JP2004196424A - Wrapping material and its manufacturing method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a wrapping material which is suitable for housing or wrapping medical goods or the like such as a tablet, a capsule or the like, enhances discrimination, through a colored resin layer, of description on a surface of the tablet or the like or description on a surface of an aluminum foil integrated into one body on the resin layer and can be used for a blister or the like, and to provide its effective manufacturing method. <P>SOLUTION: The wrapping material is formed of a polyolefin and has a colored resin layer. In the preferable embodiments of the wrapping material, the resin layer is formed of a colored polyolefin film, Brightness L of the colored polyolefin-made film by a transmitting type measurement is not less than 40, and the polyolefin is preferably a mode of polypropylene. The seal temperature of wrapping material is not lower than 230 °C and at least 1.6MPa seal pressure. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

  INDUSTRIAL APPLICABILITY The present invention is suitable for storing or enclosing pharmaceuticals such as tablets, capsules, etc., and on a colored resin layer, notation on the surface of a tablet or the like or notation on an aluminum foil surface integrated with the resin layer. The present invention relates to a packaging material which is excellent in its discriminability when viewed, and can be suitably used as a blister or the like, and an efficient production method thereof.

  Press-through pack (PTP) packaging has been used as a pharmaceutical package from the viewpoint of protecting formulations such as tablets and capsules from deterioration and deterioration due to humidity. Conventional packaging of tablets and the like by the press-through pack (PTP) uses a polyvinyl chloride (PVC) film and aluminum foil, and forms several recesses slightly larger than tablets and capsules in the PVC film. After filling the tablets and capsules into the PVC film, the aluminum foil is pressed on the PVC film.

  Drugs may cause side effects or worsen symptoms if ingested or the like. For this reason, from the viewpoint of preventing erroneous dispensing actions in hospitals, clinics, etc., accidental ingestion of patients, and the like, it is strongly demanded that the notation in the names, symbols, and the like of tablets and capsules be easily distinguished.

In the case of the above-mentioned press-through pack (PTP) packaging, the names and symbols of tablets and capsules to be included are printed on both front and back surfaces by using aluminum foil, so that tablets and capsules as inclusions are included. The type is designed to be easily visible from both sides.
In the conventional press-through pack (PTP) packaging, since the highly transparent PVC film is used as the resin layer, it is easy to see the notation on the aluminum foil through the PVC film. It could be determined. However, since the PVC film generates hydrogen chloride after decomposition and causes acid rain and dioxin, its use has recently tended to be restricted, and instead of the PVC film, it is preferable from the viewpoint of environmental protection. A polypropylene (PP) film has been used as a raw material, and the usage rate of the PP film has increased from 5% in 1997 to 25% in 2002.

  However, in the case of the PP film, since the transparency was lower than that of the PVC film, when this was used for the press-through pack (PTP) packaging, the aluminum foil was seen through the PP film. In this case, there is a problem that the discrimination of names, symbols, and the like of tablets, capsules, and the like printed on the aluminum foil is poor. In particular, in order to maintain the long-term stability of a light-labile drug, the discriminability when using the PP film colored for the purpose of shading is remarkably inferior. ing. Under such circumstances, some PP films with enhanced transparency (see Patent Literatures 1 to 3) have been proposed. However, when a colored PP film is used, the discrimination is improved. Improvement has not yet been considered.

JP-A-59-143613 JP-A-11-129417 JP-A-11-309822

  An object of the present invention is to achieve the following objects. That is, the present invention solves the above-mentioned problems in the prior art, and is suitable for containing or containing medicines such as tablets, capsules, and the like. It is an object of the present invention to provide a packaging material which is excellent in its discrimination property when looking at the notation on the surface of an aluminum foil integrated with the above, and can be suitably used as a blister or the like, and an efficient production method thereof.

