JP2017501211A - 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ - Google Patents

生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ Download PDF

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Publication number
JP2017501211A
JP2017501211A JP2016552481A JP2016552481A JP2017501211A JP 2017501211 A JP2017501211 A JP 2017501211A JP 2016552481 A JP2016552481 A JP 2016552481A JP 2016552481 A JP2016552481 A JP 2016552481A JP 2017501211 A JP2017501211 A JP 2017501211A
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Prior art keywords
antibody
seq
amino acid
chain variable
acid sequence
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Japanese (ja)
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JP2017501211A5 (enExample
Inventor
ヴィジャエンドラン，ラヴィ，エー．
ヴェンカタスッバラオ，スリヴァスタ
Original Assignee
アスチュート メディカル，インコーポレイテッド
アスチュート メディカル，インコーポレイテッド
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Publication of JP2017501211A publication Critical patent/JP2017501211A/ja
Publication of JP2017501211A5 publication Critical patent/JP2017501211A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4745—Insulin-like growth factor binding protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2016552481A 2013-11-06 2014-11-06 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ Pending JP2017501211A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361900942P 2013-11-06 2013-11-06
US61/900,942 2013-11-06
US201462054324P 2014-09-23 2014-09-23
US62/054,324 2014-09-23
US201462064380P 2014-10-15 2014-10-15
US62/064,380 2014-10-15
PCT/US2014/064327 WO2015069880A1 (en) 2013-11-06 2014-11-06 Assays for igfbp7 having improved performance in biological samples

Related Child Applications (1)

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JP2019212462A Division JP2020048569A (ja) 2013-11-06 2019-11-25 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ

Publications (2)

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JP2017501211A true JP2017501211A (ja) 2017-01-12
JP2017501211A5 JP2017501211A5 (enExample) 2017-11-24

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JP2016552481A Pending JP2017501211A (ja) 2013-11-06 2014-11-06 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ
JP2019212462A Pending JP2020048569A (ja) 2013-11-06 2019-11-25 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ
JP2022003920A Active JP7277623B2 (ja) 2013-11-06 2022-01-13 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ
JP2023000938A Pending JP2023052239A (ja) 2013-11-06 2023-01-06 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ

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JP2019212462A Pending JP2020048569A (ja) 2013-11-06 2019-11-25 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ
JP2022003920A Active JP7277623B2 (ja) 2013-11-06 2022-01-13 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ
JP2023000938A Pending JP2023052239A (ja) 2013-11-06 2023-01-06 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ

Country Status (12)

Country Link
US (3) US9822172B2 (enExample)
EP (2) EP3556863B1 (enExample)
JP (4) JP2017501211A (enExample)
KR (1) KR102404285B1 (enExample)
CN (1) CN105793439B (enExample)
AU (1) AU2014346695B2 (enExample)
BR (1) BR112016010106A2 (enExample)
CA (2) CA3185700A1 (enExample)
EA (1) EA201690731A1 (enExample)
HK (1) HK1221490A1 (enExample)
MX (1) MX375701B (enExample)
WO (1) WO2015069880A1 (enExample)

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NZ625423A (en) 2009-12-20 2015-02-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011162821A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3540440B1 (en) 2011-12-08 2022-09-28 Astute Medical, Inc. Methods and uses for evaluating renal injury and renal status
TR201807542T4 (tr) 2013-01-17 2018-06-21 Astute Medical Inc Böbrek hasarı ve böbrek yetmezliği teşhisi ve prognozuna yönelik metotlar ve bileşimler.
WO2015084939A1 (en) 2013-12-03 2015-06-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3281011B1 (en) 2015-04-09 2024-06-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR102083104B1 (ko) 2015-10-08 2020-02-28 에프. 호프만-라 로슈 아게 수술 전 측정시 ａｋｉ 의 위험 예측을 위한 ｉｇｆｂｐ７
WO2017214203A1 (en) 2016-06-06 2017-12-14 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
WO2018145117A1 (en) 2017-02-06 2018-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US11718682B2 (en) 2017-04-05 2023-08-08 Astute Medical, Inc. Assays for TIMP2 having improved performance in biological samples
JP2021526221A (ja) 2018-05-24 2021-09-30 レニバス・セラピューティクス・インコーポレイテッド 腎障害及び腎不全のリスクのある患者を治療する方法
WO2020234482A1 (en) * 2019-05-21 2020-11-26 Universität Zürich MAPKi RESISTANCE SIGNATURES
KR102533791B1 (ko) * 2022-09-15 2023-05-18 경북대학교 산학협력단 비색법 신호형질 복합체, 이를 이용하는 신장질환 진단용 키트 및 진단법

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Also Published As

Publication number Publication date
JP2020048569A (ja) 2020-04-02
BR112016010106A2 (pt) 2017-12-05
EP3556863B1 (en) 2024-09-18
EP3066221A1 (en) 2016-09-14
AU2014346695B2 (en) 2020-10-15
KR102404285B1 (ko) 2022-05-31
WO2015069880A1 (en) 2015-05-14
JP2022068143A (ja) 2022-05-09
JP7277623B2 (ja) 2023-05-19
CA2929547C (en) 2023-02-28
MX375701B (es) 2025-03-06
US9822172B2 (en) 2017-11-21
EA201690731A1 (ru) 2016-10-31
CA3185700A1 (en) 2015-05-14
US10562961B2 (en) 2020-02-18
US20160289308A1 (en) 2016-10-06
AU2014346695A1 (en) 2016-06-16
KR20160068988A (ko) 2016-06-15
CA2929547A1 (en) 2015-05-14
MX2016005834A (es) 2016-11-17
HK1221490A1 (zh) 2017-06-02
EP3556863A1 (en) 2019-10-23
CN105793439A (zh) 2016-07-20
CN105793439B (zh) 2020-09-04
EP3066221A4 (en) 2017-09-20
US20180066045A1 (en) 2018-03-08
US20200247879A1 (en) 2020-08-06
JP2023052239A (ja) 2023-04-11

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