JP2017178352A - Ptp package body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a PTP package body capable of improving visibility of information displayed on a tablet.SOLUTION: A PTP package body 1 includes a pocket part 100 for storing a tablet 20 having an information display part 21 on which information is displayed and a cover part 110 for sealing the pocket part 100. The pocket part 100 has a top surface part 101 which faces the information display part 21 of the tablet 20 when the tablet 20 is stored into the pocket part 100 and the top surface part 101 has such a bend part that a curvature radius Rp1 along at least one direction has an extent of a curvature radius Rt1 along at least one direction of the information display part 21 of the tablet 20 or less.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a PTP package having a pocket portion for accommodating a tablet.

  PTP (press-through-pack) packaging is generally used for packaging pharmaceuticals, etc., in order to seal the pocket part with a film formed with a pocket part for containing the medicines to be packed. Cover film. When a user takes out medicines, the user presses the medicines stored in the pocket part from the pocket part side toward the cover film side, and breaks the cover film with the medicines etc. stored in the pocket part. .

  By the way, on the surface of the tablet accommodated in the PTP package, information such as an active ingredient and a quantity may be displayed by printing or engraving. By forming the pocket portion of the PTP package with a transparent or translucent material, the user can confirm the information on the tablet before breaking the cover film of the PTP package and taking out the tablet.

  For example, Japanese Unexamined Patent Application Publication No. 2014-169089 (Patent Document 1) describes a PTP sheet and a manufacturing method thereof. In the PTP sheet described in Patent Document 1, when the sheet is accidentally dropped and the PTP sheet collides with the floor surface or the like from the peripheral edge of the sheet, the tablet stored in the pocket portion is placed on the side wall portion of the pocket portion. It is comprised so that it may collide at two points. Specifically, for example, the curvature radius of the curved wall portion of the pocket portion is smaller than the curvature radius of both end portions in the major axis direction of the tablet. By doing in this way, it aims at suppressing the deformation | transformation and crack of the pocket part at the time of the collision of a tablet, and aiming at suppression of the fall of the external appearance and quality of a PTP sheet.

JP 2014-169089 A

  However, in the PTP sheet described in Patent Document 1, even when the impact of causing deformation or cracking of the pocket portion at the time of collision of the tablet can be reduced, the appearance and quality are deteriorated due to a light impact during normal use. It cannot be suppressed. That is, even in normal transportation and carrying, the tablet may move in the pocket portion of the PTP package, the tablet and the inner surface of the pocket portion of the PTP package may be rubbed, and the components of the tablet may adhere to the inner surface of the pocket portion. . When the pocket part is formed of a transparent or translucent material, the pocket part may become cloudy, and it may be difficult to visually recognize information represented by printing or stamping on the surface of the tablet. In particular, when a brittle tablet such as an orally disintegrating tablet is accommodated in a PTP package, the tablet components are likely to adhere to the pocket portion, and the pocket portion is likely to become cloudy. In addition, when the information is displayed on the tablet surface by printing, even if the tablet is relatively difficult to collapse such as a film-coated tablet, the information can be visually recognized if the printed portion is rubbed against the inner surface of the pocket portion. It can be difficult.

  Then, the objective of this invention is providing the PTP package which can improve the visibility of the information displayed on the tablet.

  The present inventors have intensively studied a structure in which the components of the tablet are difficult to adhere to the inner surface of the pocket portion even when the tablet is fragile when the tablet moves in the pocket portion during normal transportation or carrying. As a result, by making a predetermined relationship between the curvature radius of the tablet surface and the curvature radius of the surface facing the tablet surface in the pocket portion, it is difficult for the components of the tablet to adhere to the inner surface of the pocket portion, It has been found that the information display part is less likely to rub against the inner surface of the pocket part.

  Based on the above knowledge, the PTP package according to the present invention includes a pocket portion for accommodating a tablet having an information display portion on which information is displayed, and a lid portion for sealing the pocket portion. The pocket portion has a top surface portion that faces the tablet information display portion when the tablet is accommodated in the pocket portion, and the top surface portion has a curvature radius along at least one direction of the tablet information display portion. It has a curved portion that is less than or equal to the radius of curvature along at least one direction.

