JP2017502967A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017502967A5 JP2017502967A5 JP2016544133A JP2016544133A JP2017502967A5 JP 2017502967 A5 JP2017502967 A5 JP 2017502967A5 JP 2016544133 A JP2016544133 A JP 2016544133A JP 2016544133 A JP2016544133 A JP 2016544133A JP 2017502967 A5 JP2017502967 A5 JP 2017502967A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- dutpase
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc1ccc(*)c(*)c1 Chemical compound Cc1ccc(*)c(*)c1 0.000 description 7
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461923534P | 2014-01-03 | 2014-01-03 | |
| US61/923,534 | 2014-01-03 | ||
| PCT/US2015/010059 WO2015103489A1 (en) | 2014-01-03 | 2015-01-02 | Heteroatom containing deoxyuridine triphosphatase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017502967A JP2017502967A (ja) | 2017-01-26 |
| JP2017502967A5 true JP2017502967A5 (https=) | 2018-02-08 |
| JP6513095B2 JP6513095B2 (ja) | 2019-05-15 |
Family
ID=53494059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544133A Active JP6513095B2 (ja) | 2014-01-03 | 2015-01-02 | ヘテロ原子含有デオキシウリジントリホスファターゼ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9790214B2 (https=) |
| EP (1) | EP3089964B1 (https=) |
| JP (1) | JP6513095B2 (https=) |
| CN (1) | CN106061952B (https=) |
| CA (1) | CA2935717C (https=) |
| IL (1) | IL246545B (https=) |
| WO (1) | WO2015103489A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2941423B1 (en) | 2013-01-07 | 2021-06-09 | University of Southern California | Deoxyuridine triphosphatase inhibitors |
| US9790214B2 (en) | 2014-01-03 | 2017-10-17 | University Of Southern California | Heteroatom containing deoxyuridine triphosphatase inhibitors |
| US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| WO2017006283A1 (en) | 2015-07-08 | 2017-01-12 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| SI3319939T1 (sl) | 2015-07-08 | 2025-04-30 | Cv6 Therapeutics (Ni) Limited | Zaviralci deoksiuridin trifosfataze, ki vsebujejo hidantoin |
| US11168059B2 (en) | 2016-11-23 | 2021-11-09 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
| WO2018098204A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
| WO2018098207A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| WO2018098208A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
| US10858344B2 (en) | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| WO2018128720A1 (en) | 2017-01-05 | 2018-07-12 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787766A (fr) | 1971-08-21 | 1973-02-19 | Merck Patent Gmbh | Imides d'acide glutarique et leur procede de preparation |
| US4304715A (en) | 1979-06-08 | 1981-12-08 | Derek Hudson | Enkephalin analogues |
| JPS5839672A (ja) | 1981-09-03 | 1983-03-08 | Chugai Pharmaceut Co Ltd | ウラシル誘導体 |
| JPH0674251B2 (ja) * | 1986-02-07 | 1994-09-21 | 全薬工業株式▲会▼社 | ビス−ジオキソピペラジン誘導体 |
| JPS63101361A (ja) | 1986-09-08 | 1988-05-06 | ブリティッシュ・テクノロジー・グループ・リミテッド | ジオキソピペリジン誘導体を含有する不安解消組成物 |
| FR2644786B1 (fr) * | 1989-03-21 | 1993-12-31 | Adir Cie | Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| US5463063A (en) | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
| US5599796A (en) | 1993-12-02 | 1997-02-04 | Emory University | Treatment of urogenital cancer with boron neutron capture therapy |
| US5962246A (en) | 1996-03-29 | 1999-10-05 | The University Of Medicine And Dentistry Of New Jersey | dUTPase, its isoforms, and diagnostic and other uses |
| JPH09286786A (ja) | 1996-04-18 | 1997-11-04 | Nippon Paper Ind Co Ltd | ピリミジン誘導体及びその抗腫瘍剤としての用途 |
| ATE388139T1 (de) | 1997-12-18 | 2008-03-15 | Boehringer Ingelheim Pharma | Pyridone als hemmer der sh2-domäne der src- familie |
| EP1165500A1 (en) | 1999-04-02 | 2002-01-02 | Du Pont Pharmaceuticals Company | Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase |
| DE10002509A1 (de) | 2000-01-21 | 2001-07-26 | Gruenenthal Gmbh | Substituierte Glutarimide |
| JP2002284686A (ja) | 2001-03-28 | 2002-10-03 | Sankyo Co Ltd | スルホンアミド化合物を含有する医薬組成物 |
| CA2444148A1 (en) * | 2001-04-11 | 2002-10-24 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
| US6822097B1 (en) | 2002-02-07 | 2004-11-23 | Amgen, Inc. | Compounds and methods of uses |
| GB0400290D0 (en) | 2004-01-08 | 2004-02-11 | Medivir Ab | dUTPase inhibitors |
| JP2008528514A (ja) | 2005-01-25 | 2008-07-31 | セルジーン・コーポレーション | ４−アミノ−２−（３−メチル−２，６−ジオキソピペリジン−３−イル）−イソインドール−１，３−ジオンを使用する方法及び組成物 |
