JP2017503014A5 - - Google Patents

Download PDF

Info

Publication number
JP2017503014A5
JP2017503014A5 JP2016559686A JP2016559686A JP2017503014A5 JP 2017503014 A5 JP2017503014 A5 JP 2017503014A5 JP 2016559686 A JP2016559686 A JP 2016559686A JP 2016559686 A JP2016559686 A JP 2016559686A JP 2017503014 A5 JP2017503014 A5 JP 2017503014A5
Authority
JP
Japan
Prior art keywords
lag
protein
preparation according
combination preparation
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016559686A
Other languages
English (en)
Japanese (ja)
Other versions
JP6691054B2 (ja
JP2017503014A (ja
Filing date
Publication date
Priority claimed from GBGB1322626.1A external-priority patent/GB201322626D0/en
Application filed filed Critical
Publication of JP2017503014A publication Critical patent/JP2017503014A/ja
Publication of JP2017503014A5 publication Critical patent/JP2017503014A5/ja
Application granted granted Critical
Publication of JP6691054B2 publication Critical patent/JP6691054B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016559686A 2013-12-19 2014-12-19 がんの治療のための組合せ調製物 Active JP6691054B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1322626.1A GB201322626D0 (en) 2013-12-19 2013-12-19 Combined preparations for the treatment of cancer
GB1322626.1 2013-12-19
PCT/EP2014/078779 WO2015091970A1 (en) 2013-12-19 2014-12-19 Combined preparations for the treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019163672A Division JP7160345B2 (ja) 2013-12-19 2019-09-09 がんの治療のための組合せ調製物

Publications (3)

Publication Number Publication Date
JP2017503014A JP2017503014A (ja) 2017-01-26
JP2017503014A5 true JP2017503014A5 (US20070167479A1-20070719-C00034.png) 2018-02-01
JP6691054B2 JP6691054B2 (ja) 2020-05-20

Family

ID=50071175

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016559686A Active JP6691054B2 (ja) 2013-12-19 2014-12-19 がんの治療のための組合せ調製物
JP2019163672A Active JP7160345B2 (ja) 2013-12-19 2019-09-09 がんの治療のための組合せ調製物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019163672A Active JP7160345B2 (ja) 2013-12-19 2019-09-09 がんの治療のための組合せ調製物

Country Status (14)

Country Link
US (2) US10736940B2 (US20070167479A1-20070719-C00034.png)
EP (3) EP4414035A3 (US20070167479A1-20070719-C00034.png)
JP (2) JP6691054B2 (US20070167479A1-20070719-C00034.png)
KR (3) KR102593917B1 (US20070167479A1-20070719-C00034.png)
CN (2) CN112957452A (US20070167479A1-20070719-C00034.png)
AU (1) AU2014368420B2 (US20070167479A1-20070719-C00034.png)
DK (2) DK3089749T3 (US20070167479A1-20070719-C00034.png)
ES (1) ES2730976T3 (US20070167479A1-20070719-C00034.png)
FI (1) FI3511004T3 (US20070167479A1-20070719-C00034.png)
GB (1) GB201322626D0 (US20070167479A1-20070719-C00034.png)
PL (1) PL3089749T3 (US20070167479A1-20070719-C00034.png)
PT (2) PT3511004T (US20070167479A1-20070719-C00034.png)
TR (1) TR201910866T4 (US20070167479A1-20070719-C00034.png)
WO (1) WO2015091970A1 (US20070167479A1-20070719-C00034.png)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
GB201322626D0 (en) 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer
US10265379B2 (en) * 2015-09-16 2019-04-23 Annabelle Rodriguez Oquendo Use of recombinant lymphocyte activation gene-3 as a companion therapeutic for patients at risk for cardiovascular disease and other chronic inflammatory diseases
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗lag3抗體及其用途
BR112018012352A2 (pt) 2015-12-16 2018-12-11 Merck Sharp & Dohme Corp. anticorpos anti-lag3 e fragmentos de ligação ao antígeno
CN108204958A (zh) * 2016-12-19 2018-06-26 伊缪泰普有限公司 结合测定
CN118557758A (zh) 2017-02-10 2024-08-30 瑞泽恩制药公司 用于免疫-pet成像的放射性标记的抗-lag3抗体
CN115667304A (zh) 2020-05-27 2023-01-31 安捷伦科技有限公司 抗人lag-3抗体及其在免疫组织化学(ihc)中的用途

