US5078996A
(en)
|
1985-08-16 |
1992-01-07 |
Immunex Corporation |
Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
|
US5098702A
(en)
|
1986-04-09 |
1992-03-24 |
Cetus Corporation |
Combination therapy using interleukin-2 and tumor necrosis factor
|
CA1341281C
(en)
|
1986-07-09 |
2001-08-07 |
Hubert J.P. Schoemaker |
Immunotherapy of tumor with monoclonal antibody against the 17-1a antigen
|
US5785973A
(en)
|
1988-02-01 |
1998-07-28 |
Praxis Biologics, Inc. |
Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
|
CA1339354C
(en)
|
1988-09-01 |
1997-08-26 |
The Whitehead Institute For Biomedical Research |
Recombinant retroviruses with amphotropic and ecotropic host ranges
|
US5665577A
(en)
|
1989-02-06 |
1997-09-09 |
Dana-Farber Cancer Institute |
Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
|
CA2047191A1
(en)
|
1989-02-17 |
1990-08-18 |
Hendrik M. Geysen |
Method for the use and synthesis of peptides
|
JP3051411B2
(ja)
|
1989-03-14 |
2000-06-12 |
持田製薬株式会社 |
新規dnaならびにそれを含有する発現プラスミド
|
US5266491A
(en)
|
1989-03-14 |
1993-11-30 |
Mochida Pharmaceutical Co., Ltd. |
DNA fragment and expression plasmid containing the DNA fragment
|
US5436146A
(en)
|
1989-09-07 |
1995-07-25 |
The Trustees Of Princeton University |
Helper-free stocks of recombinant adeno-associated virus vectors
|
US5976877A
(en)
|
1990-01-08 |
1999-11-02 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses
|
FR2656800B1
(fr)
|
1990-01-08 |
1992-05-15 |
Roussy Inst Gustave |
Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
|
US7294712B2
(en)
|
1990-06-04 |
2007-11-13 |
Aventis Pharma S.A. |
Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
|
US5981276A
(en)
|
1990-06-20 |
1999-11-09 |
Dana-Farber Cancer Institute |
Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
|
WO1992005262A1
(en)
|
1990-09-14 |
1992-04-02 |
The John Hopkins University |
Methods and compositions for genetic therapy and potentiation of anti-tumor immunity
|
JP3459268B2
(ja)
|
1990-09-17 |
2003-10-20 |
中外製薬株式会社 |
抗癌剤
|
US6596536B1
(en)
|
1991-02-08 |
2003-07-22 |
Aventis Pharma S.A. |
Nucleotide sequences coding for variable regions of the alpha chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
|
KR100242278B1
(ko)
|
1991-02-08 |
2000-02-01 |
장-끌로드 비에이으포스 |
인체 임파구 수용체의 알파사슬의 가변성영역을 코딩하는 뉴클레오티드 서열 및 그의 응용
|
EP0528007A1
(fr)
|
1991-02-12 |
1993-02-24 |
Roussel Uclaf |
SEQUENCES NUCLEOTIDIQUES CODANT POUR DES REGIONS VARIABLES DE CHAINES $g(b) DES RECEPTEURS DES LYMPHOCYTES T HUMAINS, SEGMENTS PEPTIDIQUES CORRESPONDANTS ET LES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES
|
US5904920A
(en)
|
1991-10-04 |
1999-05-18 |
Whitehead Institute For Biomedical Research |
Regulation of systemic immune responses utilizing cytokines and antigens
|
US5637483A
(en)
|
1991-10-04 |
1997-06-10 |
Whitehead Institute For Biomedical Research |
Irradiated tumor cell vaccine engineered to express GM-CSF
|
US6506604B2
(en)
|
1993-06-11 |
2003-01-14 |
Cell Genesys, Inc. |
Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
|
JP3700859B2
(ja)
|
1994-05-06 |
2005-09-28 |
アンスティテュ ギュスタブ ルシ |
Lag−3タンパク質の可溶性ポリペプチドフラクション;製造方法、治療用製剤、抗イディオタイプ抗体
|
US5872005A
(en)
|
1994-11-03 |
1999-02-16 |
Cell Genesys Inc. |
Packaging cell lines for adeno-associated viral vectors
|
US6093570A
(en)
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
US6040183A
(en)
|
1995-06-07 |
2000-03-21 |
University Of North Carloina At Chapel Hill |
Helper virus-free AAV production
|
CA2222231A1
(en)
|
1995-06-07 |
1996-12-19 |
Imclone Systems Incorporated |
Antibody and antibody fragments for inhibiting the growth of tumors
|
US6033674A
(en)
|
1995-12-28 |
2000-03-07 |
Johns Hopkins University School Of Medicine |
Method of treating cancer with a tumor cell line having modified cytokine expression
|
US5840839A
(en)
|
1996-02-09 |
1998-11-24 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
|
US6277368B1
(en)
|
1996-07-25 |
2001-08-21 |
The Regents Of The University Of California |
Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
|
AU728911B2
(en)
|
1996-11-28 |
2001-01-18 |
Institut Gustave Roussy |
Mutants of the LAG-3 proteins, products for the expression of these mutants and use
|
EA003772B1
(ru)
|
1996-11-29 |
2003-08-28 |
Апплайд Резеч Системз Арс Холдинг Н.В. |
Средство для обеспечения защиты трансплантата от отторжения иммунной системой хозяина на основе штамма генетически сконструированных эукариотических клеток, содержащих днк, кодирующую трансмембранный белок lag-3
|
CA2287478C
(en)
|
1997-04-14 |
2007-06-19 |
Richard J. Samulski |
Methods for increasing the efficiency of recombinant aav product
