 |
2002-11-26 |
Riverwood International Corporation |
Carton with an improved dispensing feature in combination with a unique handle
|
|
AR035885A1
(es)
|
2001-05-14 |
2004-07-21 |
Novartis Ag |
Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
|
|
GB0119249D0
(en)
|
2001-08-07 |
2001-10-03 |
Novartis Ag |
Organic compounds
|
|
WO2003030909A1
(en)
|
2001-09-25 |
2003-04-17 |
Bayer Pharmaceuticals Corporation |
2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
|
|
ATE407678T1
(de)
*
|
2001-10-17 |
2008-09-15 |
Boehringer Ingelheim Pharma |
Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
|
|
ES2276038T3
(es)
|
2002-01-14 |
2007-06-16 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Mimeticos de glucocorticoides, metodos para su obtencion, formulaciones farmaceuticas que los contienen y usos de los mismos.
|
|
JP4745609B2
(ja)
|
2002-01-22 |
2011-08-10 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
グルココルチコイドレセプターのための非ステロイド性リガンド、その組成物および使用
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
AU2003230700A1
(en)
|
2002-03-26 |
2003-10-13 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
PL373043A1
(en)
|
2002-03-26 |
2005-08-08 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
DE10215316C1
(de)
|
2002-04-02 |
2003-12-18 |
Schering Ag |
Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
|
|
PE20040079A1
(es)
|
2002-04-03 |
2004-04-19 |
Novartis Ag |
Derivados de indolilmaleimida
|
|
US7282591B2
(en)
|
2002-04-11 |
2007-10-16 |
Merck & Co., Inc. |
1h-benzo{f}indazol-5-yl derivatives as selective glucocorticoid receptor modulators
|
|
US7186864B2
(en)
|
2002-05-29 |
2007-03-06 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
US7074806B2
(en)
|
2002-06-06 |
2006-07-11 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
WO2004005229A1
(en)
|
2002-07-08 |
2004-01-15 |
Pfizer Products Inc. |
Modulators of the glucocorticoid receptor
|
|
PL375442A1
(en)
|
2002-07-18 |
2005-11-28 |
Bristol-Myers Squibb Company |
Modulators of the glucocorticoid receptor and method
|
|
EP1532113B1
(en)
|
2002-08-21 |
2008-08-06 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
US20050245588A1
(en)
|
2002-09-20 |
2005-11-03 |
Amjad Ali |
Octahydro-2-h-naphtho[1,2-f]indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators
|
|
GB0224084D0
(en)
|
2002-10-16 |
2002-11-27 |
Glaxo Group Ltd |
Novel compounds
|
|
US20050014753A1
(en)
*
|
2003-04-04 |
2005-01-20 |
Irm Llc |
Novel compounds and compositions as protein kinase inhibitors
|
|
AU2004265288A1
(en)
|
2003-07-30 |
2005-02-24 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
|
|
WO2005118544A2
(en)
|
2004-05-18 |
2005-12-15 |
Rigel Pharmaceuticals, Inc. |
Cycloalkyl substituted pyrimidinediamine compounds and their uses
|
|
WO2006000398A1
(en)
|
2004-06-28 |
2006-01-05 |
Glaxo Group Limited |
2,3-benzoxazin derivatives as non-steroidal glucocorticoid receptor modulators
|
|
WO2006000401A1
(en)
|
2004-06-28 |
2006-01-05 |
Glaxo Group Limited |
Substituted oxazines as glucocorticoid receptor modulators
|
|
GB0418045D0
(en)
|
2004-08-12 |
2004-09-15 |
Glaxo Group Ltd |
Compounds
|
|
RU2391338C2
(ru)
|
2004-10-19 |
2010-06-10 |
Ф.Хоффманн-Ля Рош Аг |
Производные хинолина
|
|
GB2420559B
(en)
|
2004-11-15 |
2008-08-06 |
Rigel Pharmaceuticals Inc |
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
|
|
CA2588220A1
(en)
|
2004-12-23 |
2006-06-29 |
Pfizer Products Inc. |
Heteroaromatic derivatives useful as anticancer agents
|
|
JP5208516B2
(ja)
|
2004-12-30 |
2013-06-12 |
エグゼリクシス, インコーポレイテッド |
キナーゼモジュレーターとしてのピリミジン誘導体および使用方法
|
|
US8097630B2
(en)
|
2006-10-10 |
2012-01-17 |
Rigel Pharmaceuticals, Inc. |
Pinane-substituted pyrimidinediamine derivatives useful as Axl inhibitors
|
|
GEP20125691B
(en)
|
2006-12-08 |
2012-11-26 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
US7947698B2
(en)
|
2007-03-23 |
2011-05-24 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
WO2009012421A1
(en)
|
2007-07-17 |
2009-01-22 |
Rigel Pharmaceuticals, Inc. |
Cyclic amine substituted pyrimidinediamines as pkc inhibitors
|
|
EP2234986A2
(en)
|
2007-12-20 |
2010-10-06 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
MY155639A
(en)
*
|
2008-04-16 |
2015-11-13 |
Portola Pharm Inc |
2, 6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinases inhibitors
|
|
PT2323993E
(pt)
|
2008-04-16 |
2015-10-12 |
Portola Pharm Inc |
2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak
|
|
BRPI0910668A2
(pt)
*
|
2008-04-22 |
2019-09-24 |
Portola Pharmaceutiacals Inc |
inibidores de proteína quinases
|
|
MX382352B
(es)
|
2008-06-27 |
2025-03-13 |
Celgene Car Llc |
Compuestos de heteroarilo y usos de los mismos.