  By doing in this way, the PTP package which can improve the visibility of the information displayed on the tablet can be provided.

  In the PTP package according to the present invention, the curved portion is preferably formed over the entire top surface portion.

  In the PTP package according to the present invention, the curved portion is preferably formed at a position where the distance from the lid portion is the largest in the top surface portion.

  In the PTP package according to the present invention, the radius of curvature of the curved portion is preferably smaller than the radius of curvature of the information display portion of the tablet.

  In the PTP package according to the present invention, the curvature radius of the curved portion is preferably equal to the curvature radius of the tablet information display portion.

  In the PTP package according to the present invention, the information display part is preferably formed in a curved surface shape.

  In the PTP package according to the present invention, the information display part of the tablet is preferably circular or elliptical.

  In the PTP package according to the present invention, the information display part of the tablet has an elliptical shape, and the curvature radius of the curved part is at least one of the minor axis direction and the major axis direction of the tablet information display part. The size is preferably equal to or smaller than the radius of curvature.

  In the PTP package according to the present invention, the tablet information display section preferably includes a first information display section and a second information display section formed separately.

  In the PTP package according to the present invention, the curved portion preferably includes a first curved portion having a first radius of curvature and a second curved portion having a second radius of curvature.

  In the PTP package according to the present invention, the tablet is preferably an uncoated tablet.

  In the PTP package according to the present invention, the tablet is preferably an orally disintegrating tablet.

  In the PTP package according to the present invention, the information display part is preferably formed by printing or engraving.

  In the PTP package according to the present invention, the curved portion is preferably transparent or translucent.

  In the PTP package according to the present invention, the curved portion is preferably colored.

It is the sectional side view (A) and top view (B) which show the PTP package body of 1st Embodiment, and the tablet accommodated in the PTP package body. It is a figure which shows the side cross section of the PTP package of 2nd Embodiment of the state in which the tablet was accommodated. It is a figure which shows the side cross section of the PTP package of 3rd Embodiment of the state in which the tablet was accommodated. It is a figure which shows the side cross section of the PTP package of the comparative example 1 of the state in which the tablet was accommodated. It is a figure which shows the side cross section of the PTP package of the comparative example 2 of the state in which the tablet was accommodated. It is a photograph which shows a state when the PTP package after shaking is seen from a direction perpendicular to the top surface portion of the pocket portion.

  Embodiments of the present invention will be described below.

(First embodiment)
As shown in FIG. 1, the PTP package 1 according to the first embodiment of the present invention mainly includes a pocket portion 100 and a lid portion 110 that seals the pocket portion 100. A tablet 20 is accommodated in the pocket portion 100.

  The pocket portion 100 is mainly composed of a top surface portion 101 facing the lid portion 110, a side wall portion 102, and an adhesive portion 103 bonded to the lid portion 110, and between the top surface portion 101 and the lid portion 110. There is a space. The top surface portion 101 is curved so that the outside is convex as a whole to form a curved portion having a curvature radius Rp1. The curved portion is formed at a position where the distance from the lid portion 110 is the largest in the top surface portion 101. The side wall portion 102 rises from the lid portion 110 at an angle of θp. The top surface portion 101 and the side wall portion 102 are curved so that the side wall portion 102 and the bonding portion 103 are convex so as to protrude inward through the curved portion 104 formed so as to protrude outward from the curvature radius Rp2. The whole is integrally formed through a curved portion 105 having a radius Rp3. The pocket part 100 is formed of a transparent or translucent material. The pocket part 100 may be colored. In addition, the number of the pocket parts 100 with which a PTP package is provided is not limited. Hereinafter, the top surface 101 side is the upper side of the PTP package 1, and the lid 110 side is the lower side of the PTP package 1.

  The tablet 20 is formed in a substantially cylindrical shape, and the upper surface of the tablet 20, that is, the surface facing the top surface portion 101, and the lower surface, that is, the surface facing the lid portion 110, are circular when viewed from above. It is curved with a radius of curvature Rt1 so as to be convex, and is formed into a curved surface. On the upper and lower surfaces of the tablet 20, there are formed information display portions 21 on which information such as active ingredients and amounts are displayed by printing, engraving, or other methods.