|
EP0893507A1
(en)
|
1997-07-25 |
1999-01-27 |
Institut Gustave Roussy |
Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment
|
US6037177A
(en)
|
1997-08-08 |
2000-03-14 |
Cell Genesys, Inc. |
Method for increasing the efficiency of recombinant AAV production
|
US5994136A
(en)
|
1997-12-12 |
1999-11-30 |
Cell Genesys, Inc. |
Method and means for producing high titer, safe, recombinant lentivirus vectors
|
AU741602B2
(en)
|
1998-02-02 |
2001-12-06 |
Johns Hopkins University School Of Medicine, The |
A universal immunomodulatory cytokine-expressing bystander cell line and related compositions and methods of manufacture and use
|
FR2777890B1
(fr)
|
1998-04-22 |
2000-12-29 |
Roussy Inst Gustave |
Composes peptidiques d'hsp70 utiles dans l'immunotherapie du cancer
|
AU5458500A
(en)
|
1999-06-02 |
2000-12-18 |
Cell Genesys, Inc. |
Regulation of systemic immune responses utilizing cytokines and antigens
|
FR2795415B1
(fr)
|
1999-06-28 |
2003-09-05 |
Roussy Inst Gustave |
Compose peptidique derive d'une orf decalee du gene ice
|
AT409086B
(de)
|
1999-11-16 |
2002-05-27 |
Igeneon Krebs Immuntherapie |
Neue verwendung von antikörpern als impfstoffe
|
AU2001258476A1
(en)
|
2000-04-26 |
2001-11-07 |
Biovector Therapeutics |
Use of particulate vectors in immunomodulation
|
US7919467B2
(en)
|
2000-12-04 |
2011-04-05 |
Immunotope, Inc. |
Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
|
ATE519779T1
(de)
|
2001-09-19 |
2011-08-15 |
Roussy Inst Gustave |
An das glu-pro motiv-bindende proteine und peptide, diese enthaltende therapeutische zusammensetzungen und deren anwendungen
|
EP1505973B1
(en)
|
2002-05-17 |
2010-03-03 |
Celgene Corporation |
Combinations for treating multiple myeloma
|
DE10161767T1
(de)
|
2002-07-03 |
2018-06-07 |
Honjo Tasuku |
Immunopotenzierende Zusammensetzungen, die einen Anti-PD-L1 Antikörper enthalten
|
US7439042B2
(en)
|
2002-12-16 |
2008-10-21 |
Globeimmune, Inc. |
Yeast-based therapeutic for chronic hepatitis C infection
|
US20040197312A1
(en)
|
2003-04-02 |
2004-10-07 |
Marina Moskalenko |
Cytokine-expressing cellular vaccine combinations
|
NZ547042A
(en)
|
2003-10-10 |
2010-05-28 |
Powderject Vaccines Inc |
Method for eliciting a T-cell response
|
FR2868781B1
(fr)
|
2004-04-13 |
2008-02-22 |
Immutep |
Composition de vaccin comprenant un ligand cmh de classe ii couple a un antigene, procede de preparation et utilisations
|
JP2006124383A
(ja)
|
2004-09-30 |
2006-05-18 |
Kobayashi Pharmaceut Co Ltd |
樹状細胞活性化剤
|
JP2006141346A
(ja)
|
2004-11-24 |
2006-06-08 |
Kobayashi Pharmaceut Co Ltd |
樹状細胞活性化剤
|
US7964571B2
(en)
*
|
2004-12-09 |
2011-06-21 |
Egen, Inc. |
Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
|
US7919079B2
(en)
|
2006-03-31 |
2011-04-05 |
Biosante Pharmaceuticals, Inc. |
Cancer immunotherapy compositions and methods of use
|
US20070231298A1
(en)
|
2006-03-31 |
2007-10-04 |
Cell Genesys, Inc. |
Cytokine-expressing cancer immunotherapy combinations
|
EP2170959B1
(en)
|
2007-06-18 |
2013-10-02 |
Merck Sharp & Dohme B.V. |
Antibodies to human programmed death receptor pd-1
|
US8425897B2
(en)
|
2007-08-30 |
2013-04-23 |
Immutep S.A. |
Compositions containing LAG-3 and cells that secrete GM-CSF and methods of use
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
SG191048A1
(en)
|
2010-12-06 |
2013-07-31 |
Cure Cancer Worldwide Corp |
Methods of metabolic targeting cancer cells using che mo- and immunotherapy for treating cancer
|
MX341076B
(es)
|
2011-03-31 |
2016-08-04 |
Merck Sharp & Dohme |
Formulaciones estables de anticuerpos para el receptor humano pd-1 de meurte programada y tratamientos relacionados.
|
SG11201407190TA
(en)
|
2012-05-15 |
2014-12-30 |
Bristol Myers Squibb Co |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
US9890215B2
(en)
|
2012-06-22 |
2018-02-13 |
King's College London |
Vista modulators for diagnosis and treatment of cancer
|
WO2014194293A1
(en)
|
2013-05-30 |
2014-12-04 |
Amplimmune, Inc. |
Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof
|
RS58705B1
(sr)
|
2013-09-20 |
2019-06-28 |
Bristol Myers Squibb Co |
Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora
|
GB201322626D0
(en)
|
2013-12-19 |
2014-02-05 |
Immutep S A |
Combined preparations for the treatment of cancer
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
WO2015131176A1
(en)
|
2014-02-28 |
2015-09-03 |
Podack Eckhard R |
Compositions, methods, and kits for treatment of cancer
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
GB201500374D0
(en)
|
2015-01-09 |
2015-02-25 |
Immutep S A |
Combined preparations for the treatment of cancer
|