Means for solving the above problem are as follows. That is,
<1> A packaging material formed of a polyolefin and having a colored resin layer.
<2> The packaging material according to <1>, wherein the resin layer is formed using a colored polyolefin film.
<3> The packaging material according to any one of <1> to <2>, wherein the colored polyolefin film blocks 90% or more of light having a wavelength of 580 nm or less.
<4> The packaging material according to any one of <2> to <3>, wherein the lightness L value of the colored polyolefin film in a transmission measurement is 40 or more.
<5> The packaging material according to any one of <2> to <4>, wherein a colored polyolefin film is formed at a sealing temperature of 230 ° C or higher and a sealing pressure of 0.16 MPa or higher. .
<6> The packaging material according to any one of <2> to <5>, wherein the colored polyolefin film has a single-layer structure.
<7> The packaging material according to any one of <1> to <6>, wherein the colored polyolefin film has a thickness of 0.25 to 0.3 mm or less.
<8> The packaging material according to any one of <5> to <7>, wherein the sealing temperature is 230 to 300 ° C.
<9> The packaging material according to any one of <5> to <8>, wherein the sealing pressure is 0.16 to 0.5 MPa.
<10> The packaging material according to any one of <1> to <9>, wherein the polyolefin is polypropylene.
<11> The packaging material according to any one of <1> to <10>, which is a blister.
<12> A packaging material obtained by molding a colored polyolefin film at a sealing temperature of 230 ° C or higher and a sealing pressure of 0.16 MPa or higher.
<13> A method for producing a packaging material, characterized in that a colored polyolefin film is formed at a sealing temperature of 230 ° C. or more and a sealing pressure of 0.16 MPa or more.
<14> The method for producing a packaging material according to <13>, wherein the sealing temperature is 230 to 300 ° C.
<15> The method for producing a packaging material according to any one of <13> to <14>, wherein the sealing pressure is 0.16 to 0.5 MPa.
<16> The method for producing a packaging material according to any one of <13> to <15>, wherein the colored polyolefin film blocks 90% or more of light having a wavelength of 580 nm or less.
<17> The method for producing a packaging material according to any one of <13> to <16>, wherein the lightness L value of the colored polyolefin film measured by a transmission method is 40 or more.
<18> The method for producing a packaging material according to any one of <13> to <17>, wherein the colored polyolefin film has a thickness of 0.25 to 0.3 mm or less.
<19> The method for producing a packaging material according to any one of <13> to <18>, wherein the polyolefin is polypropylene.
<20> The method for producing a packaging material according to any one of <13> to <19>, wherein the packaging material is a blister.

  According to the present invention, the above-mentioned problems in the related art are solved, and tablets and capsules are suitable for accommodating or enclosing pharmaceuticals and the like. It is possible to provide a packaging material which is excellent in its discriminability when looking at the notation on the surface of the integrated aluminum foil and can be suitably used as a blister or the like, and an efficient production method thereof.

(Packaging material and its manufacturing method)
One packaging material of the present invention is formed of a polyolefin and has a colored resin layer. Another packaging material of the present invention is formed by molding a colored polyolefin film at a sealing temperature of 230 ° C. or higher and a sealing pressure of 0.16 MPa or higher. These packaging materials of the present invention can be suitably manufactured by the manufacturing method of the packaging material of the present invention. In the method for producing a packaging material of the present invention, a colored polyolefin film is formed at a sealing temperature of 230 ° C. or higher and a sealing pressure of 0.16 MPa or higher. Hereinafter, the packaging material of the present invention and the manufacturing method thereof will be described.

The shape, structure, size, material, and the like of the packaging material of the present invention are not particularly limited and can be appropriately selected depending on the purpose. For example, the colored resin layer is integrated with the colored resin layer. And at least a layer provided with a notation.
The layer provided with the above notation is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include aluminum foil, cardboard, and opaque resin films. Among these, when the packaging material is a blister of a drug or the like, an aluminum foil is preferably used.
The notation in the layer provided with the notation is not particularly limited and can be appropriately selected depending on the intended purpose.For example, when the packaging material is a blister of a drug or the like, it is usually contained or This is a notation such as the type of medicine to be included.
A concave portion is usually formed in the resin layer, and the object to be packed is accommodated or contained in the concave portion.

In the present invention, the resin layer is formed using a colored polyolefin film.
Here, the colored polyolefin film means a colored film having a light-shielding property, and a film having an L value of 40 or more measured by a transmission spectral colorimeter. Note that the L value is preferably 45 or more, and more preferably 48 or more. In these preferable cases, when the packaging material is, for example, a blister of a drug or the like, it is advantageous in that the storage stability of the drug or the like contained or contained therein is excellent.
The degree of the light-shielding property is not particularly limited and may be appropriately selected depending on the purpose. For example, it is preferable that 90% or more of light having a wavelength of 580 nm or less can be shielded.
The method for measuring the L value is not particularly limited and can be appropriately selected depending on the intended purpose. For example, the light source is set to C / 2 (halogen lamp), and a standard white plate (Y = 95.16; X = 93.22, Z = 112.67). In addition, from the viewpoint of measuring a color difference (ΔE value) from a film used as a reference in low-brightness reflection measurement, for example, a low-brightness measurement having a spectral reflectance of about 10% or less is used as a measurement device. For this purpose, an apparatus provided with a changeover switch for increasing the sensitivity of the optical unit is preferable. Examples of such an apparatus include SZ- # 90 manufactured by Nippon Denshoku Industries Co., Ltd.

The coloration of the colored polyolefin film is not particularly limited and may be any color. For example, an orange color (color number; red 2-481) is preferable.
The packaging material has the resin layer formed using the colored polyolefin film, and the resin layer has a function of preventing deterioration of drugs such as tablets and capsules which are unstable to light. It is suitable as a blister for pharmaceuticals and the like.