  In this embodiment, the curvature radius Rp1 of the top surface portion (curved portion) 101 of the pocket portion 100 and the curvature radius Rt1 of the information display portion 21 of the tablet 20 are the same size. In the present application, the information display unit 21 refers to the entire surface on which information is displayed in the tablet 20. In this embodiment, the information display unit 21 is formed on both the upper surface and the lower surface of the tablet 20, but may be formed on only one of them. Information may also be displayed on the side.

  When the tablet 20 is accommodated in the pocket portion 100, the information display portion 21 of the tablet 20 faces the top surface portion 101 that is a curved portion. The user can visually recognize the information display part 21 of the tablet 20 accommodated in the pocket part 100 from the outside.

  Further, the distance H from the inner surface of the top surface portion 101 of the pocket portion 100 to the inner surface of the lid portion 110 is larger by the distance C1 than the height between the upper surface and the lower surface of the tablet 20. Further, the radius rp of the pocket portion is larger than the radius rt of the tablet. By doing in this way, the tablet 20 can be easily accommodated in the pocket part 101.

  As described above, the PTP package 1 includes the pocket portion 100 for housing the tablet 20 having the information display portion 21 on which information is displayed, and the lid portion 110 that seals the pocket portion 100. The pocket portion 100 has a top surface portion 101 that faces the information display portion 21 of the tablet 20 when the tablet 20 is accommodated in the pocket portion 100, and the top surface portion 101 has a curvature radius Rp1 along at least one direction. Has a curved portion having a radius of curvature Rt1 along at least one direction of the information display portion 21 of the tablet 20.

  Since the radius of curvature Rp1 along at least one direction of the top surface portion 101 is equal to the radius of curvature Rt1 along at least one direction of the information display portion 21 of the tablet 20, the pocket portion when transporting or carrying. When the tablet 20 moves within 100, the entire surface of the information display unit 21 of the tablet 20 contacts the inner surface of the top surface portion 101.

  By doing in this way, even if the tablet 20 is a brittle dosage form such as an orally disintegrating tablet or other uncoated tablet, the impact is concentrated on only one point of the tablet 20 and the tablet 20 collapses. It is possible to prevent the components of the tablet 20 from adhering to the top surface portion 101 and causing the pocket portion 100 to become cloudy. In addition, even when the tablet 20 is a tablet that is relatively difficult to collapse, such as a film-coated tablet, and the information is displayed on the surface of the tablet 20 by printing, the impact is concentrated on only a part of the printing and printing is not possible. It can prevent rubbing. In this way, it is possible to provide the PTP package 1 that can improve the visibility of the information displayed on the tablet 20.

  In this embodiment, the curved portion is formed over the entire top surface portion 101. However, the curved portion having the curvature radius Rp1 equal to the curvature radius Rt1 of the information display unit 21 is a part of the top surface portion 101. It may be formed only on.

  In this embodiment, the surface on which the information display unit 21 is formed in the tablet 20 is circular, but may be formed in an elliptical shape, a polygonal shape, or other shapes.

  When the tablet information display portion is elliptical, the curvature radius of the curved portion may be smaller than the curvature radius of at least one of the minor axis direction and the major axis direction of the tablet information display portion. That's fine.

  In addition, for example, a dividing line is put in the center of the upper surface of the tablet 20, and the information display unit 21 is formed on a plurality of discontinuous surfaces, and the first display unit and the second display unit formed separately are provided. May be included.

(Second Embodiment)
As shown in FIG. 2, the PTP package 2 of the second embodiment of the present invention is different from the PTP package 1 (FIG. 1) of the first embodiment in that the top surface is convex to the outside of the pocket portion 200. The curvature radius Rp1 of the portion 201 is smaller than the curvature radius Rt1 of the information display unit 21 of the tablet 20. Further, the top surface portion 201 and the side wall portion 102 are integrally formed through a curved portion 204 having a curvature radius Rp2. The distance from the inner surface of the top surface portion 101 of the pocket portion 100 to the inner surface of the lid portion 110 is H. Members and portions denoted by the same reference numerals as those in FIG. 1 are the same as those in the first embodiment.

