JP2018110678A - Ptp package - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a PTP package which suppresses movement of a tablet in a pocket part and is excellent in productivity and cost property.SOLUTION: A PTP package comprises: a planar sheet part 10; a pocket part 2 protruded from one side 10a of the sheet part 10; and a cover part 11 bonded to another side 10b of the sheet part 10, for sealing the pocket part 2. The PTP package stores a tablet 3 in the pocket part 2, the tablet 3 comprises a main body part 30 and a pair of protrusion parts 31 protruded from both sides of the main body part 30. A center line 3a of the tablet 3 matches a center line 2a of the pocket part 2, and when the tablet 3 comes into contact with the pocket part 2, a space S is formed between the pocket part 2 and the tablet 3 on the center lines 2a, 3a.SELECTED DRAWING: Figure 3

Description

  The present invention relates to a PTP package in which tablets are stored in a pocket portion.

  A PTP (press-through package) package is widely used for packaging pharmaceutical tablets. The PTP package includes a plurality of pocket portions for storing tablets. The pocket portion is designed based on the shape, thickness, size, and the like of the tablet to be stored.

  By the way, as pharmaceutical tablets, there are uncoated tablets (bare tablets) formed by pressing raw materials themselves or processed powders. In recent years, among the uncoated tablets, there are oral disintegrating tablets that can be taken without water for the purpose of rapidly disintegrating in the oral cavity and preventing dysphagia and the like of the elderly and children.

  For brittle tablets such as uncoated tablets and orally disintegrating tablets, if the tablet vibrates in the pocket part due to vibration during transportation, the tablet and pocket part rub, the surface of the tablet is scraped, and the inner surface of the pocket part Tablet fine powder may adhere to the surface. In recent years, a product name, a product code, and the like are printed on the surface of the tablet, and the discrimination of the tablet is greatly improved. However, if the fine powder of the tablet adheres to the inner surface of the pocket portion, the discrimination is greatly impaired.

  As shown in FIG. 5, the conventional pocket portion 2 is designed to be larger than the tablet 3 so that the storage property of the tablet 3 in the pocket portion 2 is improved, and the center line 2 a on the inner surface of the pocket portion 2 and the tablet 3. It is comprised so that the centerline 3a may contact. Therefore, the tablet 3 that has contacted the inner surface of the pocket portion 2 easily rotates around the center line 3 a with vibration during conveyance, the surface of the tablet 3 is shaved, and fine powder of the tablet 3 is formed on the inner surface of the pocket portion 2. There is a problem that tends to adhere.

  In addition, a PTP package that restricts the range of movement of the brittle tablet in the pocket has been proposed (see, for example, Patent Document 1). However, it has a special shape in which a recess is provided inside the pocket portion, and there is a problem that it is inferior in productivity and cost.

  In addition, as a kind of pharmaceutical tablet, there is a film-coated tablet to which a film such as a water-soluble polymer is applied in order to mask light shielding and bitterness. In the film-coated tablet, there is no problem that fine powder of the tablet adheres to the inner surface of the pocket portion even if the tablet vibrates in the pocket portion due to vibration during transportation.

  However, there is a step of inspecting a tablet including a film-coated tablet accommodated in the pocket portion in an apparatus for manufacturing a PTP package and filling a pocket portion with a tablet including a film-coated tablet (see, for example, Patent Document 2). . In this inspection process, an optical camera or the like is used, whether or not the tablet is securely filled in the pocket portion, whether or not there is an abnormality in the shape or color of the tablet, whether or not foreign matter is mixed in the pocket portion, etc. Inspected.

  Since this inspection is performed during the transport of the manufactured PTP package, a false detection may occur if the tablet including the film-coated tablet moves in the pocket portion due to vibration during the transport of the PTP package. There is a problem that the accuracy of the inspection is lowered.

  On the other hand, when the tablet does not move in the pocket part, it is necessary to insert the tablet into the pocket part while pushing the tablet in order to securely fill the pocket part. The shape was not.

JP 2006-117325 A JP 2008-150089 A

  Therefore, the problem to be solved by the present invention is to provide a PTP package that suppresses the movement of the tablet in the pocket portion and is excellent in productivity and cost.

