JP2017502662A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017502662A5 JP2017502662A5 JP2016540591A JP2016540591A JP2017502662A5 JP 2017502662 A5 JP2017502662 A5 JP 2017502662A5 JP 2016540591 A JP2016540591 A JP 2016540591A JP 2016540591 A JP2016540591 A JP 2016540591A JP 2017502662 A5 JP2017502662 A5 JP 2017502662A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- virus
- acid molecule
- prrs virus
- prrs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000700605 Viruses Species 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 6
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 4
- 241000282898 Sus scrofa Species 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims 2
- 230000000241 respiratory Effects 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000001756 Virus Disease Diseases 0.000 claims 1
- 230000002238 attenuated Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002458 infectious Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001681 protective Effects 0.000 claims 1
- 230000001850 reproductive Effects 0.000 claims 1
- 201000010874 syndrome Diseases 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Claims (15)
- 遺伝子型I型PRRSウイルスをコードし、細胞にトランスフェクトしたとき生ウイルスを生成することができる核酸分子であって、配列番号48の核酸配列と少なくとも99.2％の配列同一性を有する核酸配列を含む、前記核酸分子。
- ウイルスが弱毒化され、および／またはウイルスが、イノシシ科動物の豚繁殖および呼吸障害症候群(PRRS)ウイルス感染後の疾患の呼吸障害および／または繁殖障害徴候に対して防御免疫応答を誘導することができる、請求項１に記載の核酸分子。
- ウイルスが、MOI(感染多重度)0.001〜0.1でMA104細胞に感染後24時間以内に、1ミリリットル(ml)当たり少なくとも5x10 5 〜1x10 6 の50％組織培養感染量(TCID 50 )の力価に達することができる、請求項１または２に記載の核酸分子。
- DNA分子である、請求項１〜３のいずれか１項に記載の核酸分子。
- 請求項４に記載のDNA分子を含むDNA構築物。
- 請求項５に記載のDNA構築物のRNA転写産物。
- 請求項５に記載のDNA構築物または請求項６に記載のRNA転写産物でトランスフェクトされた細胞。
- 遺伝子型I型PRRSウイルスであって、そのゲノムが請求項１〜３のいずれか１項に記載の核酸分子を含むか、またはそのゲノムが請求項１〜４のいずれか1項記載の核酸分子によってコードされるRNA分子を含むか、またはそのゲノムが請求項１〜４のいずれか1項記載の核酸分子によってコードされる、遺伝子型I型PRRSウイルス。
- 請求項５に記載のDNA構築物で細胞をトランスフェクトすることを含むか、または請求項６に記載のRNA転写産物で宿主細胞をトランスフェクトすることを含む、遺伝子型I型PRRSウイルスを産生する方法。
- 適切な量の薬学的に許容される希釈剤または賦形剤に懸濁した、請求項１〜３のいずれか１項に記載の核酸分子を含む組成物。
- 豚繁殖および呼吸障害症候群の予防または治療のための、請求項８に記載のPRRSウイルスを含む、医薬組成物。
- イノシシ科動物において豚繁殖および呼吸障害症候群の予防または治療するための、請求項１１記載の医薬組成物。
- 鼻腔内、筋肉内、経口または子宮内経路で動物に投与するための、請求項１１または１２記載の医薬組成物。
- 検出マーカーとしての、請求項８に記載のPRRSウイルスの使用。
- 非ヒト感染動物と非ヒトワクチン接種動物(DIVA)との区別のための、請求項８に記載のPRRSウイルスの使用。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199177.0 | 2013-12-20 | ||
| EP13199177 | 2013-12-20 | ||
| EP14175691.6 | 2014-07-03 | ||
| EP14175691 | 2014-07-03 | ||
| PCT/EP2014/078929 WO2015092058A1 (en) | 2013-12-20 | 2014-12-19 | Prrs virus variant, european prrs virus cdna clone, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019230014A Division JP2020054380A (ja) | 2013-12-20 | 2019-12-20 | ＰＲＲＳウイルス変異株、ヨーロッパ型ＰＲＲＳウイルスｃＤＮＡクローンおよびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017502662A JP2017502662A (ja) | 2017-01-26 |
| JP2017502662A5 true JP2017502662A5 (ja) | 2018-02-08 |
| JP6886291B2 JP6886291B2 (ja) | 2021-06-16 |
Family
ID=52347295
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540591A Active JP6886291B2 (ja) | 2013-12-20 | 2014-12-19 | ＰＲＲＳウイルス変異株、ヨーロッパ型ＰＲＲＳウイルスｃＤＮＡクローンおよびそれらの使用 |
| JP2019230014A Withdrawn JP2020054380A (ja) | 2013-12-20 | 2019-12-20 | ＰＲＲＳウイルス変異株、ヨーロッパ型ＰＲＲＳウイルスｃＤＮＡクローンおよびそれらの使用 |