  When the tablet 20 is accommodated in the pocket portion 200 of the PTP package 2, not only a gap of a distance C1 is generated between the lower surface of the tablet 20 and the lid portion 110, but also the upper surface of the tablet 20 and the inner surface of the top surface portion 201. A gap having a distance C2 is generated between them.

  Thus, since the magnitude Rp1 of the curvature radius of the curved portion is smaller than the curvature radius Rt1 of the tablet information display portion 21, the tablet 20 does not contact the top surface portion 201 at one point of the information display portion 21. The top surface 201 is brought into contact with the entire periphery of the information display unit 21. Further, a gap having a distance C22 is formed between the tablet 20 and the inner surface of the top surface portion 201. By doing in this way, when the PTP package 2 is transported or carried, even if the tablet 20 is brittle like an orally disintegrating tablet, it is difficult to collapse, and the tablet component is difficult to adhere to the inner surface of the top surface portion 201, and the pocket portion 200 cloudiness can be prevented. In addition, even when the tablet 20 is a tablet that is relatively difficult to collapse, such as a film-coated tablet, and the information is displayed on the surface of the tablet 20 by printing, the impact is concentrated on only a part of the printing and printing is not possible. It can prevent rubbing.

  The curvature radius Rp1 of the top surface portion 101 is preferably 60% or more and 100% or less of the curvature radius Rt1 of the information display unit 21 of the tablet 20.

  Further, in the PTP package 2 of the second embodiment, the curved portion 204 having the curvature radius Rp2 may extend to a portion facing the information display portion 21. In this case, the top surface portion 201 facing the information display unit 21 has a so-called two-stage R including a curved portion having a curvature radius Rp1 and a curved portion having a curvature radius Rp2. When the top surface portion and / or the tablet surface has a plurality of curvature radii, if one of the curvature radii of the curved portion is at least one of the curvature radii of the information display portion in at least one direction Good.

  As described in the third embodiment, the upper surface or the lower surface of the tablet 20 may be formed to have a plurality of curvature radii, but the information display unit 21 of the tablet 20 includes only a single curvature radius Rt1. Preferably, the upper surface or the entire lower surface of the tablet 20 is formed so as to have only a single radius of curvature Rt1.

  Other configurations and operational effects of the second embodiment are the same as those of the first embodiment.

(Third embodiment)
As shown in FIG. 3, the PTP package 3 according to the third embodiment of the present invention is different from the PTP package 1 (FIG. 1) according to the first embodiment in that the top surface is convex to the outside of the pocket portion 300. The curvature radius Rp1 of the portion 301 is smaller than the curvature radius Rt1 of the information display unit 21 of the tablet 20. Further, the top surface portion 301 and the side wall portion 102 are integrally formed via a curved portion 304 having a radius of curvature Rp2. The distance from the inner surface of the top surface portion 301 of the pocket portion 300 to the inner surface of the lid portion 110 is H. The upper surface and the lower surface of the tablet 20 accommodated in the pocket portion 300 include a portion having a curvature radius Rt1 and a portion having a curvature radius Rt2, respectively.

  The information related to the tablet 20 is displayed, for example, in the portion of the curvature radius Rt1, and the portion of the curvature radius Rt1 forms the information display portion 21. Members and portions denoted by the same reference numerals as those in FIG. 1 are the same as those in the first embodiment.

  When the tablet 30 is stored in the pocket portion 300 of the PTP package 3, not only a gap of a distance C <b> 1 is generated between the lower surface of the tablet 30 and the lid portion 110, but also the upper surface of the tablet 30 and the inner surface of the top surface portion 301. A gap having a distance C2 is generated between them.

  Thus, since the magnitude Rp31 of the curvature radius of the curved portion is smaller than the curvature radius Rt1 of the tablet information display portion 21, the tablet 20 does not contact the top surface portion 301 at one point of the information display portion 21. The top surface 301 is brought into contact with the entire periphery of the information display unit 21. In addition, a gap having a distance C <b> 2 is formed between the tablet 20 and the inner surface of the top surface portion 301. If necessary, the size of the radius of curvature Rp1 of the top surface portion 301 may be reduced and the size of the gap distance C2 may be adjusted. By doing so, when the PTP package 3 is transported or carried, even if the tablet 20 is brittle like an orally disintegrating tablet, it is difficult to collapse, and the tablet components are less likely to adhere to the inner surface of the top surface portion 301, and the pocket portion 300 cloudiness can be prevented.