In order to solve the above problems, the PTP package according to the present invention is:
A PTP package comprising a planar sheet portion, a pocket portion protruding from one side of the sheet portion, and a cover portion that is bonded to the other side of the sheet portion and seals the pocket portion,
The PTP package contains tablets in the pocket,
The tablet includes a main body portion and a pair of protruding portions protruding from both sides of the main body portion,
When the center line of the tablet matches the center line of the pocket portion and the tablet contacts the pocket portion, a space is formed between the pocket portion and the tablet at the center line.

Preferably,
The pocket portion has a circular shape in plan view,
The main body has a cylindrical shape,
The protrusion has a circular shape in plan view and an arc shape in side view.

Preferably,
The protrusion has a first radius of curvature R1 in side view,
The pocket portion includes a curved portion having a second curvature radius R2 in side view, and a side wall portion connected to the curved portion,
The first curvature radius R1 is larger than the second curvature radius R2.

Preferably,
The ratio (R2 / R1) between the second curvature radius R2 and the first curvature radius R1 is 0.7 or more and 0.9 or less.

Preferably,
The protrusion is
An inner portion of a circular shape in a plan view having a third curvature radius R3 in a side view and being arranged on the center side in the plan view;
An outer portion having a ring shape in plan view and having a fourth side view radius of curvature R4 smaller than the third radius of curvature R3.
The pocket portion includes a curved portion having a second curvature radius R2 in side view, and a side wall portion connected to the curved portion,
The third radius of curvature R3 is larger than the second radius of curvature R2,
The curved portion contacts the outer portion.

Preferably,
The ratio (R2 / R3) between the second radius of curvature R2 and the third radius of curvature R3 is not less than 0.5 and not more than 0.8.

Preferably,
The tablet is an orally disintegrating tablet.

  The PTP package according to the present invention suppresses the movement of the tablet in the pocket portion and is excellent in productivity and cost.

The perspective view which shows a PTP package. The top view which shows a PTP package. The side view partial sectional view which shows the pocket part and tablet of 1st Embodiment. The side view partial sectional view which shows the pocket part and tablet of 2nd Embodiment. The side view partial sectional view which shows the conventional pocket part and a tablet.

  Hereinafter, an embodiment of a PTP package according to the present invention will be described based on the drawings.

  As shown in FIGS. 1 and 2, the PTP package 1 includes a plurality of pocket portions 2 having a circular shape in plan view. As shown in FIGS. 3 and 4, the PTP package 1 has a flat sheet portion 10, a pocket portion 2 that protrudes from one side 10 a of the sheet portion 10 and accommodates the tablet 3, and the other side 10 b of the sheet portion 10. And a cover portion 11 that is bonded and seals the pocket portion 2.

  The sheet portion 10 and the pocket portion 2 are made of a transparent synthetic resin material such as polyvinyl chloride, polypropylene, or polyethylene. For example, the pocket part 2 is formed by pressure forming or vacuum forming or the like on the planar sheet part 10.

  The cover part 11 consists of aluminum foil etc., for example, and after the tablet 3 is accommodated in the pocket part 2, it adheres to the sheet | seat part 10 and seals the pocket part 2. FIG.

  When taking out the tablet 3 from the pocket part 2, the cover part 11 is broken with the tablet 3 while crushing the pocket part 2, and the tablet 3 is discharged from the pocket part 2.

[First embodiment]
Based on FIG. 3, the pocket part 2 and the tablet 3 of 1st Embodiment are demonstrated.

The tablet 3 includes a columnar main body 30 and a pair of protrusions 31 and 31 protruding from both sides of the main body 30. Each protrusion 31 is formed in a circular shape in plan view and an arc shape in side view.
The main body 30 has a diameter φ1. The protrusion 31 has a first curvature radius R1 in side view.

  The pocket portion 2 includes a curved portion 20 facing the tablet 3 and a side wall portion 21 connected to the curved portion 20. The bending portion 20 has a second curvature radius R2 in side view. The side wall part 21 is a straight line when viewed from the side. The side wall portion 21 has a circular shape in plan view, and is configured such that its diameter increases as it approaches the cover portion 11 and decreases as it moves away from the cover portion 11.

