JP2017501738A5 - - Google Patents
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- Publication number
- JP2017501738A5 JP2017501738A5 JP2016545837A JP2016545837A JP2017501738A5 JP 2017501738 A5 JP2017501738 A5 JP 2017501738A5 JP 2016545837 A JP2016545837 A JP 2016545837A JP 2016545837 A JP2016545837 A JP 2016545837A JP 2017501738 A5 JP2017501738 A5 JP 2017501738A5
- Authority
- JP
- Japan
- Prior art keywords
- plant
- sequence
- nucleotide sequence
- expression system
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 21
- 125000003729 nucleotide group Chemical group 0.000 claims 21
- 239000003623 enhancer Substances 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 241000723655 Cowpea mosaic virus Species 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 101710154606 Hemagglutinin Proteins 0.000 claims 3
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 3
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 3
- 101710176177 Protein A56 Proteins 0.000 claims 3
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 3
- 108010067390 Viral Proteins Proteins 0.000 claims 3
- 239000000185 hemagglutinin Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 102000006010 Protein Disulfide-Isomerase Human genes 0.000 claims 2
- 230000030279 gene silencing Effects 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 108020003519 protein disulfide isomerase Proteins 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 1
- 102000007469 Actins Human genes 0.000 claims 1
- 108010085238 Actins Proteins 0.000 claims 1
- 241000723607 Comovirus Species 0.000 claims 1
- 108090000051 Plastocyanin Proteins 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461925852P | 2014-01-10 | 2014-01-10 | |
| US61/925,852 | 2014-01-10 | ||
| PCT/CA2014/050326 WO2014153674A1 (en) | 2013-03-28 | 2014-03-28 | Influenza virus-like particle production in plants |
| CAPCT/CA2014/050326 | 2014-03-28 | ||
| PCT/CA2015/050009 WO2015103704A1 (en) | 2014-01-10 | 2015-01-08 | Cpmv enhancer elements |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501738A JP2017501738A (ja) | 2017-01-19 |
| JP2017501738A5 true JP2017501738A5 (enExample) | 2018-02-15 |
| JP6518257B2 JP6518257B2 (ja) | 2019-05-22 |
Family
ID=53523412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016545837A Active JP6518257B2 (ja) | 2014-01-10 | 2015-01-08 | Cpmvエンハンサーエレメント |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11441150B2 (enExample) |
| EP (1) | EP3092309B1 (enExample) |
| JP (1) | JP6518257B2 (enExample) |
| CN (1) | CN105980561B (enExample) |
| AU (1) | AU2015205805B2 (enExample) |
| BR (1) | BR112016015875A2 (enExample) |
| CA (1) | CA2936350C (enExample) |
| DK (1) | DK3092309T3 (enExample) |
| ES (1) | ES2864081T3 (enExample) |
| RU (1) | RU2699982C2 (enExample) |
| TW (1) | TWI714522B (enExample) |
| WO (1) | WO2015103704A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| DK3092309T3 (da) * | 2014-01-10 | 2021-04-12 | Medicago Inc | Cpmv-forstærkerelementer |
| MX2020009495A (es) * | 2018-03-14 | 2020-12-07 | Medicago Inc | Potenciador de la expresion en plantas. |
| JP7512546B2 (ja) * | 2019-03-14 | 2024-07-09 | アラミス バイオテクノロジーズ インコーポレイテッド | 内因性植物発現エンハンサー |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9414118D0 (en) | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
| US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| US20010006950A1 (en) | 1998-02-11 | 2001-07-05 | Juha Punnonen | Genetic vaccine vector engineering |
| US6489537B1 (en) | 1998-08-07 | 2002-12-03 | The Trustees Of The University Of Pennsylvania | Phytochelatin synthases and uses therefor |
| US6287570B1 (en) | 1998-11-23 | 2001-09-11 | Patricia L. Foley | Vaccine against swine influenza virus |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| EP2287185A3 (en) | 1999-12-06 | 2012-10-10 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| DE10109354A1 (de) | 2001-02-27 | 2002-09-05 | Icon Genetics Ag | Rekombinante virale Schaltersysteme |
| RU2326167C2 (ru) * | 2002-12-27 | 2008-06-10 | Сентро Де Инженьериа Генетика И Биотекнологиа | Искусственный промотор для экспрессии последовательностей днк в растительных клетках |
| CA2524799A1 (en) | 2003-05-05 | 2004-11-18 | Dow Agrosciences Llc | Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production |
