JP2017503849A5 - - Google Patents
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- JP2017503849A5 JP2017503849A5 JP2016550686A JP2016550686A JP2017503849A5 JP 2017503849 A5 JP2017503849 A5 JP 2017503849A5 JP 2016550686 A JP2016550686 A JP 2016550686A JP 2016550686 A JP2016550686 A JP 2016550686A JP 2017503849 A5 JP2017503849 A5 JP 2017503849A5
- Authority
- JP
- Japan
- Prior art keywords
- protein transduction
- transduction reagent
- modified
- modification
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361895562P | 2013-10-25 | 2013-10-25 | |
| US61/895,562 | 2013-10-25 | ||
| PCT/US2014/062400 WO2015061779A1 (en) | 2013-10-25 | 2014-10-27 | Methods, systems and compositions relating to cell conversion via protein induced in-vivo cell reprogramming |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018187189A Division JP6577112B2 (ja) | 2013-10-25 | 2018-10-02 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503849A JP2017503849A (ja) | 2017-02-02 |
| JP2017503849A5 true JP2017503849A5 (https=) | 2017-09-14 |
| JP6415582B2 JP6415582B2 (ja) | 2018-10-31 |
Family
ID=52993686
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550686A Active JP6415582B2 (ja) | 2013-10-25 | 2014-10-27 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
| JP2018187189A Active JP6577112B2 (ja) | 2013-10-25 | 2018-10-02 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
| JP2019151759A Active JP6880125B2 (ja) | 2013-10-25 | 2019-08-22 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018187189A Active JP6577112B2 (ja) | 2013-10-25 | 2018-10-02 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
| JP2019151759A Active JP6880125B2 (ja) | 2013-10-25 | 2019-08-22 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10076574B2 (https=) |
| EP (2) | EP3954381A1 (https=) |
| JP (3) | JP6415582B2 (https=) |
| KR (2) | KR102113829B1 (https=) |
| CN (2) | CN106170295B (https=) |
| AU (3) | AU2014339843B2 (https=) |
| CA (3) | CA2934065C (https=) |
| DK (1) | DK3060237T3 (https=) |
| ES (1) | ES2896021T3 (https=) |
| IL (3) | IL245300B (https=) |
| PL (1) | PL3060237T3 (https=) |
| PT (1) | PT3060237T (https=) |
| SG (1) | SG11201603230UA (https=) |
| WO (1) | WO2015061779A1 (https=) |
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| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| CN106110297B (zh) * | 2016-07-05 | 2019-12-17 | 南通大学 | Gfi1截短体的应用 |
| WO2018112545A1 (en) * | 2016-12-23 | 2018-06-28 | The University Of Queensland | Inhibitors of sox18 protein activity for treating angiogenesis- and/or lymphangiogenesis-related diseases |
| JP2018132365A (ja) * | 2017-02-14 | 2018-08-23 | 株式会社神戸製鋼所 | マーキング装置 |
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| WO2019118921A1 (en) | 2017-12-14 | 2019-06-20 | Flodesign Sonics, Inc. | Acoustic transducer drive and controller |
| US11340226B2 (en) * | 2018-03-02 | 2022-05-24 | The Chinese University Of Hong Kong | Squalene epoxidase in the diagnosis and treatment of non-alcoholic fatty liver diseases |
| WO2019168697A1 (en) * | 2018-03-02 | 2019-09-06 | Northwestern University | Overexpression of foxc1 to treat corneal vascularization |
| JP7217542B2 (ja) * | 2018-03-29 | 2023-02-03 | 国立大学法人 琉球大学 | 分化コントロール化合物を用いて造腫瘍性をもつおそれのある未分化ｉＰＳ細胞等の混入を除去する方法 |
| US12274733B2 (en) | 2018-09-28 | 2025-04-15 | President And Fellows Of Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| MX2021003663A (es) | 2018-09-28 | 2021-05-28 | Harvard College | Reprogramacion celular para revertir el envejecimiento y promover la regeneracion de organos y tejidos. |
| US20220143142A1 (en) * | 2019-03-17 | 2022-05-12 | Baylor College Of Medicine | Direct reprogramming of cardiac fibroblasts into cardiomyocytes using an endothelial cell transdifferentiation strategy |
