KR102428252B1 - 치료적 투여용 수용성 o-카보닐 포스포르아미데이트 전구약물 - Google Patents
치료적 투여용 수용성 o-카보닐 포스포르아미데이트 전구약물 Download PDFInfo
- Publication number
- KR102428252B1 KR102428252B1 KR1020167022835A KR20167022835A KR102428252B1 KR 102428252 B1 KR102428252 B1 KR 102428252B1 KR 1020167022835 A KR1020167022835 A KR 1020167022835A KR 20167022835 A KR20167022835 A KR 20167022835A KR 102428252 B1 KR102428252 B1 KR 102428252B1
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- compound
- het
- pharmaceutical composition
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461943129P | 2014-02-21 | 2014-02-21 | |
| US61/943,129 | 2014-02-21 | ||
| PCT/US2015/016970 WO2015127316A1 (en) | 2014-02-21 | 2015-02-20 | Water-soluble o-carbonyl phosphoramidate prodrugs for therapeutic administration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160124772A KR20160124772A (ko) | 2016-10-28 |
| KR102428252B1 true KR102428252B1 (ko) | 2022-08-02 |
Family
ID=52627575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167022835A Active KR102428252B1 (ko) | 2014-02-21 | 2015-02-20 | 치료적 투여용 수용성 o-카보닐 포스포르아미데이트 전구약물 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9382276B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3107923B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6671303B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102428252B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105612166B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2939098A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2900838T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015127316A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111039984B (zh) * | 2018-10-15 | 2022-06-07 | 上海盟科药业股份有限公司 | 康泰唑胺酯的药物晶体及其制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997035864A1 (en) | 1996-03-26 | 1997-10-02 | Texas Biotechnology Corporation | Phosphoramidates and phosphinic amides, their use to modulate the activity of endothelin |
| WO2009020616A1 (en) | 2007-08-06 | 2009-02-12 | Micurx Pharmaceuticals, Inc. | Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections |
| WO2011088030A1 (en) * | 2010-01-15 | 2011-07-21 | Bryan William Jones | Disease diagnosis and treatment using computational molecular phenotyping |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5668286A (en) | 1994-03-15 | 1997-09-16 | Pharmacia & Upjohn Company | Oxazolidinone derivatives and pharmaceutical compositions containing them |
| TW473479B (en) | 1997-12-19 | 2002-01-21 | Takeda Chemical Industries Ltd | Phosphonocephem derivatives, their production and use |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
| KR100826487B1 (ko) | 2000-08-10 | 2008-05-02 | 다케다 야쿠힌 고교 가부시키가이샤 | 포스포노세펨 화합물 |
| YU52403A (sh) | 2000-12-26 | 2006-03-03 | Dr.Reddy's Research Foundation | Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže |
| EP1451164A2 (en) | 2001-07-12 | 2004-09-01 | PHARMACIA & UPJOHN COMPANY | Amide derivatives having improved solubility |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| EP1554273A1 (en) | 2002-10-10 | 2005-07-20 | Pharmacia & Upjohn Company LLC | Antimicrobial 1-aryl dihydropyridone compounds |
| GB0229522D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| US20040204463A1 (en) | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| WO2005019213A1 (en) | 2003-08-22 | 2005-03-03 | Pharmacia & Upjohn Company Llc | N-aryl-2-cyanooxazolidinones and their derivatives |
| US7265140B2 (en) | 2003-09-23 | 2007-09-04 | Pfizer Inc | Acyloxymethylcarbamate prodrugs of oxazolidinones |
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| WO2005113520A1 (en) | 2004-05-20 | 2005-12-01 | Pharmacia & Upjohn Company Llc | Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents |
| WO2006038100A1 (en) | 2004-10-08 | 2006-04-13 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006043121A1 (en) | 2004-10-20 | 2006-04-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2007000644A1 (en) | 2005-06-29 | 2007-01-04 | Pharmacia & Upjohn Company Llc | Homomorpholine oxazolidinones as antibacterial agents |
| WO2007004049A1 (en) | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidinones containing azetidine as antibacterial agents |
| CA2679657A1 (en) | 2007-03-02 | 2008-09-12 | Micurx Pharmaceuticals, Inc. | Antimicrobial heterocyclic compounds for treatment of bacterial infections |
| US20100069441A1 (en) | 2008-09-02 | 2010-03-18 | Mikhail Fedorovich Gordeev | Antimicrobial indoline compounds for treatment of bacterial infections |
| CN101798302B (zh) | 2009-02-06 | 2014-11-05 | 上海盟科药业有限公司 | 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺 |
| US7588690B1 (en) | 2009-02-10 | 2009-09-15 | The Purolite Company | Method of iodide removal |
| US20100267994A1 (en) | 2009-04-16 | 2010-10-21 | E. I. Du Pont De Nemours And Company | Processes for preparing polytrimethylene glycol using ion exchange resins |
| US8592427B2 (en) * | 2010-06-24 | 2013-11-26 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| WO2012033952A1 (en) | 2010-09-10 | 2012-03-15 | Micurx Pharmaceuticals, Inc. | 3 - phenyl- 2 -oxo- 1, 3 -oxazolidines for treatment of bacterial infections |
-
2015
- 2015-02-20 ES ES15708079T patent/ES2900838T3/es active Active
- 2015-02-20 CN CN201580001343.2A patent/CN105612166B/zh active Active
- 2015-02-20 US US14/628,134 patent/US9382276B2/en active Active
- 2015-02-20 WO PCT/US2015/016970 patent/WO2015127316A1/en not_active Ceased
- 2015-02-20 CA CA2939098A patent/CA2939098A1/en active Pending
- 2015-02-20 KR KR1020167022835A patent/KR102428252B1/ko active Active
- 2015-02-20 JP JP2016570920A patent/JP6671303B2/ja active Active
- 2015-02-20 EP EP15708079.7A patent/EP3107923B1/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997035864A1 (en) | 1996-03-26 | 1997-10-02 | Texas Biotechnology Corporation | Phosphoramidates and phosphinic amides, their use to modulate the activity of endothelin |
| WO2009020616A1 (en) | 2007-08-06 | 2009-02-12 | Micurx Pharmaceuticals, Inc. | Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections |
| WO2011088030A1 (en) * | 2010-01-15 | 2011-07-21 | Bryan William Jones | Disease diagnosis and treatment using computational molecular phenotyping |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105612166B (zh) | 2019-02-19 |
| ES2900838T3 (es) | 2022-03-18 |
| WO2015127316A1 (en) | 2015-08-27 |
| US9382276B2 (en) | 2016-07-05 |
| EP3107923A1 (en) | 2016-12-28 |
| JP6671303B2 (ja) | 2020-03-25 |
| EP3107923B1 (en) | 2021-11-03 |
| CA2939098A1 (en) | 2015-08-27 |
| CN105612166A (zh) | 2016-05-25 |
| US20150239922A1 (en) | 2015-08-27 |
| JP2017507183A (ja) | 2017-03-16 |
| KR20160124772A (ko) | 2016-10-28 |
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| KR102428252B1 (ko) | 치료적 투여용 수용성 o-카보닐 포스포르아미데이트 전구약물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20160822 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20200219 Comment text: Request for Examination of Application |
|
| N231 | Notification of change of applicant | ||
| PN2301 | Change of applicant |
Patent event date: 20201105 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D |
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| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20211029 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20220509 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20220728 Patent event code: PR07011E01D |
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| PR1002 | Payment of registration fee |
Payment date: 20220729 End annual number: 3 Start annual number: 1 |
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| PG1601 | Publication of registration |