  The pocket portion 2 has a diameter φ2 at one end of the side wall portion 21 (an end portion connected to the sheet portion 10). The diameter φ2 is larger than the diameter φ1 of the tablet 3 so that the pocket 2 can accommodate the tablet 3.

  The connecting portion between the curved portion 20 and the side wall portion 21 and the connecting portion between the side wall portion 21 and the sheet portion 10 have a small radius of curvature so as to be smooth.

  The first curvature radius R1 is larger than the second curvature radius R2 (R1> R2). Therefore, when the center line 3a of the tablet 3 coincides with the center line 2a of the pocket part 2 and the tablet 3 contacts the pocket part 2, a space is formed between the pocket part 2 and the tablet 3 at the center lines 2a and 3a. S is formed. Further, the bending portion 20 contacts the peripheral end portion 31 a of the protruding portion 31.

  The center line 2 a is a direction that passes through the center of the pocket portion 2 in a plan view and is perpendicular to the seat portion 10. The center line 3a is a direction passing through the centers on both sides of the main body 30 that is circular in plan view.

[Second Embodiment]
Based on FIG. 4, the pocket part 2 and the tablet 3 of 2nd Embodiment are demonstrated. In addition, in order to avoid duplication description, description of the same point as the said embodiment may be abbreviate | omitted.

  The protrusion 31 is formed in an arc shape when viewed from the side. The projecting portion 31 includes an inner portion 310 having a circular shape in a plan view disposed on the center side in plan view, and an outer portion 311 having a ring shape in a plan view disposed on the outer side in plan view. The inner part 310 and the outer part 311 are connected. The inner portion 310 has a third curvature radius R3 in side view. The outer portion 311 has a fourth curvature radius R4 in side view. The third curvature radius R3 is larger than the fourth curvature radius R4 (R3> R4).

  The curved portion 20 of the pocket portion 2 has a second curvature radius R2 in side view. The third curvature radius R3 is larger than the second curvature radius R2 (R3> R2). Therefore, when the center line 3a of the tablet 3 coincides with the center line 2a of the pocket part 2 and the tablet 3 contacts the pocket part 2, a space is formed between the pocket part 2 and the tablet 3 at the center lines 2a and 3a. S is formed. Further, the bending portion 20 contacts the outer portion 311 of the protruding portion 31.

<Evaluation test>
About each PTP packaging body of 1st Embodiment (FIG. 3), 2nd Embodiment (FIG. 4), and a prior art example (FIG. 5), a vibration testing machine (transport packaging testing machine made by IDEX Co., Ltd.:BF-50UT) Was used to evaluate whether or not the fine powder of the tablet 3 adheres to the inner surface of the pocket portion 2.

  The setting condition of the vibration tester was set to “transport packaging mode”, the PTP package of each example was stored in the cardboard box, and the cardboard box was vibrated with the vibration tester. An orally disintegrating tablet 3 was stored in the pocket portion 2 of the PTP package.

  20 minutes after the start of vibration (corresponding to 1000 km of truck), 40 minutes (corresponding to 2000 km), and 60 minutes (corresponding to 3000 km), the fine powder of the tablet 3 adhered to the inner surface of the pocket part 2 was visually confirmed.

In the first embodiment, the examples of (1) to (4) having the following dimensions were used.
(1) φ1 = 5mm, φ2 = 6.8mm
R1 = 6mm, R2 = 4.5mm, R2 / R1 = 0.75
(2) φ1 = 7mm, φ2 = 9.2mm
R1 = 10mm, R2 = 7mm, R2 / R1 = 0.7
(3) φ1 = 10 mm, φ2 = 12.6 mm
R1 = 14mm, R2 = 10.5mm, R2 / R1 = 0.75
(4) φ1 = 15 mm, φ2 = 18.2 mm
R1 = 19mm, R2 = 16mm, R2 / R1 = 0.84

In the second embodiment, the examples of (5) to (8) having the following dimensions were used.
(5) φ1 = 5 mm, φ2 = 6.2 mm
R3 = 6.5 mm, R4 = 2 mm, R2 = 3.5 mm, R2 / R3 = 0.53
(6) φ1 = 7mm, φ2 = 8.4mm
R3 = 8.5 mm, R4 = 2.8 mm, R2 = 5.5 mm, R2 / R3 = 0.65
(7) φ1 = 10mm, φ2 = 12mm
R3 = 11.5 mm, R4 = 4 mm, R2 = 8 mm, R2 / R3 = 0.7
(8) φ1 = 15mm, φ2 = 18mm
R3 = 16.5 mm, R4 = 6 mm, R2 = 12 mm, R2 / R3 = 0.73

