JP2017508777A5 - - Google Patents
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- Publication number
- JP2017508777A5 JP2017508777A5 JP2016559277A JP2016559277A JP2017508777A5 JP 2017508777 A5 JP2017508777 A5 JP 2017508777A5 JP 2016559277 A JP2016559277 A JP 2016559277A JP 2016559277 A JP2016559277 A JP 2016559277A JP 2017508777 A5 JP2017508777 A5 JP 2017508777A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- hydrogen
- alkyloxy
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- DRYPZRJFUMPJRD-UHFFFAOYSA-N CC(C)c1ccc(COc(cc2)ccc2-c2c(N)[n](CC(O)=O)nc2-c2ccncc2)cc1 Chemical compound CC(C)c1ccc(COc(cc2)ccc2-c2c(N)[n](CC(O)=O)nc2-c2ccncc2)cc1 DRYPZRJFUMPJRD-UHFFFAOYSA-N 0.000 description 1
- WFIWFSBWDSEBBR-UHFFFAOYSA-N CC(C)c1ccc(COc(cc2)ccc2-c2c(NC(C3)=O)[n]3nc2-c2ccncc2)cc1 Chemical compound CC(C)c1ccc(COc(cc2)ccc2-c2c(NC(C3)=O)[n]3nc2-c2ccncc2)cc1 WFIWFSBWDSEBBR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14161959.3 | 2014-03-27 | ||
| EP14161959 | 2014-03-27 | ||
| PCT/EP2015/056501 WO2015144801A1 (en) | 2014-03-27 | 2015-03-26 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND 2,3-DIHYDRO-1H-IMIDAZO[1,2-b]PYRAZOLE DERIVATIVES AS ROS1 INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508777A JP2017508777A (ja) | 2017-03-30 |
| JP2017508777A5 true JP2017508777A5 (https=) | 2019-02-28 |
| JP6527167B2 JP6527167B2 (ja) | 2019-06-05 |
Family
ID=50389875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016559277A Active JP6527167B2 (ja) | 2014-03-27 | 2015-03-26 | ＲＯＳ１阻害剤としての置換４，５，６，７−テトラヒドロ−ピラゾロ［１，５−ａ］ピリミジン誘導体および２，３−ジヒドロ−１Ｈ−イミダゾ［１，２−ｂ］ピラゾール誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10342795B2 (https=) |
| EP (1) | EP3126366B1 (https=) |
| JP (1) | JP6527167B2 (https=) |
| KR (1) | KR102455518B1 (https=) |
| CN (1) | CN106132967B (https=) |
| AU (1) | AU2015238298B2 (https=) |
| BR (1) | BR112016021507B1 (https=) |
| CA (1) | CA2941206C (https=) |
| EA (1) | EA031639B1 (https=) |
| ES (1) | ES2686747T3 (https=) |
| IL (1) | IL247948B (https=) |
| MX (1) | MX367913B (https=) |
| WO (1) | WO2015144801A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106580982B (zh) * | 2016-11-26 | 2017-09-22 | 王玉美 | 一种治疗药物流产后子宫出血的药物 |
| CN106866536A (zh) * | 2017-04-12 | 2017-06-20 | 中国农业大学 | 一种制备4‑卤代‑5‑氨基吡唑的方法 |
| WO2019033330A1 (en) * | 2017-08-17 | 2019-02-21 | Xw Laboratories, Inc. | PREPARATION AND USES OF DERIVATIVES TRACERS OF OXYGEN REACTIVE SPECIES |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| CN111087398A (zh) * | 2019-12-24 | 2020-05-01 | 上海万巷制药有限公司 | 一种制备拉罗替尼中间体的清洁工艺 |
| US12509438B2 (en) | 2020-01-13 | 2025-12-30 | Aptabio Therapeutics Inc. | Pyrazole derivative |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN113416140B (zh) * | 2021-06-03 | 2023-01-13 | 万华化学集团股份有限公司 | 一种制备2-甲基戊二胺的方法 |
| US20250145628A1 (en) * | 2022-02-15 | 2025-05-08 | Novo Nordisk A/S | Pyrazolopyrimidines, compositions comprising them and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
| GB9204464D0 (en) * | 1992-03-02 | 1992-04-15 | Fujisawa Pharmaceutical Co | New heterocyclic derivatives |
| US7662826B2 (en) | 2002-04-23 | 2010-02-16 | Shionogi & Co., Ltd. | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same |
| EP1572113B1 (en) | 2002-08-26 | 2017-05-17 | Takeda Pharmaceutical Company Limited | Calcium receptor modulating compound and use thereof |
| UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
| ZA200504898B (en) * | 2002-12-20 | 2006-11-29 | Pharmacia Corp | Acyclic pyrazole compounds |
| US20100324073A1 (en) | 2007-12-21 | 2010-12-23 | Wyeth Llc | Pyrazolo [1,5-A] Pyrimidine Compounds |
| US20100029657A1 (en) * | 2008-02-29 | 2010-02-04 | Wyeth | Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof |
| KR101324804B1 (ko) * | 2008-05-13 | 2013-11-01 | 아이알엠 엘엘씨 | 키나제 억제제로서의 질소 함유 융합 헤테로사이클 및 그의 조성물 |
| JP2012528175A (ja) * | 2009-05-27 | 2012-11-12 | アボット・ラボラトリーズ | キナーゼ活性のピリミジン阻害剤 |
| WO2011153553A2 (en) * | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| JO3407B1 (ar) * | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| TWI585088B (zh) * | 2012-06-04 | 2017-06-01 | 第一三共股份有限公司 | 作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物 |
-
2015
- 2015-03-26 US US15/129,618 patent/US10342795B2/en active Active
- 2015-03-26 JP JP2016559277A patent/JP6527167B2/ja active Active
- 2015-03-26 MX MX2016012669A patent/MX367913B/es active IP Right Grant
- 2015-03-26 ES ES15712138.5T patent/ES2686747T3/es active Active
- 2015-03-26 EP EP15712138.5A patent/EP3126366B1/en active Active
- 2015-03-26 CN CN201580016427.3A patent/CN106132967B/zh active Active
- 2015-03-26 BR BR112016021507-9A patent/BR112016021507B1/pt active IP Right Grant
- 2015-03-26 WO PCT/EP2015/056501 patent/WO2015144801A1/en not_active Ceased
- 2015-03-26 KR KR1020167027337A patent/KR102455518B1/ko active Active
- 2015-03-26 AU AU2015238298A patent/AU2015238298B2/en active Active
- 2015-03-26 CA CA2941206A patent/CA2941206C/en active Active
- 2015-03-26 EA EA201691934A patent/EA031639B1/ru not_active IP Right Cessation
-
2016
- 2016-09-21 IL IL247948A patent/IL247948B/en active IP Right Grant
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