| CN113710285A (zh) * | 2019-03-26 | 2021-11-26 | 宾州研究基金会 | 用于治疗癌症的方法和材料 |
| KR102150489B1 (ko) * | 2019-04-09 | 2020-09-01 | 고려대학교 산학협력단 | 소변세포로부터 신장전구세포로의 직접 역분화를 유도하는 방법 및 이의 방법으로 역분화된 신장전구세포를 포함하는 신장세포 손상 질환 예방 또는 치료용 약학 조성물 |
| WO2020243651A1 (en) | 2019-05-29 | 2020-12-03 | Encoded Therapeutics, Inc. | Compositions and methods for selective gene regulation |
| AU2020368526A1 (en) * | 2019-10-17 | 2022-05-12 | The Penn State Research Foundation | Regenerating functional neurons for treatment of neurological disorders |
| CN114729018A (zh) * | 2019-10-17 | 2022-07-08 | 宾州研究基金会 | 再生功能神经元以治疗出血性中风 |
| CA3157523A1 (en) * | 2019-10-17 | 2021-04-22 | Gong Chen | Regenerating functional neurons for treatment of spinal cord injury and als |
| EP4065227A4 (en) * | 2019-11-25 | 2023-12-20 | The Penn State Research Foundation | BRAIN REGENERATION AFTER TRAUMATIC BRAIN INJURY BY NEUROD1-MEDIATED ASTROCYTE-TO-NEURON CONVERSION |
| CN112877364B (zh) * | 2019-11-29 | 2023-07-28 | 中国医学科学院药物研究所 | 软骨下骨细胞向关节软骨细胞直接转化的重编程诱导方案 |
| WO2021149823A1 (ja) * | 2020-01-24 | 2021-07-29 | アイ ピース， インコーポレイテッド | 因子を導入された細胞の培養方法 |
| CN111214660B (zh) * | 2020-02-25 | 2022-01-18 | 北京大学第三医院（北京大学第三临床医学院） | Pax4基因表达抑制剂在制备抑制纤维化的药物中的应用 |
| US11091524B1 (en) | 2020-04-22 | 2021-08-17 | Houston Gene Therapeutics Llc | Compositions for treatment of vascular disease |
| CN114231489A (zh) * | 2020-09-08 | 2022-03-25 | 纽伦捷生物医药科技（苏州）有限公司 | 用于重编程的功能性片段、组合及其应用 |
| US20220098255A1 (en) * | 2020-09-29 | 2022-03-31 | NeuExcell Therapeutics Inc. | Neurod1 combination vector |
| PH12023550859A1 (en) * | 2020-09-29 | 2023-11-20 | Neuexcell Therapeutics Inc | Dlx2 vector |
| JP2023543361A (ja) * | 2020-09-29 | 2023-10-13 | ニューエクセル・セラピューティクス・インコーポレイテッド | Ｎｅｕｒｏｄ１及びｄｌｘ２ベクター |
| JP2022104813A (ja) | 2020-12-29 | 2022-07-11 | アイ ピース，インコーポレイテッド | リプログラミング因子を導入された細胞の培養方法 |
| CN113563428B (zh) * | 2021-06-22 | 2022-08-02 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 特定空间结构多肽及其在制备iPSC中的应用 |
| CN117070477A (zh) * | 2022-05-10 | 2023-11-17 | 纽伦捷生物医药科技（上海）有限公司 | 重组溶瘤病毒的重编程的功能性片段、组合及其应用 |
| KR102902484B1 (ko) * | 2022-11-25 | 2025-12-22 | 고려대학교 산학협력단 | 방사선 치료에 의하여 손상된 근육 재생을 위한 고기능성 세포 치료제 조성물 |
| US12252518B2 (en) | 2023-01-06 | 2025-03-18 | Life Biosciences, Inc. | Methods of treating non-arteritic anterior ischemic optic neuropathy |
| WO2025106947A1 (en) * | 2023-11-17 | 2025-05-22 | Exir, Inc. | Compositions and methods for induced stem cell differentiation to neuronal lineage |
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| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
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| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| DE69332485T2 (de) | 1992-08-11 | 2003-11-13 | The President And Fellows Of Harvard College, Cambridge | Immunmodulierende peptide |
| FR2766195A1 (fr) | 1997-07-21 | 1999-01-22 | Transgene Sa | Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique |
| DE19839491A1 (de) | 1998-08-29 | 2000-03-02 | Hermann Heumann | Verfahren zur Markierung von Biopolymeren mit Isotopen |
| US20040142474A1 (en) | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
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| EP1448772B1 (en) | 2001-11-30 | 2007-07-18 | Applied Research Systems ARS Holding N.V. | Methods of increasing expression levels of human tnf receptor |
| US20030134352A1 (en) | 2002-01-04 | 2003-07-17 | Freimuth Paul I. | Facilitating protein folding and solubility by use of peptide extensions |
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| WO2005026196A2 (en) | 2003-09-12 | 2005-03-24 | Novexin Limited | Methods for folding proteins and reducing protein aggregation |
