JP2017506622A5 - - Google Patents
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- JP2017506622A5 JP2017506622A5 JP2016549241A JP2016549241A JP2017506622A5 JP 2017506622 A5 JP2017506622 A5 JP 2017506622A5 JP 2016549241 A JP2016549241 A JP 2016549241A JP 2016549241 A JP2016549241 A JP 2016549241A JP 2017506622 A5 JP2017506622 A5 JP 2017506622A5
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- Prior art keywords
- alkyl
- compound
- formula
- protein
- sample
- Prior art date
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- 0 C*(CC*(CCC*1CCOCC1)C(OC1=C(Cc2ccc[o]2)*C2=C(Cc3ccccc3)*C(c3ccccc3)=C*12)=O)C(c(cc1)ccc1OC)=O Chemical compound C*(CC*(CCC*1CCOCC1)C(OC1=C(Cc2ccc[o]2)*C2=C(Cc3ccccc3)*C(c3ccccc3)=C*12)=O)C(c(cc1)ccc1OC)=O 0.000 description 5
- BUFSEVFXVCFYKY-UHFFFAOYSA-N O=C(C(Cc1ccc[o]1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 Chemical compound O=C(C(Cc1ccc[o]1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 BUFSEVFXVCFYKY-UHFFFAOYSA-N 0.000 description 2
- MWOYPGFRXPPBOX-UHFFFAOYSA-N O=C(C(Cc1ccccc1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 Chemical compound O=C(C(Cc1ccccc1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 MWOYPGFRXPPBOX-UHFFFAOYSA-N 0.000 description 2
- LNGUITKMTOZNAL-UHFFFAOYSA-N Oc(cc1)ccc1C1=CN(C(C(Cc2ccc[o]2)=N2)=O)C2=C(Cc2ccccc2)N1 Chemical compound Oc(cc1)ccc1C1=CN(C(C(Cc2ccc[o]2)=N2)=O)C2=C(Cc2ccccc2)N1 LNGUITKMTOZNAL-UHFFFAOYSA-N 0.000 description 2
- KAEGGIFPLJZUOZ-UHFFFAOYSA-N Oc(cc1)ccc1C1=CN(C(C(Cc2ccccc2)=N2)=O)C2=C(Cc2ccccc2)N1 Chemical compound Oc(cc1)ccc1C1=CN(C(C(Cc2ccccc2)=N2)=O)C2=C(Cc2ccccc2)N1 KAEGGIFPLJZUOZ-UHFFFAOYSA-N 0.000 description 2
- YHIPILPTUVMWQT-UHFFFAOYSA-N Oc1ccc(CC2=NC3=C(Cc4ccccc4)NC(c(cc4)ccc4O)=CN3C2=O)cc1 Chemical compound Oc1ccc(CC2=NC3=C(Cc4ccccc4)NC(c(cc4)ccc4O)=CN3C2=O)cc1 YHIPILPTUVMWQT-UHFFFAOYSA-N 0.000 description 2
- LABFYLKLEVXOBL-UHFFFAOYSA-N CC(NC(CC[O]=O)C(NC(CC(O)=O)C(N(C)CCCN(CCCN1CCOCC1)C(Oc1c(Cc2ccc[o]2)nc2[n]1cc(-c1ccccc1)nc2Cc1ccccc1)=O)=O)=O)=O Chemical compound CC(NC(CC[O]=O)C(NC(CC(O)=O)C(N(C)CCCN(CCCN1CCOCC1)C(Oc1c(Cc2ccc[o]2)nc2[n]1cc(-c1ccccc1)nc2Cc1ccccc1)=O)=O)=O)=O LABFYLKLEVXOBL-UHFFFAOYSA-N 0.000 description 1
- NMILGIZTAZXMTM-UHFFFAOYSA-N CCCN1CCOCC1 Chemical compound CCCN1CCOCC1 NMILGIZTAZXMTM-UHFFFAOYSA-N 0.000 description 1
- QEUJTSCVVGEZCB-UHFFFAOYSA-N CN(CCCN(CCCN1CCOCC1)C(Oc1c(Cc2ccc[o]2)nc2[n]1cc(-c1ccccc1)nc2Cc1ccccc1)=O)C1(COCC(O)=O)OC1 Chemical compound CN(CCCN(CCCN1CCOCC1)C(Oc1c(Cc2ccc[o]2)nc2[n]1cc(-c1ccccc1)nc2Cc1ccccc1)=O)C1(COCC(O)=O)OC1 QEUJTSCVVGEZCB-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461933210P | 2014-01-29 | 2014-01-29 | |
| US61/933,210 | 2014-01-29 | ||
| PCT/US2015/013504 WO2015116806A1 (en) | 2014-01-29 | 2015-01-29 | Pro-substrates for live cell applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506622A JP2017506622A (ja) | 2017-03-09 |
| JP2017506622A5 true JP2017506622A5 (https=) | 2018-03-08 |
| JP6588917B2 JP6588917B2 (ja) | 2019-10-09 |
Family
ID=52462487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549241A Active JP6588917B2 (ja) | 2014-01-29 | 2015-01-29 | 生細胞への適用のためのプロ基質 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9927430B2 (https=) |
| EP (1) | EP3099691B1 (https=) |
| JP (1) | JP6588917B2 (https=) |
| WO (1) | WO2015116806A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3099691B1 (en) | 2014-01-29 | 2019-11-20 | Promega Corporation | Pro-substrates for live cell applications |