The polyolefin is not particularly limited and may be appropriately selected depending on the intended purpose.Examples include polyethylene, polypropylene, and polybutylene.Of these, polypropylene is preferred because of its small environmental load at the time of disposal. preferable.
The polyolefin film may be appropriately synthesized or may be a commercially available product. Examples of the commercially available product include Sumilite in the case of the polypropylene film (hereinafter sometimes referred to as “PP film”). NS-3480-UV (Sumitomo Bakelite Co., Ltd.) and the like are preferred.

  The structure of the colored polyolefin film is not particularly limited and may be appropriately selected depending on the intended purpose. However, the structure of the resin layer is a single-layer structure in that the thickness can be easily controlled or controlled. Is preferred. In this case, the resin layer formed of the polyolefin film also has a single-layer structure.

The resin layer may contain a member appropriately selected as needed. The member is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include a colorant and an ultraviolet absorber.
Examples of the ultraviolet inhibitor include, for example, benzotriazole compounds (described in U.S. Pat. No. 3,533,794), 4-thiazolidone compounds (described in U.S. Pat. No. 3,352,681), and benzophenone compounds (described in JP-A-46-2784). ) And ultraviolet absorbing polymers (described in JP-A-62-260152).

The molding of the resin layer is not particularly limited and can be performed according to a method appropriately selected from known methods according to the purpose, and a heating and pressing method is preferable.
The heating conditions and the pressing conditions when the resin layer is molded according to the heating and pressing method are not particularly limited, and can be appropriately selected depending on the purpose.
As the heating conditions, the sealing temperature is preferably 230 ° C. or higher, from the viewpoint of excellent discrimination of the notation in the layer provided with the notation as viewed through the obtained resin layer, and 230 to 300 ° C. C. is more preferable, and 230 to 260 C. is particularly preferable.
As the pressurizing condition, the sealing pressure is preferably 0.16 MPa or more, from the viewpoint of excellent discrimination of the notation in the layer provided with the notation as seen through the obtained resin layer. The pressure is more preferably from 16 to 0.5 MPa, and particularly preferably from 0.17 to 0.22 MPa.

  As a combination condition of the seal temperature and the seal pressure, the seal temperature is 180 ° C., the seal pressure is 0.22 MPa or more, the seal temperature is 200 ° C., the seal pressure is 0.21 MPa or more, and the seal temperature is 210 ° C. and the seal pressure is 210 ° C. Is 0.21 MPa or more, the sealing temperature is 220 ° C. and the sealing pressure is 0.19 MPa or more, the sealing temperature is 230 ° C. and the sealing pressure is 0.17 MPa or more, and the sealing temperature is 240 ° C. or more and the sealing pressure is 0.16 MPa or more. Preferably, the sealing temperature is 230 ° C. and the sealing pressure is 0.2 MPa or more, the sealing temperature is 240 ° C. and the sealing pressure is 0.19 MPa or more, and the sealing temperature is 260 ° C. or more and the sealing pressure is 0.16 MPa or more. The temperature is 240 ° C and the seal pressure is 0.21MPa or more. The seal temperature is 260 ° C or more and the seal pressure is 0.18MPa or more. Preferred.

  The thickness of the colored polyolefin film is not particularly limited and can be appropriately selected depending on the purpose. For example, the thickness is preferably 0.25 to 0.3 mm, and more preferably 0.3 mm.

  The packaging material according to the present invention is a packaging material in which a layer on which character information or the like is written is integrated with the resin layer so that the container is included in a state where the container is accommodated in a concave portion formed in the resin layer. Material, which is suitable when it is necessary to visually recognize and distinguish the notation of the character information and the like through the resin layer, including PTP for pharmaceuticals, blisters, etc., quasi-drugs, food, confectionery, toys, etc. It can be suitably used as a packaging material, and can be particularly preferably used as a pharmaceutical PTP, blister, or the like.

  Hereinafter, examples of the present invention will be specifically described, but the present invention is not limited to these examples.

(Example 1)
A polypropylene film (single-layer film, manufactured by Sumitomo Bakelite Co., Ltd., Sumilite NS-3480-UV, thickness 0.3 mm) colored in orange (color number: Red 2-481) is preheated in advance to increase flexibility. A polypropylene film is used as a bottom plate and supplied to a PTP filling machine (manufactured by CK Corporation, FBP-600UC) at a speed of 10.5 m / min. The recess was filled with a tablet. Thereafter, the name of the medicine is written on both front and back sides, and an aluminum foil coated with a hot-melt adhesive as a sealing agent is pressure-formed (plug-assisted) under the conditions of sealing temperature and sealing pressure shown in Table 2. The resulting polypropylene film was pressed and heated to be integrated. Thus, a blister filled with the drug was manufactured. The lightness L value of the polypropylene film measured by a transmission spectral colorimeter (SZ- # 90, manufactured by Nippon Denshoku Industries Co., Ltd.) was 40 or more.