| JP2021049537A Active JP7158523B2 (ja) | 2013-12-20 | 2021-03-24 | ＰＲＲＳウイルス変異株、ヨーロッパ型ＰＲＲＳウイルスｃＤＮＡクローンおよびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019230014A Withdrawn JP2020054380A (ja) | 2013-12-20 | 2019-12-20 | ＰＲＲＳウイルス変異株、ヨーロッパ型ＰＲＲＳウイルスｃＤＮＡクローンおよびそれらの使用 |
| JP2021049537A Active JP7158523B2 (ja) | 2013-12-20 | 2021-03-24 | ＰＲＲＳウイルス変異株、ヨーロッパ型ＰＲＲＳウイルスｃＤＮＡクローンおよびそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10010601B2 (ja) |
| EP (2) | EP3083947B1 (ja) |
| JP (3) | JP6886291B2 (ja) |
| KR (2) | KR102446025B1 (ja) |
| CN (1) | CN105829528B (ja) |
| AU (2) | AU2014369774B2 (ja) |
| CA (1) | CA2930042C (ja) |
| DK (2) | DK3591042T3 (ja) |
| EA (1) | EA039060B1 (ja) |
| ES (2) | ES2940691T3 (ja) |
| HU (1) | HUE061768T2 (ja) |
| MX (2) | MX2016007737A (ja) |
| WO (1) | WO2015092058A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA031432B1 (ru) | 2011-02-17 | 2019-01-31 | Бёрингер Ингельхайм Ветмедика Гмбх | Способ получения вируса репродуктивно-респираторного сидрома свиней prrs |
| EA038012B1 (ru) | 2011-02-17 | 2021-06-23 | Бёрингер Ингельхайм Ветмедика Гмбх | Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса |
| EA039060B1 (ru) | 2013-12-20 | 2021-11-29 | Бёрингер Ингельхайм Ветмедика Гмбх | Вариант вируса ppcc, способ его получения с помощью молекулы нуклеиновой кислоты, конструкции днк или клетки и его применение для лечения и профилактики ррсс |
| WO2018024677A1 (en) | 2016-08-05 | 2018-02-08 | Hipra Scientific, S.L.U. | PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS cDNA CLONE AND USES THEREOF |
| KR102335864B1 (ko) * | 2018-12-27 | 2021-12-06 | 주식회사 바이오포아 | 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신 |
| WO2020138761A1 (ko) * | 2018-12-27 | 2020-07-02 | 주식회사 바이오포아 | 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신 |
| MX2021015938A (es) * | 2019-08-29 | 2022-04-26 | Elanco Us Inc | Virus para vacuna contra el síndrome respiratorio y reproductivo porcino. |
| CN110894243B (zh) * | 2019-12-16 | 2021-07-13 | 中国农业大学 | 一种猪蓝耳病毒嵌合抗原以及检测猪蓝耳病毒抗体的胶体金免疫层析试纸条 |
| KR20220129567A (ko) | 2019-12-31 | 2022-09-23 | 엘릭서젠 쎄라퓨틱스, 인크. | 핵산 및 단백질의 세포 및 조직으로의 온도-기반 일시적 전달 |
| JP2021153692A (ja) * | 2020-03-25 | 2021-10-07 | 株式会社三共 | 遊技機 |
| KR102319508B1 (ko) * | 2020-07-27 | 2021-10-28 | 연세대학교 산학협력단 | 인체 감염형 낙타 유래 메르스코로나바이러스 검출용 바이오마커 및 이의 용도 |
| CN113969267B (zh) * | 2021-11-15 | 2024-02-27 | 中国农业大学 | 一种猪繁殖与呼吸综合征突变病毒及其构建方法与应用 |
| WO2024077281A2 (en) * | 2022-10-06 | 2024-04-11 | Cornell University | Genotyping and sequencing assays for prrsv |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3137631A (en) | 1959-12-01 | 1964-06-16 | Faberge Inc | Encapsulation in natural products |
| US3959457A (en) | 1970-06-05 | 1976-05-25 | Temple University | Microparticulate material and method of making such material |
| US4015100A (en) | 1974-01-07 | 1977-03-29 | Avco Everett Research Laboratory, Inc. | Surface modification |
| EP0000062A1 (en) | 1977-06-07 | 1978-12-20 | Joseph George Spitzer | Vapor tap valve for aerosol containers used with inflammable propellants, and container provided therewith |
| US4205060A (en) | 1978-12-20 | 1980-05-27 | Pennwalt Corporation | Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use |
| EP0208672B1 (en) | 1985-07-08 | 1993-02-17 | REGION WALLONNE représentée par le Ministre des Technologies pour la Région wallonne dans ses attributions | Vaccines and diagnostics derived from bovine diarrhea virus |