  In the PTP package of the conventional example, adhesion of fine powder of the tablet 3 was recognized on the inner surface of the pocket portion 2 20 minutes after the start of vibration. It was difficult to identify the product code printed on the surface of the tablet 3 from the outside of the pocket portion 2. After 40 minutes and 60 minutes from the start of vibration, adhesion of fine powder of the tablet 3 to the inner surface of the pocket portion 2 was further increased. Therefore, it was difficult to further identify the product code printed on the surface of the tablet 3 from the outside of the pocket portion 2.

  In the PTP package of the first embodiment and the second embodiment, adhesion of fine powder of the tablet 3 is hardly recognized on the inner surface of the pocket portion 2 after 20 minutes, 40 minutes, and 60 minutes from the start of vibration. It was. Therefore, the product code printed on the surface of the tablet 3 could be identified from the outside of the pocket portion 2.

The present invention is not limited to the above embodiment, and the above configuration can be changed as appropriate. For example, the following modifications can be implemented, and the following modifications can be combined.
The pocket portion 2 may be oval or oval in plan view.
The main body 30 of the tablet 3 may be oval or oval in plan view.
-The protrusion part 31 of the tablet 3 is a planar view elliptical shape, an oval shape, etc., and side view trapezoid shape etc. may be sufficient.
-When the pocket part 2 and the tablet 3 are a plan view oval type | mold etc., a center means a gravity center.
Tablet 3 is a known pharmaceutical tablet including a plain tablet, an orally disintegrating tablet, a film-coated tablet, and the like.

  The effect of the present invention will be described.

(1) In the PTP package according to the present invention, when the center line 3a of the tablet 3 coincides with the center line 2a of the pocket portion 2 and the tablet 3 contacts the pocket portion 2, the pockets at the center lines 2a and 3a A space S is formed between the part 2 and the tablet 3.

  Therefore, since the pocket part 2 and the tablet 3 in the center lines 2a and 3a do not contact, the tablet 3 does not rotate around the center line 3a. Therefore, the PTP package can suppress the movement of the tablet 3 in the pocket portion 2. Therefore, the surface of the tablet 3 is not scraped, and the fine powder of the tablet 3 hardly adheres to the inner surface of the pocket portion 2. Further, the accuracy of inspection of the tablet 3 in the pocket portion 2 is improved. Moreover, it is not necessary to give the pocket part 2 and the tablet 3 a special shape, and it is excellent in productivity and cost efficiency. Further, when the tablet 3 is filled in the pocket portion 2, it is not necessary to insert the tablet 3 into the pocket portion 2 while pushing the tablet 3, so that the tablet 3 can be quickly and reliably filled into the pocket portion 2.

(2) When the pocket portion 2 has a circular shape in plan view, the main body portion 30 of the tablet 3 has a cylindrical shape, and the protruding portion 31 has a circular shape in plan view and an arc shape in side view, the center lines 2a and 3a When the pocket portion 2 and the tablet 3 come into contact with each other, the tablet 3 easily rotates around the center line 3a.

  However, in the present invention, since the pocket portion 2 and the tablet 3 at the center lines 2a and 3a do not contact each other, the tablet 3 does not rotate around the center line 3a due to the frictional force.

(3) The protruding portion 31 has a first side curvature radius R1 in side view, and the pocket portion 2 has a curved portion 20 having a second side curvature radius R2 in side view, a side wall portion 21 connected to the curved portion 20, and The first radius of curvature R1 is larger than the second radius of curvature R2.

  Thereby, the pocket part 2 and the tablet 3 in the center lines 2a and 3a are not in contact with each other, and the peripheral edge part 31a of the tablet 3 is in contact with the pocket part 2, so that the tablet 3 is center line by the frictional force of contact. There is no rotation around 3a. Moreover, it is not necessary to give the pocket part 2 and the tablet 3 a special shape, and it is excellent in productivity and cost efficiency.