  Moreover, the information which concerns on the tablet 20 may be displayed on both the parts of the curvature radius Rt1 and the curvature radius Rt2. In this case, the information display unit 21 has two curvatures of curvature radii Rt1 and Rt2. Thus, when the information display unit 21 has a plurality of curvature radii in a continuous plane, the curvature radius of the top surface portion 301 of the pocket unit 300 is at least one of the information display unit 21 in at least one direction. Any size that is equal to or smaller than the radius of curvature is acceptable. In other words, information may be displayed on a portion of the surface of the tablet 20 having a curvature radius smaller than that of the top surface portion 301.

  Other configurations and operational effects of the third embodiment are the same as those of the first embodiment. In this embodiment, a portion having a radius of curvature Rt1 and a portion having a radius of curvature Rt2 are formed on both the upper surface and the lower surface of the tablet 20. However, only one of the upper surface and the lower surface of the tablet 20 is formed. A portion having a curvature radius Rt1 and a portion having a curvature radius Rt2 may be formed, and only the portion having a curvature radius Rt1 may be formed on the other of the upper surface and the lower surface of the tablet 20.

  EXAMPLES Hereinafter, although an Example demonstrates this invention more concretely, this invention is not limited by these Examples.

  The PTP packaging bodies of the following examples and comparative examples were prepared, tablets were accommodated, and after being fixed on a shaker and shaken as described later, the information visibility of the information display unit was confirmed.

Example 1
The PTP package 1 according to the first embodiment shown in FIG. 1 was used. As the pocket portion 100, an unstretched polypropylene film (CPP: thickness of 300 μm, manufactured by Mitsubishi Plastics) is used, and a sheet having an accommodating portion for a circular lock of φ10 mm (the curvature radius of the top surface portion (Rp1): 11.85 mm), It formed using the vacuum forming method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 63 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 17 μm). , Manufactured by Toyo Aluminum Co., Ltd.) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 5.65 mm, C1 was 0.65 mm, Rp2 was 1 mm, Rp3 was 0.60 mm, and θp was 82 °.

(Example 2)
The PTP package 1 of the second embodiment shown in FIG. 2 was used. As the pocket part 200, an unstretched polypropylene film (CPP: thickness of 300 μm, manufactured by Mitsubishi Plastics) is used, and a sheet having a receiving part for a circular lock of φ10 mm (the curvature radius (Rp1) of the top surface part: 9.0 mm), It formed using the vacuum forming method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 63 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 17 μm). , Manufactured by Toyo Aluminum Co., Ltd.) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 6.12 mm, C1 was 0.65 mm, C2 was 0.47 mm, Rp2 was 1 mm, Rp3 was 0.60 mm, and θp was 82 °.

(Example 3)
The PTP package 2 of the second embodiment shown in FIG. 2 was used. As the pocket part 200, an unstretched polypropylene film (CPP: thickness of 300 μm, manufactured by Mitsubishi Plastics) is used, and a receiving part for a 10 mm circular tablet (curvature radius of top part: 9.0 mm (Rp1) and 11.85 mm (Rp2) The sheet | seat which has)) was formed using the vacuum forming method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 63 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 17 μm). , Manufactured by Toyo Aluminum Co., Ltd.) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 5.88 mm, C1 was 0.65 mm, C2 was 0.23 mm, Rp3 was 0.60 mm, and θp was 82 °.

Example 4
The PTP package 2 of the second embodiment shown in FIG. 2 was used. As the pocket part 200, an unstretched polypropylene film (CPP: thickness of 300 μm, manufactured by Mitsubishi Plastics) is used, and a sheet having a receiving part for a 10 mm circular tablet (curvature radius (Rp1) of the top surface part: 11.85 mm), It formed using the vacuum forming method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 63 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 17 μm). , Manufactured by Toyo Aluminum Co., Ltd.) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 5.95 mm, C1 was 0.65 mm, C2 was 0.30 mm, Rp2 was 3 mm, Rp3 was 0.60 mm, and θp was 82 °.