| NZ222465A (en) | 1986-11-07 | 1992-11-25 | Pasteur Institut | Nanb (non a, non b hepatitis viral) antigen |
| HU218431B (hu) | 1991-06-06 | 2000-08-28 | Stichting Centraal Diergeneeskundig Instituut | A rejtélyes sertésvészt okozó Lelystad-vírus, a vírusból származtatható polipeptidek, antigének és nukleinsavak és rejtélyes sertésvész elleni vakcinakészítmények |
| US6042830A (en) | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
| ES2083764T5 (es) | 1991-10-14 | 2009-04-01 | Intervet International Bv | Vacuna para el sindrome respiratorio reproductivo porcino (srrp) y diagnostico. |
| FR2686097B1 (fr) | 1992-01-14 | 1994-12-30 | Rhone Merieux | Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie. |
| US5695766A (en) | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
| ES2074950B1 (es) | 1993-09-17 | 1996-03-16 | Iberica Cyanamid | Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda. |
| EP0676467B1 (en) | 1994-04-11 | 2001-10-04 | Akzo Nobel N.V. | European vaccine strains of the porcine reproductive respiratory syndrome virus (PRRSV) |
| GB2289279B (en) | 1994-05-13 | 1998-09-16 | Iberica Cyanamid | Diagnostic kits and vaccines containing recombinant PRRSV proteins |
| DK0732340T3 (da) | 1995-03-14 | 2004-10-25 | Akzo Nobel Nv | Ekspression af porcine reproduktions- og respirationssyndromviruspolypeptider i den samme celle |
| ES2102971B1 (es) | 1996-01-25 | 1998-03-01 | Hipra Lab Sa | Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion. |
| US5866401A (en) | 1996-03-01 | 1999-02-02 | Schering Corporation | Porcine reproductive and respiratory syndrome vaccine |
| ES2157522T3 (es) | 1996-10-09 | 2001-08-16 | Akzo Nobel Nv | Cepas de vacunas europeas del virus del sindrome respiratorio reproductor porcino (prrsv). |
| EP0839912A1 (en) | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| WO2000053787A1 (en) | 1999-03-08 | 2000-09-14 | Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. | Prrsv vaccines |
| US20040224327A1 (en) | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| UA73915C2 (uk) | 1997-05-06 | 2005-10-17 | Стіхтінг Дінст Ландбаувкюндіг Ондерзук | Пептид, який індукує утворення нейтралізуючих антитіл (варіанти), антитіло, одержане за допомогою вказаного пептиду, імуногенна композиція для індукції нейтралізуючих антитіл, вакцина для профілактики зараження репродуктивно-респіраторним синдромом свиней (ррсс) та діагностичний набір для виявлення або ідентифікації антитіл, специфічних до ізоляту вррсс |
| NZ513289A (en) * | 1998-12-22 | 2003-04-29 | Pfizer Prod Inc | Infectious cDNA clone of north american procine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
| WO2000065032A1 (en) | 1999-04-22 | 2000-11-02 | United States Department Of Agriculture | Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142 |
| WO2002095040A1 (en) | 2001-05-21 | 2002-11-28 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Delections in arterivirus replicons |
| EP1255815B1 (en) | 2000-02-08 | 2006-07-19 | Regents Of The University Of Minnesota | Porcine reproductive and respiratory syndrome virus and methods of use |
| EP1156111A1 (en) | 2000-05-19 | 2001-11-21 | Stichting Dienst Landbouwkundig Onderzoek | Chimeric arterivirus-like particles |