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078996A (en) 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
US5098702A (en) 1986-04-09 1992-03-24 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
CA1341281C (en) 1986-07-09 2001-08-07 Hubert J.P. Schoemaker Immunotherapy of tumor with monoclonal antibody against the 17-1a antigen
US5785973A (en) 1988-02-01 1998-07-28 Praxis Biologics, Inc. Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
CA1339354C (en) 1988-09-01 1997-08-26 The Whitehead Institute For Biomedical Research Recombinant retroviruses with amphotropic and ecotropic host ranges
US5665577A (en) 1989-02-06 1997-09-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
CA2047191A1 (en) 1989-02-17 1990-08-18 Hendrik M. Geysen Method for the use and synthesis of peptides
JP3051411B2 (ja) 1989-03-14 2000-06-12 持田製薬株式会社 新規dnaならびにそれを含有する発現プラスミド
US5266491A (en) 1989-03-14 1993-11-30 Mochida Pharmaceutical Co., Ltd. DNA fragment and expression plasmid containing the DNA fragment
US5436146A (en) 1989-09-07 1995-07-25 The Trustees Of Princeton University Helper-free stocks of recombinant adeno-associated virus vectors
US5976877A (en) 1990-01-08 1999-11-02 Institut National De La Sante Et De La Recherche Medicale (Inserm) Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses
FR2656800B1 (fr) 1990-01-08 1992-05-15 Roussy Inst Gustave Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
US7294712B2 (en) 1990-06-04 2007-11-13 Aventis Pharma S.A. Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
US5981276A (en) 1990-06-20 1999-11-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
WO1992005262A1 (en) 1990-09-14 1992-04-02 The John Hopkins University Methods and compositions for genetic therapy and potentiation of anti-tumor immunity
JP3459268B2 (ja) 1990-09-17 2003-10-20 中外製薬株式会社 抗癌剤
US6596536B1 (en) 1991-02-08 2003-07-22 Aventis Pharma S.A. Nucleotide sequences coding for variable regions of the alpha chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
KR100242278B1 (ko) 1991-02-08 2000-02-01 장-끌로드 비에이으포스 인체 임파구 수용체의 알파사슬의 가변성영역을 코딩하는 뉴클레오티드 서열 및 그의 응용
EP0528007A1 (fr) 1991-02-12 1993-02-24 Roussel Uclaf SEQUENCES NUCLEOTIDIQUES CODANT POUR DES REGIONS VARIABLES DE CHAINES $g(b) DES RECEPTEURS DES LYMPHOCYTES T HUMAINS, SEGMENTS PEPTIDIQUES CORRESPONDANTS ET LES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES
US5904920A (en) 1991-10-04 1999-05-18 Whitehead Institute For Biomedical Research Regulation of systemic immune responses utilizing cytokines and antigens
US5637483A (en) 1991-10-04 1997-06-10 Whitehead Institute For Biomedical Research Irradiated tumor cell vaccine engineered to express GM-CSF
US6506604B2 (en) 1993-06-11 2003-01-14 Cell Genesys, Inc. Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
JP3700859B2 (ja) 1994-05-06 2005-09-28 アンスティテュ ギュスタブ ルシ Lag−3タンパク質の可溶性ポリペプチドフラクション;製造方法、治療用製剤、抗イディオタイプ抗体
US5872005A (en) 1994-11-03 1999-02-16 Cell Genesys Inc. Packaging cell lines for adeno-associated viral vectors
US6093570A (en) 1995-06-07 2000-07-25 The University Of North Carolina At Chapel Hill Helper virus-free AAV production
US6040183A (en) 1995-06-07 2000-03-21 University Of North Carloina At Chapel Hill Helper virus-free AAV production
CA2222231A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
US6033674A (en) 1995-12-28 2000-03-07 Johns Hopkins University School Of Medicine Method of treating cancer with a tumor cell line having modified cytokine expression
US5840839A (en) 1996-02-09 1998-11-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
US6277368B1 (en) 1996-07-25 2001-08-21 The Regents Of The University Of California Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
AU728911B2 (en) 1996-11-28 2001-01-18 Institut Gustave Roussy Mutants of the LAG-3 proteins, products for the expression of these mutants and use
EA003772B1 (ru) 1996-11-29 2003-08-28 Апплайд Резеч Системз Арс Холдинг Н.В. Средство для обеспечения защиты трансплантата от отторжения иммунной системой хозяина на основе штамма генетически сконструированных эукариотических клеток, содержащих днк, кодирующую трансмембранный белок lag-3