(Example 5)
The PTP package 2 of the second embodiment shown in FIG. 2 was used. As the pocket part 200, an unstretched polypropylene film (CPP: thickness 300 μm, manufactured by Mitsubishi Plastics) is used, and a sheet having an accommodating part for a circular lock of φ10 mm (the curvature radius (Rp1) of the top surface part: 10.8 mm), It formed using the vacuum forming method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 63 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 17 μm). , Manufactured by Toyo Aluminum Co., Ltd.) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 5.65 mm, C1 was 0.45 mm, C2 was 0.20 mm, Rp2 was 2.09 mm, Rp3 was 0.60 mm, and θp was 82 °.

(Example 6)
The PTP package 2 of the second embodiment shown in FIG. 2 was used. As the pocket portion 200, an unstretched polypropylene film (CPP: thickness of 300 μm, manufactured by Mitsubishi Plastics) is used, and a sheet having a receiving portion for a circular lock of φ10 mm (the curvature radius (Rp1) of the top surface portion: 11.7 mm), It formed using the vacuum forming method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 63 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 17 μm). , Manufactured by Toyo Aluminum Co., Ltd.) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 5.65 mm, C1 was 0.55 mm, C2 was 0.10 mm, Rp2 was 1.95 mm, Rp3 was 0.60 mm, and θp was 82 °.

(Example 7)
The PTP package 2 of the second embodiment shown in FIG. 2 was used. As the pocket portion 200, an unstretched polypropylene film (CPP: thickness of 300 μm, manufactured by Mitsubishi Plastics) is used, and a sheet having an accommodating portion for a circular lock of φ10 mm (the curvature radius (Rp1) of the top surface portion: 10.0 mm), It formed using the vacuum forming method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 63 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 17 μm). , Manufactured by Toyo Aluminum Co., Ltd.) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 5.65 mm, C1 was 0.35 mm, C2 was 0.30 mm, Rp2 was 2.16 mm, Rp3 was 0.60 mm, and θp was 82 °.

(Example 8)
The PTP package 2 of the second embodiment shown in FIG. 2 was used. As the pocket part 200, an unstretched polypropylene film (CPP: thickness 300 μm, manufactured by Mitsubishi Plastics) is used, and a sheet having an accommodating part for a circular lock of φ10 mm (the curvature radius (Rp1) of the top surface part: 10.8 mm), It formed using the vacuum forming method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 63 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 17 μm). , Manufactured by Toyo Aluminum Co., Ltd.) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 5.45 mm, C1 was 0.25 mm, C2 was 0.20 mm, Rp2 was 2.16 mm, Rp3 was 0.60 mm, and θp was 82 °.

(Comparative Example 1)
A PTP package 91 shown in FIG. 4 was used. As shown in FIG. 4, the PTP package 91 of Comparative Example 1 is different from the PTP package 1 (FIG. 1) of the first embodiment in that the curvature of the top surface portion 901 that protrudes outward from the pocket portion 900. The radius Rp1 is larger than the curvature radius Rt1 of the information display unit 21 of the tablet 20. Further, the top surface portion 901 and the side wall portion 102 are integrally formed through a curved portion 904 having a curvature radius Rp2. Members and portions denoted by the same reference numerals as those in FIG. 1 are the same as those in the first embodiment.

  When the tablet 20 is accommodated in the pocket portion 900 of the PTP package 91, a gap having a distance C1 is generated between the lower surface of the tablet 20 and the lid portion 110. However, there is no gap between the upper surface of the tablet 20 and the inner surface of the top surface portion 9001. The upper surface of the tablet 20 and the inner surface of the top surface portion 901 are in contact at one point on the top of the tablet 20.

  An unstretched polypropylene film (CPP: thickness of 300 μm, manufactured by Mitsubishi Plastics) is used as the pocket 900, and a sheet having a receiving portion for a circular lock of φ10 mm (the curvature radius (Rp1) of the top surface portion: 18.0 mm) is vacuumed. It was formed using a molding method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 63 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 17 μm). , Manufactured by Toyo Aluminum Co., Ltd.) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 5.65 mm, C1 was 0.65 mm, Rp2 was 1 mm, Rp3 was 0.60 mm, and θp was 82 °.

