JP2017502957A5 - - Google Patents

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JP2017502957A5
JP2017502957A5 JP2016543097A JP2016543097A JP2017502957A5 JP 2017502957 A5 JP2017502957 A5 JP 2017502957A5 JP 2016543097 A JP2016543097 A JP 2016543097A JP 2016543097 A JP2016543097 A JP 2016543097A JP 2017502957 A5 JP2017502957 A5 JP 2017502957A5
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JP6454349B2 (ja
JP2017502957A (ja
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Priority claimed from PCT/JP2014/084752 external-priority patent/WO2015099196A1/en
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JP2016543097A 2013-12-26 2014-12-25 モノアシルグリセロールリパーゼ（ｍａｇｌ）阻害剤としての４−（ピペラジン−１−イル）−ピロリジン−２−オン化合物 Active JP6454349B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013269244 2013-12-26
JP2013269244 2013-12-26
PCT/JP2014/084752 WO2015099196A1 (en) 2013-12-26 2014-12-25 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (magl) inhibitors

Publications (3)

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JP2017502957A JP2017502957A (ja) 2017-01-26
JP2017502957A5 true JP2017502957A5 (OSRAM) 2017-12-07
JP6454349B2 JP6454349B2 (ja) 2019-01-16

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JP2016543097A Active JP6454349B2 (ja) 2013-12-26 2014-12-25 モノアシルグリセロールリパーゼ（ｍａｇｌ）阻害剤としての４−（ピペラジン−１−イル）−ピロリジン−２−オン化合物