| ATE557082T1 (de) | 2002-04-05 | 2012-05-15 | Boehringer Ingelheim Vetmed | Sequenz positionen zur anpassung bei prrsv |
| US7722878B2 (en) | 2004-06-17 | 2010-05-25 | Boehringer Ingelheim Vetmedica, Inc. | PRRSV subunit vaccines |
| US7632636B2 (en) | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
| DE602006013270D1 (en) | 2005-01-13 | 2010-05-12 | Boehringer Ingelheim Vetmed | Prrs-impfstoffe |
| WO2008121958A1 (en) | 2007-04-02 | 2008-10-09 | Boehringer Ingelheim Vetmedica, Inc. | Use of prrsv vaccines to reduce pcv2 viremia |
| CN101848995A (zh) * | 2007-06-25 | 2010-09-29 | 南达科他州立大学 | 重组的北美1型猪繁殖与呼吸综合征病毒及使用方法 |
| RU2561595C2 (ru) | 2008-08-25 | 2015-08-27 | Бёрингер Ингельхайм Ветмедика, Инк. | Вакцина против высокопатогенного репродуктивно-респираторного синдрома свиней (hp prrs) |
| WO2010084648A1 (ja) * | 2009-01-20 | 2010-07-29 | シャープ株式会社 | 照明装置、表示装置、及びテレビ受信装置 |
| EP2558118B1 (en) | 2010-04-16 | 2019-06-05 | Universiteit Gent | Cross-protecting vaccine for porcine reproductive and respiratory syndrome virus |
| EA031432B1 (ru) | 2011-02-17 | 2019-01-31 | Бёрингер Ингельхайм Ветмедика Гмбх | Способ получения вируса репродуктивно-респираторного сидрома свиней prrs |
| EA038012B1 (ru) | 2011-02-17 | 2021-06-23 | Бёрингер Ингельхайм Ветмедика Гмбх | Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса |
| EP2737059A1 (en) | 2011-07-29 | 2014-06-04 | Boehringer Ingelheim Vetmedica GmbH | Novel prrs virus inducing type i interferon in susceptible cells |
| CN104203271B (zh) * | 2012-02-14 | 2017-08-25 | 梅里亚股份有限公司 | 表达狂犬病病毒和ox40蛋白的重组痘病毒载体及从其制造的疫苗 |
| JP6386999B2 (ja) * | 2012-05-17 | 2018-09-05 | ゾエティス・エルエルシー | ブタ生殖および呼吸症候群（ｐｒｒｓ）ウイルスに対する離乳前の効果的なワクチン接種 |
| CN105073130A (zh) | 2013-03-15 | 2015-11-18 | 勃林格殷格翰动物保健公司 | 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法 |
| CN105829906B (zh) * | 2013-12-19 | 2020-11-03 | 皇家飞利浦有限公司 | 具有水/脂肪分离的相位敏感的反转恢复mri |
| EA039060B1 (ru) | 2013-12-20 | 2021-11-29 | Бёрингер Ингельхайм Ветмедика Гмбх | Вариант вируса ppcc, способ его получения с помощью молекулы нуклеиновой кислоты, конструкции днк или клетки и его применение для лечения и профилактики ррсс |
-
2014
- 2014-12-19 EA EA201600476A patent/EA039060B1/ru unknown
- 2014-12-19 MX MX2016007737A patent/MX2016007737A/es active IP Right Grant
- 2014-12-19 ES ES19165389T patent/ES2940691T3/es active Active
- 2014-12-19 HU HUE19165389A patent/HUE061768T2/hu unknown
- 2014-12-19 AU AU2014369774A patent/AU2014369774B2/en active Active
- 2014-12-19 WO PCT/EP2014/078929 patent/WO2015092058A1/en active Application Filing
- 2014-12-19 ES ES14827219T patent/ES2729838T3/es active Active
- 2014-12-19 EP EP14827219.8A patent/EP3083947B1/en active Active
- 2014-12-19 US US15/105,760 patent/US10010601B2/en active Active
- 2014-12-19 DK DK19165389.8T patent/DK3591042T3/da active
- 2014-12-19 EP EP19165389.8A patent/EP3591042B1/en active Active
- 2014-12-19 CN CN201480068965.2A patent/CN105829528B/zh active Active
- 2014-12-19 KR KR1020217019360A patent/KR102446025B1/ko active IP Right Grant
- 2014-12-19 JP JP2016540591A patent/JP6886291B2/ja active Active
- 2014-12-19 MX MX2020010248A patent/MX2020010248A/es unknown
- 2014-12-19 KR KR1020167019672A patent/KR102270344B1/ko active IP Right Grant