(4) As a result of the evaluation test, when the ratio (R2 / R1) of the second curvature radius R2 and the first curvature radius R1 is 0.7 or more and 0.9 or less, even in long-distance transportation, the pocket portion The discrimination of tablet 3 from the outside of 2 was good.

(5) The projecting portion 31 is disposed on the center side in the plan view, and has a circular inner side portion 310 having the third curvature radius R3 in the side view, and is disposed on the outer side in the plan view, and has a third curvature radius. An outer portion 311 having a ring-side fourth curvature radius R4 in a ring shape smaller than R3, and the pocket portion 2 is connected to the bending portion 20 and the bending portion 20 having the second curvature radius R2 in side view. The curved portion 20 is in contact with the outer portion 311 and the third radius of curvature R3 is larger than the second radius of curvature R2.

  Thereby, the pocket part 2 and the tablet 3 in the center lines 2a and 3a are not in contact with each other, and the outer part 311 of the tablet 3 is in contact with the pocket part 2, so that the tablet 3 is centered on the center line 3a by the frictional force of contact. No rotation around. Further, since the contact between the outer portion 311 of the tablet 3 and the pocket portion 2 is not a line contact but a surface contact, the contact frictional force is also large. Moreover, it is not necessary to give the pocket part 2 and the tablet 3 a special shape, and it is excellent in productivity and cost efficiency.

(6) As a result of the evaluation test, when the ratio (R2 / R3) of the second curvature radius R2 and the third curvature radius R3 is 0.5 or more and 0.8 or less, even in long-distance transportation, the pocket portion The discrimination of tablet 3 from the outside of 2 was good.

(7) Even if the tablet is a brittle orally disintegrating tablet, in the present invention, the discrimination of the tablet 3 from the outside of the pocket portion 2 is good after long distance transportation.

DESCRIPTION OF SYMBOLS 1 PTP package 10 Sheet | seat part 10a One side 10b of a sheet | seat part 11 The other side of a sheet | seat part 11 Cover part 2 Pocket part 20 Curved part 21 Side wall part 2a Centerline of a pocket part 3 Tablet 30 Main body part 31 Projection part 310 Inner part 311 Outer Part 3a Tablet center line S space

Claims (7)

A PTP package comprising: a planar sheet portion; a pocket portion protruding from one side of the sheet portion; and a cover portion that is bonded to the other side of the sheet portion and seals the pocket portion. ,
The PTP package contains tablets in the pocket portion,
The tablet includes a main body part and a pair of projecting parts projecting from both sides of the main body part,
When the center line of the tablet coincides with the center line of the pocket portion and the tablet contacts the pocket portion, a space is formed between the pocket portion and the tablet at the center line. Characteristic PTP package. The pocket portion has a circular shape in plan view,
The main body has a cylindrical shape,
The PTP package according to claim 1, wherein the protrusion has a circular shape in a plan view and an arc shape in a side view. The protrusion has a first curvature radius R1 in side view,
The pocket portion includes a curved portion having a second curvature radius R2 in side view, and a side wall portion connected to the curved portion,
The PTP package according to claim 2, wherein the first curvature radius R1 is larger than the second curvature radius R2. The PTP package according to claim 3, wherein a ratio (R2 / R1) between the second curvature radius R2 and the first curvature radius R1 is 0.7 or more and 0.9 or less. The protrusion is
An inner portion of a circular shape in a plan view having a third curvature radius R3 in a side view and being arranged on the center side in the plan view;
An outer portion having a ring shape in plan view and having a fourth curvature radius R4 in side view smaller than the third radius of curvature R3, and disposed outside in plan view.
The pocket portion includes a curved portion having a second curvature radius R2 in side view, and a side wall portion connected to the curved portion,
The third radius of curvature R3 is larger than the second radius of curvature R2.
The PTP package according to claim 2, wherein the curved portion is in contact with the outer portion. The PTP package according to claim 5, wherein a ratio (R2 / R3) of the second radius of curvature R2 and the third radius of curvature R3 is 0.5 or more and 0.8 or less. The PTP package according to any one of claims 1 to 6, wherein the tablet is an orally disintegrating tablet.

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