CA2287478C (en) 1997-04-14 2007-06-19 Richard J. Samulski Methods for increasing the efficiency of recombinant aav product
EP0893507A1 (en) 1997-07-25 1999-01-27 Institut Gustave Roussy Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment
US6037177A (en) 1997-08-08 2000-03-14 Cell Genesys, Inc. Method for increasing the efficiency of recombinant AAV production
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
AU741602B2 (en) 1998-02-02 2001-12-06 Johns Hopkins University School Of Medicine, The A universal immunomodulatory cytokine-expressing bystander cell line and related compositions and methods of manufacture and use
FR2777890B1 (fr) 1998-04-22 2000-12-29 Roussy Inst Gustave Composes peptidiques d'hsp70 utiles dans l'immunotherapie du cancer
AU5458500A (en) 1999-06-02 2000-12-18 Cell Genesys, Inc. Regulation of systemic immune responses utilizing cytokines and antigens
FR2795415B1 (fr) 1999-06-28 2003-09-05 Roussy Inst Gustave Compose peptidique derive d'une orf decalee du gene ice
AT409086B (de) 1999-11-16 2002-05-27 Igeneon Krebs Immuntherapie Neue verwendung von antikörpern als impfstoffe
AU2001258476A1 (en) 2000-04-26 2001-11-07 Biovector Therapeutics Use of particulate vectors in immunomodulation
US7919467B2 (en) 2000-12-04 2011-04-05 Immunotope, Inc. Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
ATE519779T1 (de) 2001-09-19 2011-08-15 Roussy Inst Gustave An das glu-pro motiv-bindende proteine und peptide, diese enthaltende therapeutische zusammensetzungen und deren anwendungen
EP1505973B1 (en) 2002-05-17 2010-03-03 Celgene Corporation Combinations for treating multiple myeloma
DE10161767T1 (de) 2002-07-03 2018-06-07 Honjo Tasuku Immunopotenzierende Zusammensetzungen, die einen Anti-PD-L1 Antikörper enthalten
US7439042B2 (en) 2002-12-16 2008-10-21 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis C infection
US20040197312A1 (en) 2003-04-02 2004-10-07 Marina Moskalenko Cytokine-expressing cellular vaccine combinations
NZ547042A (en) 2003-10-10 2010-05-28 Powderject Vaccines Inc Method for eliciting a T-cell response
FR2868781B1 (fr) 2004-04-13 2008-02-22 Immutep Composition de vaccin comprenant un ligand cmh de classe ii couple a un antigene, procede de preparation et utilisations
JP2006124383A (ja) 2004-09-30 2006-05-18 Kobayashi Pharmaceut Co Ltd 樹状細胞活性化剤
JP2006141346A (ja) 2004-11-24 2006-06-08 Kobayashi Pharmaceut Co Ltd 樹状細胞活性化剤
US7964571B2 (en) * 2004-12-09 2011-06-21 Egen, Inc. Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
US7919079B2 (en) 2006-03-31 2011-04-05 Biosante Pharmaceuticals, Inc. Cancer immunotherapy compositions and methods of use
US20070231298A1 (en) 2006-03-31 2007-10-04 Cell Genesys, Inc. Cytokine-expressing cancer immunotherapy combinations
EP2170959B1 (en) 2007-06-18 2013-10-02 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor pd-1
US8425897B2 (en) 2007-08-30 2013-04-23 Immutep S.A. Compositions containing LAG-3 and cells that secrete GM-CSF and methods of use
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
SG191048A1 (en) 2010-12-06 2013-07-31 Cure Cancer Worldwide Corp Methods of metabolic targeting cancer cells using che mo- and immunotherapy for treating cancer
MX341076B (es) 2011-03-31 2016-08-04 Merck Sharp & Dohme Formulaciones estables de anticuerpos para el receptor humano pd-1 de meurte programada y tratamientos relacionados.
SG11201407190TA (en) 2012-05-15 2014-12-30 Bristol Myers Squibb Co Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
WO2014194293A1 (en) 2013-05-30 2014-12-04 Amplimmune, Inc. Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof
RS58705B1 (sr) 2013-09-20 2019-06-28 Bristol Myers Squibb Co Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora
GB201322626D0 (en) 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
WO2015131176A1 (en) 2014-02-28 2015-09-03 Podack Eckhard R Compositions, methods, and kits for treatment of cancer
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer

Similar Documents

Publication Publication Date Title
JP2017503014A5 (US20070167479A1-20070719-C00034.png)
JP2019203035A5 (US20070167479A1-20070719-C00034.png)
CY1119490T1 (el) Παραγωγα πυραζολοπυρρολιδινης και η χρηση τους στην θεραπεια νοσηματων
JP2016515628A5 (US20070167479A1-20070719-C00034.png)
CY1119886T1 (el) Μεθοδος βιομηχανικης κατασκευης μιας φαρμακευτικης συνθεσης στην μορφη δισκιων παρατεταμενης απελευθερωσης που περιεχουν πιρφενιδονη και χρηση αυτων στην υποστροφη χρονιας νεφρικης ανεπαρκειας, καψικης συσπασης μαστου και ηπατικης ινωσης σε ανθρωπους
MX2019012884A (es) Terapia de combinacion.
WO2015097621A3 (en) Pharmaceutical combinations
JP2017503820A5 (US20070167479A1-20070719-C00034.png)
MX2017004592A (es) Formulaciones farmaceuticas para la administracion oral de farmacos peptidicos o proteinicos.
JP2016512248A5 (US20070167479A1-20070719-C00034.png)
JP2015529225A5 (US20070167479A1-20070719-C00034.png)
JP2015212268A5 (US20070167479A1-20070719-C00034.png)
JP2018510132A5 (US20070167479A1-20070719-C00034.png)
EA201491285A1 (ru) Улучшенные композиции и способы доставки омепразола и ацетилсалициловой кислоты
EA201492010A1 (ru) Применение высокой дозы лахинимода для лечения рассеянного склероза
FI3511004T3 (fi) Yhdistelmävalmisteita syövän hoitoon
JP2015517488A5 (US20070167479A1-20070719-C00034.png)
JP2014513089A5 (US20070167479A1-20070719-C00034.png)
JP2018505882A5 (US20070167479A1-20070719-C00034.png)
MX2014002171A (es) Tratamientos de combinacion para hepatitis c.
BR112018012870A2 (pt) métodos e composições para o tratamento de transtornos relacionados à crise
JP2017506624A5 (US20070167479A1-20070719-C00034.png)
JP2017537105A5 (US20070167479A1-20070719-C00034.png)
JP2016510326A5 (US20070167479A1-20070719-C00034.png)
RU2017116740A (ru) Комбинации для лечения рассеянного склероза