- 2014-12-19 DK DK14827219.8T patent/DK3083947T3/da active
- 2014-12-19 CA CA2930042A patent/CA2930042C/en active Active
-
2018
- 2018-06-01 US US15/995,560 patent/US10639364B2/en active Active
-
2019
- 2019-12-20 JP JP2019230014A patent/JP2020054380A/ja not_active Withdrawn
-
2021
- 2021-02-25 AU AU2021201224A patent/AU2021201224B2/en active Active
- 2021-03-24 JP JP2021049537A patent/JP7158523B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017502662A5 (ja) | ||
| Kamel et al. | Foot-and-mouth disease vaccines: recent updates and future perspectives | |
| Qin et al. | Pathotypical characterization and molecular epidemiology of Newcastle disease virus isolates from different hosts in China from 1996 to 2005 | |
| De Los Santos et al. | The need for improved vaccines against foot-and-mouth disease | |
| Vander Veen et al. | Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine | |
| Zhu | SARS immunity and vaccination | |
| US11993789B2 (en) | Pichinde virus reverse genetics systems and methods of use | |
| Wang et al. | Orf virus: A promising new therapeutic agent | |
| JP2017522907A5 (ja) | ||
| Nunes et al. | A synthetic biology approach for a vaccine platform against known and newly emerging serotypes of bluetongue virus | |
| Barkhouse et al. | Expression of interferon gamma by a recombinant rabies virus strongly attenuates the pathogenicity of the virus via induction of type I interferon | |
| Li et al. | Adjuvant effects of interleukin-18 in DNA vaccination against infectious bursal disease virus in chickens | |
| Sun et al. | Methyltransferase-defective avian metapneumovirus vaccines provide complete protection against challenge with the homologous Colorado strain and the heterologous Minnesota strain | |
| US20210401983A1 (en) | Arthrogenic alphavirus vaccine | |
| Wu et al. | Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ‐2012 Isolated from Fujian, Southern China | |
| Zhang et al. | Construction and immunological evaluation of recombinant Newcastle disease virus vaccines expressing highly pathogenic porcine reproductive and respiratory syndrome virus GP3/GP5 proteins in pigs | |
| Wang et al. | Colloidal manganese salt improves the efficacy of rabies vaccines in mice, cats, and dogs | |
| Maekawa et al. | Protection efficacy of a recombinant herpesvirus of Turkey vaccine against infectious laryngotracheitis virus administered in ovo to broilers at three standardized doses | |
| Guo et al. | Recombinant infectious hematopoietic necrosis virus expressing infectious pancreatic necrosis virus VP2 protein induces immunity against both pathogens | |
| US11123421B2 (en) | Cold adapted and virulence factor deleted live attenuated vaccine suitable for mucosal delivery | |
| Kim et al. | Cross-protective immune responses elicited by a Korean variant of infectious bronchitis virus | |
| Li et al. | Evaluation of immunogenicity and protective efficacy of a novel Senecavirus A strain-based inactivated vaccine in mice | |
| ES2842595T3 (es) | Vacuna contra la rinitis equina | |
| JP2012517239A5 (ja) | ||
| Kim et al. | Stability and efficacy of the 3′-UTR A4G-G5A variant of viral hemorrhagic septicemia virus (VHSV) as a live attenuated immersion VHSV vaccine in olive flounder (Paralichthys olivaceus) |