JP2017507943A - Ｈｅｒ２／ｎｅｕ過剰発現腫瘍の治療のための組成物および方法 - Google Patents
Ｈｅｒ２／ｎｅｕ過剰発現腫瘍の治療のための組成物および方法 Download PDFInfo
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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| US14/189,008 | 2014-02-25 | ||
| US14/189,008 US20150366955A9 (en) | 2009-11-11 | 2014-02-25 | Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors |
| US14/268,436 | 2014-05-02 | ||
| US14/268,436 US20140234370A1 (en) | 2009-11-11 | 2014-05-02 | Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors |
| US201462076411P | 2014-11-06 | 2014-11-06 | |
| US62/076,411 | 2014-11-06 | ||
| PCT/US2015/017559 WO2015130810A2 (en) | 2014-02-25 | 2015-02-25 | Compositions and methods for the treatment of her2/neu over-expressing tumors |
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| JP2017507943A true JP2017507943A (ja) | 2017-03-23 |
| JP2017507943A5 JP2017507943A5 (enrdf_load_stackoverflow) | 2018-08-02 |
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| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| AU2012229218B2 (en) | 2011-03-11 | 2017-03-02 | Advaxis, Inc. | Listeria-based adjuvants |
| WO2013138337A1 (en) | 2012-03-12 | 2013-09-19 | Advaxis | Suppressor cell function inhibition following listeria vaccine treatment |
| SG11201606677XA (en) | 2014-02-18 | 2016-09-29 | Advaxis Inc | Biomarker directed multi-target immunotherapy |
| MX2016011537A (es) * | 2014-03-05 | 2017-05-01 | Advaxis Inc | Metodos y composiciones para aumentar una relacion de celulas t efectoras con respecto a las celulas t reguladoras. |
| AU2015250111A1 (en) | 2014-04-24 | 2016-12-08 | Advaxis, Inc. | Recombinant listeria vaccine strains and methods of producing the same |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| JP7114477B2 (ja) | 2015-12-16 | 2022-08-08 | グリットストーン バイオ インコーポレイテッド | 新生抗原の特定、製造、および使用 |
| AU2017367642A1 (en) | 2016-11-30 | 2019-05-30 | Advaxis, Inc. | Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof |
| KR102794940B1 (ko) | 2017-09-19 | 2025-04-14 | 어드박시스, 인크. | 박테리아 또는 리스테리아 균주의 동결건조를 위한 조성물 및 방법 |
| CN118888004A (zh) | 2017-10-10 | 2024-11-01 | 磨石生物公司 | 使用热点进行的新抗原鉴别 |
| AU2018373154B2 (en) | 2017-11-22 | 2025-08-07 | Seattle Project Corp. | Reducing junction epitope presentation for neoantigens |
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| WO2013025925A1 (en) * | 2011-08-16 | 2013-02-21 | Advaxis | Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors |
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| US6855320B2 (en) * | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
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| WO2013025925A1 (en) * | 2011-08-16 | 2013-02-21 | Advaxis | Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors |
| JP6039669B2 (ja) * | 2011-08-16 | 2016-12-07 | アドバクシス インコーポレイテッド | Ｈｅｒ２／ｎｅｕ発現腫瘍に対する薬剤の調製における弱毒化組換えリステリアの使用 |
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| SG11201607036XA (en) | 2016-09-29 |
| BR112016019534A2 (pt) | 2017-10-24 |
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| CN106661538A (zh) | 2017-05-10 |
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| EP3110942A4 (en) | 2017-08-30 |
| AU2015223136A1 (en) | 2016-09-22 |
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| WO2015130810A2 (en) | 2015-09-03 |
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