JP2017214410A5 - - Google Patents
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- Publication number
- JP2017214410A5 JP2017214410A5 JP2017135811A JP2017135811A JP2017214410A5 JP 2017214410 A5 JP2017214410 A5 JP 2017214410A5 JP 2017135811 A JP2017135811 A JP 2017135811A JP 2017135811 A JP2017135811 A JP 2017135811A JP 2017214410 A5 JP2017214410 A5 JP 2017214410A5
- Authority
- JP
- Japan
- Prior art keywords
- thiophen
- biphenyl
- ethoxy
- carbonyl
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BMBXBJUGRINIDQ-MRXNPFEDSA-N 1-[4-[4-[5-chloro-3-[[(1r)-1-thiophen-2-ylethoxy]carbonylamino]thiophen-2-yl]-2-methoxyphenyl]phenyl]cyclopropane-1-carboxylic acid Chemical compound COC1=CC(C2=C(C=C(Cl)S2)NC(=O)O[C@H](C)C=2SC=CC=2)=CC=C1C(C=C1)=CC=C1C1(C(O)=O)CC1 BMBXBJUGRINIDQ-MRXNPFEDSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012286425 | 2012-12-28 | ||
| JP2012286425 | 2012-12-28 | ||
| JP2013097171 | 2013-05-02 | ||
| JP2013097171 | 2013-05-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554626A Division JP6176258B2 (ja) | 2012-12-28 | 2013-12-27 | ハロゲン置換へテロ環化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018188246A Division JP6569792B2 (ja) | 2012-12-28 | 2018-10-03 | ハロゲン置換へテロ環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017214410A JP2017214410A (ja) | 2017-12-07 |
| JP2017214410A5 true JP2017214410A5 (enExample) | 2018-02-08 |
| JP6414286B2 JP6414286B2 (ja) | 2018-10-31 |
Family
ID=51021433
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554626A Active JP6176258B2 (ja) | 2012-12-28 | 2013-12-27 | ハロゲン置換へテロ環化合物 |
| JP2017135811A Active JP6414286B2 (ja) | 2012-12-28 | 2017-07-11 | ハロゲン置換へテロ環化合物 |
| JP2018188246A Active JP6569792B2 (ja) | 2012-12-28 | 2018-10-03 | ハロゲン置換へテロ環化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554626A Active JP6176258B2 (ja) | 2012-12-28 | 2013-12-27 | ハロゲン置換へテロ環化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018188246A Active JP6569792B2 (ja) | 2012-12-28 | 2018-10-03 | ハロゲン置換へテロ環化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10000463B2 (enExample) |
| EP (2) | EP2940013B1 (enExample) |
| JP (3) | JP6176258B2 (enExample) |
| KR (1) | KR102189166B1 (enExample) |
| CN (2) | CN104884447B (enExample) |
| AU (1) | AU2013366898B2 (enExample) |
| BR (1) | BR112015015275B1 (enExample) |
| CA (1) | CA2896701C (enExample) |
| DK (2) | DK3360869T3 (enExample) |
| ES (2) | ES2667798T3 (enExample) |
| MX (1) | MX369801B (enExample) |
| RU (2) | RU2756506C2 (enExample) |
| WO (1) | WO2014104372A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2940013B1 (en) * | 2012-12-28 | 2018-02-21 | Ube Industries, Ltd. | Halogen-substituted heterocyclic compound |
| SG11201507459YA (en) | 2013-03-15 | 2015-10-29 | Epigen Biosciences Inc | Heterocyclic compounds useful in the treatment of disease |
| JP2014231508A (ja) * | 2013-05-02 | 2014-12-11 | 宇部興産株式会社 | ハロゲン置換へテロ環化合物 |
| WO2015199234A1 (ja) * | 2014-06-27 | 2015-12-30 | 宇部興産株式会社 | ハロゲン置換へテロ環化合物の塩 |
| JPWO2017086430A1 (ja) * | 2015-11-20 | 2018-09-06 | 宇部興産株式会社 | Ｎａｓｈの治療又は予防のための医薬組成物 |
| IL289951B2 (en) * | 2019-07-30 | 2025-10-01 | Taisho Pharmaceutical Co Ltd | Urea compound as an LPA1 receptor antagonist |
| CN114728168B (zh) | 2019-11-15 | 2024-04-09 | 吉利德科学公司 | 三唑氨基甲酸酯吡啶基磺酰胺作为lpa受体拮抗剂及其用途 |
| TWI843503B (zh) | 2020-06-03 | 2024-05-21 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| US11702407B2 (en) | 2020-06-03 | 2023-07-18 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
| CN111909170B (zh) * | 2020-09-11 | 2022-08-12 | 吉林奥来德光电材料股份有限公司 | 一种有机电致发光化合物、其制备方法以及包含该有机电致发光化合物的有机电致发光器件 |
| JP7859068B2 (ja) * | 2021-01-28 | 2026-05-15 | 大正製薬株式会社 | Ｌｐａ１受容体を拮抗するウレア化合物を有効成分として含有する医薬 |
| AU2022273631B2 (en) | 2021-05-11 | 2025-04-17 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| KR20240007233A (ko) | 2021-05-13 | 2024-01-16 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
| US11939318B2 (en) | 2021-12-08 | 2024-03-26 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