| WO2006135763A2 (en) | 2005-06-09 | 2006-12-21 | The Johns Hopkins University | Inhibitors of dna repair enzymes and methods of use thereof |
| JP2009544710A (ja) | 2006-07-24 | 2009-12-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖ逆転写酵素インヒビター |
| EP1939186A1 (en) | 2006-12-22 | 2008-07-02 | Sulfidris S.r.l. | 5-Fluorouracil derivatives and their use for the treatment of cancer |
| MX2010006421A (es) | 2007-12-10 | 2010-06-25 | Novartis Ag | Compuestos organicos. |
| MX2010013275A (es) * | 2008-06-03 | 2011-03-15 | Taiho Pharmaceutical Co Ltd | Compuesto novedoso de uracilo o su sal que tiene actividad inhibidora de desoxiuridin trifosfatasa de humano. |
| US20110212467A1 (en) | 2008-08-27 | 2011-09-01 | University Of Southern California | INHIBITORS OF dUTPase |
| JP2011231015A (ja) * | 2008-08-29 | 2011-11-17 | Taiho Yakuhin Kogyo Kk | 含窒素複素環を有する新規ウラシル化合物又はその塩 |
| EP2398822B1 (en) | 2009-02-19 | 2013-01-02 | Novo Nordisk A/S | Modification of factor viii |
| JP2013032293A (ja) | 2009-11-30 | 2013-02-14 | Taiho Yakuhin Kogyo Kk | ヒトｄＵＴＰａｓｅ阻害活性を有する５−フルオロウラシル化合物又はその塩 |
| CN102612369B (zh) | 2009-11-30 | 2014-06-18 | 大鹏药品工业株式会社 | 抗肿瘤效果增强剂 |
| JP2013047189A (ja) | 2009-12-25 | 2013-03-07 | Kyorin Pharmaceutical Co Ltd | 新規パラバン酸誘導体及びそれらを有効成分とする医薬 |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| EP2508158B1 (en) | 2011-04-04 | 2014-07-02 | Arjo Hospital Equipment AB | Hoist apparatus |
| EP2941423B1 (en) * | 2013-01-07 | 2021-06-09 | University of Southern California | Deoxyuridine triphosphatase inhibitors |
| US9790214B2 (en) | 2014-01-03 | 2017-10-17 | University Of Southern California | Heteroatom containing deoxyuridine triphosphatase inhibitors |
| EP3290038A4 (en) | 2015-04-30 | 2018-12-26 | Taiho Pharmaceutical Co., Ltd. | Agent for alleviating adverse reaction to antitumor drug |
| WO2016178416A1 (ja) | 2015-05-01 | 2016-11-10 | 大鵬薬品工業株式会社 | ウラシル化合物の新規結晶 |
| US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| SI3319939T1 (sl) | 2015-07-08 | 2025-04-30 | Cv6 Therapeutics (Ni) Limited | Zaviralci deoksiuridin trifosfataze, ki vsebujejo hidantoin |
| WO2017006283A1 (en) | 2015-07-08 | 2017-01-12 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
-
2015
- 2015-01-02 US US15/109,616 patent/US9790214B2/en active Active
- 2015-01-02 WO PCT/US2015/010059 patent/WO2015103489A1/en not_active Ceased
- 2015-01-02 CN CN201580012064.6A patent/CN106061952B/zh active Active
- 2015-01-02 EP EP15733304.8A patent/EP3089964B1/en active Active
- 2015-01-02 CA CA2935717A patent/CA2935717C/en active Active
- 2015-01-02 JP JP2016544133A patent/JP6513095B2/ja active Active
-
2016
- 2016-06-30 IL IL246545A patent/IL246545B/en active IP Right Grant
-
2017
- 2017-09-28 US US15/719,165 patent/US10457673B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017502967A5 (https=) | ||
| JP2016505621A5 (https=) | ||
| KR102566924B1 (ko) | 케모카인 수용체 조절제 및 이의 용도 | |
| RU2017145026A (ru) | Соединение, ингибирующее brk | |
| US20250115563A1 (en) | Modulators of the integrated stress pathway | |
| WO2023140846A1 (en) | Combination cancer therapy with dyrk1 inhibitors and inhibitors of the ras-raf-mek-erk (mapk) pathway | |
| RS65214B1 (sr) | Modulatori integrisanog puta stresa | |
| JP7378394B2 (ja) | Ｔｉｍ－３およびｐｄ－１経路の二重阻害剤 | |
| KR20190022520A (ko) | Hdac 억제제 및 pd-l1 억제제의 병용 요법 | |
| JP2017528524A5 (https=) | ||
| US11529350B2 (en) | Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof | |
| RU2014152790A (ru) | Пирролопиразоновые ингибиторы танкиразы | |
| US20250339416A1 (en) | Ezh1/2 dual inhibitor-containing pharmaceutical composition to be used as a combination drug | |
| CA2976766A1 (en) | Formylated n-heterocyclic derivatives as fgfr4 inhibitors | |
| RU2017109355A (ru) | Гетероциклические соединения и их применение | |
| JP2021517146A (ja) | １，２，４−オキサジアゾール化合物を用いてｔｉｇｉｔおよびｐｄ−１のシグナル伝達経路をモジュレートする方法 | |
| EA201892460A1 (ru) | Производные аденина как ингибиторы протеинкиназ | |
| JP2018501261A5 (https=) | ||
| JP7293108B2 (ja) | Ａｘｌ阻害剤とＥＧＦＲチロシンキナーゼ阻害薬との併用治療法 | |
| JP2018519332A5 (https=) | ||
| BRPI0409374A (pt) | composto, composição farmacêutica, uso de pelo menos um composto, e, método para o tratamento de um distúrbio médico | |
| JP2018531995A5 (https=) | ||
| US20250188075A1 (en) | Substituted heterocyclic csnk1 inhibitors | |
| JP2018538241A5 (https=) | ||
| HRP20210359T1 (hr) | Spojevi aminotiolestera ili njihove farmaceutski prihvatljive soli, za upotrebu u liječenju raka |