| NZ543348A (en) | 2003-05-05 | 2008-08-29 | Thompson Boyce Plant Res | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
| US7566458B2 (en) | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| US8080255B2 (en) | 2003-07-11 | 2011-12-20 | Novavax Inc. | Functional influenza virus like particles (VLPs) |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| PL1883701T3 (pl) | 2005-04-29 | 2012-06-29 | Univ Cape Town | Ekspresja białek wirusa w roślinach |
| US20090117144A1 (en) | 2005-07-19 | 2009-05-07 | Lada Rasochova | Recombinant flu vaccines |
| SI1937301T1 (sl) | 2005-10-18 | 2015-08-31 | Novavax, Inc. | Funkcionalni influenčnemu virusu podobni delci (VLP) |
| AU2007215080A1 (en) | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Influenza antigens, vaccine compositions, and related methods |
| AU2007224034B2 (en) | 2006-03-07 | 2012-03-29 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| US7618815B2 (en) | 2006-03-08 | 2009-11-17 | University Of Kentucky Research Foundation | Viral vectors useful in soybean and methods of use |
| EP2029755A1 (en) * | 2006-05-22 | 2009-03-04 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| US8697088B2 (en) | 2007-05-25 | 2014-04-15 | Novavax, Inc. | VLPs derived from cells that do not express a viral matrix or core protein |
| AU2009202819B2 (en) | 2007-07-13 | 2014-08-28 | Aramis Biotechnologies Inc. | Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin |
| GB0724752D0 (en) * | 2007-12-19 | 2008-01-30 | Bari Mazhar A | Method for producing a thermoelectric material |
| GB0800272D0 (en) * | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| EA034733B1 (ru) * | 2008-01-21 | 2020-03-13 | Медикаго Инк. | Нуклеиновая кислота для увеличенной экспрессии гемагглютинина вируса гриппа в растении и ее применение |
| JP2012521786A (ja) | 2009-03-30 | 2012-09-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
| CN102482328B (zh) * | 2009-06-24 | 2014-11-26 | 麦迪卡格公司 | 包含血凝素的嵌合流感病毒样颗粒 |
| KR20120093193A (ko) | 2009-09-04 | 2012-08-22 | 신젠타 파티서페이션즈 아게 | 식물 폴리펩티드 발현 증가를 위한 번역 향상제 요소의 적층 |
| SI2480560T1 (en) | 2009-09-22 | 2018-04-30 | Medicago Inc. | A process for preparing proteins derived from plants |
| CA2813078A1 (en) | 2010-10-04 | 2012-04-12 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| US20130295609A1 (en) | 2010-11-04 | 2013-11-07 | Medicago Inc. | Plant expression system |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| US20140227322A1 (en) | 2011-06-13 | 2014-08-14 | Medicago Inc. | Rabies virus like particle production in plants |
| PL220281B1 (pl) | 2011-09-23 | 2015-09-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA |
| CA2850407C (en) | 2011-09-30 | 2021-11-23 | Medicago Inc. | Increasing virus-like particle yield in plants |
| CA2855252C (en) * | 2011-11-11 | 2023-03-07 | Philip Morris Products S.A. | Influenza virus-like particles (vlps) comprising hemagglutinin produced in nicotiana tabacum |
| JP6205359B2 (ja) | 2012-07-23 | 2017-09-27 | 有限会社生物資源研究所 | ワクチン |
| JP2016516415A (ja) | 2013-03-28 | 2016-06-09 | メディカゴ インコーポレイテッド | 植物におけるインフルエンザウイルス様粒子の生成 |
| DK3092309T3 (da) * | 2014-01-10 | 2021-04-12 | Medicago Inc | Cpmv-forstærkerelementer |
| WO2015143567A1 (en) * | 2014-03-27 | 2015-10-01 | Medicago Inc. | Modified cpmv enhancer elements |
-
2015
- 2015-01-08 DK DK15735364.0T patent/DK3092309T3/da active
- 2015-01-08 BR BR112016015875A patent/BR112016015875A2/pt not_active IP Right Cessation
- 2015-01-08 WO PCT/CA2015/050009 patent/WO2015103704A1/en not_active Ceased
- 2015-01-08 AU AU2015205805A patent/AU2015205805B2/en active Active
- 2015-01-08 US US15/110,696 patent/US11441150B2/en active Active
- 2015-01-08 ES ES15735364T patent/ES2864081T3/es active Active
- 2015-01-08 CN CN201580007060.9A patent/CN105980561B/zh not_active Expired - Fee Related
- 2015-01-08 RU RU2016132865A patent/RU2699982C2/ru active
- 2015-01-08 JP JP2016545837A patent/JP6518257B2/ja active Active
- 2015-01-08 EP EP15735364.0A patent/EP3092309B1/en active Active
- 2015-01-08 CA CA2936350A patent/CA2936350C/en active Active
- 2015-01-08 TW TW104100482A patent/TWI714522B/zh not_active IP Right Cessation
-
2020
- 2020-05-21 US US16/880,583 patent/US11884929B2/en active Active
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