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US (1) US9624170B2 (OSRAM)
EP (1) EP3087067B1 (OSRAM)
JP (1) JP6454349B2 (OSRAM)
WO (1) WO2015099196A1 (OSRAM)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6533799B2 (ja) * 2014-06-09 2019-06-19 武田薬品工業株式会社 放射標識された化合物
EP3268360B1 (en) 2015-03-09 2019-04-24 Bristol-Myers Squibb Company Lactams as inhibitors of rock
WO2016158956A1 (ja) 2015-03-30 2016-10-06 武田薬品工業株式会社 複素環化合物
KR20180030201A (ko) 2015-07-23 2018-03-21 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 화합물
US10434099B2 (en) * 2016-09-22 2019-10-08 The National Institute for Biotechnology in the Negev Ltd. Methods for treating central nervous system disorders using VDAC inhibitors
CN108290889B (zh) * 2015-09-14 2021-08-10 内盖夫国家生物技术研究所 新的哌嗪和哌啶衍生物、它们的合成及其在抑制vdac寡聚化、细胞凋亡和线粒体功能障碍中的用途
US10787423B2 (en) 2015-09-14 2020-09-29 The National Institute For Biotechnolgy In The Negev Ltd. Piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction
EA201890946A1 (ru) 2015-10-14 2018-09-28 Бристол-Маерс Сквибб Компани Селективные антагонисты nr2b
MY194647A (en) * 2016-03-31 2022-12-09 Takeda Pharmaceuticals Co Heterocyclic compound
US10610520B2 (en) 2016-03-31 2020-04-07 Takeda Pharmaceutical Company Limited Heterocyclic compound
JOP20190267A1 (ar) 2017-05-23 2019-11-18 Lundbeck La Jolla Research Center Inc مثبطات بيرازول magl
DK3630744T3 (da) * 2017-05-23 2023-03-06 H Lundbeck As Pyrazol-magl-inhibitorer
US10927105B1 (en) 2017-05-23 2021-02-23 Lundbeck La Jolla Research Center, Inc. Pyrazole MAGL inhibitors
CN107397955A (zh) * 2017-08-23 2017-11-28 上海黛妆国际贸易有限公司 黑色素基因抑制剂
JP7189143B2 (ja) 2017-09-29 2022-12-13 武田薬品工業株式会社 複素環化合物
CN111556867A (zh) * 2017-12-18 2020-08-18 格吕伦塔尔有限公司 经取代的吡咯烷酰胺i
TW201927769A (zh) * 2017-12-18 2019-07-16 德商歌林達有限公司 經取代之吡咯啶醯胺ｉｉ
WO2019178129A1 (en) 2018-03-13 2019-09-19 Shire Human Genetic Therapies, Inc. Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof
IL279688B2 (en) * 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
TW202028209A (zh) * 2018-09-27 2020-08-01 大陸商重慶複創醫藥研究有限公司 作為RET激酶抑制劑的取代的咪唑[1,2-a]吡啶和[1,2,4]三唑[1,5-a]吡啶化合物
CN113382990B (zh) 2019-01-11 2024-11-19 格吕伦塔尔有限公司 取代的吡咯烷酰胺iii
PT4031547T (pt) 2019-09-18 2024-08-27 Takeda Pharmaceuticals Co Inibidores de calicreína plasmática e utilizações dos mesmos
US11370803B2 (en) 2019-09-18 2022-06-28 Takeda Pharmaceutical Company Limited Heteroaryl plasma kallikrein inhibitors
CN115667216B (zh) 2020-04-07 2025-02-18 赛诺菲 用于治疗癌症的作为tead蛋白和hippo-yap1/taz信号传导级联抑制剂的(1h-吲哚-5-基)丙烯酰胺衍生物
EP3892614A1 (en) 2020-04-07 2021-10-13 Sanofi (1h-indol-5-yl)acrylamide derivatives as inhibitors of tead proteins and the hippo-yap1/taz signaling cascade for the treatment of cancer
JP2024510503A (ja) * 2021-03-17 2024-03-07 武田薬品工業株式会社 血漿カリクレイン阻害剤
CN117396473A (zh) * 2021-03-17 2024-01-12 武田药品工业株式会社 血浆激肽释放酶的咪唑并吡啶基抑制剂
EP4333982A1 (en) * 2021-05-06 2024-03-13 Exscientia Al Limited Pkc-theta modulators
WO2023031311A1 (en) * 2021-09-03 2023-03-09 F. Hoffmann-La Roche Ag Magl inhibitors
IL313987A (en) 2021-12-29 2024-08-01 Psy Therapeutics Inc Inhibiting monoacylglycerol lipase (magl)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445792A1 (de) 1964-12-18 1969-01-02 Bayer Ag Verfahren zur Herstellung von Iminopyrrolidonen
BRPI0514077A (pt) * 2004-08-02 2008-05-27 Hoffmann La Roche derivados de benzilóxi como inibidores de maob
JP2009275020A (ja) * 2008-05-16 2009-11-26 Institute Of Physical & Chemical Research 細胞増殖阻害剤
BRPI1014874A2 (pt) 2009-04-22 2016-04-12 Janssen Pharmaceutica Nv piperazinil azetidinil amidas heteroaromáticas e aromáticas como inibidores de monoacilglicerol lipase
AU2010239188B2 (en) * 2009-04-22 2016-03-31 Janssen Pharmaceutica Nv Azetidinyl diamides as monoacylglycerol lipase inhibitors
JP2012524809A (ja) 2009-04-22 2012-10-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ モノアシルグリセロールリパーゼ阻害剤としての複素芳香族及び芳香族ピペラジニルアゼチジニルアミド類
WO2011041713A2 (en) 2009-10-02 2011-04-07 Glaxosmithkline Llc Piperazinyl antiviral agents
WO2011050284A1 (en) * 2009-10-23 2011-04-28 Glaxosmithkline Llc Pyrazolylpyridine antiviral agents
CN103068798A (zh) 2010-09-03 2013-04-24 詹森药业有限公司 作为单酰甘油脂肪酶抑制剂的二-氮杂环丁烷二酰胺
AU2011307252B2 (en) * 2010-09-27 2015-06-25 Janssen Pharmaceutica Nv Oxopiperazine-azetidine amides and oxodiazepine-azetidine amides as monoacylglycerol lipase inhibitors
CN103260703A (zh) 2010-10-22 2013-08-21 詹森药业有限公司 作为单酰甘油脂肪酶抑制剂的哌啶-4-基-氮杂环丁烷二酰胺
US8987247B2 (en) 2011-09-30 2015-03-24 Janssen Pharmaceutica Nv Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders
JP2014528429A (ja) * 2011-09-30 2014-10-27 ヤンセン ファーマシューティカ エヌ．ベー． 代謝症及び関連障害の処置のためのモノアシルグリセロールリパーゼ阻害剤
US9567302B2 (en) * 2012-03-19 2017-02-14 Abide Therapeutics, Inc. Carbamate compounds and of making and using same

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