JP2017207289A - 分析方法及び分析装置 - Google Patents
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- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
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Abstract
【解決手段】検出対象物質11と検出対象物質11を標識するための金属化合物である微粒子20とが捕捉されている反応領域10を有する、樹脂材料で形成された分析用基板1にレーザ光を照射する(ステップS2)。分析用基板1からの反射光を受光して生成された信号レベルを基板信号レベルDLとして抽出する(ステップS4)。反応領域10からの反射光を受光して受光レベル信号JSを生成する(ステップS6)。反応領域10における分析用基板1からの反射光の受光レベルよりも高い信号レベルの受光レベル信号JSを微粒子検出信号KSとして抽出する(ステップS7)。抽出された微粒子検出信号KSに基づいて微粒子20を検出する(ステップS8)。
【選択図】図5
Description
図1〜図3を用いて、分析用基板に反応領域を形成する方法を説明する。
図4を用いて、分析用基板1の反応領域10に捕捉されている微粒子20を検出するための分析装置の構成例を説明する。
図5のフローチャートを用いて、微粒子20の分析方法(検出対象物質11の分析方法)を説明する。なお、試料液によっては検出対象物質11が含まれていない場合もある。この場合、分析用基板1の反応領域10には検出対象物質11及び微粒子20が捕捉されない。そこで、説明を分かりやすくするために、反応領域10に検出対象物質11及び微粒子20が捕捉されている場合について説明する。
9 未反応領域
10 反応領域
11 検出対象物質
20 微粒子
40 光ピックアップ
40a レーザ光
51 基板レベル検出回路
54 判定回路
55 計数回路
JS 受光レベル信号
KS 微粒子検出信号
Claims (5)
- 検出対象物質と前記検出対象物質を標識するための金属化合物である微粒子とが捕捉されている反応領域を有する、樹脂材料で形成された分析用基板にレーザ光を照射し、
前記分析用基板からの反射光を受光して生成された信号レベルを基板信号レベルとして抽出し、
前記反応領域からの反射光を受光して受光レベル信号を生成し、
前記反応領域において前記基板信号レベルよりも高い信号レベルの受光レベル信号を微粒子検出信号として抽出し、
抽出された微粒子検出信号に基づいて前記微粒子を検出する
ことを特徴とする分析方法。 - 前記微粒子は、複素屈折率n−kiの虚数部kiの消衰係数kが0.3以下で、かつ、実数部の屈折率nが2.1〜2.5の範囲、または、消衰係数kが0.2以下で、かつ、屈折率nが2.1〜2.6の範囲を有する
ことを特徴とする請求項1に記載の分析方法。 - 前記微粒子は樹脂被膜で被覆されている
ことを特徴とする請求項1または2に記載の分析方法。 - 前記微粒子は磁性体が内包されている
ことを特徴とする請求項1または2に記載の分析方法。 - 検出対象物質と前記検出対象物質を標識するための金属化合物である微粒子とが捕捉されている反応領域を有する、樹脂材料で形成された分析用基板にレーザ光を照射し、前記反応領域、及び、前記反応領域が形成されていない未反応領域からの反射光の受光レベルを検出して受光レベル信号を生成する光ピックアップと、
前記未反応領域からの受光レベル信号の信号レベルを基板信号レベルとして抽出する基板レベル検出回路と、
前記反応領域において前記基板信号レベルよりも高い信号レベルの受光レベル信号を微粒子検出信号として抽出する判定回路と、
前記微粒子検出信号に基づいて前記微粒子を検出する計数回路と
を備えることを特徴とする分析装置。
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JP2016097830A JP6740703B2 (ja) | 2016-05-16 | 2016-05-16 | 分析方法及び分析装置 |
PCT/JP2017/016894 WO2017199731A1 (ja) | 2016-05-16 | 2017-04-28 | 分析方法及び分析装置 |
EP17799161.9A EP3460473B1 (en) | 2016-05-16 | 2017-04-28 | Analysis method and analysis device |
CN201780026892.4A CN109154608B (zh) | 2016-05-16 | 2017-04-28 | 分析方法以及分析装置 |
US16/176,264 US10520417B2 (en) | 2016-05-16 | 2018-10-31 | Analysis method and analysis device |
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JP2016097830A JP6740703B2 (ja) | 2016-05-16 | 2016-05-16 | 分析方法及び分析装置 |
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JP6740703B2 JP6740703B2 (ja) | 2020-08-19 |
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US (1) | US10520417B2 (ja) |
EP (1) | EP3460473B1 (ja) |
JP (1) | JP6740703B2 (ja) |
CN (1) | CN109154608B (ja) |
WO (1) | WO2017199731A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020020668A (ja) * | 2018-08-01 | 2020-02-06 | 株式会社Jvcケンウッド | 分析装置及び分析方法 |
WO2020195869A1 (ja) * | 2019-03-25 | 2020-10-01 | 株式会社Jvcケンウッド | 分析装置及び分析方法 |
WO2022065043A1 (ja) | 2020-09-24 | 2022-03-31 | 株式会社Jvcケンウッド | 細胞の状態の評価方法、及び評価キット |
WO2022196036A1 (ja) | 2021-03-17 | 2022-09-22 | 株式会社Jvcケンウッド | 結合体の形成方法、対象物質の測定方法、及びキット |
EP4088815A1 (en) | 2021-05-14 | 2022-11-16 | JVCKenwood Corporation | Production method for reaction unit, production kit for reaction unit, and measurement method for substance to be detected |
Families Citing this family (2)
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CN109243660B (zh) * | 2018-09-19 | 2024-04-30 | 深圳大学 | 一种基于手性依赖透镜激发的spp光镊装置 |
WO2020184377A1 (ja) * | 2019-03-13 | 2020-09-17 | 株式会社Jvcケンウッド | 分析用基板の作製方法、分析用基板及び分析ユニット |
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- 2017-04-28 EP EP17799161.9A patent/EP3460473B1/en active Active
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JP2020020668A (ja) * | 2018-08-01 | 2020-02-06 | 株式会社Jvcケンウッド | 分析装置及び分析方法 |
JP7208468B2 (ja) | 2018-08-01 | 2023-01-19 | 株式会社Jvcケンウッド | 分析装置及び分析方法 |
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WO2020195869A1 (ja) * | 2019-03-25 | 2020-10-01 | 株式会社Jvcケンウッド | 分析装置及び分析方法 |
WO2022065043A1 (ja) | 2020-09-24 | 2022-03-31 | 株式会社Jvcケンウッド | 細胞の状態の評価方法、及び評価キット |
WO2022196036A1 (ja) | 2021-03-17 | 2022-09-22 | 株式会社Jvcケンウッド | 結合体の形成方法、対象物質の測定方法、及びキット |
EP4088815A1 (en) | 2021-05-14 | 2022-11-16 | JVCKenwood Corporation | Production method for reaction unit, production kit for reaction unit, and measurement method for substance to be detected |
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CN109154608A (zh) | 2019-01-04 |
WO2017199731A1 (ja) | 2017-11-23 |
EP3460473A4 (en) | 2019-03-27 |
EP3460473B1 (en) | 2020-12-09 |
CN109154608B (zh) | 2021-11-09 |
US20190064048A1 (en) | 2019-02-28 |
US10520417B2 (en) | 2019-12-31 |
JP6740703B2 (ja) | 2020-08-19 |
EP3460473A1 (en) | 2019-03-27 |
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