Example 9
As the tablet shown in FIG. 3, a so-called two-stage R tablet was used. Example except that an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius [2 steps R]: 12.5 mm (Rt1) and 4.4 mm (Rt2), hardness 45 N)) having information display by engraving was used In the same manner as in Example 1, a PTP package was produced. The information display part was formed in a part having a curvature radius of 12.5 mm.

(Example 10)
As the tablet shown in FIG. 3, a so-called two-stage R tablet was used. Example except that an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius [2 steps R]: 12.5 mm (Rt1) and 4.4 mm (Rt2), hardness 45 N)) having information display by engraving was used In the same manner as in Example 2, a PTP package was produced. The information display part was formed in a part having a curvature radius of 12.5 mm.

(Example 11)
As the tablet shown in FIG. 3, a so-called two-stage R tablet was used. Example except that an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius [2 steps R]: 12.5 mm (Rt1) and 4.4 mm (Rt2), hardness 45 N)) having information display by engraving was used In the same manner as in No. 3, a PTP package was produced. The information display part was formed in a part having a curvature radius of 12.5 mm.

Example 12
As the tablet shown in FIG. 3, a so-called two-stage R tablet was used. Example except that an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius [2 steps R]: 12.5 mm (Rt1) and 4.4 mm (Rt2), hardness 45 N)) having information display by engraving was used In the same manner as in Example 4, a PTP package was produced. The information display part was formed in a part having a curvature radius of 12.5 mm.

(Comparative Example 2)
A PTP package 92 shown in FIG. 5 was used. As shown in FIG. 5, the PTP package 92 of Comparative Example 2 is different from the PTP package 91 (FIG. 4) of Comparative Example 1 in that the upper surface and the lower surface of the tablet 20 accommodated in the pocket portion 900 have a curvature. A portion having a radius Rt1 and a portion having a radius of curvature Rt2 are included. Information relating to the tablet 20 is displayed in the portion of the curvature radius Rt1, and the portion of the curvature radius Rt1 forms the information display portion 21. The members and portions denoted by the same reference numerals as those in FIG. 4 are as described in Comparative Example 1.

  When the tablet 20 is stored in the pocket portion 900 of the PTP package 92, a gap having a distance C1 is generated between the lower surface of the tablet 20 and the lid portion 110. However, there is no gap between the upper surface of the tablet 20 and the inner surface of the top surface portion 901. The upper surface of the tablet 20 and the inner surface of the top surface portion 901 are in contact at one point on the top of the tablet 20.

  In Comparative Example 2, Comparative Example 1 except that an intraoral rapidly disintegrating tablet (diameter: φ10 mm, curvature radius [2 steps R]: 12.5 mm and 4.4 mm, hardness 45 N) having information display by engraving was used. In the same manner, a PTP package was produced. The information display part was formed in a part having a curvature radius of 12.5 mm (Rt1).

(Example 13)
The PTP package 2 of the second embodiment shown in FIG. 2 was used. As the pocket part 200, an unstretched polypropylene film (CPP: thickness 300 μm, manufactured by Mitsubishi Plastics) is used, and a sheet having an accommodating part for a circular lock of φ10 mm (the curvature radius (Rp1) of the top surface part: 10.8 mm), It formed using the plug assist pressure forming method. Then, an intraoral quick disintegrating tablet (diameter: φ10 mm, curvature radius (Rt1): 11.85 mm, hardness 61 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 20 μm). , Made of UACJ foil) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 5.65 mm, C1 was 0.45 mm, C2 was 0.20 mm, Rp2 was 2.09 mm, Rp3 was 0.60 mm, and θp was 82 °.

(Example 14)
The PTP package 2 of the second embodiment shown in FIG. 2 was used. Using a non-stretched polypropylene film (CPP: thickness 300 μm, manufactured by Mitsubishi Plastics), a sheet having a receiving portion for a round tablet of φ8 mm (the curvature radius (Rp1) of the top surface portion: 8.5 mm) is plug-assisted pressure forming Formed using. Then, an intraoral rapidly disintegrating tablet (diameter: φ8 mm, curvature radius (Rt1): 9.45 mm, hardness 60 N) having information display by printing is put in the sheet storage part, and a lid (aluminum foil: thickness 20 μm). , Made of UACJ foil) was superposed on the seal part of the sheet and heated and pressurized to bond the seal part and the lid material to produce a PTP package. H was 4.55 mm, C1 was 0.35 mm, C2 was 0.20 mm, Rp2 was 1.50 mm, Rp3 was 0.60 mm, and θp was 82 °.