| CA3222642A1 (en) | 2022-12-12 | 2024-06-12 | Bmic Llc | Downstream uses for briquettes and other forms of powder from asphalt shingle waste |
| WO2026094986A1 (en) * | 2024-11-01 | 2026-05-07 | Hilung Inc. | Dry powder pharmaceutical composition for inhalation comprising small molecule lpa1 antagonist and process for preparation thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE420878T1 (de) * | 2000-02-18 | 2009-01-15 | Kyowa Hakko Kirin Co Ltd | Isoxazol- und thiazolverbindungen und ihre verwendung als medikamente |
| EP1364659B1 (en) | 2001-02-08 | 2009-11-11 | Ono Pharmaceutical Co., Ltd. | Remedies for urinary diseases comprising lpa receptor controlling agents |
| JP4692281B2 (ja) * | 2003-08-05 | 2011-06-01 | 味の素株式会社 | 新規アゾール化合物 |
| MX2011003383A (es) | 2008-09-29 | 2011-04-21 | Lilly Co Eli | Modulador selectivo del receptor de estrogeno para el tratamiento de osteoartritis. |
| GB2466121B (en) | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
| GB2470833B (en) | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| JP2013501064A (ja) | 2009-08-04 | 2013-01-10 | アミラ ファーマシューティカルス，インコーポレーテッド | リゾホスファチジン酸受容体アンタゴニストとしての化合物 |
| GB2474748B (en) | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| WO2011091167A2 (en) | 2010-01-22 | 2011-07-28 | The General Hospital Corporation | Lysophosphatidic acid receptor targeting for scleroderma and other fibrotic diseases |
| WO2011159635A1 (en) | 2010-06-15 | 2011-12-22 | Amira Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonist for the treatment of dermal conditions |
| WO2011159633A1 (en) | 2010-06-15 | 2011-12-22 | Amira Pharmaceuticals, Inc. | Inhalable formulations of lysophosphatdic acid receptor antagonists |
| WO2011159632A1 (en) | 2010-06-15 | 2011-12-22 | Amira Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonists for the treatment of conditions or diseases of the eye |
| CN107721940A (zh) | 2010-12-07 | 2018-02-23 | 阿米拉制药公司 | 多环lpa1拮抗剂及其使用 |
| WO2012078593A2 (en) | 2010-12-07 | 2012-06-14 | Amira Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonists and uses thereof |
| CN103596947A (zh) | 2011-04-05 | 2014-02-19 | 艾米拉医药股份有限公司 | 用于治疗纤维化、疼痛、癌症和呼吸、过敏性、神经系统疾病或心血管疾病的基于3-或5-联苯-4-基异噁唑的化合物 |
| WO2012138648A1 (en) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
| EP2744807A4 (en) | 2011-08-15 | 2015-03-04 | Intermune Inc | COMPOUNDS AS LYSOPHOSPHIC ACID RECEPTOR ANTAGONISTS |
| EP2940013B1 (en) * | 2012-12-28 | 2018-02-21 | Ube Industries, Ltd. | Halogen-substituted heterocyclic compound |
-
2013
- 2013-12-27 EP EP13868493.1A patent/EP2940013B1/en active Active
- 2013-12-27 EP EP18157384.1A patent/EP3360869B1/en active Active
- 2013-12-27 WO PCT/JP2013/085277 patent/WO2014104372A1/ja not_active Ceased
- 2013-12-27 KR KR1020157019230A patent/KR102189166B1/ko active Active
- 2013-12-27 JP JP2014554626A patent/JP6176258B2/ja active Active
- 2013-12-27 ES ES13868493.1T patent/ES2667798T3/es active Active
- 2013-12-27 ES ES18157384T patent/ES2825031T3/es active Active
- 2013-12-27 RU RU2018109925A patent/RU2756506C2/ru active
- 2013-12-27 RU RU2015131139A patent/RU2649398C2/ru active
- 2013-12-27 DK DK18157384.1T patent/DK3360869T3/da active
- 2013-12-27 CN CN201380068911.1A patent/CN104884447B/zh active Active
- 2013-12-27 DK DK13868493.1T patent/DK2940013T3/en active
- 2013-12-27 MX MX2015008479A patent/MX369801B/es active IP Right Grant
- 2013-12-27 BR BR112015015275-9A patent/BR112015015275B1/pt active IP Right Grant
- 2013-12-27 AU AU2013366898A patent/AU2013366898B2/en active Active
- 2013-12-27 CN CN201710949188.8A patent/CN107698555B/zh active Active
- 2013-12-27 CA CA2896701A patent/CA2896701C/en active Active
-
2015
- 2015-06-26 US US14/752,623 patent/US10000463B2/en active Active
-
2017
- 2017-07-11 JP JP2017135811A patent/JP6414286B2/ja active Active
-
2018
- 2018-05-08 US US15/974,494 patent/US10597375B2/en active Active
- 2018-10-03 JP JP2018188246A patent/JP6569792B2/ja active Active
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