JP2017507183A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017507183A5 JP2017507183A5 JP2016570920A JP2016570920A JP2017507183A5 JP 2017507183 A5 JP2017507183 A5 JP 2017507183A5 JP 2016570920 A JP2016570920 A JP 2016570920A JP 2016570920 A JP2016570920 A JP 2016570920A JP 2017507183 A5 JP2017507183 A5 JP 2017507183A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- het
- compound
- aryl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 57
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 17
- -1 [3- (2,3 , 5-Trifluoro-4- (4-oxo-3,4-dihydropyridin-1 (2H) -yl) phenyl) oxazolidine-2-one-5-yl] methyl Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000000813 microbial effect Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 125000005841 biaryl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461943129P | 2014-02-21 | 2014-02-21 | |
| US61/943,129 | 2014-02-21 | ||
| PCT/US2015/016970 WO2015127316A1 (en) | 2014-02-21 | 2015-02-20 | Water-soluble o-carbonyl phosphoramidate prodrugs for therapeutic administration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507183A JP2017507183A (ja) | 2017-03-16 |
| JP2017507183A5 true JP2017507183A5 (cg-RX-API-DMAC7.html) | 2018-04-05 |
| JP6671303B2 JP6671303B2 (ja) | 2020-03-25 |
Family
ID=52627575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570920A Active JP6671303B2 (ja) | 2014-02-21 | 2015-02-20 | 治療的投与のための水溶性ｏ−カルボニルホスホルアミダートプロドラッグ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9382276B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3107923B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6671303B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102428252B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105612166B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2939098A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2900838T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015127316A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111039984B (zh) * | 2018-10-15 | 2022-06-07 | 上海盟科药业股份有限公司 | 康泰唑胺酯的药物晶体及其制备方法和应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5668286A (en) | 1994-03-15 | 1997-09-16 | Pharmacia & Upjohn Company | Oxazolidinone derivatives and pharmaceutical compositions containing them |
| US5958905A (en) * | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
| TW473479B (en) | 1997-12-19 | 2002-01-21 | Takeda Chemical Industries Ltd | Phosphonocephem derivatives, their production and use |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
| KR100826487B1 (ko) | 2000-08-10 | 2008-05-02 | 다케다 야쿠힌 고교 가부시키가이샤 | 포스포노세펨 화합물 |
| YU52403A (sh) | 2000-12-26 | 2006-03-03 | Dr.Reddy's Research Foundation | Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže |
| EP1451164A2 (en) | 2001-07-12 | 2004-09-01 | PHARMACIA & UPJOHN COMPANY | Amide derivatives having improved solubility |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| EP1554273A1 (en) | 2002-10-10 | 2005-07-20 | Pharmacia & Upjohn Company LLC | Antimicrobial 1-aryl dihydropyridone compounds |
| GB0229522D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| US20040204463A1 (en) | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| WO2005019213A1 (en) | 2003-08-22 | 2005-03-03 | Pharmacia & Upjohn Company Llc | N-aryl-2-cyanooxazolidinones and their derivatives |
| US7265140B2 (en) | 2003-09-23 | 2007-09-04 | Pfizer Inc | Acyloxymethylcarbamate prodrugs of oxazolidinones |
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| WO2005113520A1 (en) | 2004-05-20 | 2005-12-01 | Pharmacia & Upjohn Company Llc | Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents |
| WO2006038100A1 (en) | 2004-10-08 | 2006-04-13 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006043121A1 (en) | 2004-10-20 | 2006-04-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2007000644A1 (en) | 2005-06-29 | 2007-01-04 | Pharmacia & Upjohn Company Llc | Homomorpholine oxazolidinones as antibacterial agents |
| WO2007004049A1 (en) | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidinones containing azetidine as antibacterial agents |
| CA2679657A1 (en) | 2007-03-02 | 2008-09-12 | Micurx Pharmaceuticals, Inc. | Antimicrobial heterocyclic compounds for treatment of bacterial infections |
| CA2695616C (en) * | 2007-08-06 | 2015-11-24 | Micurx Pharmaceuticals, Inc. | Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections |
| US20100069441A1 (en) | 2008-09-02 | 2010-03-18 | Mikhail Fedorovich Gordeev | Antimicrobial indoline compounds for treatment of bacterial infections |
| CN101798302B (zh) | 2009-02-06 | 2014-11-05 | 上海盟科药业有限公司 | 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺 |
| US7588690B1 (en) | 2009-02-10 | 2009-09-15 | The Purolite Company | Method of iodide removal |
| US20100267994A1 (en) | 2009-04-16 | 2010-10-21 | E. I. Du Pont De Nemours And Company | Processes for preparing polytrimethylene glycol using ion exchange resins |
| WO2011088030A1 (en) * | 2010-01-15 | 2011-07-21 | Bryan William Jones | Disease diagnosis and treatment using computational molecular phenotyping |
| US8592427B2 (en) * | 2010-06-24 | 2013-11-26 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| WO2012033952A1 (en) | 2010-09-10 | 2012-03-15 | Micurx Pharmaceuticals, Inc. | 3 - phenyl- 2 -oxo- 1, 3 -oxazolidines for treatment of bacterial infections |
-
2015
- 2015-02-20 ES ES15708079T patent/ES2900838T3/es active Active
- 2015-02-20 CN CN201580001343.2A patent/CN105612166B/zh active Active
- 2015-02-20 US US14/628,134 patent/US9382276B2/en active Active
- 2015-02-20 WO PCT/US2015/016970 patent/WO2015127316A1/en not_active Ceased
- 2015-02-20 CA CA2939098A patent/CA2939098A1/en active Pending
- 2015-02-20 KR KR1020167022835A patent/KR102428252B1/ko active Active
- 2015-02-20 JP JP2016570920A patent/JP6671303B2/ja active Active
- 2015-02-20 EP EP15708079.7A patent/EP3107923B1/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6013375B2 (ja) | キナーゼ阻害剤としてのチアゾリルフェニル−ベンゼンスルホンアミド誘導体 | |
| US20230382889A1 (en) | Compounds for inhibiting kif18a | |
| JP6204462B2 (ja) | キナーゼ阻害剤としての新規環置換ｎ−ピリジニルアミド | |
| AU2014312245B2 (en) | Heterocyclic compounds and methods of use | |
| JP2016512511A5 (cg-RX-API-DMAC7.html) | ||
| PT3002283T (pt) | Derivado de tiazole | |
| JP2016506419A5 (cg-RX-API-DMAC7.html) | ||
| JP2008523041A5 (cg-RX-API-DMAC7.html) | ||
| JP2016516043A5 (cg-RX-API-DMAC7.html) | ||
| JP2011500758A5 (cg-RX-API-DMAC7.html) | ||
| JP2011513475A5 (cg-RX-API-DMAC7.html) | ||
| RU2015111133A (ru) | Ингибиторы тирозинкиназы брутона | |
| AU2017387033A1 (en) | Metalloenzyme inhibitor compounds | |
| JP2010527984A5 (cg-RX-API-DMAC7.html) | ||
| JP2019532974A5 (cg-RX-API-DMAC7.html) | ||
| JP6466465B2 (ja) | オレキシン受容体拮抗薬としての置換シクロペンタン、テトラヒドロフラン、及びピロリジン | |
| AU2010253336A1 (en) | Agent for treatment or prevention of diseases associated with activity of neurotrophic factors | |
| EP3562306A2 (en) | Metalloenzyme inhibitor compounds | |
| JP2017507183A5 (cg-RX-API-DMAC7.html) | ||
| EP4274569A1 (en) | C-myc mrna translation modulators and uses thereof in the treatment of cancer | |
| EA029044B1 (ru) | Соединения метантиона, обладающие противовирусной активностью | |
| EP4463452B1 (en) | C-myc mrna translation modulators and uses thereof in the treatment of cancer | |
| JP2017525734A5 (cg-RX-API-DMAC7.html) | ||
| AU2023317959A1 (en) | Kit inhibitors, compounds, pharmaceutical compositions, and methods of use thereof | |
| JP2013227299A5 (cg-RX-API-DMAC7.html) |