(Example 15)
A PTP package was produced in the same manner as in Example 1 except that an unstretched polypropylene film (orange CPP: thickness 300 μm, manufactured by Sumitomo Bakelite) was used.

(Example 16)
A PTP package was produced in the same manner as in Example 2 except that an unstretched polypropylene film (orange CPP: thickness 300 μm, manufactured by Sumitomo Bakelite) was used.

(Comparative Example 3)
A PTP package was produced in the same manner as in Comparative Example 1 except that an unstretched polypropylene film (orange CPP: thickness 300 μm, manufactured by Sumitomo Bakelite) was used.

(Example 17)
A PTP package was prepared in the same manner as in Example 1 except that film-coated tablets (diameter: φ9 mm, curvature radius (Rt1): 12 mm, hardness 208 N) having information display by printing were used.

(Evaluation)
The PTP packaging bodies obtained in Examples 1 to 17 and Comparative Examples 1 to 3 were fixed to a shaker (TAITEC RECIPRO SHAKER SR-20S: manufactured by Taitec Co., Ltd.), and the vertical direction was 300 times per minute. That is, it was shaken for 3 hours in a direction perpendicular to the surface of the lid. After shaking, the visibility of the information displayed on the tablets of the PTP package is performed by a sensory test (visual) by a test panel consisting of 7 people in their 20s to 60s, and the evaluation is scored by visual analog method (VAS) 10 was good information visibility and 0 was poor visibility. The evaluation results are shown in Table 1 and FIG.

  It should be considered that the embodiments and examples disclosed above are illustrative and non-restrictive in every respect. The scope of the present invention is defined by the terms of the claims, rather than the description above, and includes all modifications within the scope and meaning equivalent to the terms of the claims.

Claims (15)

A pocket portion for containing a tablet having an information display portion on which information is displayed;
A lid portion for sealing the pocket portion,
The pocket portion has a top surface portion facing the information display portion of the tablet when the tablet is accommodated in the pocket portion,
The top surface portion has a curved portion in which a curvature radius along at least one direction is a curved portion having a size equal to or smaller than a curvature radius along at least one direction of the information display portion of the tablet.   The PTP package according to claim 1, wherein the curved portion is formed over the entire top surface portion.   The PTP package according to claim 1, wherein the curved portion is formed at a position where the distance from the lid portion is the largest in the top surface portion.   The magnitude | size of the curvature radius of the said curved part is a PTP package body of any one of Claim 1- Claim 3 smaller than the curvature radius of the information display part of the said tablet.   4. The PTP package according to claim 1, wherein the curvature radius of the curved portion is equal to the curvature radius of the information display portion of the tablet. 5.   The PTP package according to any one of claims 1 to 5, wherein the information display unit is formed in a curved surface shape.   The PTP package according to any one of claims 1 to 6, wherein the information display part of the tablet is circular or elliptical.   The information display part of the tablet has an elliptical shape, and the radius of curvature of the curved part is not more than the radius of curvature of at least one of the minor axis direction and the major axis direction of the information display part of the tablet. The PTP package according to claim 7.   The PTP package according to any one of claims 1 to 6, wherein the tablet information display section includes a first information display section and a second information display section formed separately. 10. The curved portion according to any one of claims 1 to 9, wherein the curved portion includes a first curved portion having a first radius of curvature and a second curved portion having a second radius of curvature. PTP package.   The PTP package according to any one of claims 1 to 10, wherein the tablet is an uncoated tablet.   The PTP package according to claim 11, wherein the tablet is an orally disintegrating tablet.   The PTP package according to any one of claims 1 to 12, wherein the information display unit is formed by printing or stamping.   The PTP package according to any one of claims 1 to 13, wherein the curved portion is transparent or translucent.   The PTP package according to any one of claims 1 to 14, wherein the curved portion is colored.