| US9790537B2 (en) | 2014-01-29 | 2017-10-17 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| WO2016210294A1 (en) | 2015-06-25 | 2016-12-29 | Promega Corporation | Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases |
| JP7092677B2 (ja) | 2016-02-15 | 2022-06-28 | プロメガ コーポレイション | セレンテラジン類似体 |
| WO2018049241A1 (en) * | 2016-09-09 | 2018-03-15 | Promega Corporation | Dual protected pro-coelenterazine substrates |
| EP3548492B1 (en) | 2016-12-01 | 2023-07-05 | Promega Corporation | Cell impermeable coelenterazine analogues |
| WO2018125992A1 (en) | 2016-12-28 | 2018-07-05 | Promega Corporation | Functionalized nanoluc inhibitors |
| EP3395803A1 (en) * | 2017-04-28 | 2018-10-31 | Institut Pasteur | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| JP7419260B2 (ja) | 2018-05-01 | 2024-01-22 | プロメガ コーポレイション | ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物 |
| EP3802514B1 (en) | 2018-06-01 | 2022-08-03 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| CA3114424A1 (en) | 2018-10-03 | 2020-04-09 | Promega Corporation | Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof |
| EP3956352A1 (en) | 2019-04-16 | 2022-02-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften E. V. | Circularly permutated haloalkane transferase fusion molecules |
| EP3816180A1 (en) | 2019-10-31 | 2021-05-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Circularly permutated haloalkane transferase fusion molecules |
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| DE3477549D1 (en) | 1983-08-17 | 1989-05-11 | Allied Signal Inc | Gas generator and method of generating gas |
| US5683888A (en) | 1989-07-22 | 1997-11-04 | University Of Wales College Of Medicine | Modified bioluminescent proteins and their use |
| US6387675B1 (en) | 1994-01-03 | 2002-05-14 | Promega Corporation | Mutant luciferases |
| CA2157476C (en) | 1994-01-03 | 2009-08-25 | Keith V. Wood | Mutant luciferases |
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| GB9417593D0 (en) | 1994-09-01 | 1994-10-19 | Secr Defence | Luciferase labelling method |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| WO1996022376A1 (en) | 1995-01-20 | 1996-07-25 | The Secretary Of State For Defence | Mutant luciferases |
| JPH08294397A (ja) | 1995-04-27 | 1996-11-12 | Nippon Oil & Fats Co Ltd | 免疫学的活性物質の測定方法 |
| US5998204A (en) | 1997-03-14 | 1999-12-07 | The Regents Of The University Of California | Fluorescent protein sensors for detection of analytes |
| GB9707486D0 (en) | 1997-04-11 | 1997-05-28 | Secr Defence | Enzyme assays |
| WO1998046739A1 (fr) | 1997-04-16 | 1998-10-22 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Molecules immunomodulatrices et leur procede de production |
| EP2860252A1 (en) | 1997-09-19 | 2015-04-15 | Promega Corporation | Thermostable luciferases and methods of production |
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| GB9823468D0 (en) | 1998-10-28 | 1998-12-23 | Secr Defence | Novel enzyme |
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| US7879540B1 (en) | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| US20040096927A1 (en) | 2000-09-13 | 2004-05-20 | Chittock Roger Steward | Method for the detection and measurement of biomass |
| US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
| AU2003216139B2 (en) | 2002-02-01 | 2008-08-14 | Promega Corporation | Bioluminescent protease assay |
| EP1546162B1 (en) | 2002-09-20 | 2011-06-22 | Promega Corporation | Luminescence-based methods and probes for measuring cytochrome p450 activity |