|
|
JP5731976B2
(ja)
|
2008-08-20 |
2015-06-10 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
置換ピリジン誘導体および置換ピリミジン誘導体ならびにそれらのウイルス感染の治療における使用
|
|
CA2749157A1
(en)
|
2009-01-14 |
2010-07-22 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for treatment of inflammatory disorders
|
|
CA2749837C
(en)
|
2009-01-21 |
2017-07-11 |
Rigel Pharmaceuticals, Inc. |
Derivatives of n2-(3-pyridil or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases
|
|
WO2010111057A1
(en)
|
2009-03-24 |
2010-09-30 |
Banyu Pharmaceutical Co., Ltd. |
Novel aminopyridine derivatives having aurora a selective inhibitory action
|
|
ES2659725T3
(es)
|
2009-05-05 |
2018-03-19 |
Dana-Farber Cancer Institute, Inc. |
Inhibidores de EGFR y procedimiento de tratamiento de trastornos
|
|
CA2764983A1
(en)
|
2009-06-10 |
2010-12-16 |
Abbott Laboratories |
2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors
|
|
JP5802677B2
(ja)
|
2009-12-01 |
2015-10-28 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
プロテインキナーゼc阻害剤およびその使用
|
|
WO2012012619A1
(en)
|
2010-07-21 |
2012-01-26 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
WO2012059932A1
(en)
*
|
2010-11-01 |
2012-05-10 |
Aurigene Discovery Technologies Limited |
2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors
|
|
SI2638031T1
(en)
*
|
2010-11-10 |
2018-02-28 |
Genentech, Inc. |
Pyrazole aminopyrimidine derivatives as LRRK2 modulators
|
|
CA2860095A1
(en)
|
2011-12-23 |
2013-06-27 |
Cellzome Limited |
Pyrimidine-2,4-diamine derivatives as kinase inhibitors
|
|
MX2014009933A
(es)
*
|
2012-02-17 |
2015-12-16 |
Abbvie Inc |
Diaminopirimidinas utiles como inhibidores del virus sincitial respiratorio humano (rsv).
|
|
WO2013152198A1
(en)
|
2012-04-04 |
2013-10-10 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
WO2013164323A1
(en)
*
|
2012-05-03 |
2013-11-07 |
F. Hoffmann-La Roche Ag |
Pyrazole aminopyrimidine derivatives as lrrk2 modulators for use in the treatment of parkinson's disease
|
|
WO2014040555A1
(zh)
|
2012-09-12 |
2014-03-20 |
山东亨利医药科技有限责任公司 |
作为酪氨酸激酶抑制剂的含氮杂芳环衍生物
|
|
WO2014058685A1
(en)
|
2012-10-08 |
2014-04-17 |
Merck Sharp & Dohme Corp. |
Inhibitors of irak4 activity
|
|
EP2922851B8
(en)
|
2012-11-20 |
2017-09-27 |
F. Hoffmann-La Roche AG |
Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants
|
|
EP2970275B1
(en)
|
2013-03-14 |
2018-05-09 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
WO2015039613A1
(zh)
|
2013-09-18 |
2015-03-26 |
北京韩美药品有限公司 |
抑制btk和/或jak3激酶活性的化合物
|
|
WO2015148869A1
(en)
*
|
2014-03-28 |
2015-10-01 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|