| WO2005051421A2 (en) | 2003-11-25 | 2005-06-09 | The Government Of The United States, As Represented By The Secretary Of The Army | Use of shigella invaplex to transport functional proteins and transcriptionally active nucleic acids across mammalian cell membranes in vitro and in vivo |
| RU2450832C2 (ru) | 2006-10-25 | 2012-05-20 | Конинклейке Филипс Электроникс Н.В. | Контрастные вещества для детекции рака предстательной железы |
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| JP2013510563A (ja) | 2009-11-13 | 2013-03-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 操作された微小胞を用いた真核細胞のリプログラミング |
| JP2011135864A (ja) * | 2009-12-30 | 2011-07-14 | Korea Univ Research & Business Foundation | Ｏｃｔ４及びＢｍｉ１、またはその上位調節子を用いて体細胞から胚幹細胞類似細胞への逆分化を誘導する組成物及びこれを用いた胚幹細胞類似細胞の製造方法 |
| EP2531599A4 (en) * | 2010-02-04 | 2014-01-08 | Vivoscript Inc | COMPOSITIONS AND METHODS OF RENEWING CELLS WITHOUT GENETIC MODIFICATION FOR THE TREATMENT OF NEUROLOGICAL SUFFERING |
| BR112013003031A2 (pt) * | 2010-08-19 | 2016-06-14 | Hoffmann La Roche | método de produção de células hastes neurais (chn), células hastes neurais e seu uso, composição terapêutica e banco biológico de nscs |
| WO2012116064A1 (en) * | 2011-02-22 | 2012-08-30 | The Board Of Regents Of The University Of Texas | Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes |
| PT2705143T (pt) | 2011-05-02 | 2021-04-07 | Univ Wayne State | Tecnologia de células pluripotentes induzidas por proteínas e utilizações da mesma |
| EP2734622B1 (en) * | 2011-07-19 | 2018-09-05 | Vivoscript, Inc. | Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage |
| WO2013033213A1 (en) | 2011-08-30 | 2013-03-07 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| US20180223260A1 (en) * | 2011-10-21 | 2018-08-09 | Stemgenics, Inc. | Functionalized nanoparticles for the intracellular delivery of biologically active molecules and methods for their manufacture and use |
-
2014
- 2014-10-27 US US15/031,839 patent/US10076574B2/en active Active
- 2014-10-27 CA CA2934065A patent/CA2934065C/en active Active
- 2014-10-27 PT PT148550403T patent/PT3060237T/pt unknown
- 2014-10-27 EP EP21187708.9A patent/EP3954381A1/en not_active Withdrawn
- 2014-10-27 EP EP14855040.3A patent/EP3060237B1/en active Active
- 2014-10-27 SG SG11201603230UA patent/SG11201603230UA/en unknown
- 2014-10-27 CA CA3194454A patent/CA3194454C/en active Active
- 2014-10-27 JP JP2016550686A patent/JP6415582B2/ja active Active
- 2014-10-27 KR KR1020167013867A patent/KR102113829B1/ko active Active
- 2014-10-27 ES ES14855040T patent/ES2896021T3/es active Active
- 2014-10-27 DK DK14855040.3T patent/DK3060237T3/da active
- 2014-10-27 CA CA3291355A patent/CA3291355A1/en active Pending
- 2014-10-27 AU AU2014339843A patent/AU2014339843B2/en active Active
- 2014-10-27 CN CN201480071293.0A patent/CN106170295B/zh active Active
- 2014-10-27 WO PCT/US2014/062400 patent/WO2015061779A1/en not_active Ceased
- 2014-10-27 KR KR1020207014071A patent/KR20200057108A/ko not_active Ceased
- 2014-10-27 PL PL14855040T patent/PL3060237T3/pl unknown
- 2014-10-27 CN CN202011127974.8A patent/CN112245592A/zh active Pending
-
2016
- 2016-04-25 IL IL245300A patent/IL245300B/en active IP Right Grant
-
2018
- 2018-09-04 US US16/120,829 patent/US10548983B2/en active Active
- 2018-10-02 JP JP2018187189A patent/JP6577112B2/ja active Active
-
2019
- 2019-05-19 IL IL266705A patent/IL266705B/en active IP Right Grant
- 2019-06-28 AU AU2019204630A patent/AU2019204630C1/en active Active
- 2019-08-22 JP JP2019151759A patent/JP6880125B2/ja active Active
-
2020
- 2020-01-28 IL IL272324A patent/IL272324B/en unknown
-
2021
- 2021-06-29 AU AU2021204485A patent/AU2021204485B2/en active Active
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