| ATE290016T1 (de) | 2002-10-21 | 2005-03-15 | Axxam S R L | Photoprotein mit verbesserter biolumineszenz |
| JP4485470B2 (ja) | 2002-12-23 | 2010-06-23 | プロメガ コーポレイション | ルシフェラーゼ酵素活性を保護するための方法及びキット |
| DE10303265A1 (de) | 2003-01-28 | 2004-07-29 | Roche Diagnostics Gmbh | Fluorimetrische Bestimmung von Analyten durch ein intramolekulares Quencher-Fluorophor-Konjugat |
| US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
| EP1594962B1 (en) | 2003-01-31 | 2014-08-27 | Promega Corporation | Covalent tethering of functional groups to proteins |
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| US20040178545A1 (en) | 2003-03-14 | 2004-09-16 | Cates Larry E. | System for optically analyzing a molten metal bath |
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| AU2005205126A1 (en) | 2004-01-08 | 2005-07-28 | Universitat Zurich | Metal complexes having vitamin B12 as a ligand |
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| EP2272972A1 (en) | 2005-05-31 | 2011-01-12 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| KR20080039431A (ko) | 2005-08-17 | 2008-05-07 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 생물학적으로 활성인 혈청 파라옥소나제의 수준을 구하기위한 방법 및 조성물 |
| EP2004813B1 (en) | 2006-04-03 | 2015-06-03 | Promega Corporation | Permuted and nonpermuted luciferase biosensors binding cyclic nucleotides |
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| WO2008086035A2 (en) | 2007-01-10 | 2008-07-17 | Promega Corporation | Split mutant hydrolase fusion reporter and uses thereof |
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| EP2281046B1 (en) | 2008-05-19 | 2012-01-25 | Promega Corporation | LUCIFERASE BIOSENSORS FOR cAMP |
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| ES2795287T3 (es) | 2009-05-01 | 2020-11-23 | Promega Corp | Luciferasas de Oplophorus sintéticas con mayor emisión de luz |
| WO2011038219A1 (en) | 2009-09-24 | 2011-03-31 | Promega Corporation | Proteases having improved stability, solubility and activity |
| EP3508570B1 (en) | 2010-05-11 | 2020-07-22 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
| WO2011146390A2 (en) * | 2010-05-17 | 2011-11-24 | The Regents Of The University Of California | Compositions and methods for in vivo imaging |
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| US9284188B2 (en) | 2010-09-03 | 2016-03-15 | The Regents Of The University Of California | Cytosolic delivery of materials with endosome-disrupting colloids |
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| CN103180324A (zh) * | 2010-11-02 | 2013-06-26 | 普罗美加公司 | 腔肠素衍生物及其使用方法 |
| SG10202103336SA (en) | 2010-11-02 | 2021-04-29 | Promega Corp | Novel coelenterazine substrates and methods of use |
| JP6067019B2 (ja) | 2011-09-02 | 2017-01-25 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 代謝的に活性な細胞の酸化還元状態を評価するための化合物及び方法、ならびにｎａｄ（ｐ）／ｎａｄ（ｐ）ｈを測定するための方法 |
| US20140099654A1 (en) * | 2012-09-26 | 2014-04-10 | Promega Corporation | Real-time monitoring |
| US9790537B2 (en) | 2014-01-29 | 2017-10-17 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| EP3099691B1 (en) | 2014-01-29 | 2019-11-20 | Promega Corporation | Pro-substrates for live cell applications |
-
2015
- 2015-01-29 EP EP15703218.6A patent/EP3099691B1/en active Active
- 2015-01-29 US US14/608,910 patent/US9927430B2/en active Active
- 2015-01-29 WO PCT/US2015/013504 patent/WO2015116806A1/en not_active Ceased
- 2015-01-29 JP JP2016549241A patent/JP6588917B2/ja active Active
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