Table 1 shows how much the notation printed on the surface of the aluminum foil is visible (through) the colored polypropylene film on the obtained blister, that is, the discrimination of the notation is shown in Table 1. It was visually evaluated in accordance with a five-stage appearance color evaluation standard.
Further, the color difference (ΔE) was measured by low-brightness reflection measurement using the spectral colorimeter. The results are shown in Tables 2 and 3.

なお、表２中の数値は、表１中に示す評価を意味する。

In addition, the numerical value in Table 2 means the evaluation shown in Table 1.

(Comparative Example 1)
Example 1 was the same as Example 1 except that the lightness L value of the polypropylene film measured by a transmission type spectral colorimeter was 40 or less.

(Comparative Example 2)
In Example 1, it carried out similarly to Example 1 except having replaced the PP film with the PVC film (Sumitomo Bakelite Co., Ltd. product, Sumilite VSS1101-UV3).

  The transparency of the colored PVC film itself is examined by transmission measurement, and the L value of the colored PVC is 53.70.

  The measurement of the color difference (ΔE) by the low brightness reflection type measurement in Example 1 and Comparative Example 1 is based on the L value, a value, and b value of Comparative Example 2 (PVC film) (visible by reflecting the aluminum foil surface through the film). Color data) was measured, and the measurement was similarly performed based on the measured values. In the method of measuring the color difference (ΔE), the color difference was measured using an aluminum foil which was colored solid black and only the indicated portions were colored. This is because the notation discrimination of packaging materials using PVC has been confirmed to be very high by visual inspection, so that the difference from PVC is visually determined, and the difference between PVC and PVC is measured by low-brightness reflection measurement using a spectral colorimeter. Are compared to determine the discriminability.

  From the results of Tables 2 and 3, it is clear that the packaging material of the present invention has excellent notation discrimination and has no adverse effect on the environment.

The packaging material of the present invention is excellent in its distinctiveness when the notation on the surface of a tablet or the like or the notation on the surface of an aluminum foil integrated with the resin layer is excellent throughout the colored resin layer. It is suitable for applications in which notations such as character information are visually recognized and discriminated through layers, and can be suitably used for quasi-drugs, foods, confectioneries, toys, and the like, including PTPs for pharmaceuticals, blisters, and the like.

Claims (20)

  A packaging material comprising a polyolefin and having a colored resin layer.   The packaging material according to claim 1, wherein the resin layer is formed using a colored polyolefin film.   3. The packaging material according to claim 1, wherein the colored polyolefin film blocks 90% or more of light having a wavelength of 580 nm or less. 4.   The packaging material according to any one of claims 2 to 3, wherein the lightness L value of the colored polyolefin film in a transmission type measurement is 40 or more.   The packaging material according to any one of claims 2 to 4, wherein a colored polyolefin film is formed at a sealing temperature of 230 ° C or higher and a sealing pressure of 0.16 MPa or higher.   The packaging material according to any one of claims 2 to 5, wherein the colored polyolefin film has a single-layer structure.   The packaging material according to any one of claims 1 to 6, wherein the thickness of the colored polyolefin film is 0.25 to 0.3 mm or less.   The packaging material according to any one of claims 5 to 7, wherein the sealing temperature is 230 to 300 ° C.   The packaging material according to any one of claims 5 to 8, wherein the sealing pressure is 0.16 to 0.5 MPa.   The packaging material according to any one of claims 1 to 9, wherein the polyolefin is polypropylene.   The packaging material according to any one of claims 1 to 10, which is a blister.   A packaging material obtained by molding a colored polyolefin film at a sealing temperature of 230 ° C. or higher and a sealing pressure of 0.16 MPa or higher.   A method for producing a packaging material, wherein a colored polyolefin film is formed at a sealing temperature of 230 ° C. or more and a sealing pressure of 0.16 MPa or more.   The method for producing a packaging material according to claim 13, wherein the sealing temperature is 230 to 300C.   The method for producing a packaging material according to any one of claims 13 to 14, wherein the sealing pressure is 0.16 to 0.5 MPa.   The method for producing a packaging material according to any one of claims 13 to 15, wherein the colored polyolefin film blocks 90% or more of light having a wavelength of 580 nm or less.   The method for producing a packaging material according to any one of claims 13 to 16, wherein the lightness L value of the colored polyolefin film measured by a transmission method is 40 or more.   The method for producing a packaging material according to any one of claims 13 to 17, wherein the thickness of the colored polyolefin film is 0.25 to 0.3 mm or less.   The method for producing a packaging material according to any one of claims 13 to 18, wherein the polyolefin is polypropylene.   The method for producing a packaging material according to any one of claims 13 to 19, wherein the packaging material is a blister.